KEGG   PATHWAY: gga04020
Entry
gga04020                    Pathway                                
Name
Calcium signaling pathway - Gallus gallus (chicken)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
gga04020  Calcium signaling pathway
gga04020

Other DBs
GO: 0019722
Organism
Gallus gallus (chicken) [GN:gga]
Gene
395759  SLC8A3; sodium/calcium exchanger 3 precursor [KO:K05849]
395760  SLC8A1; sodium/calcium exchanger 1 precursor [KO:K05849]
107057643  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
419934  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X2 [KO:K05850] [EC:7.2.2.10]
374244  ATP2B1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
415958  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
396364  CHRM1; muscarinic acetylcholine receptor M3 [KO:K04131]
428881  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
427705  ADORA2A; adenosine receptor A2a [KO:K04266]
395971  ADORA2B; adenosine receptor A2b [KO:K04267]
101750705  ADRB1; beta-1 adrenergic receptor [KO:K04141]
427623  ADRB2; beta-2 adrenergic receptor [KO:K04142]
430991  ADRB3; beta-3 adrenergic receptor [KO:K04143]
427633  DRD1; D(1A) dopamine receptor [KO:K04144]
428961  DD1CR; dopamine D1C receptor [KO:K05840]
770277  D(1) dopamine receptor-like [KO:K05840]
427552  DRD5; D(1B) dopamine receptor [KO:K05840]
427635  HRH2; histamine H2 receptor [KO:K04150]
422929  HRH2L; octopamine receptor isoform X1 [KO:K04150]
416150  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
428409  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
430019  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
422942  HTR7L; 5-hydroxytryptamine receptor 7 like [KO:K04163]
423794  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
419313  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
474379  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
420788  ADCY1; adenylate cyclase type 1 isoform X2 [KO:K08041] [EC:4.6.1.1]
420935  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
422013  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
415732  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
420328  ADCY8; adenylate cyclase type 8 isoform X2 [KO:K08048] [EC:4.6.1.1]
395339  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
424542  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X7 [KO:K04345] [EC:2.7.11.11]
396378  PLN; cardiac phospholamban [KO:K05852]
100857277  SLN; sarcolipin [KO:K22642]
395707  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
396446  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform 2 [KO:K05853] [EC:7.2.2.10]
419082  STIM1; stromal interaction molecule 1 [KO:K16059]
422799  STIM2; stromal interaction molecule 2 isoform X3 [KO:K18196]
416845  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
417509  ORAI2; protein orai-2 [KO:K16057]
395891  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
395895  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
395985  CATSPER2; voltage-dependent L-type calcium channel subunit alpha-1S isoform 1 [KO:K04857]
107049790  LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
374169  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
424412  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
769385  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
416526  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
427900  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
374001  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 precursor [KO:K04809]
396120  CHRNA7L; neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
404296  GRIN1; glutamate receptor ionotropic, NMDA 1 precursor [KO:K05208]
427678  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X2 [KO:K05209]
417965  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
431090  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
769001  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
429171  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
395190  P2RX1; P2X purinoceptor 1 [KO:K05215]
101749217  P2RX2; P2X purinoceptor 2 [KO:K05216]
423134  PGR2/3; P2X purinoceptor 3 precursor [KO:K05217]
428856  P2RX3; P2X purinoceptor 3 [KO:K05217]
374166  P2RX4; P2X purinoceptor 4 [KO:K05218]
395507  P2RX5; P2X purinoceptor 5 [KO:K05219]
429367  P2RX6; P2X purinoceptor 6 isoform X3 [KO:K05221]
771952  P2RX7; P2X purinoceptor 7 [KO:K05220]
101748756  RYR1L1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
421508  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
396111  RYR3; ryanodine receptor 3 [KO:K04963]
421721  TRDN; triadin [KO:K23449]
395198  CASQ2; calsequestrin-2 precursor [KO:K23445]
421142  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
428691  CYSLTR1; cysteinyl leukotriene receptor 1 isoform X3 [KO:K04322]
428071  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
418126  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
428203  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
373890  ADRA1B; alpha-1B adrenergic receptor isoform X1 [KO:K04136]
422933  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
396065  AGTR1; type-1 angiotensin II receptor [KO:K04166]
373908  EDNRA; endothelin-1 receptor precursor [KO:K04197]
373909  EDNRB2; endothelin receptor B subtype 2 precursor [KO:K04198]
408082  EDNRB; endothelin receptor type B precursor [KO:K04198]
427212  F2R; proteinase-activated receptor 1 isoform X4 [KO:K03914]
421614  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
373933  GRM5; metabotropic glutamate receptor 5 precursor [KO:K04604]
378928  GRPR; gastrin-releasing peptide receptor [KO:K04169]
100858928  HRH1; histamine H1 receptor [KO:K04149]
428070  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
428707  HTR2C; 5-hydroxytryptamine receptor 2C precursor [KO:K04157]
395581  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
395776  LHCGR; lutropin-choriogonadotropic hormone receptor precursor [KO:K04248]
428149  NTSR1; neurotensin receptor type 1 [KO:K04211]
429211  OXTR; oxytocin receptor [KO:K04229]
771773  AVPR1A; vasopressin V1a receptor [KO:K04226]
428263  AVPR1B; vasopressin V1b receptor [KO:K04227]
428209  PTAFR; platelet-activating factor receptor [KO:K04279]
429116  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
424548  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
772372  BDKRB1; B1 bradykinin receptor [KO:K03915]
428906  BDKRB2; B2 bradykinin receptor [KO:K03916]
395677  TACR1; substance-P receptor [KO:K04222]
768996  TACR2; substance-K receptor [KO:K04223]
768993  TACR3; neuromedin-K receptor [KO:K04224]
100857635  TBXA2R; thromboxane A2 receptor [KO:K04264]
395770  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
428144  thyrotropin-releasing hormone receptor-like [KO:K04282]
422801  CCKAR; cholecystokinin receptor type A [KO:K04194]
414885  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
395324  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
427262  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
374077  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
431611  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
408035  EGF; pro-epidermal growth factor precursor [KO:K04357]
414743  TGFA; protransforming growth factor alpha precursor [KO:K08774]
374196  PDGFA; platelet-derived growth factor subunit A preproprotein [KO:K04359]
374128  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
395469  PDGFC; platelet-derived growth factor C precursor [KO:K05450]
418978  PDGFD; platelet-derived growth factor D precursor [KO:K05450]
396094  FGF1; fibroblast growth factor 1 precursor [KO:K18496]
396413  FGF2; fibroblast growth factor 2 precursor [KO:K18497]
422330  FGF16; fibroblast growth factor 16 [KO:K04358]
428779  FGF20; fibroblast growth factor 20 [KO:K04358]
768907  FGF6; fibroblast growth factor 6 [KO:K04358]
378917  FGF9; fibroblast growth factor 9 [KO:K04358]
770457  FGF5; fibroblast growth factor 5 isoform X2 [KO:K04358]
415439  FGF7; fibroblast growth factor 7 [KO:K04358]
396267  FGF3; fibroblast growth factor 3 precursor [KO:K04358]
428857  FGF4; fibroblast growth factor 4 precursor [KO:K04358]
395453  FGF18; fibroblast growth factor 18 precursor [KO:K04358]
396313  FGF8; fibroblast growth factor 8 precursor [KO:K04358]
395432  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
100858338  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
395394  FGF19; fibroblast growth factor 19 precursor [KO:K22603]
428104  FGF23; fibroblast growth factor 23 [KO:K22428]
395909  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
395255  VEGFD; vascular endothelial growth factor D precursor [KO:K05449]
422573  VEGFC; vascular endothelial growth factor C [KO:K05449]
396466  NGF; beta-nerve growth factor precursor [KO:K02582]
395941  HGF; hepatocyte growth factor precursor [KO:K05460]
396135  MST1; hepatocyte growth factor-like protein precursor [KO:K23441]
395569  GDNF; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
396494  EGFR; epidermal growth factor receptor precursor [KO:K04361] [EC:2.7.10.1]
426130  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
693245  ERBB3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
395671  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
395509  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
770488  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
396516  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
396259  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
396515  FGFR3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
395603  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
374100  FLT1; vascular endothelial growth factor receptor 1 precursor [KO:K05096] [EC:2.7.10.1]
422316  VEGFRKDRL; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
395742  FLT4; vascular endothelial growth factor receptor 3 precursor [KO:K05097] [EC:2.7.10.1]
395323  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
396337  NTRK1; high affinity nerve growth factor receptor precursor [KO:K03176] [EC:2.7.10.1]
396157  NTRK2; BDNF/NT-3 growth factors receptor precursor [KO:K04360] [EC:2.7.10.1]
396081  NTRK3; NT-3 growth factor receptor precursor [KO:K05101] [EC:2.7.10.1]
396134  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
427573  MST1R; macrophage-stimulating protein receptor precursor [KO:K05100] [EC:2.7.10.1]
396107  RET; proto-oncogene tyrosine-protein kinase receptor Ret precursor [KO:K05126] [EC:2.7.10.1]
770074  uncharacterized protein LOC770074 [KO:K10784]
101750160  immunoglobulin epsilon heavy chain-like [KO:K06856]
420416  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X4 [KO:K05857] [EC:3.1.4.11]
424214  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X3 [KO:K05857] [EC:3.1.4.11]
428279  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X5 [KO:K05857] [EC:3.1.4.11]
423014  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858] [EC:3.1.4.11]
416730  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
427687  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
419175  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
776273  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
415805  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
425224  PLCE1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
418182  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
395412  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
418212  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
419910  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
422827  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
417033  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
423141  TPCN2; two pore calcium channel protein 2 [KO:K14077]
426164  MCOLN1; mucolipin-1 [KO:K04992]
424531  MCOLN2; mucolipin-2 isoform X2 [KO:K04993]
429091  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
427803  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
428942  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
416320  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
395498  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
426793  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
422546  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
374072  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
772225  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
423723  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
396032  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
396434  TNNC2; troponin C, skeletal muscle [KO:K12042]
396523  CALM1; neo-calmodulin [KO:K02183]
416692  CALML3; calmodulin, striated muscle [KO:K02183]
395855  CALM2; calmodulin [KO:K02183]
427515  CALML4; calmodulin-like protein 4 [KO:K02183]
417543  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
415741  PHKB; phosphorylase b kinase regulatory subunit beta [KO:K07190]
418612  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
422181  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
415748  MYLK3; myosin light chain kinase 3 isoform X2 [KO:K00907] [EC:2.7.11.18]
396445  MYLK; myosin light chain kinase, smooth muscle isoform 1 [KO:K00907] [EC:2.7.11.18]
396356  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
428278  MYLKSML; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
420893  MYLK4; myosin light chain kinase family member 4 isoform X2 [KO:K00907] [EC:2.7.11.18]
419859  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X2 [KO:K08794] [EC:2.7.11.17]
425522  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
416049  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
374174  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
374175  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
423737  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
422688  CAMK2D; calcium/calmodulin-dependent protein kinase type II delta chain [KO:K04515] [EC:2.7.11.17]
723973  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
427267  CAMK4L; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
378890  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
395113  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101748851  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
378804  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
419922  TFEB; transcription factor EB [KO:K15590]
420815  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X9 [KO:K04446]
419346  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
415711  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
427721  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
395807  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
107057170  nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
424116  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
420752  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
777528  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
421998  PTK2B; protein-tyrosine kinase 2-beta isoform X2 [KO:K05871] [EC:2.7.10.2]
416743  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
395694  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
417430  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
416567  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
gga04010  MAPK signaling pathway
gga04070  Phosphatidylinositol signaling system
gga04210  Apoptosis
KO pathway
ko04020   
LinkDB

DBGET integrated database retrieval system