KEGG   PATHWAY: myb05415
Entry
myb05415                    Pathway                                
Name
Diabetic cardiomyopathy - Myotis brandtii (Brandt's bat)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
myb05415  Diabetic cardiomyopathy
myb05415

Organism
Myotis brandtii (Brandt's bat) [GN:myb]
Gene
102250015  SLC2A1; solute carrier family 2 member 1 [KO:K07299]
102238939  SLC2A4; solute carrier family 2 member 4 [KO:K07191]
102244609  GFPT2; glutamine-fructose-6-phosphate transaminase 2 [KO:K00820] [EC:2.6.1.16]
102238887  GFPT1; glutamine--fructose-6-phosphate transaminase 1 [KO:K00820] [EC:2.6.1.16]
102252254  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
102262365  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
102260966  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
102257317  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
102263572  RYR2; ryanodine receptor 2 [KO:K04962]
102247697  PLN; phospholamban [KO:K05852]
102242162  ATP2A1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [KO:K05853] [EC:7.2.2.10]
102239308  ATP2A3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [KO:K05853] [EC:7.2.2.10]
102263136  ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [KO:K05853] [EC:7.2.2.10]
102256096  SP1; Sp1 transcription factor [KO:K04684]
102262829  AGT; angiotensinogen [KO:K09821]
102262750  REN; renin [KO:K01380] [EC:3.4.23.15]
102252573  CMA1; chymase [KO:K01329] [EC:3.4.21.39]
102252869  mast cell protease 4-like [KO:K01329] [EC:3.4.21.39]
102243136  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102258384  AGER; advanced glycosylation end-product specific receptor [KO:K19722]
102244245  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
102252724  NCF1; neutrophil cytosolic factor 1 [KO:K08011]
102242122  cytochrome b-245 light chain [KO:K08009]
102254652  NCF2; neutrophil cytosolic factor 2 [KO:K08010]
102243613  NCF4; neutrophil cytosolic factor 4 [KO:K08012]
102259160  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102239988  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102245101  AGTR1; angiotensin II receptor type 1 [KO:K04166]
102255251  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102263790  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102254628  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102248097  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102254920  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
106723559  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102259984  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102263026  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102246292  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102260608  MMP2; matrix metallopeptidase 2 [KO:K01398] [EC:3.4.24.24]
102260281  MMP9; matrix metallopeptidase 9 [KO:K01403] [EC:3.4.24.35]
102259707  COL1A1; collagen type I alpha 1 chain [KO:K06236]
102253918  COL1A2; collagen type I alpha 2 chain [KO:K06236]
102254069  filaggrin-2-like [KO:K06236]
102263100  COL3A1; collagen type III alpha 1 chain [KO:K19720]
102262083  TGFB1; transforming growth factor beta 1 [KO:K13375]
102250887  TGFB2; transforming growth factor beta 2 [KO:K13376]
102249502  TGFB3; transforming growth factor beta 3 [KO:K13377]
102257482  CD36; CD36 molecule [KO:K06259]
102249818  PPARA; peroxisome proliferator activated receptor alpha [KO:K07294]
102252400  CPT1B; carnitine palmitoyltransferase 1B [KO:K19523] [EC:2.3.1.21]
102259213  PDK2; pyruvate dehydrogenase kinase 2 [KO:K00898] [EC:2.7.11.2]
102251531  PDK4; pyruvate dehydrogenase kinase 4 [KO:K00898] [EC:2.7.11.2]
102255458  PDK3; pyruvate dehydrogenase kinase 3 [KO:K00898] [EC:2.7.11.2]
102260557  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102256501  PRKCD; protein kinase C delta [KO:K06068] [EC:2.7.11.13]
102243812  PTPA; protein phosphatase 2 phosphatase activator [KO:K17605]
102244214  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
102253559  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102248545  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
102239740  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
102255890  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
102238785  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
106726938  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
102250265  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
102243793  CPT2; carnitine palmitoyltransferase 2 [KO:K08766] [EC:2.3.1.21]
102254396  insulin [KO:K04526]
102252005  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102247525  IRS1; insulin receptor substrate 1 [KO:K16172]
102260487  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102252921  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102239669  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102258430  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102253405  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102242302  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102257838  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102254864  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102254191  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102251050  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102241670  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102248758  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102262755  GYS1; glycogen synthase 1 [KO:K00693] [EC:2.4.1.11]
102251419  GYS2; glycogen synthase 2 [KO:K00693] [EC:2.4.1.11]
102251725  TBC1D4; TBC1 domain family member 4 [KO:K17902]
102262335  mitochondrial pyruvate carrier 1 [KO:K22138]
102258633  mitochondrial pyruvate carrier 1-like [KO:K22138]
102238702  MPC1; mitochondrial pyruvate carrier 1 [KO:K22138]
102257469  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
102244834  PDHA1; pyruvate dehydrogenase (lipoamide) alpha 1 [KO:K00161] [EC:1.2.4.1]
102254743  PDHA2; pyruvate dehydrogenase (lipoamide) alpha 2 [KO:K00161] [EC:1.2.4.1]
102263280  pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like [KO:K00161] [EC:1.2.4.1]
102259708  PDHB; pyruvate dehydrogenase (lipoamide) beta [KO:K00162] [EC:1.2.4.1]
20964692  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
20964693  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
20964699  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
20964701  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
20964700  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
20964702  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
20964703  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
102246622  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
102260201  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
102256583  NDUFV3; NADH:ubiquinone oxidoreductase subunit V3 [KO:K03944]
102251359  NDUFA1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
102260520  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
102247135  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
102245681  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
106723654  NDUFA3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
102242476  NDUFA4; NDUFA4, mitochondrial complex associated [KO:K03948]
102252735  NDUFA4L2; NDUFA4, mitochondrial complex associated like 2 [KO:K03948]
102253695  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
102250395  NDUFA5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
106725124  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
102258543  NDUFA7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
102261034  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
102256722  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
102245859  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
102262457  NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
102248319  NDUFA11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
102244003  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
102248846  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
102256003  NDUFB1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
102260343  NDUFB2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
102245439  NDUFB3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
102243450  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
102250344  NDUFB4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
102262870  NDUFB5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
102242316  NDUFB6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
102260101  NDUFB7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
102258518  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
102242906  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
102262382  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
102262600  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
102251040  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
102262139  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
102262598  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
102243749  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4 [KO:K03937]
102249038  NDUFS5; NADH:ubiquinone oxidoreductase subunit S5 [KO:K03938]
102263660  NDUFS6; NADH:ubiquinone oxidoreductase subunit S6 [KO:K03939]
102240432  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
102256678  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
102247113  NDUFC1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
102252992  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
102240483  SDHA; succinate dehydrogenase complex flavoprotein subunit A [KO:K00234] [EC:1.3.5.1]
102242794  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
102254448  SDHB; succinate dehydrogenase complex iron sulfur subunit B [KO:K00235] [EC:1.3.5.1]
102263682  SDHC; succinate dehydrogenase complex subunit C [KO:K00236]
102259933  SDHD; succinate dehydrogenase complex subunit D [KO:K00237]
102249581  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
20964704  CYTB; cytochrome b [KO:K00412]
102261758  cytochrome c1, heme protein, mitochondrial [KO:K00413]
102262645  cytochrome c1, heme protein, mitochondrial-like [KO:K00413]
102238662  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
102239933  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
102256902  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
102252155  cytochrome b-c1 complex subunit 7 [KO:K00417]
102256499  cytochrome b-c1 complex subunit 9 [KO:K00419]
102246747  cytochrome b-c1 complex subunit 10 [KO:K00420]
20964698  COX3; cytochrome c oxidase subunit III [KO:K02262]
20964694  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
20964695  COX2; cytochrome c oxidase subunit II [KO:K02261]
102261338  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
102249206  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
102256974  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
102252278  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102261874  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
102258622  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
106728119  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
102243207  cytochrome c oxidase subunit 6B1 [KO:K02267]
102247436  cytochrome c oxidase subunit 6B1 [KO:K02267]
102258861  cytochrome c oxidase subunit 6C-2 [KO:K02268]
102241508  cytochrome c oxidase subunit 6C [KO:K02268]
102243868  cytochrome c oxidase subunit 6C [KO:K02268]
102256775  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
102242411  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102261647  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
102248066  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
102249757  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
102256817  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
102257114  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
102247376  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102261765  ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle [KO:K02132]
102246768  ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [KO:K02133] [EC:7.1.2.2]
102244312  ATP5C1; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 [KO:K02136]
102242355  ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit [KO:K02134]
20964697  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
102245250  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
102260264  ATP5F1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 [KO:K02127]
102250118  ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) [KO:K02128]
102250429  ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) [KO:K02128]
102254181  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
102247128  ATP synthase lipid-binding protein, mitochondrial [KO:K02128]
102254725  ATP5G3; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) [KO:K02128]
102253099  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
102245806  ATP synthase subunit d, mitochondrial-like [KO:K02138]
102246732  ATP5H; ATP synthase, H+ transporting, mitochondrial Fo complex subunit D [KO:K02138]
102263769  ATP5O; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit [KO:K02137]
102240075  ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 [KO:K02131]
20964696  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
102249622  VDAC1; voltage dependent anion channel 1 [KO:K05862]
102245606  VDAC2; voltage dependent anion channel 2 [KO:K15040]
102263138  VDAC3; voltage dependent anion channel 3 [KO:K15041]
102255058  SLC25A4; solute carrier family 25 member 4 [KO:K05863]
102239133  SLC25A31; solute carrier family 25 member 31 [KO:K05863]
102256951  SLC25A5; solute carrier family 25 member 5 [KO:K05863]
102256266  ADP/ATP translocase 3 [KO:K05863]
102246203  ADP/ATP translocase 3-like [KO:K05863]
102248275  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
102249897  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102256555  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
102239814  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102251121  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102245543  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
102256451  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102262029  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102250966  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102248429  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102243306  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102250073  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102243888  PARP1; poly(ADP-ribose) polymerase 1 [KO:K24070] [EC:2.4.2.30]
102251499  G6PD; glucose-6-phosphate dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
102259616  glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
102255675  GSR; glutathione-disulfide reductase [KO:K00383] [EC:1.8.1.7]
102241353  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
102248472  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
102256193  SMAD2; SMAD family member 2 [KO:K04500]
102259468  SMAD3; SMAD family member 3 [KO:K23605]
102238655  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
102254054  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
102241255  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
102240650  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
102243978  ACE; angiotensin I converting enzyme [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
Riehle C, Bauersachs J
  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
DOI:10.1007/s00395-018-0711-0
Reference
PMID:24462787
  Authors
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
  Title
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Related
pathway
myb00010  Glycolysis / Gluconeogenesis
myb00020  Citrate cycle (TCA cycle)
myb00190  Oxidative phosphorylation
myb00520  Amino sugar and nucleotide sugar metabolism
myb03320  PPAR signaling pathway
myb04071  Sphingolipid signaling pathway
myb04150  mTOR signaling pathway
myb04210  Apoptosis
myb04260  Cardiac muscle contraction
myb04350  TGF-beta signaling pathway
myb04614  Renin-angiotensin system
myb04910  Insulin signaling pathway
myb04930  Type II diabetes mellitus
myb04931  Insulin resistance
myb04933  AGE-RAGE signaling pathway in diabetic complications
myb04940  Type I diabetes mellitus
KO pathway
ko05415   
LinkDB

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