Entry
Name
Salmonella infection - Mus pahari (shrew mouse)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Mus pahari (shrew mouse) [GN:
mpah ]
Gene
110331771 Plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282 ]
110327226 Vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179 ]
110318851 Vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180 ]
110317844 Vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
110312858 Vps33a; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182 ]
110333579 Vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184 ]
110324097 Dync1h1; LOW QUALITY PROTEIN: cytoplasmic dynein 1 heavy chain 1 [KO:K10413 ]
110327347 Dync2h1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414 ]
110317295 Dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
110319030 Dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415 ]
110337399 Dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416 ]
110327302 Dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416 ]
110335798 Dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417 ]
110335218 LOW QUALITY PROTEIN: dynein light chain 1, cytoplasmic-like [KO:K10418 ]
110318843 Dynlrb1; dynein light chain roadblock-type 1 isoform X1 [KO:K10419 ]
110337698 Dynlrb2; dynein light chain roadblock-type 2 isoform X1 [KO:K10419 ]
110327606 Fyco1; FYVE and coiled-coil domain-containing protein 1 [KO:K21954 ]
110322875 Plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348 ]
110316441 M6pr; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089 ]
110326816 Gcc2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282 ]
110326635 neuroblast differentiation-associated protein AHNAK-like isoform X1 [KO:K23934 ]
110326629 neuroblast differentiation-associated protein AHNAK-like [KO:K23934 ]
110319302 Elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
110312960 Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351 ]
110330683 Myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754 ]
110318312 Myl9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755 ]
110325851 Mylpf; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758 ]
110337263 Fhod1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938 ]
110322847 Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
110339030 Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
110312868 Wasf3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083 ]
110339090 Arpc1b; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757 ]
110321362 Arpc2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758 ]
110316323 Arpc4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755 ]
110321734 Arpc5; actin-related protein 2/3 complex subunit 5 isoform X1 [KO:K05754 ]
110318541 Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
110323448 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
110319750 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
110327251 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
110324300 Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
110322135 Pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923 ] [EC:2.7.1.154 ]
110316706 Pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
110324799 Pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923 ] [EC:2.7.1.154 ]
110316396 Wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612 ]
110328152 Tirap; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403 ]
110327862 Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
110334874 Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
110338176 Tab2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
110313859 Tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793 ]
110319789 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
110317065 Nod1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727 ]
110316225 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
110337608 Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
110320972 Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
110325978 Tnfrsf10b; tumor necrosis factor receptor superfamily member 10B [KO:K04722 ]
110324246 Rhob; rho-related GTP-binding protein RhoB isoform X1 [KO:K07856 ]
110332320 Nlrp3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800 ]
110333045 apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
mpah04621 NOD-like receptor signaling pathway
KO pathway
LinkDB
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