KEGG   PATHWAY: mjv04020
Entry
mjv04020                    Pathway                                
Name
Calcium signaling pathway - Manis javanica (Malayan pangolin)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mjv04020  Calcium signaling pathway
mjv04020

Other DBs
GO: 0019722
Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108398859  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
108393952  SLC8A1; sodium/calcium exchanger 1 isoform X2 [KO:K05849]
108393751  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
108409522  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
108408139  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
108383479  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
108398426  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
108397051  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
108394983  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
108397399  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
108398879  ADORA2A; LOW QUALITY PROTEIN: adenosine receptor A2a [KO:K04266]
108403987  ADORA2B; adenosine receptor A2b isoform X1 [KO:K04267]
108384355  ADRB1; beta-1 adrenergic receptor [KO:K04141]
108400886  ADRB2; beta-2 adrenergic receptor isoform X1 [KO:K04142]
108409143  ADRB3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
108397515  DRD1; D(1A) dopamine receptor [KO:K04144]
108384084  DRD5; D(1B) dopamine receptor [KO:K05840]
108397514  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
108386356  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
108393105  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
108395158  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 5B-like [KO:K04161]
108406037  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
108399555  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
108406177  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
108406179  neuroendocrine secretory protein 55-like [KO:K04632]
118970338  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
108405272  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X2 [KO:K04633]
108403511  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
108409724  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
108397345  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
108410207  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
108407296  ADCY7; adenylate cyclase type 7 isoform X2 [KO:K08047] [EC:4.6.1.1]
108397669  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
108388549  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
108408343  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108409437  PLN; cardiac phospholamban [KO:K05852]
108407637  SLN; sarcolipin [KO:K22642]
108407392  MRLN; myoregulin [KO:K22643]
108403951  CUNH4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
108400643  SMIM6; small integral membrane protein 6 [KO:K26468]
108385494  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
108404162  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3 [KO:K05853] [EC:7.2.2.10]
108400537  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
108400323  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
108384363  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
108401355  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
108390400  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
108383779  ORAI2; protein orai-2 isoform X1 [KO:K16057]
108385474  ORAI3; protein orai-3 [KO:K16058]
108387253  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
108402355  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
108404213  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
108396001  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
108399643  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
108404638  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
108385633  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
108402776  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
108402892  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
108397370  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
108409828  CHRFAM7A; CHRNA7-FAM7A fusion protein isoform X1 [KO:K04809]
108388298  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
108405840  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
108406616  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
108385884  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
108386781  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
108386667  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
108395535  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
108404165  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
108390424  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
108409781  P2RX3; P2X purinoceptor 3 [KO:K05217]
108384599  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
108392661  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
108408976  P2RX6; P2X purinoceptor 6 [KO:K05221]
108386280  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
108399498  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
108401977  RYR2; ryanodine receptor 2 [KO:K04962]
108400973  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
108384900  TRDN; triadin [KO:K23449]
108402866  CASQ1; calsequestrin-1 isoform X1 [KO:K23468]
108391037  CASQ2; calsequestrin-2 isoform X1 [KO:K23445]
108395459  aspartyl/asparaginyl beta-hydroxylase isoform X3 [KO:K00476] [EC:1.14.11.16]
108392536  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
108395856  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
108391646  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
118969906  muscarinic acetylcholine receptor M2-like [KO:K04130]
108393548  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
108403736  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
108399239  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
108388618  AGTR1; type-1 angiotensin II receptor [KO:K04166]
108385478  EDNRA; endothelin-1 receptor [KO:K04197]
108392827  EDNRB; endothelin receptor type B [KO:K04198]
108383641  F2R; proteinase-activated receptor 1 [KO:K03914]
108401022  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
108386876  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
108391991  GRPR; gastrin-releasing peptide receptor [KO:K04169]
108394130  HRH1; histamine H1 receptor isoform X1 [KO:K04149]
108409285  5-hydroxytryptamine receptor 2B [KO:K04157]
108400063  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
118968205  5-hydroxytryptamine receptor 2B [KO:K04157]
108402174  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
108384953  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
108399148  NTSR1; neurotensin receptor type 1 [KO:K04211]
108401771  OXTR; oxytocin receptor [KO:K04229]
108402175  AVPR1A; vasopressin V1a receptor [KO:K04226]
108390194  AVPR1B; vasopressin V1b receptor [KO:K04227]
108410205  LTB4R2; leukotriene B4 receptor 2 isoform X1 [KO:K04297]
108399278  PTAFR; platelet-activating factor receptor [KO:K04279]
108397630  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X4 [KO:K04260]
108404683  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
108398692  B2 bradykinin receptor isoform X1 [KO:K03916]
108389979  TACR1; substance-P receptor [KO:K04222]
108390999  TACR3; neuromedin-K receptor [KO:K04224]
108393272  TBXA2R; thromboxane A2 receptor [KO:K04264]
108405357  TRHR; thyrotropin-releasing hormone receptor isoform X1 [KO:K04282]
108399802  CCKAR; cholecystokinin receptor type A [KO:K04194]
108401124  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
108401250  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
108397041  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
108403596  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
108387859  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
108403592  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
108408073  EGF; pro-epidermal growth factor [KO:K04357]
108388206  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
118970652  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
108397360  PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
108393368  PDGFC; platelet-derived growth factor C isoform X4 [KO:K05450]
108390154  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
108405921  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
108393279  FGF20; fibroblast growth factor 20 [KO:K04358]
108402439  FGF16; fibroblast growth factor 16 [KO:K04358]
108397295  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
108397792  FGF10; fibroblast growth factor 10 [KO:K04358]
108383974  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
108391342  fibroblast growth factor 6 [KO:K04358]
108393043  FGF9; fibroblast growth factor 9 [KO:K04358]
108396343  FGF5; fibroblast growth factor 5 [KO:K04358]
118970663  FGF6; fibroblast growth factor 6 [KO:K04358]
108389506  FGF4; fibroblast growth factor 4 [KO:K04358]
108394626  FGF3; fibroblast growth factor 3 [KO:K04358]
118973114  FGF7; fibroblast growth factor 7 [KO:K04358]
118971119  FGF19; fibroblast growth factor 19 [KO:K22603]
108400332  FGF21; fibroblast growth factor 21 isoform X2 [KO:K22429]
108391341  FGF23; fibroblast growth factor 23 isoform X2 [KO:K22428]
108407135  VEGFA; vascular endothelial growth factor A [KO:K05448]
108407564  VEGFB; vascular endothelial growth factor B isoform X3 [KO:K16858]
108391501  VEGFC; vascular endothelial growth factor C [KO:K05449]
108384371  VEGFD; vascular endothelial growth factor D [KO:K05449]
108386081  NGF; beta-nerve growth factor [KO:K02582]
108399212  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
108393341  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
108389097  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
108397962  EGFR; epidermal growth factor receptor isoform X5 [KO:K04361] [EC:2.7.10.1]
108390012  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108398133  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
108400921  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
108385741  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
108385397  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
108403050  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
108395520  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
108383914  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
108398432  FGFR4; fibroblast growth factor receptor 4 isoform X2 [KO:K05095] [EC:2.7.10.1]
108385338  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
108408755  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
108400781  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
108383338  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
108400418  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
108402158  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
108399322  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
108402850  macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
108392617  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
108403685  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
108388410  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
108390511  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
108407569  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
108394257  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X3 [KO:K05858] [EC:3.1.4.11]
108394259  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
108401653  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
108407248  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
108400464  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
108393532  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
108395952  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108403293  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
108402938  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
108408183  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X2 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
108386925  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
108385313  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
108399684  MCOLN1; mucolipin-1 [KO:K04992]
118969396  mucolipin-1-like [KO:K04992]
108403810  MCOLN2; mucolipin-2 [KO:K04993]
108403890  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
108393157  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
108398675  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
108394930  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
108410239  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
108393309  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
108399800  voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
118968497  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
108410160  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
108389683  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
108396047  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
108386810  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
108393494  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
108404428  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
108392913  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
108406654  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
108386142  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
108383704  calmodulin-A-like [KO:K02183]
108406136  CALM3; calmodulin-3 [KO:K02183]
108391461  CALM2; calmodulin-2 [KO:K02183]
108389026  CALM1; calmodulin-1 [KO:K02183]
108405955  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
108385379  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
108407537  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
108396139  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
108398608  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
108396719  MYLK; myosin light chain kinase, smooth muscle isoform X4 [KO:K00907] [EC:2.7.11.18]
108393093  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
108402114  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
108385316  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
108407975  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
108384500  CAMK1G; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
108394998  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
108385398  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
108394027  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
108398760  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
108400883  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
108390709  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
108393196  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108398753  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108391436  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108386668  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
108393727  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
108395074  TFEB; transcription factor EB isoform X1 [KO:K15590]
108385943  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
108391749  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
108402601  NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
108410202  nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
118972277  nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
108397443  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
108397044  NOS2; nitric oxide synthase, inducible isoform X3 [KO:K13241] [EC:1.14.13.39]
108391841  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
108408529  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
108397007  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
108403435  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
108394326  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
108384525  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
108396216  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
118972461  ITPKA; inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
108387768  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
108385666  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108395733  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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J Biol Chem 272:19125-32 (1997)
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Reference
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Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
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Acta Physiol (Oxf) 204:151-7 (2012)
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Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Pflugers Arch 458:869-76 (2009)
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
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Marty I
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Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
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Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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Related
pathway
mjv04010  MAPK signaling pathway
mjv04070  Phosphatidylinositol signaling system
mjv04210  Apoptosis
mjv04720  Long-term potentiation
mjv04730  Long-term depression
KO pathway
ko04020   
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