KEGG   PATHWAY: mbez04151
Entry
mbez04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Moschus berezovskii (Chinese forest musk deer)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mbez04151  PI3K-Akt signaling pathway
mbez04151

Other DBs
GO: 0043491
Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129561712  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
129539010  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
129561639  EREG; proepiregulin [KO:K09784]
129562045  AREG; amphiregulin [KO:K09782]
129559536  FGF1; fibroblast growth factor 1 [KO:K18496]
129542296  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
129555960  FGF8; fibroblast growth factor 8 [KO:K04358]
129556389  FGF9; fibroblast growth factor 9 [KO:K04358]
129549223  FGF20; fibroblast growth factor 20 [KO:K04358]
129557346  FGF17; fibroblast growth factor 17 [KO:K04358]
129537016  FGF6; fibroblast growth factor 6 isoform X1 [KO:K04358]
129559049  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
129553142  FGF18; fibroblast growth factor 18 [KO:K04358]
129553277  FGF10; fibroblast growth factor 10 [KO:K04358]
129562082  FGF5; fibroblast growth factor 5 [KO:K04358]
129562501  FGF7; fibroblast growth factor 7 [KO:K04358]
129534906  FGF16; fibroblast growth factor 16 [KO:K04358]
129548662  FGF3; fibroblast growth factor 3 [KO:K04358]
129548663  FGF4; fibroblast growth factor 4 [KO:K04358]
129548328  FGF19; fibroblast growth factor 19 [KO:K22603]
129546182  FGF21; fibroblast growth factor 21 [KO:K22429]
129536537  FGF23; fibroblast growth factor 23 [KO:K22428]
129541318  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
129554712  BDNF; brain-derived neurotrophic factor [KO:K04355]
129536400  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
129546565  NTF4; neurotrophin-4 [KO:K12457]
129548407  INS; insulin [KO:K04526]
129535856  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
129548638  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
129545815  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
129536369  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
129542873  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
129554238  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
129541681  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
129535752  KITLG; kit ligand isoform X1 [KO:K05461]
129546548  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
129548822  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
129563157  PGF; placenta growth factor isoform X1 [KO:K16859]
129549287  VEGFC; vascular endothelial growth factor C [KO:K05449]
129564310  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
129552336  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
129559853  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
129549280  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
129561848  ANGPT4; angiopoietin-4 [KO:K05467]
129558723  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
129559061  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
129540424  EFNA4; ephrin-A4 [KO:K05462]
129540960  EFNA3; ephrin-A3 [KO:K05462]
129541056  EFNA1; ephrin-A1 [KO:K05462]
129553310  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
129559221  NRTN; neurturin [KO:K25414]
129540731  ARTN; artemin isoform X1 [KO:K25415]
129559238  PSPN; persephin [KO:K25416]
129548207  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
129544356  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
129535701  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
129538320  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
129549407  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
129555293  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
129561939  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
129559284  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
129544277  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
129540753  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
129556974  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
129558099  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
129550230  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
129562088  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
129558396  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
129559582  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
129561998  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
129556612  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
129556364  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
129559190  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
129561762  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
129552423  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
129557527  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
129537851  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
129555834  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
129544725  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
129539931  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
129562678  SOS2; son of sevenless homolog 2 [KO:K03099]
129548597  HRAS; GTPase HRas isoform X1 [KO:K02833]
129537164  KRAS; GTPase KRas isoform X1 [KO:K07827]
129541808  NRAS; GTPase NRas [KO:K07828]
129547721  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129562372  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
129558523  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129542485  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129545501  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129537506  IRS1; insulin receptor substrate 1 [KO:K16172]
129542442  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
129557207  TLR4; toll-like receptor 4 [KO:K10160]
129545763  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129539810  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
129554914  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
129557183  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
129545119  CD19; B-lymphocyte antigen CD19 [KO:K06465]
129555501  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
129537887  GH1; somatotropin [KO:K05438]
129543303  chorionic somatomammotropin hormone 1-like [KO:K05439]
129543305  LOW QUALITY PROTEIN: chorionic somatomammotropin hormone 2-like [KO:K05439]
129543400  LOW QUALITY PROTEIN: placental prolactin-related protein 3-like [KO:K05439]
129543410  prolactin [KO:K05439]
129543476  LOW QUALITY PROTEIN: placental prolactin-related protein 4-like [KO:K05439]
129542740  OSM; oncostatin-M [KO:K05418]
129542297  IL2; interleukin-2 [KO:K05429]
129558732  interleukin-3 [KO:K04736]
129558702  IL4; interleukin-4 [KO:K05430]
129560364  IL7; interleukin-7 isoform X1 [KO:K05431]
129557109  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
129557111  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
129557266  interferon alpha-1-like [KO:K05414]
129557270  interferon alpha-1-like [KO:K05414]
129557271  interferon alpha-1 [KO:K05414]
129557272  interferon alpha-1-like [KO:K05414]
129557274  interferon alpha-1-like [KO:K05414]
129557279  interferon alpha-1-like [KO:K05414]
129557285  interferon alpha-1-like [KO:K05414]
129557286  interferon alpha-H [KO:K05414]
129557110  interferon beta-2-like [KO:K05415]
129557288  interferon beta-2 [KO:K05415]
129557307  interferon beta-2-like [KO:K05415]
129557308  interferon beta-2-like [KO:K05415]
129545146  EPO; erythropoietin [KO:K05437]
129537423  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
129553292  GHR; growth hormone receptor isoform X1 [KO:K05080]
129553323  PRLR; prolactin receptor [KO:K05081]
129553307  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
129556783  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
129536097  interleukin-2 receptor subunit beta-like [KO:K05069]
129537055  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
129564419  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
129564539  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
129540720  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
129545473  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
129553320  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
129552638  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
129559251  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
129540790  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
129541821  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
129557601  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
129559327  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
129544266  COL1A1; collagen alpha-1(I) chain [KO:K06236]
129552228  COL1A2; collagen alpha-2(I) chain [KO:K06236]
129536162  COL2A1; collagen alpha-1(II) chain [KO:K19719]
129556509  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
129556510  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
129564249  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
129564349  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
129538374  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
129538376  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
129548784  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
129548841  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
129549388  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
129549397  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
129541824  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
129560944  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
129561184  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
129540831  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
129549633  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
129561261  LAMA2; laminin subunit alpha-2 [KO:K05637]
129549727  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
129561272  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
129560680  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
129552404  LAMB1; laminin subunit beta-1 [KO:K05636]
129547527  LOW QUALITY PROTEIN: laminin subunit beta-2-like [KO:K06243]
129547827  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
129551233  LAMB3; laminin subunit beta-3 [KO:K06244]
129552406  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
129551306  LAMC1; laminin subunit gamma-1 [KO:K05635]
129551301  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
129539573  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
129544261  CHAD; chondroadherin [KO:K06248]
129552370  RELN; reelin [KO:K06249] [EC:3.4.21.-]
129562363  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
129558012  COMP; cartilage oligomeric matrix protein [KO:K04659]
129561006  THBS2; thrombospondin-2 [KO:K04659]
129540703  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
129562544  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
129537610  FN1; fibronectin isoform X1 [KO:K05717]
129562034  SPP1; osteopontin [KO:K06250]
129536806  VTN; vitronectin [KO:K06251]
129557201  TNC; tenascin isoform X1 [KO:K06252]
129543838  TNXB; tenascin-X isoform X1 [KO:K06252]
129551066  TNR; tenascin-R [KO:K06252]
129551067  TNN; tenascin-N [KO:K06252]
129535668  VWF; von Willebrand factor [KO:K03900]
129561563  IBSP; bone sialoprotein 2 [KO:K06253]
129553271  ITGA1; integrin alpha-1 [KO:K06480]
129553269  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
129544490  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
129544270  ITGA3; integrin alpha-3 [KO:K06482]
129538089  ITGA4; integrin alpha-4 [KO:K06483]
129535852  ITGA5; integrin alpha-5 [KO:K06484]
129538654  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
129535732  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
129558269  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
129548149  ITGA9; integrin alpha-9 [KO:K06585]
129540534  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
129563190  ITGA11; integrin alpha-11 [KO:K06587]
129538673  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
129557511  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
129544525  ITGB3; LOW QUALITY PROTEIN: integrin beta-3 [KO:K06493]
129544714  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
129537587  ITGB5; integrin beta-5 [KO:K06588]
129538496  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
129537242  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
129552289  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
129559901  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
129551508  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129547146  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129559156  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129553207  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
129540801  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129563109  F2R; proteinase-activated receptor 1 [KO:K03914]
129548449  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
129552682  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
129557044  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
129559073  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
129540888  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
129534915  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
129535685  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
129556265  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
129551433  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
129545675  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
129536555  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
129562435  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
129548858  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
129555099  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
129558470  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
129552025  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
129552393  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
129543633  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
129543654  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
129545284  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
129558567  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
129553297  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
129540466  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
129555732  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
129539141  TSC1; hamartin isoform X1 [KO:K07206]
129545260  TSC2; tuberin isoform X1 [KO:K07207]
129550533  GTP-binding protein Rheb-like [KO:K07208]
129552798  RHEB; GTP-binding protein Rheb [KO:K07208]
129545267  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
129551531  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
129544632  RPTOR; LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
129549398  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
129555980  eukaryotic translation initiation factor 4E type 1B-like [KO:K03259]
129537884  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
129558417  eukaryotic translation initiation factor 4E-like [KO:K03259]
129558881  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
129561564  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
129539357  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
129548695  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
129537152  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
129557554  RPS6; 40S ribosomal protein S6 [KO:K02991]
129551411  40S ribosomal protein S6-like [KO:K02991]
129544793  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
129558503  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
129541704  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
129539132  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
129561018  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
129555819  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
129560443  SGK3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
129550706  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129551602  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129546814  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129547993  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
129552348  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
129555578  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
129541793  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
129549379  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
129564222  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
129558414  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
129539208  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
129563803  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
129563804  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
129546445  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
129554318  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
129542474  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform-like [KO:K04354]
129556913  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
129559074  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
129562057  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
129564509  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
129550514  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
129547508  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
129548796  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
129563521  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
129543513  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
129550662  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
129551253  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
129549628  LOW QUALITY PROTEIN: uncharacterized protein LOC129549628 [KO:K04079]
129543247  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
129550661  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
129550665  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
129535215  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
129537273  HSP90B1; endoplasmin [KO:K09487]
129559133  CDC37; hsp90 co-chaperone Cdc37 isoform X1 [KO:K09554]
129560523  CREB-regulated transcription coactivator 2-like [KO:K16333]
129540563  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
129549900  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
129546934  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
129550096  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
129552779  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
129544459  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
129561928  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
129536627  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
129546567  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
129563025  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
129555628  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
129544453  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
129544477  G6PC3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
129538478  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
129560340  MYC; myc proto-oncogene protein [KO:K04377]
129548664  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
129543530  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
129536837  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
129536910  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
129551017  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
129562125  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
129536501  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
129552220  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
129536390  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
129543836  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
129560436  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
129546919  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
129561025  FOXO3; forkhead box protein O3 [KO:K09408]
129547109  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
129551094  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129564046  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
129536624  14-3-3 protein zeta/delta-like [KO:K16197]
129551009  14-3-3 protein zeta/delta-like [KO:K16197]
129539050  YWHAQ; 14-3-3 protein theta [KO:K16197]
129559874  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
129555231  14-3-3 protein theta-like [KO:K16197]
129535078  14-3-3 protein zeta/delta-like [KO:K16197]
129541281  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
129542447  YWHAH; 14-3-3 protein eta [KO:K16198]
129545642  YWHAG; 14-3-3 protein gamma [KO:K16198]
129548816  BAD; bcl2-associated agonist of cell death [KO:K02158]
129538419  bcl-2-like protein 1 [KO:K04570]
129562040  BCL2L1; bcl-2-like protein 1 [KO:K04570]
129549902  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129551377  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
129538457  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
129537505  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
129536687  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
129540547  LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
129556793  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
129559023  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
129552685  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
129540564  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
129554794  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
129552502  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
129543841  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
129541406  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
129538974  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
129535747  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
129564146  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
129555451  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
129549430  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
129548767  RELA; transcription factor p65 [KO:K04735]
129562101  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129561012  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
129535751  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
129543141  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mbez00010  Glycolysis / Gluconeogenesis
mbez04010  MAPK signaling pathway
mbez04012  ErbB signaling pathway
mbez04062  Chemokine signaling pathway
mbez04064  NF-kappa B signaling pathway
mbez04068  FoxO signaling pathway
mbez04110  Cell cycle
mbez04115  p53 signaling pathway
mbez04150  mTOR signaling pathway
mbez04210  Apoptosis
mbez04370  VEGF signaling pathway
mbez04510  Focal adhesion
mbez04620  Toll-like receptor signaling pathway
mbez04630  JAK-STAT signaling pathway
mbez04662  B cell receptor signaling pathway
mbez04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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