KEGG   PATHWAY: mfot05208
Entry
mfot05208                   Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Microtus fortis (reed vole)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
mfot05208  Chemical carcinogenesis - reactive oxygen species
mfot05208

Organism
Microtus fortis (reed vole) [GN:mfot]
Gene
126504270  arsenite methyltransferase isoform X1 [KO:K07755] [EC:2.1.1.137]
126491445  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
126491866  glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
126491867  glutathione S-transferase Mu 6 isoform X1 [KO:K00799] [EC:2.5.1.18]
126491868  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
126491869  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
126491870  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
126491889  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
126499212  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
126499222  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126499232  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
126499310  microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
126487880  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126487881  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
126487883  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
126487884  glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
126501513  glutathione S-transferase theta-2-like [KO:K00799] [EC:2.5.1.18]
126495752  glutathione S-transferase alpha-3 [KO:K00799] [EC:2.5.1.18]
126489682  glutathione S-transferase-like isoform X1 [KO:K00799] [EC:2.5.1.18]
126496924  glutathione S-transferase alpha-3-like [KO:K00799] [EC:2.5.1.18]
126496940  glutathione S-transferase A6 isoform X1 [KO:K00799] [EC:2.5.1.18]
126496941  glutathione S-transferase A6-like [KO:K00799] [EC:2.5.1.18]
126503400  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
126497282  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
126504036  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
126511192  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
126511276  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
126491101  glutathione S-transferase A1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126491187  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
126498279  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
126507262  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
126508279  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
126499007  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
126488457  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
126493381  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
126493070  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
126493187  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126516031  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126489705  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126510209  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126491846  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126514784  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
126496415  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126497317  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126503900  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
126490692  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126504632  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
126501288  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
126490155  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
126503936  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
126515720  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
126494056  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
126491254  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
126488476  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
126514264  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
126498075  acyl carrier protein, mitochondrial-like [KO:K03955]
126502390  acyl carrier protein, mitochondrial [KO:K03955]
126490343  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
126503819  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
126494376  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
126507225  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
126487768  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [KO:K03958]
126505152  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
126511864  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
126505812  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
126492690  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
126494085  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
126499252  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
126503634  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
126487757  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
126503834  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
126503423  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
126497451  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
126512001  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
126512894  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
126487507  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
126508872  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
126502202  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
126489754  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
126507973  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
126513137  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
126501147  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
126503799  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
126489275  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
126498626  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
126513396  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial-like [KO:K03941] [EC:7.1.1.2]
126499235  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
126508996  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
126503725  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
126508843  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
126502707  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
126502136  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
126509992  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
126501702  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
126503410  cytochrome c1, heme protein, mitochondrial [KO:K00413]
126499948  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
126502311  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
126494154  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
126511799  cytochrome b-c1 complex subunit 7-like [KO:K00417]
126492264  cytochrome b-c1 complex subunit 7-like [KO:K00417]
126513918  cytochrome b-c1 complex subunit 7 [KO:K00417]
126510968  cytochrome b-c1 complex subunit 8 [KO:K00418]
126501003  cytochrome b-c1 complex subunit 9 [KO:K00419]
126489287  cytochrome b-c1 complex subunit 10 [KO:K00420]
126491355  cytochrome b-c1 complex subunit 10-like [KO:K00420]
126507121  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
126515512  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
126507546  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
126486612  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
126496236  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
126496955  cytochrome c oxidase subunit 5B, mitochondrial isoform X1 [KO:K02265]
126491352  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
126494303  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
126496085  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
126515979  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
126486677  cytochrome c oxidase subunit 6B1 [KO:K02267]
126493644  cytochrome c oxidase subunit 6B2 [KO:K02267]
126487443  cytochrome c oxidase subunit 6B1-like [KO:K02267]
126496305  cytochrome c oxidase subunit 6B1 [KO:K02267]
126505161  cytochrome c oxidase subunit 6B1-like [KO:K02267]
126514379  cytochrome c oxidase subunit 6C-2 [KO:K02268]
126486765  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
126504082  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
126491240  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
126506197  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
126493461  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
126487178  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
126504594  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
126491142  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126507173  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
126514755  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
126498347  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
126498551  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
126507340  ATP synthase subunit alpha, mitochondrial [KO:K02132]
126492030  ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
126506708  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
126489362  ATP synthase subunit delta, mitochondrial [KO:K02134]
126499919  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
126508081  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
126493838  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
126506839  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
126513175  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
126487955  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
126501626  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126489147  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126489195  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126503436  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
126497246  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126510508  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
126491213  ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
126491305  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
126500429  ATP synthase subunit d, mitochondrial [KO:K02138]
126515273  ATP synthase subunit O, mitochondrial [KO:K02137]
126499379  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
126497614  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
126510981  voltage-dependent anion-selective channel protein 1 [KO:K05862]
126509080  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
126491346  voltage-dependent anion-selective channel protein 2 [KO:K15040]
126504450  voltage-dependent anion-selective channel protein 3 [KO:K15041]
126498665  ADP/ATP translocase 2 [KO:K05863]
126499302  ADP/ATP translocase 4 [KO:K05863]
126488451  ADP/ATP translocase 2 [KO:K05863]
126504837  LOW QUALITY PROTEIN: ADP/ATP translocase 1 [KO:K05863]
126499040  peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
126515286  superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
126504612  catalase [KO:K03781] [EC:1.11.1.6]
126509630  sulfate anion transporter 1 [KO:K14700]
126511104  sulfate transporter [KO:K14701]
126500005  solute carrier family 26 member 6 isoform X1 [KO:K14704]
126505111  solute carrier family 26 member 9 [KO:K14706]
126507532  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
126507533  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
126507534  LOW QUALITY PROTEIN: cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
126498260  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
126492527  cytochrome P450 2F2 [KO:K07416] [EC:1.14.14.1]
126507531  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
126514555  cytochrome P450 1B1 isoform X1 [KO:K07410] [EC:1.14.14.1]
126502146  epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
126502147  epoxide hydrolase 1-like [KO:K01253] [EC:3.3.2.9]
126507630  bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
126504071  epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
126509751  epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
126491502  aldo-keto reductase family 1 member A1-like [KO:K00002] [EC:1.1.1.2]
126494143  aldo-keto reductase family 1 member A1 isoform X1 [KO:K00002] [EC:1.1.1.2]
126501693  aldo-keto reductase family 1 member C21-like [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
126506800  aldo-keto reductase family 1 member C15-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
126501679  aldo-keto reductase family 1 member C15 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
126501680  aldo-keto reductase family 1 member C15-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
126501681  aldo-keto reductase family 1 member C15-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
126502838  NAD(P)H dehydrogenase [quinone] 1 isoform X1 [KO:K00355] [EC:1.6.5.2]
126505058  NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
126513574  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
126513575  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
126513576  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
126511515  aryl hydrocarbon receptor [KO:K09093]
126510564  lactoperoxidase [KO:K12550] [EC:1.11.1.7]
126491513  NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
126515561  cytochrome b-245 light chain [KO:K08009]
126491541  NADPH oxidase 1 isoform X1 [KO:K08008]
126516028  neutrophil cytosol factor 1 [KO:K08011]
126497365  neutrophil cytosol factor 2 [KO:K08010]
126509286  LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
126500934  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
126500116  hepatocyte growth factor isoform X1 [KO:K05460]
126503908  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
126500407  growth factor receptor-bound protein 2 [KO:K04364]
126514526  son of sevenless homolog 1 isoform X1 [KO:K03099]
126508440  son of sevenless homolog 2 isoform X1 [KO:K03099]
126498807  GTPase HRas [KO:K02833]
126515221  GTPase KRas isoform X1 [KO:K07827]
126510868  GTPase NRas [KO:K07828]
126496069  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
126505149  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
126505550  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126507499  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
126489299  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
126489023  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126515955  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
126511959  mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
126513961  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
126491615  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
126500615  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126509741  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126511413  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126492719  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
126492755  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
126501977  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
126502008  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
126497948  transcription factor Jun [KO:K04448]
126515189  protein c-Fos [KO:K04379]
126491758  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
126512534  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
126494148  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
126499173  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126499912  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126508229  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126489822  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126514348  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
126492538  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126502126  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126509082  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126487590  forkhead box protein O3 [KO:K09408]
126498361  bcl2-associated agonist of cell death isoform X1 [KO:K02158]
126487393  tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
126504083  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
126504411  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
126490256  NF-kappa-B essential modulator isoform X1 [KO:K07210]
126499590  NF-kappa-B inhibitor alpha [KO:K04734]
126498562  transcription factor p65 isoform X1 [KO:K04735]
126502367  nuclear factor NF-kappa-B p105 subunit [KO:K02580]
126511136  protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
126489758  receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
126508770  low molecular weight phosphotyrosine protein phosphatase-like [KO:K14394] [EC:3.1.3.2 3.1.3.48]
126491111  low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
126495739  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
126511661  tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
126507045  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
126509448  tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
126497347  tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
126499606  serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
126514576  serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
126494785  serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
126503359  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
126514028  phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
126501433  phospholipase D1 [KO:K01115] [EC:3.1.4.4]
126510438  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
126508397  hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
126489970  aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
126488914  vascular endothelial growth factor A isoform X1 [KO:K05448]
126490522  kelch-like ECH-associated protein 1 isoform X1 [KO:K10456]
126487111  nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
126489141  heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
Reference
PMID:24281075
  Authors
Henkler F, Brinkmann J, Luch A
  Title
The role of oxidative stress in carcinogenesis induced by metals and xenobiotics.
  Journal
Cancers (Basel) 2:376-96 (2010)
DOI:10.3390/cancers2020376
Reference
PMID:22705365
  Authors
Lee JC, Son YO, Pratheeshkumar P, Shi X
  Title
Oxidative stress and metal carcinogenesis.
  Journal
Free Radic Biol Med 53:742-57 (2012)
DOI:10.1016/j.freeradbiomed.2012.06.002
Reference
PMID:32033297
  Authors
Hu Y, Li J, Lou B, Wu R, Wang G, Lu C, Wang H, Pi J, Xu Y
  Title
The Role of Reactive Oxygen Species in Arsenic Toxicity.
  Journal
Biomolecules 10:E240 (2020)
DOI:10.3390/biom10020240
Reference
PMID:33864199
  Authors
Ozturk M, Metin M, Altay V, Bhat RA, Ejaz M, Gul A, Unal BT, Hasanuzzaman M, Nibir L, Nahar K, Bukhari A, Dervash MA, Kawano T
  Title
Arsenic and Human Health: Genotoxicity, Epigenomic Effects, and Cancer Signaling.
  Journal
Biol Trace Elem Res 10.1007/s12011-021-02719-w (2021)
DOI:10.1007/s12011-021-02719-w
Reference
PMID:23510327
  Authors
Hubaux R, Becker-Santos DD, Enfield KS, Rowbotham D, Lam S, Lam WL, Martinez VD
  Title
Molecular features in arsenic-induced lung tumors.
  Journal
Mol Cancer 12:20 (2013)
DOI:10.1186/1476-4598-12-20
Reference
PMID:21648415
  Authors
Naranmandura H, Xu S, Sawata T, Hao WH, Liu H, Bu N, Ogra Y, Lou YJ, Suzuki N
  Title
Mitochondria are the main target organelle for trivalent monomethylarsonous acid (MMA(III))-induced cytotoxicity.
  Journal
Chem Res Toxicol 24:1094-103 (2011)
DOI:10.1021/tx200156k
Reference
PMID:23583964
  Authors
Faita F, Cori L, Bianchi F, Andreassi MG
  Title
Arsenic-induced genotoxicity and genetic susceptibility to arsenic-related pathologies.
  Journal
Int J Environ Res Public Health 10:1527-46 (2013)
DOI:10.3390/ijerph10041527
Reference
PMID:28179585
  Authors
Sage AP, Minatel BC, Ng KW, Stewart GL, Dummer TJB, Lam WL, Martinez VD
  Title
Oncogenomic disruptions in arsenic-induced carcinogenesis.
  Journal
Oncotarget 8:25736-25755 (2017)
DOI:10.18632/oncotarget.15106
Reference
PMID:21414382
  Authors
Jomova K, Valko M
  Title
Advances in metal-induced oxidative stress and human disease.
  Journal
Toxicology 283:65-87 (2011)
DOI:10.1016/j.tox.2011.03.001
Reference
PMID:16430879
  Authors
Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M
  Title
Free radicals, metals and antioxidants in oxidative stress-induced cancer.
  Journal
Chem Biol Interact 160:1-40 (2006)
DOI:10.1016/j.cbi.2005.12.009
Reference
PMID:32731582
  Authors
Tumolo M, Ancona V, De Paola D, Losacco D, Campanale C, Massarelli C, Uricchio VF
  Title
Chromium Pollution in European Water, Sources, Health Risk, and Remediation Strategies: An Overview.
  Journal
Int J Environ Res Public Health 17:E5438 (2020)
DOI:10.3390/ijerph17155438
Reference
PMID:28860815
  Authors
Wang Y, Su H, Gu Y, Song X, Zhao J
  Title
Carcinogenicity of chromium and chemoprevention: a brief update.
  Journal
Onco Targets Ther 10:4065-4079 (2017)
DOI:10.2147/OTT.S139262
Reference
PMID:24820114
  Authors
Jin X, Chen M, Song L, Li H, Li Z
  Title
The evaluation of p,p'-DDT exposure on cell adhesion of hepatocellular carcinoma.
  Journal
Toxicology 322:99-108 (2014)
DOI:10.1016/j.tox.2014.05.002
Reference
PMID:20370557
  Authors
Liou GY, Storz P
  Title
Reactive oxygen species in cancer.
  Journal
Free Radic Res 44:479-96 (2010)
DOI:10.3109/10715761003667554
Reference
PMID:11275476
  Authors
Murata M, Tamura A, Tada M, Kawanishi S
  Title
Mechanism of oxidative DNA damage induced by carcinogenic 4-aminobiphenyl.
  Journal
Free Radic Biol Med 30:765-73 (2001)
DOI:10.1016/S0891-5849(01)00463-4
Reference
PMID:31283132
  Authors
  Title
  Journal
Pentachlorophenol and Some Related Compounds (2019)
Reference
PMID:19408893
  Authors
Zhu BZ, Shan GQ
  Title
Potential mechanism for pentachlorophenol-induced carcinogenicity: a novel mechanism for metal-independent production of hydroxyl radicals.
  Journal
Chem Res Toxicol 22:969-77 (2009)
DOI:10.1021/tx900030v
Reference
PMID:22166497
  Authors
McHale CM, Zhang L, Smith MT
  Title
Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment.
  Journal
Carcinogenesis 33:240-52 (2012)
DOI:10.1093/carcin/bgr297
Reference
PMID:32977499
  Authors
Scharf P, Broering MF, Oliveira da Rocha GH, Farsky SHP
  Title
Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis.
  Journal
Int J Mol Sci 21:E6996 (2020)
DOI:10.3390/ijms21196996
Reference
PMID:23066403
  Authors
Snyder R
  Title
Leukemia and benzene.
  Journal
Int J Environ Res Public Health 9:2875-93 (2012)
DOI:10.3390/ijerph9082875
Reference
PMID:9118888
  Authors
Snyder R, Hedli CC
  Title
An overview of benzene metabolism.
  Journal
Environ Health Perspect 104 Suppl 6:1165-71 (1996)
DOI:10.1289/ehp.961041165
Reference
PMID:11978484
  Authors
Kawanishi S, Hiraku Y, Murata M, Oikawa S
  Title
The role of metals in site-specific DNA damage with reference to carcinogenesis.
  Journal
Free Radic Biol Med 32:822-32 (2002)
DOI:10.1016/S0891-5849(02)00779-7
Reference
PMID:27919191
  Authors
Das DN, Panda PK, Naik PP, Mukhopadhyay S, Sinha N, Bhutia SK
  Title
Phytotherapeutic approach: a new hope for polycyclic aromatic hydrocarbons induced cellular disorders, autophagic and apoptotic cell death.
  Journal
Toxicol Mech Methods 27:1-17 (2017)
DOI:10.1080/15376516.2016.1268228
Reference
PMID:21910479
  Authors
Shultz CA, Quinn AM, Park JH, Harvey RG, Bolton JL, Maser E, Penning TM.
  Title
Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone.
  Journal
Chem Res Toxicol 24:2153-66 (2011)
DOI:10.1021/tx200294c
Reference
PMID:25279998
  Authors
Penning TM
  Title
Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons.
  Journal
Chem Res Toxicol 27:1901-17 (2014)
DOI:10.1021/tx500298n
Reference
PMID:10706104
  Authors
Burczynski ME, Penning TM
  Title
Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor.
  Journal
Cancer Res 60:908-15 (2000)
Reference
PMID:15963346
  Authors
Xue W, Warshawsky D
  Title
Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review.
  Journal
Toxicol Appl Pharmacol 206:73-93 (2005)
DOI:10.1016/j.taap.2004.11.006
Reference
PMID:15142886
  Authors
Chen ZH, Hurh YJ, Na HK, Kim JH, Chun YJ, Kim DH, Kang KS, Cho MH, Surh YJ
  Title
Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells.
  Journal
Carcinogenesis 25:2005-13 (2004)
DOI:10.1093/carcin/bgh183
Reference
PMID:16684662
  Authors
Rifkind AB
  Title
CYP1A in TCDD toxicity and in physiology-with particular reference to CYP dependent arachidonic acid metabolism and other endogenous substrates.
  Journal
Drug Metab Rev 38:291-335 (2006)
DOI:10.1080/03602530600570107
Reference
PMID:9380738
  Authors
Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML, Gooden JK, Ramanathan R, Cerny RL, Rogan EG
  Title
Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.
  Journal
Proc Natl Acad Sci U S A 94:10937-42 (1997)
DOI:10.1073/pnas.94.20.10937
Reference
PMID:9472688
  Authors
Zhu BT, Conney AH
  Title
Functional role of estrogen metabolism in target cells: review and perspectives.
  Journal
Carcinogenesis 19:1-27 (1998)
DOI:10.1093/carcin/19.1.1
Reference
PMID:19387921
  Authors
McKillop IH, Schrum LW
  Title
Role of alcohol in liver carcinogenesis.
  Journal
Semin Liver Dis 29:222-32 (2009)
DOI:10.1055/s-0029-1214377
Reference
PMID:15603755
  Authors
Gonzalez FJ
  Title
Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1.
  Journal
Mutat Res 569:101-10 (2005)
DOI:10.1016/j.mrfmmm.2004.04.021
Reference
PMID:31864052
  Authors
Montalbano AM, Albano GD, Anzalone G, Moscato M, Gagliardo R, Di Sano C, Bonanno A, Ruggieri S, Cibella F, Profita M
  Title
Cytotoxic and genotoxic effects of the flame retardants (PBDE-47, PBDE-99 and PBDE-209) in human bronchial epithelial cells.
  Journal
Chemosphere 245:125600 (2020)
DOI:10.1016/j.chemosphere.2019.125600
Reference
PMID:33907575
  Authors
Sun HN, Ren CX, Gong YX, Xie DP, Kwon T
  Title
Regulatory function of peroxiredoxin I on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer development.
  Journal
Oncol Lett 21:465 (2021)
DOI:10.3892/ol.2021.12726
Reference
PMID:25372613
  Authors
Pluchino LA, Wang HC
  Title
Chronic exposure to combined carcinogens enhances breast cell carcinogenesis with mesenchymal and stem-like cell properties.
  Journal
PLoS One 9:e108698 (2014)
DOI:10.1371/journal.pone.0108698
Reference
PMID:25535943
  Authors
Pluchino LA, Liu AK, Wang HC
  Title
Reactive oxygen species-mediated breast cell carcinogenesis enhanced by multiple carcinogens and intervened by dietary ergosterol and mimosine.
  Journal
Free Radic Biol Med 80:12-26 (2015)
DOI:10.1016/j.freeradbiomed.2014.12.015
Reference
PMID:30327380
  Authors
Moldogazieva NT, Lutsenko SV, Terentiev AA
  Title
Reactive Oxygen and Nitrogen Species-Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy.
  Journal
Cancer Res 78:6040-6047 (2018)
DOI:10.1158/0008-5472.CAN-18-0980
Reference
PMID:32358622
  Authors
Kirtonia A, Sethi G, Garg M
  Title
The multifaceted role of reactive oxygen species in tumorigenesis.
  Journal
Cell Mol Life Sci 77:4459-4483 (2020)
DOI:10.1007/s00018-020-03536-5
Reference
PMID:29449774
  Authors
Kumari S, Badana AK, G MM, G S, Malla R
  Title
Reactive Oxygen Species: A Key Constituent in Cancer Survival.
  Journal
Biomark Insights 13:1177271918755391 (2018)
DOI:10.1177/1177271918755391
Reference
PMID:28881698
  Authors
Gao X, Schottker B
  Title
Reduction-oxidation pathways involved in cancer development: a systematic review of literature reviews.
  Journal
Oncotarget 8:51888-51906 (2017)
DOI:10.18632/oncotarget.17128
Reference
PMID:15769673
  Authors
Storz P
  Title
Reactive oxygen species in tumor progression.
  Journal
Front Biosci 10:1881-96 (2005)
DOI:10.2741/1667
Reference
PMID:28835450
  Authors
Assi M
  Title
The differential role of reactive oxygen species in early and late stages of cancer.
  Journal
Am J Physiol Regul Integr Comp Physiol 313:R646-R653 (2017)
DOI:10.1152/ajpregu.00247.2017
Reference
PMID:15024053
  Authors
Storz P, Doppler H, Toker A
  Title
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling.
  Journal
Mol Cell Biol 24:2614-26 (2004)
DOI:10.1128/MCB.24.7.2614-2626.2004
Reference
PMID:24998536
  Authors
Nourazarian AR, Kangari P, Salmaninejad A
  Title
Roles of oxidative stress in the development and progression of breast cancer.
  Journal
Asian Pac J Cancer Prev 15:4745-51 (2014)
DOI:10.7314/apjcp.2014.15.12.4745
Reference
PMID:32336668
  Authors
Zheng F, Goncalves FM, Abiko Y, Li H, Kumagai Y, Aschner M
  Title
Redox toxicology of environmental chemicals causing oxidative stress.
  Journal
Redox Biol 34:101475 (2020)
DOI:10.1016/j.redox.2020.101475
Related
pathway
mfot00190  Oxidative phosphorylation
mfot00980  Metabolism of xenobiotics by cytochrome P450
mfot04010  MAPK signaling pathway
mfot04064  NF-kappa B signaling pathway
mfot04066  HIF-1 signaling pathway
mfot04151  PI3K-Akt signaling pathway
mfot04370  VEGF signaling pathway
mfot05207  Chemical carcinogenesis - receptor activation
mfot05211  Renal cell carcinoma
mfot05215  Prostate cancer
mfot05219  Bladder cancer
mfot05221  Acute myeloid leukemia
mfot05222  Small cell lung cancer
mfot05223  Non-small cell lung cancer
mfot05224  Breast cancer
mfot05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

DBGET integrated database retrieval system