KEGG   PATHWAY: hai04151
Entry
hai04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Hipposideros armiger (great roundleaf bat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
hai04151  PI3K-Akt signaling pathway
hai04151

Other DBs
GO: 0043491
Organism
Hipposideros armiger (great roundleaf bat) [GN:hai]
Gene
109379436  EGF; pro-epidermal growth factor [KO:K04357]
109385384  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
109371839  EREG; proepiregulin [KO:K09784]
109371841  AREG; amphiregulin [KO:K09782]
109393705  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
109374154  FGF2; fibroblast growth factor 2 [KO:K18497]
109379381  FGF18; fibroblast growth factor 18 [KO:K04358]
109379623  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
109394542  FGF7; fibroblast growth factor 7 [KO:K04358]
109382437  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
109385680  FGF16; fibroblast growth factor 16 [KO:K04358]
109389289  FGF3; fibroblast growth factor 3 [KO:K04358]
109389290  FGF4; fibroblast growth factor 4 [KO:K04358]
109394578  FGF20; fibroblast growth factor 20 [KO:K04358]
109373530  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
109392478  FGF6; fibroblast growth factor 6 [KO:K04358]
109392844  FGF10; fibroblast growth factor 10 [KO:K04358]
109377773  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
109390582  FGF22; fibroblast growth factor 22 [KO:K04358]
109389288  FGF19; fibroblast growth factor 19 [KO:K22603]
109391024  FGF21; fibroblast growth factor 21 [KO:K22429]
109392469  FGF23; fibroblast growth factor 23 [KO:K22428]
109392809  NGF; beta-nerve growth factor [KO:K02582]
109387036  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
109373318  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
109391022  NTF4; neurotrophin-4 [KO:K12457]
109395936  INS; insulin [KO:K04526]
109387785  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
109395935  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
109380137  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
109392273  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
109372936  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
109394938  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
109371584  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
109376220  KITLG; kit ligand [KO:K05461]
109391102  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
109382864  VEGFA; vascular endothelial growth factor A [KO:K05448]
109384216  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
109381519  PGF; placenta growth factor isoform X1 [KO:K16859]
109395927  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
109387670  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
109392334  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
109375006  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
109388191  ANGPT2; angiopoietin-2 [KO:K05466]
109384341  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
109393452  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
109388439  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
109390629  EFNA2; ephrin-A2 [KO:K05462]
109393359  EFNA1; ephrin-A1 [KO:K05462]
109393364  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
109387040  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
109388552  NRTN; neurturin [KO:K25414]
109383362  ARTN; artemin isoform X1 [KO:K25415]
109388639  PSPN; persephin [KO:K25416]
109388365  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
109380800  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
109396911  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
109390432  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
109373149  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
109383003  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
109390958  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
109389796  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
109380655  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
109393379  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
109372375  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
109374619  BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
109396062  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
109380372  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
109381815  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
109375002  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
109374995  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
109381816  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
109395206  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
109395227  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
109390085  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
109392740  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
109381812  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
109389346  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
109388180  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
109389413  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
109395552  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
109383688  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
109385471  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
109375221  SOS2; son of sevenless homolog 2 [KO:K03099]
109375639  HRAS; GTPase HRas isoform X1 [KO:K02833]
109385150  GTPase HRas-like [KO:K02833]
109389264  KRAS; GTPase KRas isoform X1 [KO:K07827]
109377015  NRAS; GTPase NRas [KO:K07828]
109384548  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109385252  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109388626  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109385803  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
109394900  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109396328  IRS1; insulin receptor substrate 1 [KO:K16172]
109382017  TLR2; toll-like receptor 2 [KO:K10159]
109385740  TLR4; toll-like receptor 4 [KO:K10160]
109380150  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109375897  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
109385818  CD19; B-lymphocyte antigen CD19 [KO:K06465]
109380921  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
109380250  somatotropin [KO:K05438]
109381635  PRL; prolactin isoform X1 [KO:K05439]
109383043  OSM; oncostatin-M [KO:K05418]
109395924  IL2; interleukin-2 [KO:K05429]
109382577  IL3; interleukin-3 [KO:K04736]
109387871  IL6; interleukin-6 [KO:K05405]
109382592  IL4; interleukin-4 [KO:K05430]
109387835  IL7; interleukin-7 isoform X1 [KO:K05431]
109374670  interferon alpha-4-like [KO:K05414]
109396418  IFNB1; interferon beta [KO:K05415]
109374918  EPO; erythropoietin [KO:K05437]
109380729  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
109375245  GHR; growth hormone receptor isoform X1 [KO:K05080]
109385509  PRLR; prolactin receptor [KO:K05081]
109387069  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
109383783  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
109394467  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
109385585  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
109375560  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
109373511  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
109385965  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
109376825  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
109373231  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
109373246  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
109391584  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
109390482  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
109384938  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
109384506  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
109382346  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
109380648  COL1A1; collagen alpha-1(I) chain [KO:K06236]
109371948  COL1A2; collagen alpha-2(I) chain [KO:K06236]
109372512  COL2A1; collagen alpha-1(II) chain [KO:K19719]
109396325  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
109393347  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
109393353  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
109390501  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
109383936  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
109383910  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
109374954  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
109374373  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
109373828  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
109373829  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
109395820  collagen alpha-4(VI) chain-like [KO:K06238]
109380077  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
109383345  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
109394154  collagen alpha-1(IX) chain isoform X1 [KO:K08131]
109375466  laminin subunit alpha-2 [KO:K05637]
109377451  LAMA1; laminin subunit alpha-1 [KO:K05637]
109380081  LAMA5; laminin subunit alpha-5 [KO:K06240]
109390109  LAMA3; laminin subunit alpha-3 [KO:K06240]
109384762  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
109372668  LAMB1; laminin subunit beta-1 [KO:K05636]
109376158  laminin subunit beta-2-like isoform X1 [KO:K06243]
109376176  laminin subunit beta-2 isoform X1 [KO:K06243]
109396115  LAMB3; laminin subunit beta-3 [KO:K06244]
109372664  LAMB4; laminin subunit beta-4 [KO:K06245]
109379100  laminin subunit gamma-1 [KO:K05635]
109379101  LAMC2; laminin subunit gamma-2 [KO:K06246]
109380683  LAMC3; laminin subunit gamma-3 [KO:K06247]
109380758  CHAD; chondroadherin [KO:K06248]
109389504  RELN; reelin [KO:K06249] [EC:3.4.21.-]
109384080  THBS1; thrombospondin-1 [KO:K16857]
109381904  THBS4; thrombospondin-4 [KO:K04659]
109382454  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
109393407  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
109391677  THBS2; thrombospondin-2 [KO:K04659]
109380590  FN1; fibronectin isoform X1 [KO:K05717]
109396331  SPP1; osteopontin [KO:K06250]
109385176  VTN; vitronectin [KO:K06251]
109385116  TNN; tenascin-N [KO:K06252]
109385122  TNR; tenascin-R [KO:K06252]
109373091  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
109390423  TNC; tenascin isoform X1 [KO:K06252]
109373317  VWF; von Willebrand factor [KO:K03900]
109396344  IBSP; bone sialoprotein 2 [KO:K06253]
109382143  ITGA1; integrin alpha-1 [KO:K06480]
109382125  ITGA2; integrin alpha-2 [KO:K06481]
109394948  ITGA2B; integrin alpha-IIb [KO:K06476]
109380829  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
109392600  ITGA4; integrin alpha-4 [KO:K06483]
109391860  ITGA5; integrin alpha-5 [KO:K06484]
109390397  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
109396843  ITGA7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
109374603  ITGA8; integrin alpha-8 [KO:K06584]
109385214  ITGA9; integrin alpha-9 [KO:K06585]
109373692  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
109385221  ITGA11; integrin alpha-11 [KO:K06587]
109372713  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
109388160  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
109380323  ITGB3; integrin beta-3 [KO:K06493]
109383761  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
109387967  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
109379873  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
109391828  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
109386990  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
109390857  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
109381238  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109394108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109372681  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109382484  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109395865  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109373811  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
109381883  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
109384108  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
109388540  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
109379349  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
109382376  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
109372903  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
109385677  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
109373640  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
109387139  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
109391171  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
109374903  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
109373669  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
109372679  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
109394673  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
109384336  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
109384198  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
109387705  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
109385438  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
109390646  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
109372215  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
109371938  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
109394259  uncharacterized LOC105372280 homolog [KO:K04347]
109385811  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
109371939  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
109380824  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
109375969  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
109395140  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
109395146  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
109385875  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
109390619  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
109376169  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
109374016  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
109371588  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
109380979  TSC1; hamartin isoform X1 [KO:K07206]
109385868  TSC2; tuberin isoform X1 [KO:K07207]
109389671  RHEB; GTP-binding protein Rheb [KO:K07208]
109385872  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
109381262  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
109393012  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
109393572  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
109374404  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
109392932  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
109389770  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
109379764  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
109384219  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
109381955  eukaryotic translation initiation factor 4B [KO:K03258]
109391787  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
109387379  40S ribosomal protein S6 [KO:K02991]
109391475  RPS6; 40S ribosomal protein S6 [KO:K02991]
109380289  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
109394244  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
109376724  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
109380270  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
109371924  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
109375109  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
109381083  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109385878  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
109374859  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109385353  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109387882  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
109387530  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109374393  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
109382627  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
109382969  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
109388695  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
109377484  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
109392769  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
109391741  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
109374120  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
109383556  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
109375567  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
109383886  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
109389233  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
109381056  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
109379146  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
109384306  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
109382865  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
109375911  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
109381021  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
109382930  HSP90AB1; LOW QUALITY PROTEIN: heat shock protein HSP 90-beta [KO:K04079]
109387780  HSP90B1; endoplasmin [KO:K09487]
109391611  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
109373525  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
109389025  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
109390773  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
109382733  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
109373624  MTCP1; protein p13 MTCP-1 [KO:K16837]
109389680  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
109395752  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
109388396  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
109390996  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
109375142  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
109380001  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
109393663  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
109394967  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
109390294  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
109395716  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
109383211  MYC; myc proto-oncogene protein [KO:K04377]
109389297  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
109395991  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
109383166  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
109396882  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
109390747  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
109373596  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
109392488  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
109382891  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
109383495  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
109376215  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
109391421  FOXO3; forkhead box protein O3 [KO:K09408]
109383411  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
109385146  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109393533  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
109382800  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
109379983  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
109386669  YWHAQ; 14-3-3 protein theta [KO:K16197]
109386914  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
109383089  YWHAH; 14-3-3 protein eta [KO:K16198]
109385039  YWHAG; 14-3-3 protein gamma [KO:K16198]
109384256  BAD; bcl2-associated agonist of cell death [KO:K02158]
109384429  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
109373362  bcl-2-like protein 1 isoform X1 [KO:K04570]
109390784  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
109381302  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
109388316  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
109388738  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
109392248  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
109373471  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
109393756  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
109388532  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
109390233  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
109388636  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
109381368  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
109373089  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
109372291  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
109381229  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
109371418  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
109377344  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
109379632  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109386279  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
109384322  RELA; transcription factor p65 isoform X1 [KO:K04735]
109372541  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109371913  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
109381699  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
109394672  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
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Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
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Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
hai00010  Glycolysis / Gluconeogenesis
hai04010  MAPK signaling pathway
hai04012  ErbB signaling pathway
hai04062  Chemokine signaling pathway
hai04064  NF-kappa B signaling pathway
hai04068  FoxO signaling pathway
hai04110  Cell cycle
hai04115  p53 signaling pathway
hai04150  mTOR signaling pathway
hai04210  Apoptosis
hai04370  VEGF signaling pathway
hai04510  Focal adhesion
hai04620  Toll-like receptor signaling pathway
hai04630  JAK-STAT signaling pathway
hai04662  B cell receptor signaling pathway
hai04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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