Entry
Name
Salmonella infection - Meriones unguiculatus (Mongolian gerbil)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Meriones unguiculatus (Mongolian gerbil) [GN:
mun ]
Gene
110545642 Plekhm1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282 ]
110562575 Vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179 ]
110553271 Vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180 ]
110550613 Vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
110545339 Vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182 ]
110561673 Vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184 ]
110558093 Dync2h1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414 ]
110549832 Dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X3 [KO:K10415 ]
110549277 Dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
110559740 Dync1li2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416 ]
110547901 Dync1li1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
110558076 Dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417 ]
110550574 Dynlrb1; dynein light chain roadblock-type 1 isoform X2 [KO:K10419 ]
110554129 Fyco1; FYVE and coiled-coil domain-containing protein 1 [KO:K21954 ]
110552139 Arl8b; ADP-ribosylation factor-like protein 8B isoform X1 [KO:K07955 ]
110545018 Plekhm2; pleckstrin homology domain-containing family M member 2 isoform X2 [KO:K15348 ]
110560705 Gcc2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282 ]
110561834 Arhgef26; rho guanine nucleotide exchange factor 26 isoform X1 [KO:K13744 ]
110549229 Elmo2; engulfment and cell motility protein 2 isoform X3 [KO:K18985 ]
110545344 Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351 ]
110546082 Myl7; myosin regulatory light chain 2, atrial isoform isoform X2 [KO:K12754 ]
110545010 Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393 ]
110557417 Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
110557961 Cyfip1; cytoplasmic FMR1-interacting protein 1 isoform X2 [KO:K05749 ]
110554045 Cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749 ]
110563106 Arpc1a; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757 ]
110546507 Arpc5l; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754 ]
110565112 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
110556252 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
110548394 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
110565083 Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289 ] [EC:2.7.1.153 ]
110548259 Pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
110554649 Pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
110549541 Wasl; actin nucleation-promoting factor WASL isoform X1 [KO:K23612 ]
110555283 Tirap; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403 ]
110555059 Myd88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729 ]
110557813 Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
110540621 Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
110541022 Tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2 [KO:K12793 ]
110558602 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580 ]
110555055 Nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727 ]
132650544 Map2k7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431 ] [EC:2.7.12.2 ]
110548604 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
110545551 Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
110553751 Birc3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060 ]
110553757 Birc2; baculoviral IAP repeat-containing protein 2 isoform X4 [KO:K16060 ]
110557487 Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
110557077 tumor necrosis factor receptor superfamily member 10B-like [KO:K04722 ]
110563439 LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738 ]
110550006 Nlrp3; NACHT, LRR and PYD domains-containing protein 3 isoform X2 [KO:K12800 ]
132654707 baculoviral IAP repeat-containing protein 1b-like isoform X1 [KO:K12807 ]
110565106 Nlrc4; NLR family CARD domain-containing protein 4 isoform X1 [KO:K12805 ]
110564542 Pycard; apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
mun04621 NOD-like receptor signaling pathway
KO pathway
LinkDB
All DBs