KEGG   PATHWAY: npo04024
Entry
npo04024                    Pathway                                
Name
cAMP signaling pathway - Nyctereutes procyonoides (raccoon dog)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
npo04024  cAMP signaling pathway
npo04024

Other DBs
GO: 0019933
Organism
Nyctereutes procyonoides (raccoon dog) [GN:npo]
Gene
129500686  VIP; VIP peptides [KO:K05264]
129505285  CRH; corticoliberin [KO:K05256]
129513092  CGA; glycoprotein hormones alpha chain [KO:K08522]
129500108  LHB; lutropin subunit beta [KO:K08521]
129500392  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
129496360  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
129501188  TSHB; thyrotropin subunit beta [KO:K05251]
129511116  POMC; pro-opiomelanocortin [KO:K05228]
129498394  GCG; pro-glucagon [KO:K05259]
129512588  GIP; gastric inhibitory polypeptide [KO:K05258]
129504709  FSHB; follitropin subunit beta [KO:K05250]
129513571  NPPA; LOW QUALITY PROTEIN: natriuretic peptides A [KO:K12334]
129509019  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
129523256  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
129509323  ADRB2; beta-2 adrenergic receptor [KO:K04142]
129509757  DRD1; D(1A) dopamine receptor [KO:K04144]
129510132  DRD5; D(1B) dopamine receptor [KO:K05840]
129508049  ADORA2A; adenosine receptor A2a [KO:K04266]
129509379  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
129513818  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
129496219  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
129502932  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
129515986  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X1 [KO:K04590]
129493694  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
129502837  CRHR2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
129512183  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
129496374  TSHR; thyrotropin receptor isoform X1 [KO:K04249]
129495431  adrenocorticotropic hormone receptor [KO:K04200]
129514502  adrenocorticotropic hormone receptor [KO:K04200]
129512976  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
129500854  GIPR; gastric inhibitory polypeptide receptor isoform X1 [KO:K04580]
129517581  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
129511840  FSHR; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
129508932  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
129497792  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
129497848  neuroendocrine secretory protein 55 [KO:K04632]
129512833  guanine nucleotide-binding protein G(s) subunit alpha-like isoform X1 [KO:K04632]
129508391  EDN1; endothelin-1 [KO:K16366]
129520676  EDN2; endothelin-2 [KO:K16367]
129497768  EDN3; endothelin-3 isoform X1 [KO:K05227]
129498851  SST; somatostatin [KO:K05237]
129502916  NPY; pro-neuropeptide Y [KO:K05232]
129522261  GHRL; appetite-regulating hormone isoform X1 [KO:K05254]
129497086  OXT; oxytocin-neurophysin 1 [KO:K05243]
129502643  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
129512721  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
129512951  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
129513285  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
129513893  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
129499185  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
129515649  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
129497515  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
129494520  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
129505743  ADORA1; adenosine receptor A1 isoform X1 [KO:K04265]
129516825  EDNRA; endothelin-1 receptor [KO:K04197]
129516746  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
129499343  SSTR1; somatostatin receptor type 1 isoform X1 [KO:K04217]
129515278  SSTR2; somatostatin receptor type 2 isoform X1 [KO:K04218]
129520086  SSTR5; somatostatin receptor type 5 [KO:K04221]
129507946  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
129507949  hydroxycarboxylic acid receptor 2 [KO:K08402]
129500585  FFAR2; free fatty acid receptor 2 [KO:K04328]
129507086  SUCNR1; succinate receptor 1 isoform X1 [KO:K10042]
129519281  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
129522045  OXTR; oxytocin receptor [KO:K04229]
129498395  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
129494269  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
129519569  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
129522106  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
129515724  LOW QUALITY PROTEIN: adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
129516202  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
129498939  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
129510932  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
129499511  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
129503910  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
129517234  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
129513386  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
129502672  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129519450  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
129508573  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
129512837  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
129519153  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
129518668  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
129511450  CNGA3; cyclic nucleotide-gated cation channel alpha-3 isoform X1 [KO:K04950]
129504710  CNGA4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
129513801  CNGB1; LOW QUALITY PROTEIN: cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
129495728  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
129495972  CALM1; calmodulin-1 [KO:K02183]
129497741  CALML6; calmodulin-like protein 6 [KO:K02183]
129506414  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
129500769  CALM3; calmodulin-3 [KO:K02183]
129511712  CALM2; calmodulin-2 isoform X1 [KO:K02183]
129513685  calmodulin-like protein 3 [KO:K02183]
129513765  CALML5; calmodulin-like protein 5 [KO:K02183]
129515997  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
129509461  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
129509507  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
129521159  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
129503274  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
129513087  BVES; blood vessel epicardial substance [KO:K21108]
129503625  POPDC2; popeye domain-containing protein 2 [KO:K26206]
129512743  POPDC3; popeye domain-containing protein 3 [KO:K26207]
129506035  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
129522542  HCN2; LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
129506169  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
129516678  ABCC4; ATP-binding cassette sub-family C member 4 isoform X1 [KO:K05673]
129505637  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
129498672  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
129500260  RRAS; ras-related protein R-Ras [KO:K07829]
129504807  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
129497555  PLD2; LOW QUALITY PROTEIN: phospholipase D2 [KO:K01115] [EC:3.1.4.4]
129498486  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
129493759  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
129494670  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129501796  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129522825  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129501387  RAP1A; ras-related protein Rap-1A [KO:K04353]
129511430  RAP1B; ras-related protein Rap-1b [KO:K07836]
129501991  TIAM1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
129506552  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
129519437  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
129521483  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
129519689  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129511656  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
129513923  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
129506775  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
129514011  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
129521354  RHOA; transforming protein RhoA [KO:K04513]
129499893  AFDN; afadin isoform X1 [KO:K05702]
129496789  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129498637  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129507069  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129513452  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
129520803  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129522073  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129508823  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129495892  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129499851  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129517633  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
129514778  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
129515848  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129522592  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129506345  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129522322  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129502349  mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
129507918  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129519082  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129519960  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129521768  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
129517515  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
129508013  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
129503123  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
129510821  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
129522997  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
129518269  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
129508719  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
129494799  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
129503105  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
129515926  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
129522278  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
129502771  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
129511409  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
129520280  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
129504949  BDNF; brain-derived neurotrophic factor [KO:K04355]
129496401  FOS; protein c-Fos [KO:K04379]
129497811  JUN; transcription factor Jun [KO:K04448]
129494414  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
129512054  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
129499614  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
129516987  HHIP; hedgehog-interacting protein isoform X1 [KO:K06231]
129499457  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
129521190  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129503049  RELA; transcription factor p65 isoform X1 [KO:K04735]
129516577  SOX9; transcription factor SOX-9 [KO:K18435]
129521463  AMH; muellerian-inhibiting factor [KO:K04665]
129511914  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
129505875  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
129510119  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
129495445  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
129514485  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
129521053  F2R; proteinase-activated receptor 1 [KO:K03914]
129503119  BAD; bcl2-associated agonist of cell death [KO:K02158]
129500999  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
129508826  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
129510900  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
129520637  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
129493897  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
129503326  myosin regulatory light polypeptide 9-like isoform X1 [KO:K12755]
129500670  TNNI3; troponin I, cardiac muscle [KO:K12044]
129500678  PLN; cardiac phospholamban [KO:K05852]
129508024  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
129520194  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
129513950  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
129499256  RYR2; ryanodine receptor 2 [KO:K04962]
129505656  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
129520006  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
129517144  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
129511343  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
129500619  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
129495048  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
129522251  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
129509702  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
129516741  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
129518361  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
129497696  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
129502846  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
129500869  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
129501310  ATP1A1; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
129515147  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
129515238  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
129508607  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
129496654  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
129507194  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
129517508  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
129499624  FXYD1; phospholemman isoform X1 [KO:K13360]
129513730  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
129508071  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
129515367  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
129522380  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
129516845  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
129517447  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
129503382  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129521343  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
129517804  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
129505985  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
129505625  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1 [KO:K19021] [EC:3.1.4.17]
129505013  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
129497662  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
129522378  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
129513442  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
129521319  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
129500774  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
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Related
pathway
npo00071  Fatty acid degradation
npo04015  Rap1 signaling pathway
npo04020  Calcium signaling pathway
npo04151  PI3K-Akt signaling pathway
npo04210  Apoptosis
npo04260  Cardiac muscle contraction
npo04340  Hedgehog signaling pathway
npo04720  Long-term potentiation
npo04740  Olfactory transduction
npo04972  Pancreatic secretion
npo04976  Bile secretion
KO pathway
ko04024   
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