KEGG   PATHWAY: mdo04015
Entry
mdo04015                    Pathway                                
Name
Rap1 signaling pathway - Monodelphis domestica (gray short-tailed opossum)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
mdo04015  Rap1 signaling pathway
mdo04015

Other DBs
GO: 0007264
Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100033128  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
100014092  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
100017121  MRAS; muscle RAS oncogene homolog [KO:K07831]
100016990  RAPGEF5; Rap guanine nucleotide exchange factor 5 [KO:K08019]
100012058  DOCK4; dedicator of cytokinesis 4 [KO:K17697]
100023485  GRIN1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
100018255  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
100017355  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
100021688  CALM3; calmodulin 3 [KO:K02183]
100018191  CALM1; calmodulin 1 [KO:K02183]
100032171  CALM2; calmodulin 2 [KO:K02183]
100025795  CALML4; calmodulin like 4 [KO:K02183]
100015722  calmodulin-alpha-like [KO:K02183]
100022649  calmodulin-alpha-like [KO:K02183]
100010071  F2R; coagulation factor II thrombin receptor [KO:K03914]
100015541  proteinase-activated receptor 4-like [KO:K04236]
100015642  proteinase-activated receptor 4-like [KO:K04236]
100020509  P2RY1; purinergic receptor P2Y1 [KO:K04270]
100016607  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103103209  lysophosphatidic acid receptor 1-A-like [KO:K04289]
100014105  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100012415  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
100020275  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100015472  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100029653  ADORA2A; adenosine A2a receptor [KO:K04266]
100617435  ADORA2B; adenosine A2b receptor [KO:K04267]
100021523  GNAS; GNAS complex locus [KO:K04632]
100029582  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
100030463  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
100013164  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
100025332  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
100030872  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
100019274  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
100013823  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
100026554  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
100013831  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
100025283  RAPGEF4; Rap guanine nucleotide exchange factor 4 [KO:K04351]
100011605  GNAQ; G protein subunit alpha q [KO:K04634]
100033281  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
100031660  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
100031869  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
100031263  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
100031591  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
100619143  EGF; epidermal growth factor [KO:K04357]
100023197  FGF1; fibroblast growth factor 1 [KO:K18496]
619384  FGF2; fibroblast growth factor 2 [KO:K18497]
100012692  FGF10; fibroblast growth factor 10 [KO:K04358]
100019563  FGF6; fibroblast growth factor 6 [KO:K04358]
100025923  FGF7; fibroblast growth factor 7 [KO:K04358]
100014690  FGF5; fibroblast growth factor 5 [KO:K04358]
100031074  FGF18; fibroblast growth factor 18 [KO:K04358]
100012499  FGF16; fibroblast growth factor 16 [KO:K04358]
100021631  FGF4; fibroblast growth factor 4 [KO:K04358]
100023400  FGF8; fibroblast growth factor 8 [KO:K04358]
100021692  FGF3; fibroblast growth factor 3 [KO:K04358]
100030474  FGF17; fibroblast growth factor 17 [KO:K04358]
100021885  FGF20; fibroblast growth factor 20 [KO:K04358]
100024639  FGF22; fibroblast growth factor 22 [KO:K04358]
100023928  FGF9; fibroblast growth factor 9 [KO:K04358]
100021575  FGF19; fibroblast growth factor 19 [KO:K22603]
100019656  FGF23; fibroblast growth factor 23 [KO:K22428]
100010246  NGF; nerve growth factor [KO:K02582]
100021295  IGF1; insulin like growth factor 1 [KO:K05459]
100020951  PDGFA; platelet derived growth factor subunit A [KO:K04359]
100012899  PDGFB; platelet derived growth factor subunit B [KO:K17386]
100011261  PDGFD; platelet derived growth factor D [KO:K05450]
100023701  PDGFC; platelet derived growth factor C [KO:K05450]
100033077  CSF1; colony stimulating factor 1 [KO:K05453]
100021399  KITLG; KIT ligand [KO:K05461]
100012132  VEGFA; vascular endothelial growth factor A [KO:K05448]
100028411  VEGFB; vascular endothelial growth factor B [KO:K16858]
100023623  PGF; placental growth factor [KO:K16859]
100031803  VEGFD; vascular endothelial growth factor D [KO:K05449]
100013301  VEGFC; vascular endothelial growth factor C [KO:K05449]
100016122  HGF; hepatocyte growth factor [KO:K05460]
100024331  ANGPT1; angiopoietin 1 [KO:K05465]
100028850  ANGPT2; angiopoietin 2 [KO:K05466]
100012457  ANGPT4; angiopoietin 4 [KO:K05467]
100015707  EFNA5; ephrin A5 [KO:K05462]
100016521  EFNA1; ephrin A1 [KO:K05462]
100021625  EFNA4; ephrin A4 [KO:K05462]
100021250  EFNA2; ephrin A2 [KO:K05462]
100617157  EFNA3; ephrin A3 [KO:K05462]
100029625  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100029852  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
100025727  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
100023287  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100031838  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100021774  NGFR; nerve growth factor receptor [KO:K02583]
100024870  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
100027215  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
100020095  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100013088  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100028943  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100028926  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100017501  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
100025304  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
100017469  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
100032078  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
100017311  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
100013788  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
100023250  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
100619759  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
100012317  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
100015312  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
100016537  RAPGEF1; Rap guanine nucleotide exchange factor 1 [KO:K06277]
100027800  CDH1; cadherin 1 [KO:K05689]
100022896  CTNNB1; catenin beta 1 [KO:K02105]
100011484  MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
100017028  MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2 [KO:K05629]
100033161  MAGI3; membrane associated guanylate kinase, WW and PDZ domain containing 3 [KO:K06112]
100023159  RAPGEF2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
100015023  RAPGEF6; Rap guanine nucleotide exchange factor 6 [KO:K08020]
100010040  TRB; T-cell receptor beta-2 chain C region [KO:K10785]
100617727  T-cell receptor beta-2 chain C region [KO:K10785]
103104196  LAT; linker for activation of T-cells [KO:K07362]
100019146  FYB; FYN binding protein [KO:K17698]
100026299  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
100020386  SKAP1; src kinase associated phosphoprotein 1 [KO:K17699]
100032696  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
100024674  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
100013346  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
100013333  PRKD1; protein kinase D1 [KO:K06070] [EC:2.7.11.13]
100011137  PRKD3; protein kinase D3 [KO:K06070] [EC:2.7.11.13]
100026172  DRD2; dopamine receptor D2 [KO:K04145]
100019458  CNR1; cannabinoid receptor 1 [KO:K04277]
100013052  GNAI1; G protein subunit alpha i1 [KO:K04630]
100030095  GNAI3; G protein subunit alpha i3 [KO:K04630]
100032986  GNAI2; G protein subunit alpha i2 [KO:K04630]
100015137  GNAO1; G protein subunit alpha o1 [KO:K04534]
100617875  RAP1GAP; RAP1 GTPase activating protein [KO:K17700]
100019973  SIPA1L1; signal induced proliferation associated 1 like 1 [KO:K17701]
100021842  SIPA1L2; signal induced proliferation associated 1 like 2 [KO:K17702]
100012469  SIPA1L3; signal induced proliferation associated 1 like 3 [KO:K17703]
100010733  ID1; inhibitor of DNA binding 1, HLH protein [KO:K04680]
100031767  THBS1; thrombospondin 1 [KO:K16857]
100017777  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
100011023  RALA; RAS like proto-oncogene A [KO:K07834]
100010449  RALB; RAS like proto-oncogene B [KO:K07835]
100026992  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
100017517  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
100029873  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
100025059  APBB1IP; amyloid beta precursor protein binding family B member 1 interacting protein [KO:K17704]
100016699  TLN2; talin 2 [KO:K06271]
100028083  TLN1; talin 1 [KO:K06271]
100023354  ITGA2B; integrin subunit alpha 2b [KO:K06476]
100025359  ITGB3; integrin subunit beta 3 [KO:K06493]
100012072  PFN2; profilin 2 [KO:K05759]
100016522  PFN1; profilin 1 [KO:K05759]
100031959  PFN3; profilin 3 [KO:K05759]
107650459  PFN4; profilin family member 4 [KO:K05759]
103099139  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
100025688  ENAH; enabled homolog (Drosophila) [KO:K05746]
100022783  EVL; Enah/Vasp-like [KO:K23487]
100025924  ACTG1; actin gamma 1 [KO:K05692]
100029767  actin, cytoplasmic type 5 [KO:K05692]
100011313  actin, cytoplasmic 1 [KO:K05692]
100016601  actin, cytoplasmic 1-like [KO:K05692]
100020439  actin, cytoplasmic 1-like [KO:K05692]
100024060  actin, cytoplasmic 1-like [KO:K05692]
100028958  actin, cytoplasmic 1-like [KO:K05692]
103096124  actin, cytoplasmic 1-like [KO:K05692]
100011351  ACTB; actin beta [KO:K05692]
100027875  ARAP3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [KO:K12490]
100021110  RHOA; ras homolog family member A [KO:K04513]
100029391  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
100022723  FARP2; FERM, ARH/RhoGEF and pleckstrin domain protein 2 [KO:K06082]
100023099  CDC42; cell division cycle 42 [KO:K04393]
100009767  cell division control protein 42 homolog [KO:K04393]
100029844  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
100015350  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100020150  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
100015064  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
100022889  PARD3; par-3 family cell polarity regulator [KO:K04237]
100022922  PARD6B; par-6 family cell polarity regulator beta [KO:K06093]
100021195  PARD6A; par-6 family cell polarity regulator alpha [KO:K06093]
100017248  PARD6G; par-6 family cell polarity regulator gamma [KO:K06093]
100020001  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
100030202  PRKCZ; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
100020306  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
103103873  mucin-16-like [KO:K18952] [EC:2.7.11.13]
100617582  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
100010646  PRKCI; protein kinase C iota [KO:K06069] [EC:2.7.11.13]
100032641  AFDN; afadin, adherens junction formation factor [KO:K05702]
100023012  CTNND1; catenin delta 1 [KO:K05690]
100028133  KRIT1; KRIT1, ankyrin repeat containing [KO:K17705]
100031963  RGS14; regulator of G-protein signaling 14 [KO:K17706]
100014771  RASSF5; Ras association domain family member 5 [KO:K08015]
100017790  ITGAL; integrin subunit alpha L [KO:K05718]
100016833  integrin alpha-M-like [KO:K06461]
100016871  ITGAM; integrin alpha-M [KO:K06461]
100024596  ITGB2; integrin subunit beta 2 [KO:K06464]
100018342  ITGB1; integrin subunit beta 1 [KO:K05719]
100024057  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
100015410  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
100018410  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100018044  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100028096  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100012916  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100016872  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100029049  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100010279  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100010891  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100026324  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
100028821  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100010412  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
100017332  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
100024769  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
100019317  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100032726  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
100616957  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
100014564  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
100019947  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
100027373  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
100023487  PLCE1; phospholipase C epsilon 1 [KO:K05860] [EC:3.1.4.11]
100032921  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
554186  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
554197  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
100022523  GTPase NRas-like [KO:K07828]
100030293  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
mdo04010  MAPK signaling pathway
mdo04014  Ras signaling pathway
mdo04020  Calcium signaling pathway
mdo04151  PI3K-Akt signaling pathway
mdo04510  Focal adhesion
mdo04520  Adherens junction
mdo04660  T cell receptor signaling pathway
mdo04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
LinkDB

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