KEGG   PATHWAY: oas04014
Entry
oas04014                    Pathway                                
Name
Ras signaling pathway - Ovis aries (sheep)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
oas04014  Ras signaling pathway
oas04014

Other DBs
GO: 0032318
Organism
Ovis aries (sheep) [GN:oas]
Gene
101106508  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
101109353  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
443306  FGF2; fibroblast growth factor 2 precursor [KO:K18497]
101116844  FGF9; fibroblast growth factor 9 [KO:K04358]
101116004  FGF4; fibroblast growth factor 4 [KO:K04358]
443074  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
101113716  FGF8; fibroblast growth factor 8 [KO:K04358]
101104968  FGF16; fibroblast growth factor 16 [KO:K04358]
443095  FGF7; fibroblast growth factor 7 [KO:K04358]
100642180  FGF5; fibroblast growth factor 5 isoform 1 precursor [KO:K04358]
101121489  FGF20; fibroblast growth factor 20 [KO:K04358]
101118502  FGF17; fibroblast growth factor 17 isoform X2 [KO:K04358]
101114608  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
101116719  FGF6; fibroblast growth factor 6 [KO:K04358]
780460  FGF18; fibroblast growth factor 18 [KO:K04358]
101116269  FGF3; fibroblast growth factor 3 isoform X1 [KO:K04358]
101115744  FGF19; fibroblast growth factor 19 [KO:K22603]
101108510  FGF21; fibroblast growth factor 21 [KO:K22429]
101112475  FGF23; fibroblast growth factor 23 [KO:K22428]
101104540  NGF; beta-nerve growth factor [KO:K02582]
101117275  BDNF; brain-derived neurotrophic factor [KO:K04355]
101115018  NTF3; neurotrophin-3 isoform X2 [KO:K04356]
101104334  NTF4; neurotrophin-4 [KO:K12457]
114110121  INS; insulin [KO:K04526]
443318  IGF1; insulin-like growth factor I precursor [KO:K05459]
443325  IGF2; insulin-like growth factor II preproprotein [KO:K13769]
114110564  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
443545  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
101117784  PDGFD; platelet-derived growth factor D isoform X3 [KO:K05450]
101112600  PDGFC; platelet-derived growth factor C isoform X4 [KO:K05450]
101104200  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
443371  KITLG; kit ligand precursor [KO:K05461]
780525  FLT3LG; fms-related tyrosine kinase 3 ligand precursor [KO:K05454]
443103  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
101115840  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
443245  PGF; placenta growth factor isoform X2 [KO:K16859]
101105629  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
101102873  VEGFD; vascular endothelial growth factor D [KO:K05449]
443075  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
497271  ANGPT1; angiopoietin-1 [KO:K05465]
497273  ANGPT2; angiopoietin-2 [KO:K05466]
101107460  ANGPT4; angiopoietin-4 [KO:K05467]
101105380  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
101105624  EFNA1; ephrin-A1 isoform X3 [KO:K05462]
101115414  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
101114443  EFNA2; ephrin-A2 [KO:K05462]
101115792  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
780479  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
780507  FGFR1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
443548  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
554324  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101120660  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101119064  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101109763  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101116015  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
443431  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
443515  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101106012  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101122783  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101109969  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
780504  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
101112331  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
443088  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
101117247  FLT4; vascular endothelial growth factor receptor 3 isoform X2 [KO:K05097] [EC:2.7.10.1]
443087  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
443076  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
497272  TEK; angiopoietin-1 receptor isoform X4 [KO:K05121] [EC:2.7.10.1]
101110575  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
101109893  GRB2; growth factor receptor-bound protein 2 isoform X5 [KO:K04364]
114110058  growth factor receptor-bound protein 2 [KO:K04364]
101112165  GAB1; GRB2-associated-binding protein 1 isoform X4 [KO:K09593]
101115743  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
101113548  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
101113847  SHC2; SHC-transforming protein 2 [KO:K17447]
101107936  SHC3; SHC-transforming protein 3 [KO:K17448]
101110241  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
101114308  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X3 [KO:K07293] [EC:3.1.3.48]
101107037  tyrosine-protein phosphatase non-receptor type 11-like isoform X4 [KO:K07293] [EC:3.1.3.48]
101118865  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
101102732  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101103341  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101122126  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
101105504  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
101104023  RASGRP2; RAS guanyl-releasing protein 2 isoform X2 [KO:K12361]
101101969  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
101112342  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
101114438  T cell receptor beta variable 7-9 [KO:K10785]
101112639  tyrosine-protein kinase ZAP-70 isoform X1 [KO:K07360] [EC:2.7.10.2]
101110725  LAT; linker for activation of T-cells family member 1 isoform X3 [KO:K07362]
101122994  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
101104166  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2 [KO:K04536]
101102864  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101110493  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101108976  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101106267  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
101106689  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101114066  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101114927  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101110631  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105611474  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101116593  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
114112926  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100192421  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
106991180  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101115838  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101112183  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101114097  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
105608415  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
443094  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101108785  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101113014  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
101121934  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
443281  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X9 [KO:K05208]
101106989  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101118179  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101105840  calmodulin [KO:K02183]
443230  CALM2; calmodulin [KO:K02183]
105614854  calmodulin-alpha [KO:K02183]
101116338  CALM3; calmodulin-3 [KO:K02183]
101115216  CALM1; calmodulin-1 isoform X2 [KO:K02183]
100037684  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
121820456  calmodulin-1-like [KO:K02183]
101123572  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
101104357  HRAS; GTPase HRas isoform X1 [KO:K02833]
114114919  GTPase HRas-like [KO:K02833]
101114005  KRAS; GTPase KRas isoform X1 [KO:K07827]
101102438  NRAS; GTPase NRas [KO:K07828]
101110290  MRAS; ras-related protein M-Ras [KO:K07831]
101107545  RRAS; ras-related protein R-Ras [KO:K07829]
101118556  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101117432  NF1; neurofibromin isoform X1 [KO:K08052]
101119216  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
101108362  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
101121434  RASA3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
101117299  ras GTPase-activating protein 4 isoform X4 [KO:K17630]
101117886  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
101109393  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
101119234  RASAL2; ras GTPase-activating protein nGAP isoform X7 [KO:K17633]
101122784  RASAL3; RAS protein activator like-3 [KO:K17634]
100302080  RASSF1; ras association domain-containing protein 1 [KO:K09850]
101117178  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
101110437  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
101103280  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
100101233  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101107592  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
101112406  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
101111756  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101123517  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101110391  PAK3; serine/threonine-protein kinase PAK 3 isoform X2 [KO:K05733] [EC:2.7.11.1]
101115152  PAK4; serine/threonine-protein kinase PAK 4 isoform X2 [KO:K05734] [EC:2.7.11.1]
101107882  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101112573  PAK6; serine/threonine-protein kinase PAK 6 isoform X2 [KO:K05735] [EC:2.7.11.1]
100302078  RHOA; transforming protein RhoA [KO:K04513]
114116812  transforming protein RhoA-like [KO:K04513]
101106246  transforming protein RhoA [KO:K04513]
101109759  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101110015  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101117348  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101123247  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101111546  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
101121455  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
101118462  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101119242  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100294652  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101107332  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
101111143  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
780484  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
101108228  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
101102191  RELA; transcription factor p65 [KO:K04735]
780444  BAD; bcl2-associated agonist of cell death [KO:K02158]
105610887  LOW QUALITY PROTEIN: bcl-2-like protein 1 [KO:K04570]
443061  BCL2L1; bcl-2-like protein 1 [KO:K04570]
101106158  bcl-2-like protein 1 [KO:K04570]
101103040  FOXO4; forkhead box protein O4 [KO:K12358]
100135696  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101120113  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X9 [KO:K25768]
101123574  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
101104846  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
101118864  RALGDS; ral guanine nucleotide dissociation stimulator isoform X5 [KO:K08732]
101106955  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X2 [KO:K17635]
101117118  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X2 [KO:K17636]
101121767  RALA; ras-related protein Ral-A isoform X2 [KO:K07834]
101113566  RALB; ras-related protein Ral-B isoform X3 [KO:K07835]
101110687  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
101114661  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101110975  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
101110830  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101118600  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
101116201  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101120826  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101120665  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
101107653  RALBP1; ralA-binding protein 1 isoform X3 [KO:K08773]
114112048  LOW QUALITY PROTEIN: ralA-binding protein 1-like [KO:K08773]
101102792  CDC42; cell division control protein 42 homolog [KO:K04393]
114108599  cell division control protein 42 homolog [KO:K04393]
101115800  AFDN; afadin isoform X17 [KO:K05702]
101120536  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
101103190  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
101123635  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
101113846  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101115485  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
101123008  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101106480  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
101115852  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
101109935  group 10 secretory phospholipase A2 isoform X4 [KO:K01047] [EC:3.1.1.4]
101120062  PLA2G5; phospholipase A2 group V isoform X3 [KO:K01047] [EC:3.1.1.4]
101104134  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101103632  PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X2 [KO:K01047] [EC:3.1.1.4]
101106664  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101107171  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
101107675  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
101107420  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
101119561  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101117700  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101113959  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105605991  PLA2G2D; group IID secretory phospholipase A2 isoform X4 [KO:K01047] [EC:3.1.1.4]
101111472  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101115372  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
101115878  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X2 [KO:K16342] [EC:3.1.1.4]
101116150  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
101116403  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
101103799  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
101120283  PLAAT3; phospholipase A and acyltransferase 3 isoform X2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101120029  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101113988  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101114986  ETS1; protein C-ets-1 isoform X4 [KO:K02678]
443026  ETS2; protein C-ets-2 isoform X1 [KO:K21932]
101107047  BRAP; BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
101117683  kinase suppressor of Ras 1 isoform X1 [KO:K14958]
101110179  KSR2; kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]
101108303  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X2 [KO:K08019]
101115080  RAP1A; ras-related protein Rap-1A [KO:K04353]
101106317  RAP1B; ras-related protein Rap-1b [KO:K07836]
114113232  ras-related protein Rap-1b [KO:K07836]
101105703  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
101110074  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101118410  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101116423  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101113711  RIN1; ras and Rab interactor 1 [KO:K17638]
101122941  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
101121110  ABL2; tyrosine-protein kinase ABL2 isoform X3 [KO:K08887] [EC:2.7.10.2]
100302084  RAB5A; ras-related protein Rab-5A [KO:K07887]
101112211  RAB5B; ras-related protein Rab-5B [KO:K07888]
101122039  RAB5C; ras-related protein Rab-5C [KO:K07889]
100302306  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
oas04010  MAPK signaling pathway
oas04015  Rap1 signaling pathway
oas04020  Calcium signaling pathway
oas04144  Endocytosis
oas04151  PI3K-Akt signaling pathway
oas04660  T cell receptor signaling pathway
oas04720  Long-term potentiation
oas04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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