KEGG   PATHWAY: mcc05206
Entry
mcc05206                    Pathway                                
Name
MicroRNAs in cancer - Macaca mulatta (rhesus monkey)
Description
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
Class
Human Diseases; Cancer: overview
Pathway map
mcc05206  MicroRNAs in cancer
mcc05206

Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100315147  MIR17; mml-miR-17-5p [KO:K17002]
100315148  MIR18A; mml-miR-18a-5p [KO:K17003]
100315149  MIR19A; mml-miR-19a-5p [KO:K17005]
100315156  MIR19B-2; mml-miR-19b [KO:K23559]
100315385  MIR20A; mml-miR-20a-5p [KO:K17006]
100315508  MIR92A-2; mml-miR-92a-5p [KO:K17008]
705121  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100315142  MIR221; mml-miR-221-5p [KO:K17010]
100315522  MIR222; mml-miR-222-5p [KO:K17011]
697188  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100315127  MIR21; mml-miR-21-5p [KO:K16863]
574381  TIMP3; metalloproteinase inhibitor 3 precursor [KO:K16866]
100315442  MIRLET7A-3; mml-let-7a-5p [KO:K16980]
100315501  MIRLET7A-1; mml-let-7a-5p [KO:K16980]
100315174  MIRLET7F-2; mml-let-7f-5p [KO:K16980]
100315170  MIRLET7A-2; mml-let-7a-5p [KO:K16980]
100315389  MIRLET7B; mml-let-7b-5p [KO:K16980]
100315172  MIRLET7D; mml-let-7d [KO:K16980]
100315173  MIRLET7F-1; mml-let-7f-5p [KO:K16980]
100315502  MIRLET7E; mml-let-7e-5p [KO:K16980]
100315390  MIRLET7G; mml-let-7g-5p [KO:K16980]
100315443  MIRLET7I; mml-let-7i-5p [KO:K16980]
100315171  MIRLET7C; mml-let-7c-5p [KO:K17397]
707977  KRAS; GTPase KRas [KO:K07827]
701822  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
710858  CDC25A; M-phase inducer phosphatase 1 isoform X2 [KO:K06645] [EC:3.1.3.48]
717573  CDC25B; M-phase inducer phosphatase 2 isoform X6 [KO:K05866] [EC:3.1.3.48]
714115  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
717721  HMGA2; high mobility group protein HMGI-C isoform X1 [KO:K09283]
100315478  MIR107; mml-miR-107-5p [KO:K17396]
100315145  MIR15A; mml-miR-15a-5p [KO:K16986]
100315379  MIR15B; mml-miR-15b-5p [KO:K16987]
100315146  MIR16-1; mml-miR-16-5p [KO:K16988]
100315505  MIR16-2; mml-miR-16-5p [KO:K16988]
574320  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
710379  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
700589  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
700382  CCNE2; G1/S-specific cyclin-E2 isoform X2 [KO:K06626]
100315193  MIR126; mml-miR-126 [KO:K16978]
696584  CRKL; crk-like protein [KO:K04438]
701185  CRK; adapter molecule crk isoform X1 [KO:K04438]
100315169  MIR1-2; mml-miR-1-2-5p [KO:K16972]
100315168  MIR1-1; mml-miR-1-1-5p [KO:K16972]
710797  HDAC4; histone deacetylase 4 isoform X6 [KO:K11406] [EC:3.5.1.98]
711456  HDAC5; histone deacetylase 5 [KO:K11406] [EC:3.5.1.98]
694726  FOXP1; forkhead box protein P1 [KO:K23582]
719232  serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
114677751  PIM1; LOW QUALITY PROTEIN: serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
704562  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100315129  MIR29A; mml-miR-29a-5p [KO:K16995]
100315182  MIR29B-1; mml-miR-29b-1-5p [KO:K16996]
100315392  MIR29B-2; mml-miR-29b-2-5p [KO:K16996]
100315183  MIR29C; mml-miR-29c-5p [KO:K16997]
694822  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
711553  DNMT3B; DNA (cytosine-5)-methyltransferase 3B isoform X1 [KO:K17399] [EC:2.1.1.37]
100315579  MIR133C; mml-miR-133c-5p [KO:K16970]
100315122  MIR133A; mml-miR-133a [KO:K16970]
100315196  MIR133B; mml-miR-133b-5p [KO:K16971]
707539  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
713572  bcl-2-like protein 2 isoform X2 [KO:K02163]
100315123  MIR145; mml-miR-145-5p [KO:K16974]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
574209  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
100315484  MIR200C; mml-miR-200c-5p [KO:K17017]
701157  ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
100315119  MIR141; mml-miR-141-5p [KO:K17018]
707540  TGFB2; transforming growth factor beta-2 precursor [KO:K13376]
100315155  MIR183; mml-miR-183-5p [KO:K17116]
704716  EZR; ezrin isoform X1 [KO:K08007]
100315394  MIR125A; mml-miR-125a-5p [KO:K16993]
100315120  MIR125B-1; mml-miR-125b-5p [KO:K16994]
100315486  MIR125B-2; mml-miR-125b-5p [KO:K16994]
695345  PDCD4; programmed cell death protein 4 [KO:K16865]
100315513  MIR143; mml-miR-143-5p [KO:K17023]
100315517  MIR192; mml-miR-192-5p [KO:K17131]
100315150  MIR194-1; mml-miR-194-5p [KO:K17371]
100315580  MIR194-2; mml-miR-194-5p [KO:K17371]
706258  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
704331  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
100315151  MIR215; mml-miR-215-5p [KO:K17167]
100315381  MIR28; mml-miR-28-5p [KO:K17366]
100315186  MIR30E; mml-miR-30e-5p [KO:K17110]
100315185  MIR30D; mml-miR-30d-5p [KO:K17110]
100315130  MIR30A; mml-miR-30a-5p [KO:K17110]
100315434  MIR30B; mml-miR-30b-5p [KO:K17111]
100315184  MIR30C-1; mml-miR-30c-5p [KO:K17040]
100315507  MIR30C-2; mml-miR-30c-5p [KO:K17040]
705236  TPM1; tropomyosin alpha-1 chain isoform X8 [KO:K10373]
702103  SPRY2; protein sprouty homolog 2 [KO:K17383]
707407  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
700713  SERPINB5; serpin B5 [KO:K10139]
100315397  MIR155; mml-miR-155 [KO:K17009]
100315519  MIR203; mml-miR-203 [KO:K16975]
100315598  MIR205; mml-miR-205 [KO:K17150]
100315576  MIR27A; mml-miR-27a-5p [KO:K17112]
100315596  MIR27B; mml-miR-27b-5p [KO:K17113]
718848  ST14; suppressor of tumorigenicity 14 protein isoform X1 [KO:K08670] [EC:3.4.21.109]
710385  CYP1B1; cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
100315488  MIR31; mml-miR-31-5p [KO:K17183]
100315133  MIR99A; mml-miR-99a-5p [KO:K17367]
100315489  MIR100; mml-miR-100-5p [KO:K17041]
106992736  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
712848  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
698937  1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [KO:K07436] [EC:1.14.15.16]
697573  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
711407  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
722449  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
703997  TP63; tumor protein 63 isoform X6 [KO:K10149]
705439  ZEB2; zinc finger E-box-binding homeobox 2 isoform X1 [KO:K23560]
100430727  FSCN1; fascin [KO:K23551]
100315529  MIR375; mml-miR-375 [KO:K16976]
702385  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
100315178  MIR10B; mml-miR-10b-5p [KO:K17393]
700318  HOXD10; homeobox protein Hox-D10 [KO:K09295]
715307  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
706239  BMF; LOW QUALITY PROTEIN: bcl-2-modifying factor [KO:K17460]
100315143  MIR224; mml-miR-224-5p [KO:K17042]
696676  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
708084  MMP9; matrix metalloproteinase-9 precursor [KO:K01403] [EC:3.4.24.35]
100315527  MIR363; mml-miR-363-5p [KO:K17036]
100315538  MIR494; mml-miR-494-5p [KO:K17378]
100315329  MIR615; mml-miR-615-5p [KO:K17380]
100315332  MIR625; mml-miR-625 [KO:K17381]
100315439  MIR25; mml-miR-25 [KO:K17038]
100315136  MIR34A; mml-miR-34a-5p [KO:K16982]
100315386  MIR96; mml-miR-96 [KO:K17114]
100315444  MIR10A; mml-miR-10a-5p [KO:K16864]
100315152  MIR23A; mml-miR-23a-5p [KO:K17165]
100315180  MIR23B; mml-miR-23b-5p [KO:K17394]
100315191  MIR122A; mml-miR-122a-5p [KO:K17020]
712410  SLC7A1; high affinity cationic amino acid transporter 1 [KO:K13863]
697738  CCNG1; cyclin-G1 [KO:K10145]
719266  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
100315206  MIR150; mml-miR-150-5p [KO:K17024]
100315438  MIR223; mml-miR-223 [KO:K17001]
719733  STMN1; stathmin isoform X1 [KO:K04381]
100315526  MIR342; mml-miR-342-5p [KO:K17132]
100315260  MIR423; mml-miR-423-5p [KO:K17376]
574128  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
694626  MYC; myc proto-oncogene protein [KO:K04377]
694473  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
698830  HRAS; GTPase HRas [KO:K02833]
709089  NRAS; GTPase NRas [KO:K07828]
100315402  MIR324; mml-miR-324-5p [KO:K17152]
100315436  MIR26A-1; mml-miR-26a-5p [KO:K16984]
100315181  MIR26A-2; mml-miR-26a-5p [KO:K16984]
100315506  MIR26B; mml-miR-26b-5p [KO:K16985]
100315515  MIR152; mml-miR-152-5p [KO:K17370]
574321  DNMT1; DNA (cytosine-5)-methyltransferase 1 isoform X4 [KO:K00558] [EC:2.1.1.37]
100315198  MIR135B; mml-miR-135b-5p [KO:K17144]
100315197  MIR135A-1; mml-miR-135a-5p [KO:K17144]
100315574  MIR135A-2; mml-miR-135a-5p [KO:K17144]
707345  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
693443  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
707870  IRS1; insulin receptor substrate 1 [KO:K16172]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
702837  MAPK7; mitogen-activated protein kinase 7 isoform X4 [KO:K04464] [EC:2.7.11.24]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100315399  MIR200A; mml-miR-200a-5p [KO:K17015]
709112  HNRNPK; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
694043  RECK; reversion-inducing cysteine-rich protein with Kazal motifs isoform X1 [KO:K17461]
100315192  MIR124A-2; mml-miR-124a-5p [KO:K17126]
100315490  MIR124A-1; mml-miR-124a-5p [KO:K17126]
100315395  MIR137; mml-miR-137-5p [KO:K17369]
100315121  MIR128A; mml-miR-128a-5p [KO:K17130]
100315510  MIR128B; mml-miR-128b-5p [KO:K17130]
713904  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
100315175  MIR7-1; mml-miR-7 [KO:K17365]
100315503  MIR7-2; mml-miR-7 [KO:K17365]
100315504  MIR7-3; mml-miR-7 [KO:K17365]
698536  IRS2; insulin receptor substrate 2 [KO:K07187]
709947  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
713798  NOTCH2; neurogenic locus notch homolog protein 2 precursor [KO:K20994]
719119  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
717323  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
106992288  BMI1; polycomb complex protein BMI-1 [KO:K11459]
100315202  MIR146A; mml-miR-146a-5p [KO:K17012]
695120  MMP16; matrix metalloproteinase-16 [KO:K07996] [EC:3.4.24.-]
100315137  MIR181A-2; mml-miR-181a-5p [KO:K17025]
100315493  MIR181A-1; mml-miR-181a-5p [KO:K17025]
100315209  MIR181B-2; mml-miR-181b-5p [KO:K17026]
100315384  MIR181B-1; mml-miR-181b-5p [KO:K17026]
100315138  MIR181C; mml-miR-181c-5p [KO:K17027]
100315210  MIR181D; mml-miR-181d [KO:K17028]
100427400  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
711180  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
100315405  MIR373; mml-miR-373 [KO:K17000]
100315292  MIR520A; mml-miR-520a-5p [KO:K17175]
100315545  MIR520G; mml-miR-520g [KO:K17175]
717204  CD44; CD44 antigen isoform X1 [KO:K06256]
100315509  MIR103-2; mml-miR-103-3p [KO:K16989]
100315593  MIR103-1; mml-miR-103-5p [KO:K16989]
702516  DICER1; endoribonuclease Dicer [KO:K11592] [EC:3.1.26.-]
713839  FZD3; frizzled-3 precursor [KO:K02329]
574315  ITGA5; integrin alpha-5 [KO:K06484]
709018  RDX; radixin isoform X2 [KO:K05762]
706455  RHOA; transforming protein RhoA [KO:K04513]
100315215  MIR193B; mml-miR-193b-5p [KO:K17148]
705853  PLAU; urokinase-type plasminogen activator isoform X1 [KO:K01348] [EC:3.4.21.73]
706534  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
114675515  bcl-2 homologous antagonist/killer-like [KO:K14021]
696568  ZFPM2; zinc finger protein ZFPM2 isoform X1 [KO:K17442]
717379  ITGB3; integrin beta-3 [KO:K06493]
722434  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
100315403  MIR335; mml-miR-335-5p [KO:K17033]
706531  SOX4; transcription factor SOX-4 [KO:K23581]
702720  TNC; tenascin isoform X1 [KO:K06252]
708707  TNR; tenascin-R [KO:K06252]
708587  TNN; tenascin-N isoform X1 [KO:K06252]
716998  TNXB; tenascin-X isoform X7 [KO:K06252]
100315220  MIR206; mml-miR-206 [KO:K16973]
100315266  MIR451; mml-miR-451 [KO:K17172]
574235  ABCB1; multidrug resistance protein 1 [KO:K05658] [EC:7.6.2.2]
100315404  MIR345; mml-miR-345 [KO:K17375]
717857  ABCC1; multidrug resistance-associated protein 1 [KO:K05665] [EC:7.6.2.3]
100315140  MIR214; mml-miR-214-5p [KO:K17151]
712634  BRCA1; breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
100315153  MIR106B; mml-miR-106b-5p [KO:K17035]
719199  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100315520  MIR210; mml-miR-210-5p [KO:K17178]
717399  EFNA1; ephrin-A1 [KO:K05462]
717373  EFNA3; ephrin-A3 precursor [KO:K05462]
704351  EFNA5; ephrin-A5 precursor [KO:K05462]
717315  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
721231  EFNA2; ephrin-A2 [KO:K05462]
705413  THBS1; thrombospondin-1 [KO:K16857]
698462  IGF2BP1; insulin-like growth factor 2 mRNA-binding protein 1 [KO:K17391]
705341  TRIM71; E3 ubiquitin-protein ligase TRIM71 [KO:K12035] [EC:2.3.2.27]
100315445  MIR34B; mml-miR-34b [KO:K16983]
100315187  MIR34C; mml-miR-34c-5p [KO:K23572]
100315391  MIR9-2; mml-miR-9-5p [KO:K16977]
100315176  MIR9-1; mml-miR-9-5p [KO:K16977]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
100315218  MIR199A-2; mml-miR-199a-5p [KO:K17118]
100315491  MIR199A-1; mml-miR-199a [KO:K17118]
704683  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
716671  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
718412  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
701195  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
720263  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
702041  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
712829  FGFR3; fibroblast growth factor receptor 3 isoform X10 [KO:K05094] [EC:2.7.10.1]
699798  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
716170  TP53; cellular tumor antigen p53 [KO:K04451]
718284  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
699563  MDM4; protein Mdm4 isoform X1 [KO:K10127]
697002  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
697069  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
714173  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
100315134  MIR101-1; mml-miR-101-1-5p [KO:K17129]
100315190  MIR101-2; mml-miR-101-2-5p [KO:K17129]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100315450  MIR195; mml-miR-195-5p [KO:K17029]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
713777  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
705601  SOS2; son of sevenless homolog 2 [KO:K03099]
718982  SHC1; SHC-transforming protein 1 [KO:K06279]
707725  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100315194  MIR129-1; mml-miR-129-5p [KO:K17368]
100315431  MIR129-2; mml-miR-129-5p [KO:K17368]
714611  SHC4; SHC-transforming protein 4 [KO:K17449]
703173  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
711353  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
709988  cyclin-dependent kinase inhibitor 2A [KO:K06621]
714126  E2F1; transcription factor E2F1 [KO:K17454]
710200  E2F2; transcription factor E2F2 [KO:K09389]
100315131  MIR32; mml-miR-32-5p [KO:K17039]
697082  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
694077  MARCKS; myristoylated alanine-rich C-kinase substrate isoform X1 [KO:K12561]
704088  BMPR2; bone morphogenetic protein receptor type-2 precursor [KO:K04671] [EC:2.7.11.30]
100315408  MIR449A; mml-miR-449a-5p [KO:K17377]
708441  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
694662  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
709075  EZH2; histone-lysine N-methyltransferase EZH2 [KO:K11430] [EC:2.1.1.356]
693520  GLS; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
712962  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
695682  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
716909  WNT3; proto-oncogene Wnt-3 [KO:K00312]
696200  WNT3A; protein Wnt-3a [KO:K00312]
100315237  MIR330; mml-miR-330-5p [KO:K17373]
100315525  MIR331; mml-miR-331-5p [KO:K17374]
721998  CDCA5; sororin isoform X2 [KO:K17390]
695229  KIF23; kinesin-like protein KIF23 isoform X2 [KO:K17387]
698223  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
714533  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
697420  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
705289  VIM; vimentin [KO:K07606]
Reference
PMID:18817506
  Authors
Lee YS, Dutta A
  Title
MicroRNAs in cancer.
  Journal
Annu Rev Pathol 4:199-227 (2009)
DOI:10.1146/annurev.pathol.4.110807.092222
Reference
PMID:21402473
  Authors
Babashah S, Soleimani M
  Title
The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.
  Journal
Eur J Cancer 47:1127-37 (2011)
DOI:10.1016/j.ejca.2011.02.008
Reference
PMID:19630570
  Authors
Garzon R, Calin GA, Croce CM
  Title
MicroRNAs in Cancer.
  Journal
Annu Rev Med 60:167-79 (2009)
DOI:10.1146/annurev.med.59.053006.104707
Reference
PMID:23075324
  Authors
Chen PS, Su JL, Hung MC
  Title
Dysregulation of microRNAs in cancer.
  Journal
J Biomed Sci 19:90 (2012)
DOI:10.1186/1423-0127-19-90
Reference
PMID:22035854
  Authors
Ling H, Zhang W, Calin GA
  Title
Principles of microRNA involvement in human cancers.
  Journal
Chin J Cancer 30:739-48 (2011)
DOI:10.5732/cjc.011.10243
Reference
PMID:22351564
  Authors
Iorio MV, Croce CM
  Title
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
  Journal
EMBO Mol Med 4:143-59 (2012)
DOI:10.1002/emmm.201100209
Reference
PMID:21742789
  Authors
Sayed D, Abdellatif M
  Title
MicroRNAs in development and disease.
  Journal
Physiol Rev 91:827-87 (2011)
DOI:10.1152/physrev.00006.2010
Reference
PMID:22345301
  Authors
Wang Q, Wang S, Wang H, Li P, Ma Z
  Title
MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment.
  Journal
Exp Biol Med (Maywood) 237:227-35 (2012)
DOI:10.1258/ebm.2011.011192
Reference
PMID:22580099
  Authors
Song JH, Meltzer SJ
  Title
MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers.
  Journal
Gastroenterology 143:35-47.e2 (2012)
DOI:10.1053/j.gastro.2012.05.003
Reference
PMID:23462054
  Authors
Chu Y, Zhu H, Lv L, Zhou Y, Huo J
  Title
MiRNA s in oesophageal squamous cancer.
  Journal
Neth J Med 71:69-75 (2013)
Reference
PMID:19773200
  Authors
Kan T, Meltzer SJ
  Title
MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma.
  Journal
Curr Opin Pharmacol 9:727-32 (2009)
DOI:10.1016/j.coph.2009.08.009
Reference
PMID:20128019
  Authors
Smith CM, Watson DI, Michael MZ, Hussey DJ
  Title
MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.
  Journal
World J Gastroenterol 16:531-7 (2010)
DOI:10.3748/wjg.v16.i5.531
Reference
PMID:23165235
  Authors
Song S, Ajani JA
  Title
The role of microRNAs in cancers of the upper gastrointestinal tract.
  Journal
Nat Rev Gastroenterol Hepatol 10:109-18 (2013)
DOI:10.1038/nrgastro.2012.210
Reference
PMID:21565290
  Authors
Liu WH, Yeh SH, Chen PJ
  Title
Role of microRNAs in hepatitis B virus replication and pathogenesis.
  Journal
Biochim Biophys Acta 1809:678-85 (2011)
DOI:10.1016/j.bbagrm.2011.04.008
Reference
PMID:23091478
  Authors
Hrasovec S, Glavac D
  Title
MicroRNAs as Novel Biomarkers in Colorectal Cancer.
  Journal
Front Genet 3:180 (2012)
DOI:10.3389/fgene.2012.00180
Reference
PMID:22926415
  Authors
Liu H
  Title
MicroRNAs in breast cancer initiation and progression.
  Journal
Cell Mol Life Sci 69:3587-99 (2012)
DOI:10.1007/s00018-012-1128-9
Reference
PMID:20345848
  Authors
Li SD, Zhang JR, Wang YQ, Wan XP
  Title
The role of microRNAs in ovarian cancer initiation and progression.
  Journal
J Cell Mol Med 14:2240-9 (2010)
DOI:10.1111/j.1582-4934.2010.01058.x
Reference
PMID:23316212
  Authors
Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA
  Title
Characteristic patterns of microRNA expression in human bladder cancer.
  Journal
Front Genet 3:310 (2012)
DOI:10.3389/fgene.2012.00310
Reference
PMID:20221895
  Authors
Saini S, Majid S, Dahiya R
  Title
Diet, microRNAs and prostate cancer.
  Journal
Pharm Res 27:1014-26 (2010)
DOI:10.1007/s11095-010-0086-x
Related
pathway
mcc05210  Colorectal cancer
mcc05214  Glioma
mcc05215  Prostate cancer
mcc05219  Bladder cancer
mcc05222  Small cell lung cancer
mcc05223  Non-small cell lung cancer
KO pathway
ko05206   
LinkDB

DBGET integrated database retrieval system