KEGG   PATHWAY: maua05152
Entry
maua05152                   Pathway                                
Name
Tuberculosis - Mesocricetus auratus (golden hamster)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
maua05152  Tuberculosis
maua05152

Organism
Mesocricetus auratus (golden hamster) [GN:maua]
Gene
101843732  Tnf; tumor necrosis factor [KO:K03156]
101840696  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101844833  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101839512  Fadd; FAS-associated death domain protein [KO:K02373]
101825474  Casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101828960  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
110340167  Bid; BH3-interacting domain death agonist [KO:K04726]
101842912  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
106021303  cytochrome c, somatic [KO:K08738]
101842058  cytochrome c, somatic-like [KO:K08738]
110342638  cytochrome c, testis-specific [KO:K08738]
101840173  cytochrome c, somatic-like [KO:K08738]
121136793  cytochrome c, somatic [KO:K08738]
101828663  cytochrome c, somatic-like [KO:K08738]
121140190  cytochrome c, somatic-like [KO:K08738]
101844218  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101832699  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
101842312  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101825464  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101840296  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101836153  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
101833785  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
101830635  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5 [KO:K04515] [EC:2.7.11.17]
101833722  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X13 [KO:K04515] [EC:2.7.11.17]
101833285  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
101841273  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101825431  Ifng; interferon gamma precursor [KO:K04687]
101827289  Ifngr1; interferon gamma receptor 1 [KO:K05132]
101828108  Ifngr2; interferon gamma receptor 2 isoform X1 [KO:K05133]
101843653  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101831977  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101827798  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101825611  Ciita; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
101833879  Rfx5; DNA-binding protein RFX5 [KO:K08061]
101836168  Rfxank; DNA-binding protein RFXANK isoform X3 [KO:K08062]
101823038  regulatory factor X-associated protein [KO:K08063]
101834455  Nfya; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
101843839  Nfyb; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
101839606  Nfyc; nuclear transcription factor Y subunit gamma [KO:K08066]
101838929  Creb1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
110339871  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
110339725  H-2 class II histocompatibility antigen, E-D beta chain-like [KO:K06752]
101833734  H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752]
101829780  H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752]
101844521  class II histocompatibility antigen, M beta 1 chain [KO:K06752]
101834602  H-2 class II histocompatibility antigen, A-U alpha chain [KO:K06752]
101834868  rano class II histocompatibility antigen, A beta chain [KO:K06752]
101822444  RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
101822719  HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 [KO:K06752]
101828355  H-2 class II histocompatibility antigen, E-U alpha chain [KO:K06752]
101844256  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
101844787  class II histocompatibility antigen, M alpha chain [KO:K06752]
101837127  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
101843733  H-2 class II histocompatibility antigen, E-D beta chain-like [KO:K06752]
101841546  Cd74; HLA class II histocompatibility antigen gamma chain isoform X2 [KO:K06505]
101838297  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
101842987  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
101840942  Il10; interleukin-10 [KO:K05443]
101838397  Il10ra; interleukin-10 receptor subunit alpha [KO:K05134]
101828644  Il10rb; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
101842997  Ctss; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
101838451  Clec4e; C-type lectin domain family 4 member E [KO:K10059]
101837124  Fcer1g; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
101824662  Clec7a; C-type lectin domain family 7 member A isoform X2 [KO:K10074]
101834139  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101830753  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
101839684  Card9; caspase recruitment domain-containing protein 9 isoform X6 [KO:K12794]
101833071  Malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
101844056  Bcl10; B-cell lymphoma/leukemia 10 [KO:K07368]
101838071  Nod2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
101824238  Ripk2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
101837753  Hspa9; stress-70 protein, mitochondrial [KO:K04043]
106021236  60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
101844216  Hspd1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
121137093  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
101826995  lipopolysaccharide-binding protein [KO:K05399]
101838156  Tlr2; toll-like receptor 2 isoform X1 [KO:K10159]
101829979  Tlr1; toll-like receptor 1 [KO:K05398]
101829709  Tlr6; toll-like receptor 6 isoform X1 [KO:K10169]
101824088  Tlr4; toll-like receptor 4 [KO:K10160]
101839548  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
101839883  toll/interleukin-1 receptor domain-containing adapter protein isoform X2 [KO:K05403]
101828578  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101824326  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101830300  Irak1; interleukin-1 receptor-associated kinase 1 isoform X4 [KO:K04730] [EC:2.7.11.1]
101830137  Irak2; interleukin-1 receptor-associated kinase-like 2 isoform X1 [KO:K04731] [EC:2.7.11.1]
101830563  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101839499  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101831177  Rela; transcription factor p65 isoform X1 [KO:K04735]
101824303  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101824910  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101826592  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101833914  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101825943  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101841668  Mapk3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101832187  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101827071  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101841730  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101823656  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101839443  Il6; interleukin-6 [KO:K05405]
101844248  Il12a; interleukin-12 subunit alpha precursor [KO:K05406]
101843678  Il12b; interleukin-12 subunit beta precursor [KO:K05425]
101836016  Il18; interleukin-18 [KO:K05482]
101827862  Il23a; interleukin-23 subunit alpha isoform X1 [KO:K05426]
101838741  Il1a; interleukin-1 alpha [KO:K04383]
101839008  Il1b; interleukin-1 beta [KO:K04519]
121134467  Cebpb; CCAAT/enhancer-binding protein beta [KO:K10048]
101828934  Cebpg; CCAAT/enhancer-binding protein gamma [KO:K10049]
101844198  Tlr9; toll-like receptor 9 [KO:K10161]
101824534  interferon alpha-12-like [KO:K05414]
101836898  interferon alpha-12-like [KO:K05414]
101836618  interferon alpha-12-like [KO:K05414]
101824794  interferon alpha-9-like [KO:K05414]
121144094  interferon alpha-12-like [KO:K05414]
121144095  interferon alpha-12-like [KO:K05414]
121144097  interferon alpha-12-like [KO:K05414]
121144098  interferon alpha-12-like [KO:K05414]
121144100  interferon alpha-9-like [KO:K05414]
121144101  interferon alpha-12-like [KO:K05414]
121144102  interferon alpha-12-like [KO:K05414]
121144103  interferon alpha-12-like [KO:K05414]
121144104  interferon alpha-12-like [KO:K05414]
121144105  interferon alpha-12-like [KO:K05414]
121144026  Ifnb1; interferon beta [KO:K05415]
110343764  CD209 antigen-like protein C [KO:K06563]
121133987  CD209 antigen-like protein E [KO:K06563]
110340038  CD209 antigen-like protein C [KO:K06563]
106022434  CD209 antigen-like protein C isoform X1 [KO:K06563]
101825620  CD209 antigen-like protein C [KO:K06563]
110343762  CD209 antigen-like protein E [KO:K06563]
101836572  CD209 antigen-like protein A [KO:K06563]
101825102  CD209 antigen-like protein B isoform X2 [KO:K06563]
106022439  CD209 antigen-like protein E [KO:K06563]
101826512  Arhgef12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
101833518  transforming protein RhoA-like [KO:K04513]
101831918  Rhoa; transforming protein RhoA [KO:K04513]
101828851  Lsp1; lymphocyte-specific protein 1 isoform X4 [KO:K14957]
101834719  Plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
101823206  Ksr1; kinase suppressor of Ras 1 isoform X6 [KO:K14958]
101843997  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101834601  Tgfb1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
101832748  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
101840590  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
101840476  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [KO:K07438] [EC:1.14.15.18]
101829584  Vdr; vitamin D3 receptor [KO:K08539]
101829350  cathelicidin antimicrobial peptide [KO:K13916]
101842900  C3; complement C3 [KO:K03990]
101839335  Itgax; integrin alpha-X isoform X1 [KO:K06462]
101832272  Itgb2; integrin beta-2 [KO:K06464]
101843173  Itgam; integrin alpha-M isoform X1 [KO:K06461]
101826356  Mrc2; LOW QUALITY PROTEIN: C-type mannose receptor 2 [KO:K06560]
101831037  Pla2r1; secretory phospholipase A2 receptor [KO:K06560]
101834395  Mrc1; macrophage mannose receptor 1 [KO:K06560]
101840320  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
101822923  Sphk1; sphingosine kinase 1 isoform X2 [KO:K04718] [EC:2.7.1.91]
121135759  Calml6; calmodulin-like protein 6 [KO:K02183]
101825969  calmodulin-1-like [KO:K02183]
101840179  calmodulin-like protein 3 [KO:K02183]
101840457  calmodulin-4 [KO:K02183]
101823161  Calm3; calmodulin-3 [KO:K02183]
101832379  Calm2; calmodulin-2 [KO:K02183]
101828975  Calm1; calmodulin-1 [KO:K02183]
121136988  calmodulin-alpha-like [KO:K02183]
101834468  Calml4; calmodulin-like protein 4 [KO:K02183]
101833206  calmodulin-A-like [KO:K02183]
101833643  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101838485  Rab5a; ras-related protein Rab-5A [KO:K07887]
101822596  Rab5b; ras-related protein Rab-5B [KO:K07888]
101833039  Rab5c; ras-related protein Rab-5C [KO:K07889]
101837128  Eea1; early endosome antigen 1 [KO:K12478]
101839102  Rab7a; ras-related protein Rab-7a [KO:K07897]
101830112  Ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
101823409  Atp6v0a2; V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
101823317  Atp6v0a4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
101833148  Atp6v0a1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
101829318  Tcirg1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
101828470  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
101823171  Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146]
101822803  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
101827210  Atp6ap1; V-type proton ATPase subunit S1 isoform X1 [KO:K03662]
101834495  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
101835568  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
101822960  Lamp1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
101830016  Lamp2; lysosome-associated membrane glycoprotein 2 isoform X2 [KO:K06528]
101833150  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101838431  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101840210  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121134668  Ppp3r1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
106021831  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
101841934  Coro1a; coronin-1A [KO:K13882]
101840592  Fcgr1a; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
101831114  LOW QUALITY PROTEIN: low affinity immunoglobulin gamma Fc region receptor III [KO:K06472]
101844813  Fcgr2b; low affinity immunoglobulin gamma Fc region receptor II-b isoform X2 [KO:K12560]
101822472  Fcgr4; low affinity immunoglobulin gamma Fc region receptor III-like precursor [KO:K06463]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Mycobacterial trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:21274449
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
PMID:20415982
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
PMID:11932234
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
PMID:18288961
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
PMID:17359235
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
PMID:21274433
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
PMID:15083155
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
PMID:20199890
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
PMID:15228522
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
PMID:19563525
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
PMID:19369951
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
PMID:18541216
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
PMID:19634703
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:17785780
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
PMID:18407066
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
PMID:11378475
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
maua04010  MAPK signaling pathway
maua04210  Apoptosis
maua04612  Antigen processing and presentation
maua04620  Toll-like receptor signaling pathway
maua04621  NOD-like receptor signaling pathway
maua04630  JAK-STAT signaling pathway
KO pathway
ko05152   
LinkDB

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