KEGG   PATHWAY: mdo04728
Entry
mdo04728                    Pathway                                
Name
Dopaminergic synapse - Monodelphis domestica (gray short-tailed opossum)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
Pathway map
mdo04728  Dopaminergic synapse
mdo04728

Other DBs
GO: 0001963
Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100021373  tyrosine 3-monooxygenase-like [KO:K00501] [EC:1.14.16.2]
100030001  DDC; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
100033069  SLC18A1; solute carrier family 18 member A1 [KO:K08155]
100020699  SLC18A2; solute carrier family 18 member A2 [KO:K08155]
100026854  DRD1; dopamine receptor D1 [KO:K04144]
100017852  DRD5; dopamine receptor D5 [KO:K05840]
100011605  GNAQ; G protein subunit alpha q [KO:K04634]
100033281  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
100031660  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
100031869  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
100031263  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
100013305  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100010212  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100025596  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100021688  CALM3; calmodulin 3 [KO:K02183]
100018191  CALM1; calmodulin 1 [KO:K02183]
100032171  CALM2; calmodulin 2 [KO:K02183]
100025795  CALML4; calmodulin like 4 [KO:K02183]
100015722  calmodulin-alpha-like [KO:K02183]
100022649  calmodulin-alpha-like [KO:K02183]
100011784  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
100010898  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
100024521  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
100028973  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
100014900  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100011077  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
100033104  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
100024674  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
100013346  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
100018285  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
100021523  GNAS; GNAS complex locus [KO:K04632]
100029582  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
100013751  GNAL; G protein subunit alpha L [KO:K04633]
100019274  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
100011211  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
100026861  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100032298  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100014049  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
100025939  ATF2; activating transcription factor 2 [KO:K04450]
100012224  ATF4; activating transcription factor 4 [KO:K04374]
100017208  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
100020067  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
100022547  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
100015046  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
103104366  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
100032634  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
100025603  ATF6B; activating transcription factor 6 beta [KO:K09049]
100010279  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100010891  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100026324  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
100028821  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100028089  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
100618895  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100017341  PPP1R1B; protein phosphatase 1 regulatory inhibitor subunit 1B [KO:K15494]
100031298  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
100019898  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
100029055  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
100016606  SCN1A; sodium voltage-gated channel alpha subunit 1 [KO:K04833]
100021421  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
100014450  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
100021108  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
100023896  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
100014566  KCNJ3; potassium voltage-gated channel subfamily J member 3 [KO:K04997]
100019404  KCNJ6; potassium voltage-gated channel subfamily J member 6 [KO:K05000]
100029817  KCNJ9; potassium voltage-gated channel subfamily J member 9 [KO:K05002]
100020905  KCNJ5; potassium voltage-gated channel subfamily J member 5 [KO:K04999]
100014112  DRD3; dopamine receptor D3 [KO:K04146]
100618204  DRD4; dopamine receptor D4 [KO:K04147]
100013052  GNAI1; G protein subunit alpha i1 [KO:K04630]
100030095  GNAI3; G protein subunit alpha i3 [KO:K04630]
100032986  GNAI2; G protein subunit alpha i2 [KO:K04630]
100015137  GNAO1; G protein subunit alpha o1 [KO:K04534]
100010736  GNB1; G protein subunit beta 1 [KO:K04536]
100017392  GNB2; G protein subunit beta 2 [KO:K04537]
100013759  GNB3; G protein subunit beta 3 [KO:K07825]
100013546  GNB4; G protein subunit beta 4 [KO:K04538]
100031383  GNB5; G protein subunit beta 5 [KO:K04539]
100010452  GNG3; G protein subunit gamma 3 [KO:K04540]
100021132  GNG4; G protein subunit gamma 4 [KO:K04541]
100011015  GNG5; G protein subunit gamma 5 [KO:K04542]
100014687  GNG7; G protein subunit gamma 7 [KO:K04543]
100016961  GNG8; G protein subunit gamma 8 [KO:K04544]
100018189  GNG10; G protein subunit gamma 10 [KO:K04545]
100016914  GNG12; G protein subunit gamma 12 [KO:K04347]
100010184  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
100017439  GNG13; G protein subunit gamma 13 [KO:K04547]
100018838  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
100026172  DRD2; dopamine receptor D2 [KO:K04145]
100012179  ARRB1; arrestin beta 1 [KO:K04439]
100016052  ARRB2; arrestin beta 2 [KO:K04439]
100014847  beta-arrestin-2-like [KO:K04439]
100012652  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
100017519  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
100026516  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
100028805  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
100023749  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
100014202  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
100018121  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
100023958  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
100011289  PPP2R3B; protein phosphatase 2 regulatory subunit B''beta [KO:K11583]
100011688  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
100016573  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
100017824  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
100010758  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
100022186  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
100016488  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
100014564  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
100019947  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
100027373  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
100012447  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
100018255  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
100017355  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
100029673  GRIA1; glutamate ionotropic receptor AMPA type subunit 1 [KO:K05197]
100023645  GRIA2; glutamate ionotropic receptor AMPA type subunit 2 [KO:K05198]
100030019  GRIA3; glutamate ionotropic receptor AMPA type subunit 3 [KO:K05199]
100027109  GRIA4; glutamate ionotropic receptor AMPA type subunit 4 [KO:K05200]
100013478  KIF5C; kinesin family member 5C [KO:K10396]
100023318  KIF5B; kinesin family member 5B [KO:K10396]
100017022  CLOCK; clock circadian regulator [KO:K02223] [EC:2.3.1.48]
100021673  ARNTL; aryl hydrocarbon receptor nuclear translocator like [KO:K02296]
100015498  SLC6A3; solute carrier family 6 member 3 [KO:K05036]
100618242  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
100027805  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
100031097  COMT; catechol-O-methyltransferase [KO:K00545] [EC:2.1.1.6]
103102723  transmembrane O-methyltransferase [KO:K00545] [EC:2.1.1.6]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00238  Potassium cation
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C01161  3,4-Dihydroxyphenylacetate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C03758  Dopamine
C05582  Homovanillate
C05587  3-Methoxytyramine
Reference
PMID:21303898
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642
Reference
PMID:15521361
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
Reference
PMID:17408758
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008
Reference
PMID:20224735
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133
Reference
PMID:10433257
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9
Reference
PMID:15590733
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004
Reference
PMID:17349698
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006
Reference
PMID:19138563
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002
Reference
PMID:15381316
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006
Reference
PMID:18353279
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018
Reference
PMID:20727368
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001
Reference
PMID:15292232
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200
Reference
PMID:12967774
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189
Reference
PMID:19251795
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908
Related
pathway
mdo00350  Tyrosine metabolism
mdo04020  Calcium signaling pathway
mdo04721  Synaptic vesicle cycle
mdo04724  Glutamatergic synapse
mdo05012  Parkinson disease
KO pathway
ko04728   
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