KEGG   PATHWAY: hhv05169
Entry
hhv05169                    Pathway                                
Name
Epstein-Barr virus infection - Hyaena hyaena (striped hyena)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
hhv05169  Epstein-Barr virus infection
hhv05169

Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120230487  CR2; complement receptor type 2 [KO:K04012]
120242187  CD19; B-lymphocyte antigen CD19 [KO:K06465]
120238142  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
120238167  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
120238168  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
120238173  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
120238174  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
120238191  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
120238197  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
120238202  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
120238203  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
120238214  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
120238217  SLA class II histocompatibility antigen, DQ haplotype C beta chain [KO:K06752]
120233209  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
120235110  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
120246010  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
120221716  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
120232555  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
120233644  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
120237570  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
120231881  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
120243217  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
120233999  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
120226622  IKBKG; NF-kappa-B essential modulator [KO:K07210]
120248609  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
120222817  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120240185  RELA; transcription factor p65 [KO:K04735]
120221913  TNF; tumor necrosis factor [KO:K03156]
120236228  IL6; interleukin-6 isoform X1 [KO:K05405]
120241719  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
120225772  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
120244583  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
120233179  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
120228866  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
120223400  IRF7; interferon regulatory factor 7 [KO:K09447]
120244065  IRF3; interferon regulatory factor 3 [KO:K05411]
120239878  interferon alpha-like [KO:K05414]
120223241  interferon alpha-like [KO:K05414]
120223242  interferon alpha-like [KO:K05414]
120239877  IFNB1; interferon beta [KO:K05415]
120229314  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
120229615  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
120232606  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
120244482  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
120233455  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
120219936  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
120247003  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
120248750  EIF2AK2; LOW QUALITY PROTEIN: interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
120233382  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
120233460  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
120222964  2'-5'-oligoadenylate synthase 3-like [KO:K14216] [EC:2.7.7.84]
120231068  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
120242560  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
120223778  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
120233869  FADD; FAS-associated death domain protein [KO:K02373]
120220675  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
120243781  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
120231559  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
120245032  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
120243716  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
120238211  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
120224242  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
120232774  cytochrome c-like [KO:K08738]
120233433  cytochrome c-like [KO:K08738]
120221184  cytochrome c [KO:K08738]
120221556  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
120230330  cytochrome c [KO:K08738]
120231297  cytochrome c-like [KO:K08738]
120236951  cytochrome c-like [KO:K08738]
120247050  cytochrome c-like [KO:K08738]
120225026  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
120229837  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
120246375  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
120229941  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
120229957  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
120229959  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
120238260  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
120236351  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
120232093  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
120219760  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
120221742  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
120236583  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
120248557  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
120243615  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
120237268  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
120228452  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
120234188  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
120238111  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
120233353  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
120229077  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
120234192  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
120249015  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035]
120245843  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
120236954  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
120225099  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
120223420  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
120241304  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
120246116  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
120220629  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
120234954  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
120240916  SEM1; LOW QUALITY PROTEIN: 26S proteasome complex subunit SEM1 [KO:K10881]
120238159  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
120238160  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
120238209  tapasin [KO:K08058]
120232197  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
120243718  LOW QUALITY PROTEIN: calreticulin-like [KO:K08057]
120245285  CALR; calreticulin [KO:K08057]
120226363  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
120221878  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
120221918  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
120222660  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
120243816  B2M; beta-2-microglobulin [KO:K08055]
120231947  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
120235748  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
120243735  HDAC2; LOW QUALITY PROTEIN: histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
120231446  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
120237868  NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]
120239132  SAP30; histone deacetylase complex subunit SAP30 [KO:K19202]
120248987  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
120236398  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
120234700  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
120242629  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
120230662  HES1; transcription factor HES-1 [KO:K06054]
120244861  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
120230608  RUNX3; runt-related transcription factor 3 [KO:K09279]
120240874  MYC; myc proto-oncogene protein [KO:K04377]
120239827  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
120234269  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
120240795  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
120231386  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
120233834  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
120232638  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
120237943  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
120242325  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
120228475  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
120240722  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
120230541  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
120233608  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120220979  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
120246696  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120219997  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120239233  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120247089  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
120235277  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120244696  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120247774  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120222278  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
120242548  RELB; transcription factor RelB isoform X1 [KO:K09253]
120239622  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
120223347  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
120244615  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
120231261  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
120231429  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
120244848  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
120244180  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120232781  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120245677  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120226445  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
120241444  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
120228759  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
120230246  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
120233796  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
120233829  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
120234701  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
120235253  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
120236252  JUN; transcription factor AP-1 [KO:K04448]
120235101  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
120222785  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
120230583  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
120243315  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
120232548  CD44; CD44 antigen isoform X1 [KO:K06256]
120242213  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
120238785  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
120244477  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
120240973  VIM; vimentin [KO:K07606]
120239375  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
120239234  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
120248434  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
120222462  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
120237950  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
120219708  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
120227958  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
120220893  BTK; tyrosine-protein kinase BTK isoform X1 [KO:K07370] [EC:2.7.10.2]
120230555  BLNK; B-cell linker protein isoform X1 [KO:K07371]
120228197  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
120244162  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
120236900  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
120233874  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
120247732  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
120238692  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
120248012  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
120247482  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
120238030  CCNA2; cyclin-A2 [KO:K06627]
120245010  CCNA1; cyclin-A1 [KO:K06627]
120219657  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
120231725  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
120219963  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
120220837  RB1; retinoblastoma-associated protein [KO:K06618]
120242807  E2F1; transcription factor E2F1 [KO:K17454]
120232903  E2F2; transcription factor E2F2 [KO:K09389]
120235248  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
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Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
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Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
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Ning S
  Title
Innate immune modulation in EBV infection.
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Herpesviridae 2:1 (2011)
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Reference
PMID:28408983
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Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
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F1000Res 6:386 (2017)
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Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
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Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
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Trends Immunol 36:124-38 (2015)
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Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
hhv03050  Proteasome
hhv04010  MAPK signaling pathway
hhv04020  Calcium signaling pathway
hhv04064  NF-kappa B signaling pathway
hhv04110  Cell cycle
hhv04115  p53 signaling pathway
hhv04210  Apoptosis
hhv04612  Antigen processing and presentation
hhv04620  Toll-like receptor signaling pathway
hhv04622  RIG-I-like receptor signaling pathway
hhv04630  JAK-STAT signaling pathway
hhv04662  B cell receptor signaling pathway
KO pathway
ko05169   
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