KEGG   PATHWAY: hai04062
Entry
hai04062                    Pathway                                
Name
Chemokine signaling pathway - Hipposideros armiger (great roundleaf bat)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
hai04062  Chemokine signaling pathway
hai04062

Other DBs
GO: 0070098
Organism
Hipposideros armiger (great roundleaf bat) [GN:hai]
Gene
109371836  growth-regulated protein homolog gamma-like [KO:K05505]
109394813  growth-regulated protein homolog gamma-like [KO:K05505]
109371834  growth-regulated protein homolog gamma-like [KO:K05505]
109394816  C-X-C motif chemokine 6-like isoform X1 [KO:K05506]
109394815  PPBP; platelet basic protein isoform X1 [KO:K10029]
109394819  CXCL8; interleukin-8 [KO:K10030]
109371166  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
109371167  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
109371169  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
109395869  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
109377100  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
109394681  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
109394820  platelet factor 4-like [KO:K05407]
109382623  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
109385334  XCL1; lymphotactin isoform X1 [KO:K05507]
109395633  CX3CL1; fractalkine [KO:K05508]
109374977  CCL1; C-C motif chemokine 1 [KO:K05514]
109379758  C-C motif chemokine 3-like [KO:K05408]
109379755  regakine-1-like [KO:K05408]
109379751  C-C motif chemokine 4 [KO:K12964]
109373168  CCL5; C-C motif chemokine 5 [KO:K12499]
109374973  CCL7; C-C motif chemokine 7 [KO:K05509]
109374975  CCL8; C-C motif chemokine 8 [KO:K16596]
109374972  CCL11; eotaxin [KO:K16597]
109374976  C-C motif chemokine 13-like [KO:K16595]
109379750  C-C motif chemokine 15-like [KO:K05511]
109395623  CCL17; C-C motif chemokine 17 isoform X1 [KO:K21083]
109390508  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
109371763  C-C motif chemokine 21-like isoform X1 [KO:K16062]
109395637  CCL22; C-C motif chemokine 22 [KO:K21095]
109384985  CCL24; C-C motif chemokine 24 [KO:K21097]
109396102  CCL25; C-C motif chemokine 25 isoform X1 [KO:K13072]
109384986  CCL26; C-C motif chemokine 26 [KO:K21096]
109371780  CCL27; LOW QUALITY PROTEIN: C-C motif chemokine 27 [KO:K16598]
109371781  uncharacterized protein LOC109371781 isoform X1 [KO:K16598]
109392845  CCL28; C-C motif chemokine 28 isoform X1 [KO:K05513]
109380534  C-X-C chemokine receptor type 2-like isoform X1 [KO:K05050]
109380537  C-X-C chemokine receptor type 2-like [KO:K04175]
109385587  CXCR3; C-X-C chemokine receptor type 3 isoform X1 [KO:K04188]
109392711  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
109393894  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
109376804  CXCR6; C-X-C chemokine receptor type 6 isoform X1 [KO:K04191]
109375627  XCR1; chemokine XC receptor 1 [KO:K04193]
109393464  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
109393480  CCR8; C-C chemokine receptor type 8 [KO:K04183]
109391678  CCR6; C-C chemokine receptor type 6 [KO:K04181]
109376784  CCR9; C-C chemokine receptor type 9 isoform X1 [KO:K04184]
109377939  CCR4; C-C chemokine receptor type 4 [KO:K04179]
109380674  CCR7; C-C chemokine receptor type 7 [KO:K04182]
109375227  CCR2; C-C chemokine receptor type 2 isoform X1 [KO:K04177]
109375175  CCR5; C-C chemokine receptor type 5 [KO:K04180]
109375268  CCR1; C-C chemokine receptor type 1 [KO:K04176]
109375636  CCR3; C-C chemokine receptor type 3 [KO:K04178]
109395756  CCR10; C-C chemokine receptor type 10 isoform X1 [KO:K04185]
109384506  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
109382346  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
109393276  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
109396910  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
109395763  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
109377665  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
109375288  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
109392892  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
109373011  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
109375976  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
109385186  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
109393593  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
109387200  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
109393238  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
109383261  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
109372359  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
109392133  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
109385440  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109394225  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
109394449  LYN; tyrosine-protein kinase Lyn [KO:K05854] [EC:2.7.10.2]
109384426  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
109386779  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
109377191  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
109393422  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
109390676  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
109376923  SHC3; SHC-transforming protein 3 [KO:K17448]
109394486  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
109383688  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
109385471  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
109375221  SOS2; son of sevenless homolog 2 [KO:K03099]
109375639  HRAS; GTPase HRas isoform X1 [KO:K02833]
109385150  GTPase HRas-like [KO:K02833]
109389264  KRAS; GTPase KRas isoform X1 [KO:K07827]
109377015  NRAS; GTPase NRas [KO:K07828]
109384548  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109395605  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109385252  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109385803  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
109394900  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109381238  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109394108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109372681  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109382484  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109395865  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109373811  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
109375969  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
109395140  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
109395146  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
109391154  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
109381083  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109385878  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
109374859  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109385353  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109391421  FOXO3; forkhead box protein O3 [KO:K09408]
109379632  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109386279  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
109377344  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
109383860  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
109395326  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
109372541  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109384322  RELA; transcription factor p65 isoform X1 [KO:K04735]
109384256  BAD; bcl2-associated agonist of cell death [KO:K02158]
109374469  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
109388396  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
109388902  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
109381168  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
109374297  guanine nucleotide exchange factor VAV3 [KO:K05730]
109378054  VAV1; proto-oncogene vav [KO:K05730]
109375381  guanine nucleotide exchange factor VAV3-like isoform X1 [KO:K05730]
109380150  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109394502  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109393041  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
109376015  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
109396744  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
109374777  WAS; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
109376114  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
109388840  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
109386644  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
109391171  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
109374903  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
109373669  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
109372679  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
109394673  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
109384336  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
109384198  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
109387705  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
109385438  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
109390646  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
109372215  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
109371938  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
109394259  uncharacterized LOC105372280 homolog [KO:K04347]
109385811  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
109371939  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
109380824  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
109381865  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
109389817  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
109379373  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
109390857  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
109386147  paxillin-like [KO:K05760]
109386148  mediator of DNA damage checkpoint protein 1-like [KO:K05760]
109384807  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
109386906  CRK; adapter molecule crk isoform X1 [KO:K04438]
109376239  CRKL; crk-like protein [KO:K04438]
109379535  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
109385746  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
109378976  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
109378977  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
109384329  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
109383976  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
109379925  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
109378365  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
109384326  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
109373546  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
109381707  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
109388150  PARD3; partitioning defective 3 homolog [KO:K04237]
109393508  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
109386578  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
109395953  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
109384978  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
109384568  GRK7; LOW QUALITY PROTEIN: rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
109383915  GRK1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
109384296  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
109394134  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
109390911  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
109382992  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
109389794  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
109394691  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
109386336  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
hai04010  MAPK signaling pathway
hai04060  Cytokine-cytokine receptor interaction
hai04120  Ubiquitin mediated proteolysis
hai04630  JAK-STAT signaling pathway
hai04670  Leukocyte transendothelial migration
hai04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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