KEGG   PATHWAY: mmf04151
Entry
mmf04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Molossus molossus (Pallas's mastiff bat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mmf04151  PI3K-Akt signaling pathway
mmf04151

Other DBs
GO: 0043491
Organism
Molossus molossus (Pallas's mastiff bat) [GN:mmf]
Gene
118634494  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
118630701  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
118619242  EREG; proepiregulin [KO:K09784]
118620253  AREG; amphiregulin [KO:K09782]
118616081  FGF1; fibroblast growth factor 1 [KO:K18496]
118616042  FGF2; fibroblast growth factor 2 [KO:K18497]
118640121  FGF5; fibroblast growth factor 5 [KO:K04358]
118626130  FGF7; fibroblast growth factor 7 [KO:K04358]
118628260  FGF4; fibroblast growth factor 4 [KO:K04358]
118628761  FGF3; fibroblast growth factor 3 [KO:K04358]
118642448  FGF10; fibroblast growth factor 10 [KO:K04358]
118636475  FGF16; fibroblast growth factor 16 [KO:K04358]
118622757  FGF20; fibroblast growth factor 20 [KO:K04358]
118615941  FGF18; fibroblast growth factor 18 [KO:K04358]
118616022  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
118624310  FGF9; fibroblast growth factor 9 [KO:K04358]
118624552  FGF6; fibroblast growth factor 6 [KO:K04358]
118616546  FGF22; fibroblast growth factor 22 [KO:K04358]
118632384  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
118628259  FGF19; fibroblast growth factor 19 [KO:K22603]
118639620  FGF21; fibroblast growth factor 21 [KO:K22429]
118623804  FGF23; fibroblast growth factor 23 [KO:K22428]
118637713  NGF; beta-nerve growth factor [KO:K02582]
118628031  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
118624365  NTF3; neurotrophin-3 [KO:K04356]
118639454  NTF4; neurotrophin-4 [KO:K12457]
118628933  INS; insulin [KO:K04526]
118624040  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118628029  IGF2; insulin-like growth factor II [KO:K13769]
118615652  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
118623957  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
118629069  PDGFD; platelet-derived growth factor D [KO:K05450]
118615386  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
118637506  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
118637611  kit ligand-like [KO:K05461]
118624003  KITLG; kit ligand [KO:K05461]
118639068  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
118621078  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
118628000  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
118637179  PGF; placenta growth factor [KO:K16859]
118636328  VEGFD; vascular endothelial growth factor D [KO:K05449]
118622788  VEGFC; vascular endothelial growth factor C [KO:K05449]
118620202  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
118631516  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
118622259  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
118618819  ANGPT4; angiopoietin-4 [KO:K05467]
118616115  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
118642864  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
118637533  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
118637549  EFNA1; ephrin-A1 [KO:K05462]
118637658  EFNA4; ephrin-A4 [KO:K05462]
118642548  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
118616286  NRTN; neurturin [KO:K25414]
118626296  ARTN; artemin [KO:K25415]
118615452  PSPN; persephin [KO:K25416]
118620077  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118633888  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118624257  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
118625188  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
118622697  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
118632260  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118633856  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118643683  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
118634578  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
118637108  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
118629607  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
118615134  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
118640813  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
118624129  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
118615300  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118616505  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
118615155  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
118624675  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
118635912  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
118623942  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
118643768  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
118639624  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
118619859  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
118629453  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
118626884  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
118632108  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
118633806  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118630966  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
118616724  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118643162  HRAS; GTPase HRas isoform X1 [KO:K02833]
118624619  KRAS; GTPase KRas isoform X1 [KO:K07827]
118637822  NRAS; GTPase NRas [KO:K07828]
118633343  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118628434  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118615385  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
118640210  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118642307  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
118625363  IRS1; insulin receptor substrate 1 [KO:K16172]
118616119  TLR2; toll-like receptor 2 [KO:K10159]
118629497  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
118616519  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
118641349  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
118642292  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
118632219  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
118634340  somatotropin [KO:K05438]
118626233  PRL; prolactin [KO:K05439]
118640106  OSM; oncostatin-M isoform X1 [KO:K05418]
118643998  IL2; interleukin-2 [KO:K05429]
118620458  IL6; interleukin-6 isoform X1 [KO:K05405]
118616277  IL4; interleukin-4 [KO:K05430]
118631690  IL7; interleukin-7 isoform X1 [KO:K05431]
118629333  interferon omega-1-like [KO:K05414]
118629850  interferon alpha-14-like [KO:K05414]
118629329  IFNB1; interferon beta [KO:K05415]
118642813  EPO; erythropoietin [KO:K05437]
118634776  CSF3; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor [KO:K05423]
118642611  GHR; growth hormone receptor [KO:K05080]
118642673  PRLR; prolactin receptor [KO:K05081]
118641557  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
118632297  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
118624074  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
118635917  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
118636573  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
118637082  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
118641533  interleukin-4 receptor subunit alpha-like [KO:K05071]
118641654  interleukin-4 receptor subunit alpha-like [KO:K05071]
118641726  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
118617107  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
118617288  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
118615339  EPOR; erythropoietin receptor [KO:K05079]
118626357  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
118626049  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
118629676  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
118615617  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
118633930  COL1A1; collagen alpha-1(I) chain [KO:K06236]
118620424  COL1A2; collagen alpha-2(I) chain [KO:K06236]
118623613  COL2A1; collagen alpha-1(II) chain [KO:K19719]
118635971  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
118636270  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
118622695  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
118622696  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
118625059  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
118625279  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
118617176  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
118617702  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
118633335  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
118633442  collagen alpha-4(VI) chain-like [KO:K06238]
118633557  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
118625073  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
118618958  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
118626913  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
118621076  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
118619232  LAMA1; laminin subunit alpha-1 [KO:K05637]
118620756  LAMA2; laminin subunit alpha-2 [KO:K05637]
118618302  LAMA5; laminin subunit alpha-5 [KO:K06240]
118618751  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
118621696  LAMA4; laminin subunit alpha-4 [KO:K06241]
118620200  LAMB1; laminin subunit beta-1 [KO:K05636]
118632978  LOW QUALITY PROTEIN: laminin subunit beta-2-like [KO:K06243]
118633325  LAMB2; laminin subunit beta-2 [KO:K06243]
118637303  LAMB3; laminin subunit beta-3 [KO:K06244]
118619640  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
118637553  LAMC1; laminin subunit gamma-1 [KO:K05635]
118637413  LAMC2; laminin subunit gamma-2 [KO:K06246]
118629990  LAMC3; laminin subunit gamma-3 [KO:K06247]
118633925  CHAD; chondroadherin [KO:K06248]
118619956  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
118632173  THBS1; thrombospondin-1 [KO:K16857]
118641667  THBS4; LOW QUALITY PROTEIN: thrombospondin-4 [KO:K04659]
118621172  THBS2; thrombospondin-2 [KO:K04659]
118637246  THBS3; thrombospondin-3 [KO:K04659]
118615181  cartilage oligomeric matrix protein [KO:K04659]
118625141  FN1; fibronectin isoform X1 [KO:K05717]
118639020  SPP1; osteopontin [KO:K06250]
118634858  VTN; vitronectin [KO:K06251]
118621308  TNXB; tenascin-X [KO:K06252]
118629852  TNC; tenascin [KO:K06252]
118637568  TNR; tenascin-R [KO:K06252]
118637800  TNN; tenascin-N [KO:K06252]
118623334  VWF; von Willebrand factor [KO:K03900]
118617999  bone sialoprotein 2 [KO:K06253]
118642544  ITGA1; integrin alpha-1 [KO:K06480]
118641528  ITGA2; integrin alpha-2 [KO:K06481]
118633914  ITGA2B; integrin alpha-IIb [KO:K06476]
118634657  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
118625164  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
118623674  ITGA5; integrin alpha-5 [KO:K06484]
118625272  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
118624244  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
118631428  ITGA8; integrin alpha-8 [KO:K06584]
118633392  ITGA9; integrin alpha-9 [KO:K06585]
118637313  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
118635003  ITGA11; integrin alpha-11 [KO:K06587]
118625208  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
118629439  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
118634259  ITGB3; integrin beta-3 [KO:K06493]
118634538  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
118617706  ITGB5; integrin beta-5 [KO:K06588]
118625216  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
118624421  ITGB7; integrin beta-7 [KO:K06590]
118620387  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
118631501  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
118632927  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118626944  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118617106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118626685  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118642883  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118616460  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118642780  F2R; proteinase-activated receptor 1 [KO:K03914]
118628294  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
118620177  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
118629489  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
118615973  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
118626923  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
118635809  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
118624741  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
118622514  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
118643409  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
118641555  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
118624402  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
118616885  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
118617165  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
118629739  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
118627522  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
118640651  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
118626418  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
118638371  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118615888  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
118639405  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
118621254  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
118629801  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
118619968  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
118626713  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
118616113  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
118642671  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
118620007  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
118634527  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
118619840  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
118634593  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
118634929  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
118642806  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
118643522  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
118626404  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
118641812  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
118632636  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
118636664  DNA damage-inducible transcript 4 protein-like [KO:K08270]
118629416  TSC1; hamartin isoform X1 [KO:K07206]
118642250  TSC2; tuberin isoform X1 [KO:K07207]
118619958  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
118642565  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
118627075  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118633821  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
118622710  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
118627662  eukaryotic translation initiation factor 4E-like [KO:K03259]
118615445  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
118616276  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
118625420  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
118634239  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
118627654  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
118623888  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
118632909  40S ribosomal protein S6-like [KO:K02991]
118634553  40S ribosomal protein S6-like [KO:K02991]
118641681  40S ribosomal protein S6-like [KO:K02991]
118642003  40S ribosomal protein S6-like [KO:K02991]
118629558  RPS6; 40S ribosomal protein S6 [KO:K02991]
118633872  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118615180  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
118626024  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
118629435  PKN3; serine/threonine-protein kinase N3 [KO:K23692] [EC:2.7.11.13]
118621399  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
118618606  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
118631372  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
118640620  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118619617  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
118630299  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118638405  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118633045  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
118620079  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
118632142  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118637684  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
118622832  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
118643693  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
118627487  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
118638301  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
118634735  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
118643480  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
118615747  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
118632198  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
118633034  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
118624247  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
118616796  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
118628352  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
118620823  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
118636159  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform-like [KO:K11584]
118637920  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
118631218  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
118624718  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
118627838  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
118634876  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
118635330  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
118621022  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
118637063  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
118637778  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
118624183  HSP90B1; endoplasmin [KO:K09487]
118615278  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
118637757  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
118618200  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
118638257  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
118623677  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
118635979  MTCP1; protein p13 MTCP-1 [KO:K16837]
118620067  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
118634791  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
118617870  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118623578  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
118638432  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
118618925  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
118615675  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
118633799  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
118634305  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
118625387  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
118631560  MYC; myc proto-oncogene protein [KO:K04377]
118628257  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
118621843  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118624260  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
118624453  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
118624208  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
118620055  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
118624468  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
118621102  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
118631401  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
118639006  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
118621858  FOXO3; forkhead box protein O3 [KO:K09408]
118639540  RBL2; retinoblastoma-like protein 2 [KO:K16332]
118637768  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118630927  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
118618301  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
118627272  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
118635359  14-3-3 protein zeta/delta-like [KO:K16197]
118636127  LOW QUALITY PROTEIN: 14-3-3 protein beta/alpha-like [KO:K16197]
118631194  YWHAQ; 14-3-3 protein theta [KO:K16197]
118631396  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
118617540  LOW QUALITY PROTEIN: 14-3-3 protein epsilon-like [KO:K06630]
118633880  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
118640091  YWHAH; 14-3-3 protein eta [KO:K16198]
118642351  YWHAG; LOW QUALITY PROTEIN: 14-3-3 protein gamma [KO:K16198]
118627989  BAD; bcl2-associated agonist of cell death [KO:K02158]
118618234  BCL2L1; bcl-2-like protein 1 [KO:K04570]
118619009  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
118626427  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
118624959  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
118625175  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
118623538  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
118620417  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
118628166  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
118629628  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
118637511  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
118615816  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
118620061  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
118621725  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
118637247  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
118629388  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
118623887  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
118635619  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118632312  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118622317  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118628367  RELA; transcription factor p65 [KO:K04735]
118624789  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118620919  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
118623649  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118634552  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mmf00010  Glycolysis / Gluconeogenesis
mmf04010  MAPK signaling pathway
mmf04012  ErbB signaling pathway
mmf04062  Chemokine signaling pathway
mmf04064  NF-kappa B signaling pathway
mmf04068  FoxO signaling pathway
mmf04110  Cell cycle
mmf04115  p53 signaling pathway
mmf04150  mTOR signaling pathway
mmf04210  Apoptosis
mmf04370  VEGF signaling pathway
mmf04510  Focal adhesion
mmf04620  Toll-like receptor signaling pathway
mmf04630  JAK-STAT signaling pathway
mmf04662  B cell receptor signaling pathway
mmf04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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