KEGG   PATHWAY: nasi05208
Entry
nasi05208                   Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
nasi05208  Chemical carcinogenesis - reactive oxygen species
nasi05208

Organism
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) [GN:nasi]
Gene
112393006  AS3MT; arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
112397719  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
112397818  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
112412247  glutathione S-transferase theta-3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
112412315  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
112406852  GSTA4; glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
112406855  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
112393799  MGST2; LOW QUALITY PROTEIN: microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
112391761  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
112392999  glutathione S-transferase omega-2-like [KO:K00799] [EC:2.5.1.18]
112393047  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
112402423  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
112404308  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
112412202  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
112408591  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
112404044  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
112404389  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
112397996  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
112414589  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
112394284  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
112408227  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
112394690  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
112400130  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
112411425  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
112391782  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
112409216  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
112399448  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
112400192  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
112405799  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
112414924  NDUFA13; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
112406732  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
112393871  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
112398101  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
112407866  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
112416055  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
112406354  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
112405478  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
112414932  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
112393039  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
112396997  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
112409395  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 isoform X1 [KO:K03966]
112402591  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
112395231  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
112407930  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
112402152  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
112396567  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
112395486  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
112390907  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
112396332  NDUFS7; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
112402525  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
112399795  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
112402670  NADH dehydrogenase [ubiquinone] 1 subunit C2-like [KO:K03968]
112390876  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
112402686  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
112407909  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
112405719  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
112401142  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
112397075  cytochrome c1, heme protein, mitochondrial [KO:K00413]
112403809  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
112399364  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
112400398  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
112398719  cytochrome b-c1 complex subunit 7-like [KO:K00417]
112407331  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
112401388  cytochrome b-c1 complex subunit 8 [KO:K00418]
112415117  cytochrome b-c1 complex subunit 9 [KO:K00419]
112396394  cytochrome b-c1 complex subunit 10 [KO:K00420]
112393437  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
112410961  cytochrome c oxidase subunit 5A, mitochondrial isoform X1 [KO:K02264]
112398970  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
112397274  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
112399312  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
112392309  cytochrome c oxidase subunit 6B1 [KO:K02267]
112398864  cytochrome c oxidase subunit 6C-like [KO:K02268]
112413993  cytochrome c oxidase subunit 6C-like [KO:K02268]
112407288  cytochrome c oxidase subunit 6C [KO:K02268]
112394363  cytochrome c oxidase subunit 6C-like [KO:K02268]
112405272  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
112392299  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
112390829  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
112400382  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
112390686  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
112390687  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
112392581  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
112402273  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
112392832  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
112394303  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
112391122  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
112402934  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
112413021  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
112398819  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
112394257  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
112391537  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
112410517  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
112408626  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
112390936  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
112401580  SOD2; superoxide dismutase [Mn], mitochondrial isoform X1 [KO:K04564] [EC:1.15.1.1]
112399681  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
112406956  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
112413211  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
112391027  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 3-like [KO:K15041]
112409707  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
112404045  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
112399780  SLC25A31; LOW QUALITY PROTEIN: ADP/ATP translocase 4 [KO:K05863]
112415236  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
112396496  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
112396093  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
112408558  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
112404579  CAT; catalase [KO:K03781] [EC:1.11.1.6]
112399696  SLC26A1; sulfate anion transporter 1 [KO:K14700]
112395188  SLC26A2; sulfate transporter [KO:K14701]
112403758  solute carrier family 26 member 6-like isoform X1 [KO:K14704]
112403550  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
112410949  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
112411197  LOW QUALITY PROTEIN: cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
112415372  LOW QUALITY PROTEIN: cytochrome P450 2F5-like [KO:K07416] [EC:1.14.14.1]
112410978  cytochrome P450 1A1 isoform X1 [KO:K07408] [EC:1.14.14.1]
112405151  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
112404976  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
112415002  EPHX2; bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
112414931  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
112398858  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
112400437  AKR1A1; alcohol dehydrogenase [NADP(+)] [KO:K00002] [EC:1.1.1.2]
112407550  dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
112407551  aldo-keto reductase family 1 member C3 homolog [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
112411795  NQO1; LOW QUALITY PROTEIN: NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
112408618  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
112414536  AHR; aryl hydrocarbon receptor [KO:K09093]
112408070  LPO; lactoperoxidase isoform X1 [KO:K12550] [EC:1.11.1.7]
112410941  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
112393500  cytochrome b-245 light chain [KO:K08009]
112400678  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
112401116  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
112391168  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
112397683  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112412693  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112404733  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112408223  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
112410317  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112405189  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112391586  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
112402519  HRAS; GTPase HRas isoform X1 [KO:K02833]
112391643  KRAS; GTPase KRas isoform X1 [KO:K07827]
112413065  NRAS; GTPase NRas [KO:K07828]
112402589  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
112398096  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
112407243  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112393112  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112400165  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112412232  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112399342  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112409119  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
112404578  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
112400298  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
112395723  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112412478  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112413113  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112413792  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112413934  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
112394646  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
112394700  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
112407080  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
112394907  FOS; proto-oncogene c-Fos [KO:K04379]
112404930  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112400438  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112414874  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112402798  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112403325  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112406349  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112399896  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112409350  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
112405757  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112408453  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112415459  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112406578  FOXO3; forkhead box protein O3 [KO:K09408]
112402326  BAD; bcl2-associated agonist of cell death [KO:K02158]
112403107  PTPN1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
112399575  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112392983  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112413114  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
112400454  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112411167  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
112402272  RELA; transcription factor p65 [KO:K04735]
112393728  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112400532  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
112402103  PTPRJ; receptor-type tyrosine-protein phosphatase eta isoform X1 [KO:K05698] [EC:3.1.3.48]
112407591  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
112397307  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
112409948  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
112398489  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
112411335  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
112408928  ABL2; Abelson tyrosine-protein kinase 2 isoform X1 [KO:K08887] [EC:2.7.10.2]
112405233  PRKD3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
112406225  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
112415328  PRKD2; LOW QUALITY PROTEIN: serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
112397030  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
112394504  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
112392372  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
112410215  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
112401826  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
112411615  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
112413893  VEGFA; vascular endothelial growth factor A [KO:K05448]
112400167  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
112391513  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
112398776  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
Reference
PMID:24281075
  Authors
Henkler F, Brinkmann J, Luch A
  Title
The role of oxidative stress in carcinogenesis induced by metals and xenobiotics.
  Journal
Cancers (Basel) 2:376-96 (2010)
DOI:10.3390/cancers2020376
Reference
PMID:22705365
  Authors
Lee JC, Son YO, Pratheeshkumar P, Shi X
  Title
Oxidative stress and metal carcinogenesis.
  Journal
Free Radic Biol Med 53:742-57 (2012)
DOI:10.1016/j.freeradbiomed.2012.06.002
Reference
PMID:32033297
  Authors
Hu Y, Li J, Lou B, Wu R, Wang G, Lu C, Wang H, Pi J, Xu Y
  Title
The Role of Reactive Oxygen Species in Arsenic Toxicity.
  Journal
Biomolecules 10:E240 (2020)
DOI:10.3390/biom10020240
Reference
PMID:33864199
  Authors
Ozturk M, Metin M, Altay V, Bhat RA, Ejaz M, Gul A, Unal BT, Hasanuzzaman M, Nibir L, Nahar K, Bukhari A, Dervash MA, Kawano T
  Title
Arsenic and Human Health: Genotoxicity, Epigenomic Effects, and Cancer Signaling.
  Journal
Biol Trace Elem Res 10.1007/s12011-021-02719-w (2021)
DOI:10.1007/s12011-021-02719-w
Reference
PMID:23510327
  Authors
Hubaux R, Becker-Santos DD, Enfield KS, Rowbotham D, Lam S, Lam WL, Martinez VD
  Title
Molecular features in arsenic-induced lung tumors.
  Journal
Mol Cancer 12:20 (2013)
DOI:10.1186/1476-4598-12-20
Reference
PMID:21648415
  Authors
Naranmandura H, Xu S, Sawata T, Hao WH, Liu H, Bu N, Ogra Y, Lou YJ, Suzuki N
  Title
Mitochondria are the main target organelle for trivalent monomethylarsonous acid (MMA(III))-induced cytotoxicity.
  Journal
Chem Res Toxicol 24:1094-103 (2011)
DOI:10.1021/tx200156k
Reference
PMID:23583964
  Authors
Faita F, Cori L, Bianchi F, Andreassi MG
  Title
Arsenic-induced genotoxicity and genetic susceptibility to arsenic-related pathologies.
  Journal
Int J Environ Res Public Health 10:1527-46 (2013)
DOI:10.3390/ijerph10041527
Reference
PMID:28179585
  Authors
Sage AP, Minatel BC, Ng KW, Stewart GL, Dummer TJB, Lam WL, Martinez VD
  Title
Oncogenomic disruptions in arsenic-induced carcinogenesis.
  Journal
Oncotarget 8:25736-25755 (2017)
DOI:10.18632/oncotarget.15106
Reference
PMID:21414382
  Authors
Jomova K, Valko M
  Title
Advances in metal-induced oxidative stress and human disease.
  Journal
Toxicology 283:65-87 (2011)
DOI:10.1016/j.tox.2011.03.001
Reference
PMID:16430879
  Authors
Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M
  Title
Free radicals, metals and antioxidants in oxidative stress-induced cancer.
  Journal
Chem Biol Interact 160:1-40 (2006)
DOI:10.1016/j.cbi.2005.12.009
Reference
PMID:32731582
  Authors
Tumolo M, Ancona V, De Paola D, Losacco D, Campanale C, Massarelli C, Uricchio VF
  Title
Chromium Pollution in European Water, Sources, Health Risk, and Remediation Strategies: An Overview.
  Journal
Int J Environ Res Public Health 17:E5438 (2020)
DOI:10.3390/ijerph17155438
Reference
PMID:28860815
  Authors
Wang Y, Su H, Gu Y, Song X, Zhao J
  Title
Carcinogenicity of chromium and chemoprevention: a brief update.
  Journal
Onco Targets Ther 10:4065-4079 (2017)
DOI:10.2147/OTT.S139262
Reference
PMID:24820114
  Authors
Jin X, Chen M, Song L, Li H, Li Z
  Title
The evaluation of p,p'-DDT exposure on cell adhesion of hepatocellular carcinoma.
  Journal
Toxicology 322:99-108 (2014)
DOI:10.1016/j.tox.2014.05.002
Reference
PMID:20370557
  Authors
Liou GY, Storz P
  Title
Reactive oxygen species in cancer.
  Journal
Free Radic Res 44:479-96 (2010)
DOI:10.3109/10715761003667554
Reference
PMID:11275476
  Authors
Murata M, Tamura A, Tada M, Kawanishi S
  Title
Mechanism of oxidative DNA damage induced by carcinogenic 4-aminobiphenyl.
  Journal
Free Radic Biol Med 30:765-73 (2001)
DOI:10.1016/S0891-5849(01)00463-4
Reference
PMID:31283132
  Authors
  Title
  Journal
Pentachlorophenol and Some Related Compounds (2019)
Reference
PMID:19408893
  Authors
Zhu BZ, Shan GQ
  Title
Potential mechanism for pentachlorophenol-induced carcinogenicity: a novel mechanism for metal-independent production of hydroxyl radicals.
  Journal
Chem Res Toxicol 22:969-77 (2009)
DOI:10.1021/tx900030v
Reference
PMID:22166497
  Authors
McHale CM, Zhang L, Smith MT
  Title
Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment.
  Journal
Carcinogenesis 33:240-52 (2012)
DOI:10.1093/carcin/bgr297
Reference
PMID:32977499
  Authors
Scharf P, Broering MF, Oliveira da Rocha GH, Farsky SHP
  Title
Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis.
  Journal
Int J Mol Sci 21:E6996 (2020)
DOI:10.3390/ijms21196996
Reference
PMID:23066403
  Authors
Snyder R
  Title
Leukemia and benzene.
  Journal
Int J Environ Res Public Health 9:2875-93 (2012)
DOI:10.3390/ijerph9082875
Reference
PMID:9118888
  Authors
Snyder R, Hedli CC
  Title
An overview of benzene metabolism.
  Journal
Environ Health Perspect 104 Suppl 6:1165-71 (1996)
DOI:10.1289/ehp.961041165
Reference
PMID:11978484
  Authors
Kawanishi S, Hiraku Y, Murata M, Oikawa S
  Title
The role of metals in site-specific DNA damage with reference to carcinogenesis.
  Journal
Free Radic Biol Med 32:822-32 (2002)
DOI:10.1016/S0891-5849(02)00779-7
Reference
PMID:27919191
  Authors
Das DN, Panda PK, Naik PP, Mukhopadhyay S, Sinha N, Bhutia SK
  Title
Phytotherapeutic approach: a new hope for polycyclic aromatic hydrocarbons induced cellular disorders, autophagic and apoptotic cell death.
  Journal
Toxicol Mech Methods 27:1-17 (2017)
DOI:10.1080/15376516.2016.1268228
Reference
PMID:21910479
  Authors
Shultz CA, Quinn AM, Park JH, Harvey RG, Bolton JL, Maser E, Penning TM.
  Title
Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone.
  Journal
Chem Res Toxicol 24:2153-66 (2011)
DOI:10.1021/tx200294c
Reference
PMID:25279998
  Authors
Penning TM
  Title
Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons.
  Journal
Chem Res Toxicol 27:1901-17 (2014)
DOI:10.1021/tx500298n
Reference
PMID:10706104
  Authors
Burczynski ME, Penning TM
  Title
Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor.
  Journal
Cancer Res 60:908-15 (2000)
Reference
PMID:15963346
  Authors
Xue W, Warshawsky D
  Title
Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review.
  Journal
Toxicol Appl Pharmacol 206:73-93 (2005)
DOI:10.1016/j.taap.2004.11.006
Reference
PMID:15142886
  Authors
Chen ZH, Hurh YJ, Na HK, Kim JH, Chun YJ, Kim DH, Kang KS, Cho MH, Surh YJ
  Title
Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells.
  Journal
Carcinogenesis 25:2005-13 (2004)
DOI:10.1093/carcin/bgh183
Reference
PMID:16684662
  Authors
Rifkind AB
  Title
CYP1A in TCDD toxicity and in physiology-with particular reference to CYP dependent arachidonic acid metabolism and other endogenous substrates.
  Journal
Drug Metab Rev 38:291-335 (2006)
DOI:10.1080/03602530600570107
Reference
PMID:9380738
  Authors
Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML, Gooden JK, Ramanathan R, Cerny RL, Rogan EG
  Title
Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.
  Journal
Proc Natl Acad Sci U S A 94:10937-42 (1997)
DOI:10.1073/pnas.94.20.10937
Reference
PMID:9472688
  Authors
Zhu BT, Conney AH
  Title
Functional role of estrogen metabolism in target cells: review and perspectives.
  Journal
Carcinogenesis 19:1-27 (1998)
DOI:10.1093/carcin/19.1.1
Reference
PMID:19387921
  Authors
McKillop IH, Schrum LW
  Title
Role of alcohol in liver carcinogenesis.
  Journal
Semin Liver Dis 29:222-32 (2009)
DOI:10.1055/s-0029-1214377
Reference
PMID:15603755
  Authors
Gonzalez FJ
  Title
Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1.
  Journal
Mutat Res 569:101-10 (2005)
DOI:10.1016/j.mrfmmm.2004.04.021
Reference
PMID:31864052
  Authors
Montalbano AM, Albano GD, Anzalone G, Moscato M, Gagliardo R, Di Sano C, Bonanno A, Ruggieri S, Cibella F, Profita M
  Title
Cytotoxic and genotoxic effects of the flame retardants (PBDE-47, PBDE-99 and PBDE-209) in human bronchial epithelial cells.
  Journal
Chemosphere 245:125600 (2020)
DOI:10.1016/j.chemosphere.2019.125600
Reference
PMID:33907575
  Authors
Sun HN, Ren CX, Gong YX, Xie DP, Kwon T
  Title
Regulatory function of peroxiredoxin I on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer development.
  Journal
Oncol Lett 21:465 (2021)
DOI:10.3892/ol.2021.12726
Reference
PMID:25372613
  Authors
Pluchino LA, Wang HC
  Title
Chronic exposure to combined carcinogens enhances breast cell carcinogenesis with mesenchymal and stem-like cell properties.
  Journal
PLoS One 9:e108698 (2014)
DOI:10.1371/journal.pone.0108698
Reference
PMID:25535943
  Authors
Pluchino LA, Liu AK, Wang HC
  Title
Reactive oxygen species-mediated breast cell carcinogenesis enhanced by multiple carcinogens and intervened by dietary ergosterol and mimosine.
  Journal
Free Radic Biol Med 80:12-26 (2015)
DOI:10.1016/j.freeradbiomed.2014.12.015
Reference
PMID:30327380
  Authors
Moldogazieva NT, Lutsenko SV, Terentiev AA
  Title
Reactive Oxygen and Nitrogen Species-Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy.
  Journal
Cancer Res 78:6040-6047 (2018)
DOI:10.1158/0008-5472.CAN-18-0980
Reference
PMID:32358622
  Authors
Kirtonia A, Sethi G, Garg M
  Title
The multifaceted role of reactive oxygen species in tumorigenesis.
  Journal
Cell Mol Life Sci 77:4459-4483 (2020)
DOI:10.1007/s00018-020-03536-5
Reference
PMID:29449774
  Authors
Kumari S, Badana AK, G MM, G S, Malla R
  Title
Reactive Oxygen Species: A Key Constituent in Cancer Survival.
  Journal
Biomark Insights 13:1177271918755391 (2018)
DOI:10.1177/1177271918755391
Reference
PMID:28881698
  Authors
Gao X, Schottker B
  Title
Reduction-oxidation pathways involved in cancer development: a systematic review of literature reviews.
  Journal
Oncotarget 8:51888-51906 (2017)
DOI:10.18632/oncotarget.17128
Reference
PMID:15769673
  Authors
Storz P
  Title
Reactive oxygen species in tumor progression.
  Journal
Front Biosci 10:1881-96 (2005)
DOI:10.2741/1667
Reference
PMID:28835450
  Authors
Assi M
  Title
The differential role of reactive oxygen species in early and late stages of cancer.
  Journal
Am J Physiol Regul Integr Comp Physiol 313:R646-R653 (2017)
DOI:10.1152/ajpregu.00247.2017
Reference
PMID:15024053
  Authors
Storz P, Doppler H, Toker A
  Title
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling.
  Journal
Mol Cell Biol 24:2614-26 (2004)
DOI:10.1128/MCB.24.7.2614-2626.2004
Reference
PMID:24998536
  Authors
Nourazarian AR, Kangari P, Salmaninejad A
  Title
Roles of oxidative stress in the development and progression of breast cancer.
  Journal
Asian Pac J Cancer Prev 15:4745-51 (2014)
DOI:10.7314/apjcp.2014.15.12.4745
Reference
PMID:32336668
  Authors
Zheng F, Goncalves FM, Abiko Y, Li H, Kumagai Y, Aschner M
  Title
Redox toxicology of environmental chemicals causing oxidative stress.
  Journal
Redox Biol 34:101475 (2020)
DOI:10.1016/j.redox.2020.101475
Related
pathway
nasi00190  Oxidative phosphorylation
nasi00980  Metabolism of xenobiotics by cytochrome P450
nasi04010  MAPK signaling pathway
nasi04064  NF-kappa B signaling pathway
nasi04066  HIF-1 signaling pathway
nasi04151  PI3K-Akt signaling pathway
nasi04370  VEGF signaling pathway
nasi05207  Chemical carcinogenesis - receptor activation
nasi05211  Renal cell carcinoma
nasi05215  Prostate cancer
nasi05219  Bladder cancer
nasi05221  Acute myeloid leukemia
nasi05222  Small cell lung cancer
nasi05223  Non-small cell lung cancer
nasi05224  Breast cancer
nasi05225  Hepatocellular carcinoma
KO pathway
ko05208   
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