KEGG   PATHWAY: nasi04072
Entry
nasi04072                   Pathway                                
Name
Phospholipase D signaling pathway - Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Description
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively.
Class
Environmental Information Processing; Signal transduction
Pathway map
nasi04072  Phospholipase D signaling pathway
nasi04072

Organism
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) [GN:nasi]
Gene
112397683  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112412068  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
112410849  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
112400383  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
112415757  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
112410676  KITLG; kit ligand isoform X1 [KO:K05461]
112402369  INS; insulin [KO:K04526]
112412693  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112400744  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
112391109  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
112400776  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
112400209  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
112410317  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112393782  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
112402513  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
112401764  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
112396342  SHC2; SHC-transforming protein 2 [KO:K17447]
112390850  SHC3; SHC-transforming protein 3 [KO:K17448]
112402165  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
112397307  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
112409948  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
112405189  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112391586  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
112402519  HRAS; GTPase HRas isoform X1 [KO:K02833]
112391643  KRAS; GTPase KRas isoform X1 [KO:K07827]
112413065  NRAS; GTPase NRas [KO:K07828]
112403338  MRAS; ras-related protein M-Ras [KO:K07831]
112415390  RRAS; ras-related protein R-Ras [KO:K07829]
112404921  LOW QUALITY PROTEIN: ras-related protein R-Ras2-like [KO:K07830]
112407609  RRAS2; ras-related protein R-Ras2 [KO:K07830]
112411278  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
112403276  RALA; ras-related protein Ral-A [KO:K07834]
112409213  RALB; ras-related protein Ral-B isoform X1 [KO:K07835]
112402798  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112403325  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112406349  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112404930  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112400438  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112414874  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112405757  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112408453  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112415459  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112411342  TSC1; hamartin isoform X1 [KO:K07206]
112409519  TSC2; tuberin isoform X1 [KO:K07207]
112405904  RHEB; GTP-binding protein Rheb [KO:K07208]
112402675  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112395211  RHOA; transforming protein RhoA [KO:K04513]
112410490  ADP-ribosylation factor 2 [KO:K07937]
112412968  ARF1; ADP-ribosylation factor 1 [KO:K07937]
112390927  ARF6; ADP-ribosylation factor 6 [KO:K07941]
112398380  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
112393390  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
112403545  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha isoform X1 [KO:K08089]
112402309  MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090]
112407938  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
112396968  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
112390842  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
112410312  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112394504  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
112392372  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
112403548  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
112391147  cytosolic phospholipase A2 beta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
112391280  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
112391289  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
112391290  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
112395386  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
112411334  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
112401610  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
112408551  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
112415212  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1 [KO:K19007] [EC:2.3.1.51]
112410306  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
112415409  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
112407243  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112393112  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112400165  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112412232  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112399342  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112396291  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
112411617  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
112392537  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
112402362  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
112397454  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
112404677  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
112399159  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
112399691  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
112406656  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
112394070  DGKA; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
112414539  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
112408057  DGKE; diacylglycerol kinase epsilon isoform X1 [KO:K00901] [EC:2.7.1.107]
112415031  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
112396380  PLPP2; LOW QUALITY PROTEIN: phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
112413393  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
112407066  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
112402070  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
112413621  AGT; angiotensinogen [KO:K09821]
112398466  vasopressin-neurophysin 2-copeptin-like [KO:K05242]
112405659  CXCL8; interleukin-8 [KO:K10030]
112415934  AGTR1; type-1 angiotensin II receptor [KO:K04166]
112391428  F2R; proteinase-activated receptor 1 [KO:K03914]
112401627  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
112400596  GRM2; metabotropic glutamate receptor 2 [KO:K04605]
112395334  GRM3; metabotropic glutamate receptor 3 isoform X1 [KO:K04606]
112413929  GRM4; metabotropic glutamate receptor 4 isoform X1 [KO:K04607]
112410930  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
112412808  GRM6; metabotropic glutamate receptor 6 [KO:K04608]
112396786  GRM7; metabotropic glutamate receptor 7 [KO:K04609]
112408197  GRM8; metabotropic glutamate receptor 8 [KO:K04610]
112394228  AVPR1A; vasopressin V1a receptor [KO:K04226]
112403448  AVPR1B; vasopressin V1b receptor [KO:K04227]
112406822  AVPR2; vasopressin V2 receptor isoform X1 [KO:K04228]
112407853  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
112414774  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
112415092  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
112408422  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
112391757  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
112406558  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
112392803  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
112411919  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
112411917  C-X-C chemokine receptor type 2 isoform X1 [KO:K05050]
112402291  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
112412530  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
112412538  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
112391181  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
112412027  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
112414976  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
112410234  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
112410487  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
112401896  PIK3R5; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
112401930  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
112410537  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
112410847  CYTH4; cytohesin-4 isoform X1 [KO:K18441]
112399897  CYTH3; cytohesin-3 [KO:K18441]
112415321  CYTH2; cytohesin-2 [KO:K18441]
112402955  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
112402987  neuroendocrine secretory protein 55-like [KO:K04632]
112400149  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
112404518  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112412774  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
112405010  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
112407274  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
112394265  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
112401228  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
112397114  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
112409457  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
112394063  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
112391501  RAPGEF4; rap guanine nucleotide exchange factor 4 [KO:K04351]
112396205  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
112411527  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
112400139  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C00639  Prostaglandin F2alpha
C00681  1-Acyl-sn-glycerol 3-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:17245604
  Authors
Oude Weernink PA, Lopez de Jesus M, Schmidt M
  Title
Phospholipase D signaling: orchestration by PIP2 and small GTPases.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 374:399-411 (2007)
DOI:10.1007/s00210-007-0131-4
Reference
PMID:21936578
  Authors
Selvy PE, Lavieri RR, Lindsley CW, Brown HA
  Title
Phospholipase D: enzymology, functionality, and chemical modulation.
  Journal
Chem Rev 111:6064-119 (2011)
DOI:10.1021/cr200296t
Reference
PMID:24995811
  Authors
Brandenburg LO, Pufe T, Koch T
  Title
Role of phospholipase d in g-protein coupled receptor function.
  Journal
Membranes (Basel) 4:302-18 (2014)
DOI:10.3390/membranes4030302
Reference
PMID:17054901
  Authors
Oude Weernink PA, Han L, Jakobs KH, Schmidt M
  Title
Dynamic phospholipid signaling by G protein-coupled receptors.
  Journal
Biochim Biophys Acta 1768:888-900 (2007)
DOI:10.1016/j.bbamem.2006.09.012
Reference
PMID:24990952
  Authors
Foster DA, Salloum D, Menon D, Frias MA
  Title
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).
  Journal
J Biol Chem 289:22583-8 (2014)
DOI:10.1074/jbc.R114.566091
Reference
PMID:16143829
  Authors
Jenkins GM, Frohman MA
  Title
Phospholipase D: a lipid centric review.
  Journal
Cell Mol Life Sci 62:2305-16 (2005)
DOI:10.1007/s00018-005-5195-z
Reference
PMID:19815110
  Authors
Metcalfe DD, Peavy RD, Gilfillan AM
  Title
Mechanisms of mast cell signaling in anaphylaxis.
  Journal
J Allergy Clin Immunol 124:639-46; quiz 647-8 (2009)
DOI:10.1016/j.jaci.2009.08.035
Reference
PMID:18936782
  Authors
Kalesnikoff J, Galli SJ
  Title
New developments in mast cell biology.
  Journal
Nat Immunol 9:1215-23 (2008)
DOI:10.1038/ni.f.216
Reference
PMID:12217395
  Authors
Cockcroft S, Way G, O'Luanaigh N, Pardo R, Sarri E, Fensome A
  Title
Signalling role for ARF and phospholipase D in mast cell exocytosis stimulated by crosslinking of the high affinity FcepsilonR1 receptor.
  Journal
Mol Immunol 38:1277-82 (2002)
DOI:10.1016/S0161-5890(02)00075-5
Reference
PMID:19410013
  Authors
Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH
  Title
The roles of phospholipase D in EGFR signaling.
  Journal
Biochim Biophys Acta 1791:862-8 (2009)
DOI:10.1016/j.bbalip.2009.04.007
Reference
PMID:16622417
  Authors
Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH
  Title
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.
  Journal
Nat Cell Biol 8:477-84 (2006)
DOI:10.1038/ncb1401
Reference
PMID:14769825
  Authors
Kam Y, Exton JH
  Title
Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.
  Journal
FASEB J 18:311-9 (2004)
DOI:10.1096/fj.03-0731com
Reference
PMID:9310372
  Authors
Kozawa O, Blume-Jensen P, Heldin CH, Ronnstrand L
  Title
Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.
  Journal
Eur J Biochem 248:149-55 (1997)
DOI:10.1111/j.1432-1033.1997.00149.x
Reference
PMID:11042115
  Authors
Slaaby R, Du G, Altshuller YM, Frohman MA, Seedorf K
  Title
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.
  Journal
Biochem J 351 Pt 3:613-9 (2000)
DOI:10.1042/bj3510613
Reference
PMID:11991733
  Authors
Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T
  Title
Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.
  Journal
J Mol Cell Cardiol 34:441-53 (2002)
DOI:10.1006/jmcc.2002.1525
Reference
PMID:10666319
  Authors
Freeman EJ
  Title
The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.
  Journal
Arch Biochem Biophys 374:363-70 (2000)
DOI:10.1006/abbi.1999.1608
Reference
PMID:9119890
  Authors
Naro F, Donchenko V, Minotti S, Zolla L, Molinaro M, Adamo S
  Title
Role of phospholipase C and D signalling pathways in vasopressin-dependent myogenic differentiation.
  Journal
J Cell Physiol 171:34-42 (1997)
DOI:10.1002/(SICI)1097-4652(199704)171:1<34::AID-JCP5>3.0.CO;2-I
Reference
PMID:10807766
  Authors
Murdoch C, Finn A
  Title
Chemokine receptors and their role in inflammation and infectious diseases.
  Journal
Blood 95:3032-43 (2000)
Reference
PMID:8135758
  Authors
Sugiyama T, Sakai T, Nozawa Y, Oka N
  Title
Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production.
  Journal
Biochem J 298 ( Pt 2):479-84 (1994)
DOI:10.1042/bj2980479
Reference
PMID:17210675
  Authors
Foster DA
  Title
Regulation of mTOR by phosphatidic acid?
  Journal
Cancer Res 67:1-4 (2007)
DOI:10.1158/0008-5472.CAN-06-3016
Reference
PMID:15310762
  Authors
Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, Ktistakis NT
  Title
Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.
  Journal
J Biol Chem 279:44763-74 (2004)
DOI:10.1074/jbc.M405771200
Reference
PMID:23076158
  Authors
Park JB, Lee CS, Jang JH, Ghim J, Kim YJ, You S, Hwang D, Suh PG, Ryu SH
  Title
Phospholipase signalling networks in cancer.
  Journal
Nat Rev Cancer 12:782-92 (2012)
DOI:10.1038/nrc3379
Reference
PMID:19264150
  Authors
Foster DA
  Title
Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.
  Journal
Biochim Biophys Acta 1791:949-55 (2009)
DOI:10.1016/j.bbalip.2009.02.009
Related
pathway
nasi00561  Glycerolipid metabolism
nasi04010  MAPK signaling pathway
nasi04014  Ras signaling pathway
nasi04020  Calcium signaling pathway
nasi04024  cAMP signaling pathway
nasi04071  Sphingolipid signaling pathway
nasi04144  Endocytosis
nasi04150  mTOR signaling pathway
nasi04151  PI3K-Akt signaling pathway
nasi04664  Fc epsilon RI signaling pathway
KO pathway
ko04072   
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