KEGG   PATHWAY: nfu04020
Entry
nfu04020                    Pathway                                
Name
Calcium signaling pathway - Nothobranchius furzeri (turquoise killifish)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
nfu04020  Calcium signaling pathway
nfu04020

Other DBs
GO: 0019722
Organism
Nothobranchius furzeri (turquoise killifish) [GN:nfu]
Gene
107375887  slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
107380147  sodium/calcium exchanger 2-like [KO:K05849]
107377125  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
107391736  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
107386674  sodium/calcium exchanger 1-like [KO:K05849]
107394051  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
107385984  sodium/calcium exchanger 2-like [KO:K05849]
107385469  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
107385293  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
107384816  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
107391539  atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
107396072  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
107395176  muscarinic acetylcholine receptor M3-like [KO:K04131]
107375944  muscarinic acetylcholine receptor M3-like [KO:K04131]
107377814  chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
107392444  muscarinic acetylcholine receptor M5-like [KO:K04133]
107393489  adora2a; adenosine receptor A2a [KO:K04266]
107397223  adenosine receptor A2b-like [KO:K04266]
107386647  adora2b; adenosine receptor A2b [KO:K04267]
107387883  adrb1; beta-1 adrenergic receptor [KO:K04141]
107372451  beta-2 adrenergic receptor-like [KO:K04142]
107386754  beta-2 adrenergic receptor-like [KO:K04142]
107393740  beta-1 adrenergic receptor-like [KO:K04143]
107397208  D(1) dopamine receptor-like [KO:K04144]
107382429  D(1) dopamine receptor-like [KO:K04144]
107395488  D(1)-like dopamine receptor [KO:K04144]
107387424  D(5)-like dopamine receptor [KO:K05840]
107373706  D(1) dopamine receptor-like [KO:K05840]
107385456  drd5; D(1B) dopamine receptor [KO:K05840]
107386608  histamine H2 receptor-like [KO:K04150]
107376558  histamine H2 receptor-like [KO:K04150]
107396897  5-hydroxytryptamine receptor 4-like [KO:K04160]
107380623  5-hydroxytryptamine receptor 4-like isoform X1 [KO:K04160]
107382475  htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
107390984  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
107393556  htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
107390594  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
107385351  guanine nucleotide-binding protein G(s) subunit alpha-like isoform X1 [KO:K04632]
107396846  guanine nucleotide-binding protein G(olf) subunit alpha-like isoform X1 [KO:K04633]
107383531  gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
107383914  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
107393050  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
107383184  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
107378756  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
107376988  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
107378974  adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
107381237  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
107377600  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
107383681  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
107384598  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
107376487  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
107390534  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
107392711  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107383895  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
107378291  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
107395214  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107380937  pln; cardiac phospholamban [KO:K05852]
107380435  sln; sarcolipin [KO:K22642]
107388301  small integral membrane protein 6-like [KO:K26468]
107382365  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
107393493  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
107397196  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
107387023  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
107387945  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
107376685  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
107387985  sarcoplasmic reticulum histidine-rich calcium-binding protein-like [KO:K23450]
107396666  stromal interaction molecule 1-like isoform X1 [KO:K16059]
107380021  stromal interaction molecule 1-like isoform X1 [KO:K16059]
107377323  stim2; stromal interaction molecule 2 [KO:K18196]
107381667  stromal interaction molecule 2-like [KO:K18196]
107393664  calcium release-activated calcium channel protein 1-like [KO:K16056]
107373313  orai1; calcium release-activated calcium channel protein 1 [KO:K16056]
107387218  orai2; protein orai-2 [KO:K16057]
107385235  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
107390617  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
107385116  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
107391407  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
107390498  cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
107390862  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
107391184  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
107376625  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like isoform X1 [KO:K04344]
107397069  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
107375116  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
107383886  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
107393140  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
107387548  voltage-dependent T-type calcium channel subunit alpha-1G-like [KO:K04854]
107376712  voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855]
107372838  voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04856]
107376164  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
107391375  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
107393730  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
107381761  chrna7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
107377068  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
107394591  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
107379599  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
107375132  glutamate receptor ionotropic, NMDA 1-like [KO:K05208]
107386166  glutamate receptor ionotropic, NMDA 1-like [KO:K05208]
107376713  grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
107376282  grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
107382198  glutamate receptor ionotropic, NMDA 2B-like isoform X1 [KO:K05210]
107378608  glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
107387701  grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
107394391  glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
107379570  glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
107396711  glutamate receptor ionotropic, NMDA 3A-like [KO:K05213]
107392080  glutamate receptor ionotropic, NMDA 3B-like [KO:K05214]
107387027  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
107393956  p2rx6; P2X purinoceptor 6 [KO:K05216]
107374327  p2rx3; P2X purinoceptor 3 [KO:K05217]
107374424  P2X purinoceptor 3-like [KO:K05217]
107393858  LOW QUALITY PROTEIN: P2X purinoceptor 4-like [KO:K05218]
107387066  p2rx5; P2X purinoceptor 5 [KO:K05219]
107386088  p2rx7; P2X purinoceptor 7 [KO:K05220]
107386401  ryanodine receptor 1-like isoform X1 [KO:K04961]
107379827  ryanodine receptor 1-like isoform X1 [KO:K04961]
107395022  ryanodine receptor 2-like [KO:K04962]
107375803  ryanodine receptor 2-like [KO:K04962]
107396799  ryanodine receptor 2-like isoform X1 [KO:K04962]
107377812  ryanodine receptor 3-like [KO:K04963]
107392446  ryanodine receptor 3-like [KO:K04963]
107377860  triadin-like isoform X1 [KO:K23449]
107384256  calsequestrin-1-like [KO:K23468]
107376974  calsequestrin-1-like isoform X1 [KO:K23468]
107381038  calsequestrin-2-like [KO:K23445]
107389916  calsequestrin-2-like [KO:K23445]
107395322  asph; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
107384363  fibrous sheath CABYR-binding protein-like isoform X1 [KO:K00476] [EC:1.14.11.16]
107395896  cysteinyl leukotriene receptor 1-like [KO:K04322]
107375567  cysteinyl leukotriene receptor 1-like [KO:K04322]
107388934  muscarinic acetylcholine receptor M2-like [KO:K04130]
107386482  muscarinic acetylcholine receptor M2-like [KO:K04130]
107396248  alpha-1A adrenergic receptor-like [KO:K04135]
107393699  alpha-1A adrenergic receptor-like [KO:K04135]
107375503  adra1b; alpha-1B adrenergic receptor [KO:K04136]
107375224  adra1d; alpha-1D adrenergic receptor [KO:K04137]
107382808  agtr1; type-1 angiotensin II receptor [KO:K04166]
107376805  endothelin B receptor-like isoform X1 [KO:K04197]
107388317  endothelin B receptor-like [KO:K04197]
107375731  endothelin B receptor-like [KO:K04198]
107384300  endothelin B receptor-like [KO:K04198]
107389954  endothelin B receptor-like [KO:K04198]
107374832  proteinase-activated receptor 1-like [KO:K03914]
107393891  f2r; proteinase-activated receptor 1 [KO:K03914]
107377567  grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
107391977  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
107380453  grm5; metabotropic glutamate receptor 5 [KO:K04604]
107386961  metabotropic glutamate receptor 5-like [KO:K04604]
107389835  gastrin-releasing peptide receptor-like [KO:K04169]
107381683  grpr; gastrin-releasing peptide receptor [KO:K04169]
107385290  hrh1; histamine H1 receptor [KO:K04149]
107392734  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
107376997  5-hydroxytryptamine receptor 2A-like [KO:K04157]
107389582  htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
107375748  lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
107396693  neurotensin receptor type 1-like [KO:K04211]
107385740  oxtr; oxytocin receptor isoform X1 [KO:K04229]
107385185  isotocin receptor-like [KO:K04229]
107386914  arg8-vasotocin receptor-like [KO:K04226]
107396339  arg8-vasotocin receptor-like [KO:K04226]
107377158  leukotriene B4 receptor 1-like [KO:K04297]
107383490  leukotriene B4 receptor 1-like [KO:K04297]
107392203  platelet-activating factor receptor-like [KO:K04279]
107376169  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
107393122  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
107378314  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
107392699  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
107393241  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
107392184  B2 bradykinin receptor-like [KO:K03916]
107392185  B2 bradykinin receptor-like isoform X1 [KO:K03916]
107392186  B2 bradykinin receptor-like [KO:K03916]
107392056  B2 bradykinin receptor-like [KO:K03916]
107395595  substance-P receptor-like [KO:K04222]
107374220  substance-P receptor-like [KO:K04222]
107381869  tacr2; substance-K receptor [KO:K04223]
107373994  substance-P receptor-like [KO:K04224]
107375236  tacr3; neuromedin-K receptor [KO:K04224]
107375299  neuromedin-K receptor-like [KO:K04224]
107392777  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
107378911  trhr; thyrotropin-releasing hormone receptor [KO:K04282]
107389153  thyrotropin-releasing hormone receptor-like [KO:K04282]
107391239  thyrotropin-releasing hormone receptor-like [KO:K04282]
107381016  cholecystokinin receptor-like [KO:K04194]
107377319  cckar; cholecystokinin receptor type A [KO:K04194]
107389856  cholecystokinin receptor-like [KO:K04194]
107384286  C-X-C chemokine receptor type 4-like [KO:K04189]
107390218  cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
107394013  gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
107392134  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
107374739  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
107374742  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04634]
107393186  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
107394012  guanine nucleotide-binding protein subunit alpha-14-like [KO:K04636]
107393185  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
107374766  egf; pro-epidermal growth factor [KO:K04357]
107385163  tomoregulin-2-like isoform X1 [KO:K08774]
107376493  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
107373888  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
107375167  pdgfb; platelet-derived growth factor subunit B [KO:K17386]
107379856  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
107380445  pdgfd; platelet-derived growth factor D [KO:K05450]
107386707  fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
107375089  putative fibroblast growth factor 1 [KO:K18496]
107380334  fgf2; fibroblast growth factor 2 [KO:K18497]
107373800  fgf3; fibroblast growth factor 3 [KO:K04358]
107374982  fgf16; fibroblast growth factor 16 [KO:K04358]
107381727  fgf7; fibroblast growth factor 7 [KO:K04358]
107396136  fibroblast growth factor 18-like [KO:K04358]
107376280  fibroblast growth factor 18-like isoform X1 [KO:K04358]
107377308  fibroblast growth factor 20-like [KO:K04358]
107375498  fibroblast growth factor 8 [KO:K04358]
107373887  fibroblast growth factor 4B-like [KO:K04358]
107390881  fibroblast growth factor 20-like [KO:K04358]
107386057  fgf5; fibroblast growth factor 5 [KO:K04358]
107393313  fgf22; fibroblast growth factor 22 [KO:K04358]
107394286  fgf10; fibroblast growth factor 10 [KO:K04358]
107395364  fgf8; fibroblast growth factor 8 [KO:K04358]
107372696  fibroblast growth factor 10-like [KO:K04358]
107387436  fibroblast growth factor 4-like isoform X1 [KO:K04358]
107395144  LOW QUALITY PROTEIN: fibroblast growth factor 17-like [KO:K04358]
107386254  fibroblast growth factor 6-like [KO:K04358]
107389324  fgf6; fibroblast growth factor 6 [KO:K04358]
107372661  fibroblast growth factor 19-like isoform X1 [KO:K22603]
107387534  fgf21; fibroblast growth factor 21 [KO:K22429]
107386263  fgf23; fibroblast growth factor 23 [KO:K22428]
107389325  uncharacterized protein LOC107389325 [KO:K22428]
107378043  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
107378093  vascular endothelial growth factor A-like [KO:K05448]
107377612  vegfb; vascular endothelial growth factor B [KO:K05448]
107380855  vascular endothelial growth factor C-like [KO:K05449]
107381684  figf; vascular endothelial growth factor D isoform X1 [KO:K05449]
107382268  vegfc; vascular endothelial growth factor C [KO:K05449]
107390964  nerve growth factor-like [KO:K02582]
107385046  nerve growth factor-like [KO:K02582]
107388871  hgf; hepatocyte growth factor [KO:K05460]
107385652  hepatocyte growth factor-like isoform X1 [KO:K05460]
107385224  mst1; hepatocyte growth factor-like protein [KO:K23441]
107373767  gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
107394023  glial cell line-derived neurotrophic factor-like [KO:K05452]
107383161  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
107383833  egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107387934  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
107385695  erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
107390894  receptor tyrosine-protein kinase erbB-3-like isoform X1 [KO:K05084] [EC:2.7.10.1]
107389874  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
107377226  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
107393382  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
107375657  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
107394749  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
107393607  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
107375397  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
107391665  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
107386693  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
107382874  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
107378530  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
107385122  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
107393390  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
107379148  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
107394032  ntrk2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
107374736  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
107396553  NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
107381974  ntrk3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
107388350  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
107385200  macrophage-stimulating protein receptor-like [KO:K05100] [EC:2.7.10.1]
107375369  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
107376166  uncharacterized protein LOC107376166 [KO:K06856]
107378556  plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
107382825  plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
107384265  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like isoform X1 [KO:K05857] [EC:3.1.4.11]
107384528  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
107395431  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like isoform X1 [KO:K05857] [EC:3.1.4.11]
107395436  plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
107378111  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
107376107  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
107377124  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
107392485  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
107378065  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
107393039  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like [KO:K01116] [EC:3.1.4.11]
107391021  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
107389305  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
107387902  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
107384050  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
107385796  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
107388954  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
107391515  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
107382594  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
107382595  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
107393941  tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
107372374  tpcn2; two pore calcium channel protein 2 [KO:K14077]
107372664  two pore calcium channel protein 2-like [KO:K14077]
107382349  mucolipin-1-like [KO:K04992]
107396843  mcoln1; mucolipin-1 isoform X1 [KO:K04992]
107392692  mucolipin-2-like [KO:K04993]
107392950  mucolipin-3-like isoform X1 [KO:K04994]
107383824  mucolipin-3-like [KO:K04994]
107379707  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
107382243  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
107374236  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
107375762  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
107386835  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
107387551  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
107376051  voltage-dependent anion-selective channel protein 2 [KO:K15040]
107396040  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
107394258  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
107388665  ADP/ATP translocase 3-like [KO:K05863]
107375305  slc25a4; ADP/ATP translocase 1 [KO:K05863]
107386430  ADP/ATP translocase 2-like [KO:K05863]
107378486  ADP/ATP translocase 2 [KO:K05863]
107376198  ferritin, middle subunit-like [KO:K05863]
107376037  peptidyl-prolyl cis-trans isomerase A-like isoform X1 [KO:K09565] [EC:5.2.1.8]
107387845  ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
107391089  troponin C, slow skeletal and cardiac muscles [KO:K05865]
107390564  troponin C, slow skeletal and cardiac muscles-like isoform X1 [KO:K05865]
107391428  troponin C, skeletal muscle [KO:K12042]
107391429  troponin C, skeletal muscle-like [KO:K12042]
107381759  calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
107396109  calmodulin [KO:K02183]
107380292  calmodulin [KO:K02183]
107375532  calm2; calmodulin [KO:K02183]
107396020  calmodulin-like [KO:K02183]
107388054  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like [KO:K00871] [EC:2.7.11.19]
107388073  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
107380364  phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
107377008  phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
107381696  phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
107381996  phkb; phosphorylase b kinase regulatory subunit beta [KO:K07190]
107395143  mylk; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
107393068  myosin light chain kinase 3-like [KO:K00907] [EC:2.7.11.18]
107378449  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
107383904  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
107387566  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
107385178  calcium/calmodulin-dependent protein kinase type 1-like [KO:K08794] [EC:2.7.11.17]
107390459  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
107382563  camk1d; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
107385572  calcium/calmodulin-dependent protein kinase type 1-like isoform X1 [KO:K08794] [EC:2.7.11.17]
107395908  camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
107384728  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
107382167  calcium/calmodulin-dependent protein kinase type II delta 2 chain [KO:K04515] [EC:2.7.11.17]
107375859  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
107387740  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
107386224  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
107387181  calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
107393094  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
107390263  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
107376893  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
107386394  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
107380138  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
107393481  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
107376079  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
107385591  tfeb; transcription factor EB isoform X1 [KO:K15590]
107378925  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
107394905  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
107390454  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
107385406  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
107388393  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
107381886  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
107383484  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
107386248  nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
107385307  pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
107383797  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like isoform X1 [KO:K13755] [EC:3.1.4.17]
107389528  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
107397038  ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
107380902  protein-tyrosine kinase 2-beta-like isoform X1 [KO:K05871] [EC:2.7.10.2]
107374676  uncharacterized protein LOC107374676 [KO:K00911] [EC:2.7.1.127]
107380261  inositol-trisphosphate 3-kinase A-like [KO:K00911] [EC:2.7.1.127]
107378003  itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
107392282  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
107391584  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
107376518  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
107388621  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
107376405  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107379571  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
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Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
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Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
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Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
nfu04010  MAPK signaling pathway
nfu04070  Phosphatidylinositol signaling system
nfu04210  Apoptosis
KO pathway
ko04020   
LinkDB

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