KEGG   PATHWAY: mmf05208
Entry
mmf05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Molossus molossus (Pallas's mastiff bat)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
mmf05208  Chemical carcinogenesis - reactive oxygen species
mmf05208

Organism
Molossus molossus (Pallas's mastiff bat) [GN:mmf]
Gene
118639987  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
118640180  glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
118640181  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
118640182  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
118617766  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
118621066  glutathione S-transferase A4-like isoform X1 [KO:K00799] [EC:2.5.1.18]
118621176  LOW QUALITY PROTEIN: glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
118621227  LOW QUALITY PROTEIN: glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
118621411  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
118621930  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
118637232  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
118637233  GSTM4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
118637243  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
118637302  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
118624026  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
118616000  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
118632213  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
118632464  GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
118628491  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
118618922  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
118617761  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
118624749  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial-like [KO:K03944]
118636240  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
118615822  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
118636132  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
118639270  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
118641507  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118620175  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118620432  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
118622983  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118624392  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
118617404  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
118619959  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
118620352  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
118628841  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
118624219  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
118643615  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
118629630  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
118623664  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
118625722  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
118641728  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
118625530  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
118615826  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
118623430  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
118616212  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
118635562  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
118639258  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
118620023  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
118625554  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
118617418  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
118617206  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
118629707  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
118615911  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
118632679  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
118631404  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
118642383  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
118635751  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
118625186  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
118637356  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
118627637  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
118642847  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
118627153  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
118636589  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
118642440  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
118616172  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
118628795  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
118616082  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
118628115  NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
118641768  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
118626881  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
118637582  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
118627931  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
118638700  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
118643333  cytochrome c1, heme protein, mitochondrial isoform X1 [KO:K00413]
118633355  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
118642275  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
118626099  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
118618164  cytochrome b-c1 complex subunit 7-like [KO:K00417]
118631617  cytochrome b-c1 complex subunit 7 [KO:K00417]
118615608  cytochrome b-c1 complex subunit 8 [KO:K00418]
118639942  cytochrome b-c1 complex subunit 9 [KO:K00419]
118615755  cytochrome b-c1 complex subunit 10 [KO:K00420]
118618823  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
118639463  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
118616232  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
118626867  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
118627159  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
118631187  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
118640293  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
118642653  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
118634769  cytochrome c oxidase subunit 6B1-like [KO:K02267]
118620770  cytochrome c oxidase subunit 6B1-like [KO:K02267]
118638658  cytochrome c oxidase subunit 6B1 [KO:K02267]
118638808  cytochrome c oxidase subunit 6B2 [KO:K02267]
118617840  cytochrome c oxidase subunit 6C-like [KO:K02268]
118631656  cytochrome c oxidase subunit 6C [KO:K02268]
118640175  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
118621159  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
118630759  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
118638661  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
118640230  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
118618411  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
118627002  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
118635961  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
118615384  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
118626491  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
118642243  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
118615936  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
118628022  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
118624707  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
118618785  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
118616339  ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
118639201  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
118624196  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
118638769  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
118615754  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
118618728  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
118637863  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
118625818  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
118634232  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
118620224  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
118623869  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
118634324  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
118643520  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118643635  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118622754  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118631376  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118617273  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
118626752  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118620305  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118617089  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
118621119  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
118627971  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
118615375  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
118632500  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
118635695  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 3-like [KO:K15041]
118622548  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
118615394  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
118620018  ADP/ATP translocase 3-like [KO:K05863]
118635791  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
118636454  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
118622563  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
118616075  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
118632332  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
118617715  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
118627656  CAT; catalase isoform X1 [KO:K03781] [EC:1.11.1.6]
118633454  SLC26A1; sulfate anion transporter 1 isoform X1 [KO:K14700]
118616491  SLC26A2; sulfate transporter [KO:K14701]
118633109  SLC26A6; solute carrier family 26 member 6 isoform X1 [KO:K14704]
118637585  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
118637248  LOW QUALITY PROTEIN: cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
118632687  LOW QUALITY PROTEIN: cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
118643668  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
118631254  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
118640564  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
118615699  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
118626639  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
118626342  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
118632067  aldo-keto reductase family 1 member C23-like protein [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
118632135  aldo-keto reductase family 1 member C15-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
118636652  NAD(P)H dehydrogenase [quinone] 1-like [KO:K00355] [EC:1.6.5.2]
118630831  LOW QUALITY PROTEIN: NAD(P)H dehydrogenase [quinone] 1-like [KO:K00355] [EC:1.6.5.2]
118639022  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
118617249  carbonyl reductase [NADPH] 1 isoform X1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
118620249  AHR; aryl hydrocarbon receptor [KO:K09093]
118634595  LPO; lactoperoxidase isoform X1 [KO:K12550] [EC:1.11.1.7]
118627695  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
118638681  cytochrome b-245 light chain [KO:K08009]
118635887  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
118641800  NCF1; neutrophil cytosol factor 1 [KO:K08011]
118637429  NCF2; neutrophil cytosol factor 2 [KO:K08010]
118634494  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
118620077  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118620202  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
118619859  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
118633806  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118630966  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
118616724  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118643162  HRAS; GTPase HRas isoform X1 [KO:K02833]
118624619  KRAS; GTPase KRas isoform X1 [KO:K07827]
118637822  NRAS; GTPase NRas [KO:K07828]
118635666  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
118619570  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118633343  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118628434  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118615385  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
118640210  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118642307  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
118620900  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
118633861  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
118615560  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118642157  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118615122  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118632456  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118641186  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118641187  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
118621004  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118621005  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
118627223  JUN; transcription factor AP-1 [KO:K04448]
118618599  FOS; proto-oncogene c-Fos [KO:K04379]
118626685  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118642883  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118616460  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118632927  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118626944  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118617106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118616519  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
118642806  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
118640620  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118619617  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
118630299  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118638405  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118621858  FOXO3; forkhead box protein O3 [KO:K09408]
118627989  BAD; bcl2-associated agonist of cell death [KO:K02158]
118618192  PTPN1; tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
118632142  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118632312  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118622317  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118635619  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118617230  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
118628367  RELA; transcription factor p65 [KO:K04735]
118624789  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118633138  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
118628307  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
118630887  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
118639877  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
118618720  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
118629546  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
118637242  ABL2; tyrosine-protein kinase ABL2 [KO:K08887] [EC:2.7.10.2]
118632755  PRKD1; serine/threonine-protein kinase D1 [KO:K06070] [EC:2.7.11.13]
118631019  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
118639050  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
118631501  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
118633939  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
118617100  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
118634183  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
118627941  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
118637089  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
118621078  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
118615462  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
118625163  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
118624557  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
mmf00190  Oxidative phosphorylation
mmf00980  Metabolism of xenobiotics by cytochrome P450
mmf04010  MAPK signaling pathway
mmf04064  NF-kappa B signaling pathway
mmf04066  HIF-1 signaling pathway
mmf04151  PI3K-Akt signaling pathway
mmf04370  VEGF signaling pathway
mmf05207  Chemical carcinogenesis - receptor activation
mmf05211  Renal cell carcinoma
mmf05215  Prostate cancer
mmf05219  Bladder cancer
mmf05221  Acute myeloid leukemia
mmf05222  Small cell lung cancer
mmf05223  Non-small cell lung cancer
mmf05224  Breast cancer
mmf05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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