Entry
Name
Cytokine-cytokine receptor interaction - Neomonachus schauinslandi (Hawaiian monk seal)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
nsu04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Neomonachus schauinslandi (Hawaiian monk seal) [GN:
nsu ]
Gene
110591203 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
110593135 CSF3; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor [KO:K05423 ]
110587573 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
110580319 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
110593940 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
110574012 FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389 ]
110581790 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
110591656 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X2 [KO:K04721 ]
110587728 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
110581760 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
110594056 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
110574009 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
110574010 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
110584519 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
110585882 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
110590084 TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375 ]
110588122 TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376 ]
110586033 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
110586502 IL15RA; LOW QUALITY PROTEIN: interleukin-15 receptor subunit alpha [KO:K05074 ]
110570377 CRLF2; LOW QUALITY PROTEIN: cytokine receptor-like factor 2 [KO:K05078 ]
110593303 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
110574902 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
110590912 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
110581370 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
110571812 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
110593687 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
110581488 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
110589867 OSMR; oncostatin-M-specific receptor subunit beta isoform X4 [KO:K05057 ]
110570832 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
110583311 IFNGR1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132 ]
110572074 IL1R1; LOW QUALITY PROTEIN: interleukin-1 receptor type 1 [KO:K04386 ]
110580878 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
110574678 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141 ]
110581090 LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159 ]
110574613 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
110578537 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
110585971 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
110575348 TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160 ]
110582094 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
110572021 EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
110571791 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163 ]
110593102 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
110578861 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
110577009 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
110588081 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
110575358 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
110579528 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
110574643 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
110575331 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
110574587 TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X2 [KO:K05154 ]
110587831 TNFRSF17; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
110584635 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
110578227 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
110570335 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155 ]
110593417 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
LinkDB
All DBs