KEGG   PATHWAY: gat04020
Entry
gat04020                    Pathway                                
Name
Calcium signaling pathway - Gasterosteus aculeatus (three-spined stickleback)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
gat04020  Calcium signaling pathway
gat04020

Other DBs
GO: 0019722
Organism
Gasterosteus aculeatus (three-spined stickleback) [GN:gat]
Gene
120832473  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
120823009  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
120824582  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
120821400  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
120821401  sodium/calcium exchanger 2-like [KO:K05849]
120813119  sodium/calcium exchanger 1-like [KO:K05849]
120822178  sodium/calcium exchanger 1-like [KO:K05849]
120834865  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
120835188  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
120818098  atp2b1a; plasma membrane calcium-transporting ATPase 1a isoform X1 [KO:K05850] [EC:7.2.2.10]
120809894  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
120828981  atp2b3b; plasma membrane calcium-transporting ATPase 3b [KO:K05850] [EC:7.2.2.10]
120820946  chrm3a; muscarinic acetylcholine receptor M3 [KO:K04131]
120819761  muscarinic acetylcholine receptor M1 [KO:K04131]
120832543  chrm5a; muscarinic acetylcholine receptor M5a [KO:K04133]
120808426  muscarinic acetylcholine receptor M5-like [KO:K04133]
120832059  adenosine receptor A2a-like [KO:K04266]
120830360  adora2aa; LOW QUALITY PROTEIN: adenosine A2a receptor a [KO:K04266]
120822464  adora2b; adenosine receptor A2b [KO:K04267]
120819287  adrb1; beta-1 adrenergic receptor [KO:K04141]
120818107  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
120821781  beta-2 adrenergic receptor-like [KO:K04142]
120830601  adrb3a; adrenoceptor beta 3a [KO:K04143]
120822810  drd1b; dopamine receptor D1b [KO:K04144]
120817540  drd1a; D(1) dopamine receptor [KO:K04144]
120825612  D(1A) dopamine receptor-like [KO:K04144]
120834724  drd5a; D(1B) dopamine receptor [KO:K05840]
120820200  D(1)-like dopamine receptor [KO:K05840]
120817380  hrh2a; histamine receptor H2a [KO:K04150]
120821405  hrh2b; histamine receptor H2b [KO:K04150]
120831518  5-hydroxytryptamine receptor 4-like isoform X1 [KO:K04160]
120818007  htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
120824877  5-hydroxytryptamine receptor 4 [KO:K04160]
120811925  htr5ab; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate b isoform X1 [KO:K04161]
120829909  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
120831240  htr7c; 5-hydroxytryptamine receptor 7 [KO:K04163]
120820967  5-hydroxytryptamine receptor 7 [KO:K04163]
120835150  guanine nucleotide-binding protein G(s) subunit alpha-like isoform X1 [KO:K04632]
120829642  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
120816039  guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
120811607  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(olf) subunit alpha-like [KO:K04633]
120816002  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
120824385  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
120810605  adcy2a; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
120826532  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
120810053  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
120811617  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
120808486  LOW QUALITY PROTEIN: adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
120825138  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
120827674  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
120816180  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
120823962  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
120825751  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
120827282  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
120819045  pln; cardiac phospholamban [KO:K05852]
120828319  sarcolipin [KO:K22642]
120831359  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
120832057  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b isoform X1 [KO:K05853] [EC:7.2.2.10]
120824897  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
120819150  atp2a1l; LOW QUALITY PROTEIN: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like [KO:K05853] [EC:7.2.2.10]
120827205  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
120821634  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
120819113  sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
120818126  LOW QUALITY PROTEIN: stromal interaction molecule 1-like [KO:K16059]
120822947  stim2b; stromal interaction molecule 2 isoform X1 [KO:K18196]
120825794  stromal interaction molecule 2-like isoform X1 [KO:K18196]
120832131  orai1b; calcium release-activated calcium channel protein 1 [KO:K16056]
120830329  calcium release-activated calcium channel protein 1-like [KO:K16056]
120822934  orai2; protein orai-2 isoform X1 [KO:K16057]
120818340  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
120835798  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
120829866  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
120828763  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04853]
120814961  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
120835575  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
120829078  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b isoform X1 [KO:K04857]
120827313  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
120831493  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
120830281  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
120823822  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
120815831  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
120819163  cacna1g; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
120827895  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04855]
120824749  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
120827659  cacna1ia; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
120831572  chrna7a; neuronal acetylcholine receptor subunit alpha-7a [KO:K04809]
120816962  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
120825163  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
120810484  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
120826583  chrna11; cholinergic receptor, nicotinic, alpha 11 isoform X1 [KO:K04809]
120831888  grin1a; glutamate receptor ionotropic, NMDA 1a isoform X1 [KO:K05208]
120827606  grin2aa; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
120825001  grin2bb; glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b isoform X1 [KO:K05210]
120827916  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
120819441  glutamate receptor ionotropic, NMDA 2C-like isoform X1 [KO:K05211]
120828035  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
120809972  glutamate receptor ionotropic, NMDA 2D [KO:K05212]
120832185  grin3a; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3A [KO:K05213]
120833150  glutamate receptor ionotropic, NMDA 3B-like isoform X1 [KO:K05214]
120823396  grin3bb; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
120821978  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
120830231  p2rx2; P2X purinoceptor 2 isoform X1 [KO:K05216]
120817452  p2rx3a; P2X purinoceptor 3a [KO:K05217]
120825826  p2rx3b; P2X purinoceptor 3b [KO:K05217]
120830358  P2X purinoceptor 4-like [KO:K05218]
120821512  p2rx5; P2X purinoceptor 5 isoform X1 [KO:K05219]
120827939  P2X purinoceptor 5-like [KO:K05219]
120817717  ryr1b; ryanodine receptor 1b isoform X1 [KO:K04961]
120822199  ryanodine receptor 1-like isoform X1 [KO:K04961]
120819737  ryr2a; ryanodine receptor 2 isoform X1 [KO:K04962]
120820824  ryr2b; ryanodine receptor 2 [KO:K04962]
120832509  ryanodine receptor 3-like isoform X1 [KO:K04963]
120808424  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
120808243  spore wall protein 2-like isoform X1 [KO:K23449]
120816502  casq1a; calsequestrin-1a isoform X1 [KO:K23468]
120813748  LOW QUALITY PROTEIN: calsequestrin-1-like [KO:K23468]
120834426  casq2; LOW QUALITY PROTEIN: calsequestrin-2 [KO:K23445]
120820778  calsequestrin-2-like [KO:K23445]
120813001  aspartyl/asparaginyl beta-hydroxylase-like isoform X1 [KO:K00476] [EC:1.14.11.16]
120818296  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
120813288  cysteinyl leukotriene receptor 2-like [KO:K04322]
120818375  chrm2a; muscarinic acetylcholine receptor M2a [KO:K04130]
120809871  muscarinic acetylcholine receptor M2-like [KO:K04130]
120812186  LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M2-like [KO:K04130]
120831356  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
120831811  adra1ab; alpha-1A adrenergic receptor [KO:K04135]
120817633  alpha-1A adrenergic receptor-like [KO:K04136]
120824876  adra1d; alpha-1D adrenergic receptor [KO:K04137]
120811966  agtr1b; type-1A angiotensin II receptor [KO:K04166]
120825732  ednraa; endothelin receptor type Aa [KO:K04197]
120822095  endothelin receptor type B-like isoform X1 [KO:K04197]
120833745  ednrbb; endothelin receptor type B [KO:K04198]
120816485  ednrba; endothelin receptor Ba [KO:K04198]
120818050  endothelin receptor type B-like [KO:K04198]
120831137  f2r; LOW QUALITY PROTEIN: proteinase-activated receptor 1 [KO:K03914]
120831731  LOW QUALITY PROTEIN: proteinase-activated receptor 1-like [KO:K03914]
120833264  grm1b; metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
120807652  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
120822131  grm5a; glutamate receptor, metabotropic 5a [KO:K04604]
120815686  grm5b; metabotropic glutamate receptor 5b [KO:K04604]
120834371  gastrin-releasing peptide receptor-like [KO:K04169]
120811097  gastrin-releasing peptide receptor-like [KO:K04169]
120835795  hrh1; histamine H1 receptor isoform X1 [KO:K04149]
120834185  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2A-like [KO:K04157]
120823866  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
120821104  lutropin-choriogonadotropic hormone receptor-like isoform X1 [KO:K04248]
120829761  ntsr1; neurotensin receptor type 1 [KO:K04211]
120835247  oxtr; oxytocin receptor [KO:K04229]
120809721  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
120816376  ltb4r2b; leukotriene B4 receptor 2b [KO:K04297]
120833160  platelet-activating factor receptor-like [KO:K04279]
120833181  platelet-activating factor receptor-like [KO:K04279]
120824801  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
120827189  ptger1c; prostaglandin E receptor 1c (subtype EP1) [KO:K04258]
120828187  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
120823861  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
120824447  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
120833217  bdkrb1; B1 bradykinin receptor [KO:K03916]
120833218  B2 bradykinin receptor-like [KO:K03916]
120833219  B2 bradykinin receptor-like [KO:K03916]
120833220  B2 bradykinin receptor-like [KO:K03916]
120833221  B2 bradykinin receptor-like [KO:K03916]
120831046  tacr1a; tachykinin receptor 1a [KO:K04222]
120834986  tacr2; substance-K receptor [KO:K04223]
120825008  tacr3l; tachykinin receptor 3-like [KO:K04224]
120825737  tacr3a; tachykinin receptor 3a [KO:K04224]
120823799  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
120829853  thyrotropin-releasing hormone receptor [KO:K04282]
120809112  trhr2; thyrotropin releasing hormone receptor 2 [KO:K04282]
120810974  trhra; thyrotropin-releasing hormone receptor [KO:K04282]
120826637  trhrb; thyrotropin-releasing hormone receptor b [KO:K04282]
120834210  LOW QUALITY PROTEIN: cholecystokinin receptor [KO:K04194]
120822950  cckar; cholecystokinin receptor type A [KO:K04194]
120825695  LOW QUALITY PROTEIN: cholecystokinin receptor-like [KO:K04194]
120834068  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
120816637  C-X-C chemokine receptor type 4-like [KO:K04189]
120831436  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
120822838  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04634]
120830300  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
120833304  gna11b; guanine nucleotide-binding protein subunit alpha-11b isoform X1 [KO:K04635]
120823903  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04635]
120830463  gna14a; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
120824361  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
120818259  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
120834900  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
120828147  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
120813682  trinucleotide repeat-containing gene 18 protein-like [KO:K17386]
120818176  pdgfc; LOW QUALITY PROTEIN: platelet-derived growth factor C [KO:K05450]
120825608  pdgfd; platelet-derived growth factor D [KO:K05450]
120822726  fibroblast growth factor 1-like isoform X1 [KO:K18496]
120816997  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
120817426  fgf2; fibroblast growth factor 2 [KO:K18497]
120834449  fgf9; fibroblast growth factor 4A [KO:K04358]
120816872  fibroblast growth factor 4-like [KO:K04358]
120830111  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
120830542  fgf3; fibroblast growth factor 3 [KO:K04358]
120830569  fgf10b; fibroblast growth factor 10b [KO:K04358]
120824363  fgf22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
120809458  fibroblast growth factor 6-like isoform X1 [KO:K04358]
120817986  fgf20b; fibroblast growth factor 20b [KO:K04358]
120818034  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
120818258  fibroblast growth factor 6-like [KO:K04358]
120818323  fgf24; fibroblast growth factor 24 [KO:K04358]
120825116  fibroblast growth factor 20-like [KO:K04358]
120818513  fgf16; fibroblast growth factor 16 [KO:K04358]
120825852  fgf8b; fibroblast growth factor 8b isoform X1 [KO:K04358]
120821082  fgf8a; fibroblast growth factor 8 isoform X1 [KO:K04358]
120812901  fgf7; fibroblast growth factor 7 [KO:K04358]
120813391  fgf4; fibroblast growth factor 4 [KO:K04358]
120814217  fgf5; fibroblast growth factor 5 [KO:K04358]
120834465  fgf19; fibroblast growth factor 19 [KO:K22603]
120819143  fgf21; fibroblast growth factor 21 [KO:K22429]
120818190  fgf23; fibroblast growth factor 23 [KO:K22428]
120809657  fibroblast growth factor 23-like [KO:K22428]
120812525  fibroblast growth factor 23-like [KO:K22428]
120808063  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
120817915  vegfba; vascular endothelial growth factor B [KO:K05448]
120810632  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
120808764  vegfd; vascular endothelial growth factor D [KO:K05449]
120824244  vascular endothelial growth factor C-like [KO:K05449]
120825733  vegfc; vascular endothelial growth factor C [KO:K05449]
120835834  ngfb; LOW QUALITY PROTEIN: nerve growth factor [KO:K02582]
120829856  ngfa; neurotrophin-7 [KO:K02582]
120808778  hepatocyte growth factor-like [KO:K05460]
120818299  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
120812715  hepatocyte growth factor-like [KO:K05460]
120834644  mst1; hepatocyte growth factor-like protein [KO:K23441]
120831357  glial cell line-derived neurotrophic factor-like [KO:K05452]
120831684  gdnfa; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
120816150  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
120811612  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
120819148  erbb2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
120835587  erbb3a; receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
120829080  erbb3b; receptor tyrosine-protein kinase erbB-3b isoform X1 [KO:K05084] [EC:2.7.10.1]
120833897  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
120825010  si:ch73-383l1.1; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
120824143  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
120817382  pdgfrb; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
120831703  fgfr1b; fibroblast growth factor receptor 1b isoform X1 [KO:K04362] [EC:2.7.10.1]
120830735  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
120817859  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca [KO:K05093] [EC:2.7.10.1]
120820493  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
120833006  fgfr3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
120822583  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
120817726  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
120811852  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
120817506  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
120824144  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
120810204  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
120831671  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
120830317  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
120835421  NT-3 growth factor receptor-like isoform X1 [KO:K05101] [EC:2.7.10.1]
120809241  NT-3 growth factor receptor-like isoform X1 [KO:K05101] [EC:2.7.10.1]
120809534  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
120835482  macrophage-stimulating protein receptor-like isoform X1 [KO:K05100] [EC:2.7.10.1]
120835136  mst1rb; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
120820232  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
120834088  plcd4b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
120822907  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
120819770  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like isoform X1 [KO:K05857] [EC:3.1.4.11]
120811918  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a isoform X1 [KO:K05857] [EC:3.1.4.11]
120828145  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A isoform X1 [KO:K05857] [EC:3.1.4.11]
120815618  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like isoform X1 [KO:K05857] [EC:3.1.4.11]
120832519  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
120808412  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
120808518  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
120820843  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
120822086  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
120823912  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
120808617  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
120819165  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
120809647  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1-like [KO:K05861] [EC:3.1.4.11]
120835398  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
120835789  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
120808946  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
120812471  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
120829151  itpr3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
120811807  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
120811890  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
120811891  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
120830515  tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
120835166  tpcn2; two pore calcium channel protein 2 [KO:K14077]
120825574  mcoln1a; mucolipin-1a [KO:K04992]
120827490  mcoln1b; mucolipin-1b [KO:K04992]
120823952  mcoln2; mucolipin-2 isoform X1 [KO:K04993]
120824200  mcoln3b; mucolipin-3 isoform X1 [KO:K04994]
120815671  mcoln3a; mucolipin-3 isoform X1 [KO:K04994]
120825085  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
120811037  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
120827599  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
120820866  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
120821969  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
120819421  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
120820659  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
120831086  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
120831755  zgc:56235; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
120817253  slc25a5; ADP/ATP translocase 2 [KO:K05863]
120825462  slc25a4; ADP/ATP translocase 1 [KO:K05863]
120822248  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
120819177  peptidyl-prolyl cis-trans isomerase A-like [KO:K09565] [EC:5.2.1.8]
120820209  ppifa; peptidylprolyl isomerase Fa isoform X1 [KO:K09565] [EC:5.2.1.8]
120829178  tnnc1b; troponin C type 1b (slow) isoform X1 [KO:K05865]
120828877  troponin C, slow skeletal and cardiac muscles isoform X1 [KO:K05865]
120829015  troponin C, skeletal muscle [KO:K12042]
120829016  tnnc2; troponin C, skeletal muscle isoform X1 [KO:K12042]
120831594  calml4a; calmodulin-like protein 4a [KO:K02183]
120832662  calm1a; calmodulin-1a isoform X1 [KO:K02183]
120807840  calmodulin-1 [KO:K02183]
120820584  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
120820837  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
120835316  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like [KO:K00871] [EC:2.7.11.19]
120819044  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
120811467  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
120812208  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
120822415  phka1a; LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
120833692  mylkb; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
120816425  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
120824084  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
120827945  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
120818925  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
120834852  calcium/calmodulin-dependent protein kinase type 1D-like isoform X1 [KO:K08794] [EC:2.7.11.17]
120834952  camk1a; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
120835087  camk1b; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
120829290  camk1gb; calcium/calmodulin-dependent protein kinase IGb [KO:K08794] [EC:2.7.11.17]
120817663  camk1da; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
120825607  calcium/calmodulin-dependent protein kinase type II delta 2 chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
120819535  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
120820869  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
120821702  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
120822206  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
120823668  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
120830982  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
120817636  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120821625  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120821676  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120815443  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like [KO:K04348] [EC:3.1.3.16]
120825347  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
120820412  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
120834936  tfeb; LOW QUALITY PROTEIN: transcription factor EB [KO:K15590]
120810967  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
120826826  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
120835123  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
120829609  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
120835154  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
120808971  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
120816378  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
120830799  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
120834058  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
120834807  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like [KO:K13755] [EC:3.1.4.17]
120816009  LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
120812001  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like [KO:K13755] [EC:3.1.4.17]
120812004  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like [KO:K13755] [EC:3.1.4.17]
120812008  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
120813196  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like [KO:K13755] [EC:3.1.4.17]
120814248  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like [KO:K13755] [EC:3.1.4.17]
120814787  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
120808070  ptk2bb; protein tyrosine kinase 2 beta, b [KO:K05871] [EC:2.7.10.2]
120824977  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
120832826  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
120823003  itpkca; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
120816936  uncharacterized protein LOC120816936 [KO:K00911] [EC:2.7.1.127]
120808414  itpkb; LOW QUALITY PROTEIN: inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
120826214  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
120825380  prkcaa; LOW QUALITY PROTEIN: protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
120828293  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
120825887  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120828414  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
120809973  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
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Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
gat04010  MAPK signaling pathway
gat04070  Phosphatidylinositol signaling system
gat04210  Apoptosis
KO pathway
ko04020   
LinkDB

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