KEGG   PATHWAY: mmyo04151
Entry
mmyo04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Myotis myotis (greater mouse-eared bat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mmyo04151  PI3K-Akt signaling pathway
mmyo04151

Other DBs
GO: 0043491
Organism
Myotis myotis (greater mouse-eared bat) [GN:mmyo]
Gene
118672981  EGF; pro-epidermal growth factor [KO:K04357]
118668883  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
118669844  EREG; proepiregulin [KO:K09784]
118669870  AREG; amphiregulin [KO:K09782]
118658742  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
118657980  FGF2; fibroblast growth factor 2 [KO:K18497]
118651638  FGF7; fibroblast growth factor 7 [KO:K04358]
118649770  FGF6; fibroblast growth factor 6 [KO:K04358]
118651170  FGF20; fibroblast growth factor 20 [KO:K04358]
118657925  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
118657946  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
118658335  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
118651945  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
118653962  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
118654722  FGF16; fibroblast growth factor 16 [KO:K04358]
118670266  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
118664022  FGF3; fibroblast growth factor 3 [KO:K04358]
118664023  FGF4; fibroblast growth factor 4 [KO:K04358]
118656661  FGF10; fibroblast growth factor 10 [KO:K04358]
118664060  FGF19; fibroblast growth factor 19 [KO:K22603]
118655446  FGF21; fibroblast growth factor 21 [KO:K22429]
118651326  FGF23; fibroblast growth factor 23 [KO:K22428]
118673575  NGF; beta-nerve growth factor [KO:K02582]
118664943  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
118651861  NTF3; neurotrophin-3 [KO:K04356]
118655444  NTF4; neurotrophin-4 [KO:K12457]
118659596  insulin-like [KO:K04526]
118659608  insulin-like [KO:K04526]
118659612  insulin-like [KO:K04526]
118651145  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118659613  IGF2; insulin-like growth factor II [KO:K13769]
118658213  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
118651562  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
118658606  PDGFC; platelet-derived growth factor C [KO:K05450]
118664382  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
118672850  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
118650035  KITLG; kit ligand isoform X1 [KO:K05461]
118655367  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
118660010  VEGFA; vascular endothelial growth factor A [KO:K05448]
118665372  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
118658139  PGF; placenta growth factor isoform X1 [KO:K16859]
118651245  VEGFC; vascular endothelial growth factor C [KO:K05449]
118654158  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
118666274  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
118670723  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
118653233  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
118657532  ANGPT4; angiopoietin-4 [KO:K05467]
118657994  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
118672982  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
118673021  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
118673025  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
118656123  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
118657018  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
118658792  NRTN; neurturin isoform X1 [KO:K25414]
118677547  ARTN; artemin [KO:K25415]
118658174  PSPN; persephin [KO:K25416]
118665909  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
118671218  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
118650120  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
118661478  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
118649562  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
118655613  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118665364  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118659099  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
118672350  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
118673526  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
118667416  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
118659286  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
118679204  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118668634  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
118658697  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
118657649  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
118668862  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
118651974  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
118650828  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
118654202  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
118658880  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
118668891  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
118666481  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
118667603  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
118675056  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
118670212  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
118671153  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
118669078  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
118654741  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118648965  HRAS; GTPase HRas isoform X1 [KO:K02833]
118649554  KRAS; GTPase KRas isoform X1 [KO:K07827]
118672986  NRAS; GTPase NRas [KO:K07828]
118668076  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118654213  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118657986  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
118678650  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118656605  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118661524  IRS1; insulin receptor substrate 1 [KO:K16172]
118658736  TLR2; toll-like receptor 2 [KO:K10159]
118667106  TLR4; toll-like receptor 4 [KO:K10160]
118657696  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
118652511  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
118652937  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
118669913  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
118671432  somatotropin-like [KO:K05438]
118675065  PRL; prolactin [KO:K05439]
118678304  OSM; oncostatin-M isoform X1 [KO:K05418]
118658725  IL2; interleukin-2 [KO:K05429]
118666134  IL6; interleukin-6 [KO:K05405]
118657905  IL4; interleukin-4 [KO:K05430]
118671020  IL7; interleukin-7 isoform X1 [KO:K05431]
118667586  interferon omega-1-like [KO:K05414]
118666805  IFNB1; interferon beta [KO:K05415]
118657054  EPO; erythropoietin [KO:K05437]
118672467  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
118656324  GHR; growth hormone receptor isoform X1 [KO:K05080]
118656206  PRLR; prolactin receptor isoform X1 [KO:K05081]
118655723  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
118672311  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
118651872  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
118661694  METTL8; mRNA N(3)-methylcytidine methyltransferase METTL8 isoform X1 [KO:K05070]
118654549  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
118657316  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
118672712  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
118652869  interleukin-4 receptor subunit alpha-like isoform X1 [KO:K05071]
118656213  interleukin-4 receptor subunit alpha-like isoform X1 [KO:K05071]
118656297  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
118676057  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
118676213  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
118659055  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
118676572  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
118675339  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
118667512  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
118658721  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
118666213  COL1A2; collagen alpha-2(I) chain [KO:K06236]
118671908  COL1A1; collagen alpha-1(I) chain [KO:K06236]
118651665  COL2A1; collagen alpha-1(II) chain [KO:K19719]
118651398  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
118651399  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
118654149  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
118654373  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
118661805  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
118661915  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
118668193  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
118668194  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
118668195  collagen alpha-4(VI) chain-like [KO:K06238]
118661519  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
118676403  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
118676671  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
118677314  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
118660173  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
118663693  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
118659861  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
118663257  LAMA1; laminin subunit alpha-1 [KO:K05637]
118662808  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
118663687  LAMA5; laminin subunit alpha-5 [KO:K06240]
118660060  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
118665985  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
118668489  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
118672717  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
118665984  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
118672671  LAMC1; laminin subunit gamma-1 [KO:K05635]
118672978  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
118666951  LAMC3; laminin subunit gamma-3 [KO:K06247]
118672321  CHAD; chondroadherin [KO:K06248]
118666027  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
118649603  THBS1; thrombospondin-1 [KO:K16857]
118660255  THBS2; thrombospondin-2 [KO:K04659]
118656424  THBS4; thrombospondin-4 [KO:K04659]
118657572  cartilage oligomeric matrix protein [KO:K04659]
118672802  THBS3; thrombospondin-3 [KO:K04659]
118661269  FN1; fibronectin isoform X1 [KO:K05717]
118671281  SPP1; osteopontin [KO:K06250]
118672342  VTN; vitronectin [KO:K06251]
118673566  TNN; tenascin-N [KO:K06252]
118673756  TNR; tenascin-R isoform X1 [KO:K06252]
118667101  TNC; tenascin isoform X1 [KO:K06252]
118679562  TNXB; tenascin-X [KO:K06252]
118650211  VWF; von Willebrand factor [KO:K03900]
118654608  bone sialoprotein 2 [KO:K06253]
118655725  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
118655743  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
118671403  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
118671288  ITGA3; integrin alpha-3 [KO:K06482]
118661108  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
118650963  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
118661789  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
118650215  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
118677239  ITGA8; integrin alpha-8 [KO:K06584]
118668336  ITGA9; integrin alpha-9 [KO:K06585]
118672990  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
118654530  ITGA11; integrin alpha-11 [KO:K06587]
118661050  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
118676628  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
118671715  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
118671145  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
118675382  ITGB5; integrin beta-5 [KO:K06588]
118661965  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
118650229  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
118666144  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
118670566  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
118677590  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118668125  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118675045  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118675217  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118656203  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118657573  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
118656246  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
118649078  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
118666361  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
118667192  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
118657971  LPAR2; lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
118676951  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
118654701  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
118651359  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
118651070  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
118655599  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
118655733  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
118649724  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
118676150  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
118651993  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
118655246  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
118648957  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
118678724  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
118666631  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118673940  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118653683  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118661166  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118663367  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118675273  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
118658681  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
118652811  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
118658043  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
118667187  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
118666214  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
118652667  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
118677067  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
118652936  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
118666579  guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548]
118672316  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
118666001  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
118672132  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
118672231  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
118656443  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
118659345  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
118656158  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
118677140  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
118670126  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
118666926  TSC1; hamartin isoform X1 [KO:K07206]
118656215  TSC2; tuberin isoform X1 [KO:K07207]
118651521  GTP-binding protein Rheb [KO:K07208]
118679434  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
118656155  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
118675322  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118671632  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
118651220  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
118661256  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
118671661  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
118657632  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
118649569  LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
118649570  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
118671643  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
118665219  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
118649810  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
118678902  40S ribosomal protein S6 [KO:K02991]
118667577  RPS6; 40S ribosomal protein S6 [KO:K02991]
118675992  40S ribosomal protein S6 [KO:K02991]
118676503  40S ribosomal protein S6-like [KO:K02991]
118671569  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118652689  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
118675447  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
118666994  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
118660084  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
118663083  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
118670911  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
118678909  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118655031  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118674834  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118667913  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
118666049  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
118677363  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118670001  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118673388  THEM4; LOW QUALITY PROTEIN: acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
118650809  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
118658020  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
118649206  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
118664327  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
118658359  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
118666309  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
118659262  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
118669650  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
118677985  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
118668147  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
118657301  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
118672968  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
118659834  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
118659943  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
118656278  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
118665341  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
118658235  heat shock protein HSP 90-beta [KO:K04079]
118666392  heat shock protein HSP 90-alpha-like [KO:K04079]
118659878  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
118659932  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
118654244  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
118650291  HSP90B1; endoplasmin isoform X1 [KO:K09487]
118658796  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
118672873  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
118674241  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
118663126  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 isoform X1 [KO:K16340] [EC:3.1.3.16]
118649545  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
118664174  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
118657325  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
118657326  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
118657327  T-cell leukemia/lymphoma protein 1A-like [KO:K10167]
118653952  MTCP1; protein p13 MTCP-1 [KO:K16837]
118679429  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
118671456  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
118675932  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118651519  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
118655404  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
118678882  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
118663538  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
118662103  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
118671425  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
118671469  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
118670599  MYC; myc proto-oncogene protein [KO:K04377]
118665181  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
118659964  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118650327  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
118651193  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
118651037  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
118666224  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
118650032  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
118660354  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
118653038  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
118670629  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
118659794  FOXO3; forkhead box protein O3 [KO:K09408]
118674330  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
118673639  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118655230  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
118669295  YWHAQ; 14-3-3 protein theta [KO:K16197]
118670689  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
118663627  YWHAB; 14-3-3 protein beta/alpha isoform X1 [KO:K16197]
118671895  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
118678231  YWHAH; 14-3-3 protein eta [KO:K16198]
118655882  YWHAG; 14-3-3 protein gamma [KO:K16198]
118665363  BAD; bcl2-associated agonist of cell death [KO:K02158]
118663066  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
118663765  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
118677148  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
118661646  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
118661230  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
118649462  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
118666845  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
118673054  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
118666355  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
118658839  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
118667339  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
118665089  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
118666077  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
118679616  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
118673323  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
118666894  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
118650824  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
118653690  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118669852  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118650776  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118665292  RELA; transcription factor p65 [KO:K04735]
118671867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118660262  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
118650326  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118672084  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mmyo00010  Glycolysis / Gluconeogenesis
mmyo04010  MAPK signaling pathway
mmyo04012  ErbB signaling pathway
mmyo04062  Chemokine signaling pathway
mmyo04064  NF-kappa B signaling pathway
mmyo04068  FoxO signaling pathway
mmyo04110  Cell cycle
mmyo04115  p53 signaling pathway
mmyo04150  mTOR signaling pathway
mmyo04210  Apoptosis
mmyo04370  VEGF signaling pathway
mmyo04510  Focal adhesion
mmyo04620  Toll-like receptor signaling pathway
mmyo04630  JAK-STAT signaling pathway
mmyo04662  B cell receptor signaling pathway
mmyo04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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