KEGG   PATHWAY: mna04020
Entry
mna04020                    Pathway                                
Name
Calcium signaling pathway - Miniopterus natalensis (Natal long-fingered bat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mna04020  Calcium signaling pathway
mna04020

Other DBs
GO: 0019722
Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:mna]
Gene
107541794  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
107536251  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
107540036  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
107538560  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
107538818  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
107538895  ATP2B1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
107534770  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
107539778  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
107542477  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
107526945  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
107530474  ADORA2A; adenosine receptor A2a [KO:K04266]
107524507  ADORA2B; adenosine receptor A2b [KO:K04267]
107536422  ADRB1; beta-1 adrenergic receptor [KO:K04141]
107540586  ADRB2; beta-2 adrenergic receptor [KO:K04142]
107535434  ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
107533905  DRD1; D(1A) dopamine receptor [KO:K04144]
107530077  DRD5; D(1B) dopamine receptor [KO:K05840]
107533911  HRH2; histamine H2 receptor [KO:K04150]
107540592  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
107524920  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
107538315  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
107543256  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
107529329  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
107529353  neuroendocrine secretory protein 55-like [KO:K04632]
107533994  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
107526004  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
107540528  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
107534062  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
107531740  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
107531029  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
107539500  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
107535777  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
107544336  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107543188  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107526298  PLN; cardiac phospholamban [KO:K05852]
107532915  SLN; sarcolipin [KO:K22642]
107543286  MRLN; myoregulin [KO:K22643]
107529595  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
107528003  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
107541012  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
107531895  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
107544173  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
107541216  STIM2; stromal interaction molecule 2 [KO:K18196]
107529588  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
107526520  ORAI2; protein orai-2 isoform X1 [KO:K16057]
107540810  ORAI3; protein orai-3 [KO:K16058]
107546425  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
107534931  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
107541372  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
107536018  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
107541038  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
107536136  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
107546251  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
107529836  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
107533412  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
107531235  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
107527910  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
107536149  GRIN1; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 1 [KO:K05208]
107525462  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
107525331  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
107542924  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
107531815  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
107546596  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
107534564  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
107528031  P2RX1; P2X purinoceptor 1 [KO:K05215]
107529657  P2RX2; P2X purinoceptor 2 [KO:K05216]
107527670  P2RX3; P2X purinoceptor 3 [KO:K05217]
107529591  P2RX4; P2X purinoceptor 4 [KO:K05218]
107527975  P2RX5; P2X purinoceptor 5 [KO:K05219]
107530490  P2RX6; P2X purinoceptor 6 [KO:K05221]
107529593  P2RX7; P2X purinoceptor 7 [KO:K05220]
107532181  RYR1; ryanodine receptor 1 [KO:K04961]
107542403  ryanodine receptor 2 [KO:K04962]
107527206  ryanodine receptor 2-like [KO:K04962]
107526989  RYR3; ryanodine receptor 3 [KO:K04963]
107537116  triadin-like [KO:K23449]
107537010  triadin-like [KO:K23449]
107539224  CASQ1; calsequestrin-1 [KO:K23468]
107545371  CASQ2; calsequestrin-2 [KO:K23445]
107526441  aspartyl/asparaginyl beta-hydroxylase-like isoform X1 [KO:K00476] [EC:1.14.11.16]
107526448  ASPH; aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
107532762  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
107531365  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
107544520  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
107529888  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
107537855  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
107536281  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
107544042  AGTR1; type-1 angiotensin II receptor [KO:K04166]
107532511  EDNRA; endothelin-1 receptor [KO:K04197]
107539876  EDNRB; endothelin B receptor [KO:K04198]
107531201  F2R; proteinase-activated receptor 1 [KO:K03914]
107532400  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
107529517  GRPR; gastrin-releasing peptide receptor [KO:K04169]
107534767  HRH1; histamine H1 receptor [KO:K04149]
107537524  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
107530766  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
107526926  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
107544281  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
107529748  NTSR1; neurotensin receptor type 1 [KO:K04211]
107534780  OXTR; LOW QUALITY PROTEIN: oxytocin receptor [KO:K04229]
107527253  AVPR1A; vasopressin V1a receptor [KO:K04226]
107539423  AVPR1B; vasopressin V1b receptor [KO:K04227]
107531665  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
107542352  PTAFR; platelet-activating factor receptor [KO:K04279]
107542363  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
107540123  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
107540119  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
107528072  BDKRB1; B1 bradykinin receptor [KO:K03915]
107528081  BDKRB2; B2 bradykinin receptor [KO:K03916]
107529218  TACR1; substance-P receptor [KO:K04222]
107526066  TACR2; substance-K receptor [KO:K04223]
107545487  TACR3; neuromedin-K receptor [KO:K04224]
107525731  TBXA2R; thromboxane A2 receptor [KO:K04264]
107546012  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
107541217  CCKAR; cholecystokinin receptor type A [KO:K04194]
107540492  CCKBR; LOW QUALITY PROTEIN: gastrin/cholecystokinin type B receptor [KO:K04195]
107531145  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
107544926  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
107544328  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
107544880  guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
107544324  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
107534373  EGF; pro-epidermal growth factor [KO:K04357]
107543141  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
107531241  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
107527538  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
107532411  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
107531500  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
107529795  FGF2; fibroblast growth factor 2 [KO:K18497]
107536980  FGF9; fibroblast growth factor 9 [KO:K04358]
107542543  FGF8; fibroblast growth factor 8 [KO:K04358]
107543550  FGF17; fibroblast growth factor 17 [KO:K04358]
107540349  FGF18; fibroblast growth factor 18 [KO:K04358]
107526261  FGF10; fibroblast growth factor 10 [KO:K04358]
107537102  FGF5; fibroblast growth factor 5 [KO:K04358]
107538886  FGF6; fibroblast growth factor 6 [KO:K04358]
107532758  FGF16; fibroblast growth factor 16 [KO:K04358]
107534875  FGF7; fibroblast growth factor 7 [KO:K04358]
107538572  FGF22; fibroblast growth factor 22 [KO:K04358]
107542168  fibroblast growth factor 3-like [KO:K04358]
107534042  FGF20; fibroblast growth factor 20 [KO:K04358]
107542172  FGF19; fibroblast growth factor 19 [KO:K22603]
107531851  FGF21; fibroblast growth factor 21 [KO:K22429]
107538868  FGF23; fibroblast growth factor 23 [KO:K22428]
107536886  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
107539800  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
107541939  VEGFC; vascular endothelial growth factor C [KO:K05449]
107529497  FIGF; vascular endothelial growth factor D [KO:K05449]
107545260  NGF; beta-nerve growth factor [KO:K02582]
107527167  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
107529398  MST1; hepatocyte growth factor-like protein [KO:K23441]
107545968  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
107525996  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107529006  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
107546211  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
107524731  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
107532710  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
107535230  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
107535065  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
107532684  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
107524118  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
107529769  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
107534361  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
107528437  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
107532764  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
107543738  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
107545009  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
107527826  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
107528536  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
107529399  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
107532547  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
107528831  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
107524330  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
107524764  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
107542967  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
107536366  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
107536369  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
107539797  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
107542131  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
107524904  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
107543248  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
107525326  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
107529142  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
107525255  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
107541588  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
107529621  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
107537413  TPCN2; two pore calcium channel protein 2 [KO:K14077]
107540645  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
107543174  MCOLN2; mucolipin-2 [KO:K04993]
107543204  MCOLN3; mucolipin-3 [KO:K04994]
107536591  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
107531908  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
107545816  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
107525398  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
107545842  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
107523910  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
107529763  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
107535760  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
107529320  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
107542290  ADP/ATP translocase 3-like [KO:K05863]
107543961  ADP/ATP translocase 3 [KO:K05863]
107523868  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
107534791  TNNC1; troponin C, slow skeletal and cardiac muscles isoform X1 [KO:K05865]
107542429  CALML3; calmodulin-like protein 3 [KO:K02183]
107542435  CALML5; calmodulin-like protein 5 [KO:K02183]
107536794  CALM3; calmodulin [KO:K02183]
107540147  CALML6; calmodulin-like protein 6 [KO:K02183]
107544318  CALM2; calmodulin isoform X1 [KO:K02183]
107531584  CALM1; calmodulin [KO:K02183]
107525969  CALML4; calmodulin-like protein 4 [KO:K02183]
107542003  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
107524377  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
107526785  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
107540794  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
107542483  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
107542256  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
107535858  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
107527759  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
107534757  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
107530231  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
107532942  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
107545830  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
107542053  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
107535228  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
107527851  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
107546482  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
107545505  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107545813  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107536108  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107545969  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
107536932  TFEB; transcription factor EB [KO:K15590]
107541561  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
107538236  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
107527885  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
107531741  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
107528483  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
107533063  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
107524933  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
107541075  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
107544407  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
107536128  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
107538557  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
107528345  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
107534210  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
107536548  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
107538300  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
107544745  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
107540426  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
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Calcium signalling: dynamics, homeostasis and remodelling.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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Reference
PMID:11413485
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The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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Reference
PMID:15111104
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Reference
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
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  Authors
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Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
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J Bioenerg Biomembr 35:577-98 (2003)
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Reference
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  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Reference
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A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Reference
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
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Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
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Reference
PMID:14572802
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Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
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Reference
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  Authors
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  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
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Crompton M.
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Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
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Reference
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Extracellular-signal-regulated kinase signalling in neurons.
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Curr Opin Neurobiol 9:544-53 (1999)
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Reference
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Mol Cell Biol 23:7068-81 (2003)
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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
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Tornquist K
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
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Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
PMID:22002090
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
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Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
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Reference
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Beard NA, Wei L, Dulhunty AF
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
mna04010  MAPK signaling pathway
mna04070  Phosphatidylinositol signaling system
mna04210  Apoptosis
mna04720  Long-term potentiation
mna04730  Long-term depression
KO pathway
ko04020   
LinkDB

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