KEGG   PATHWAY: oor05152
Entry
oor05152                    Pathway                                
Name
Tuberculosis - Orcinus orca (killer whale)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
oor05152  Tuberculosis
oor05152

Organism
Orcinus orca (killer whale) [GN:oor]
Gene
101269870  TNF; tumor necrosis factor [KO:K03156]
101282502  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101271709  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101272962  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
101281780  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101282021  CASP10; caspase-10 isoform X1 [KO:K04400] [EC:3.4.22.63]
101289847  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
101277745  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
101285349  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105747906  cytochrome c-like [KO:K08738]
101283052  cytochrome c [KO:K08738]
101275631  cytochrome c-like [KO:K08738]
105747703  cytochrome c 2 [KO:K08738]
101272869  cytochrome c-like [KO:K08738]
117203203  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
101271677  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101280303  APAF1; apoptotic protease-activating factor 1 isoform X4 [KO:K02084]
101272095  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101288103  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101273316  AKT1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101274967  BAD; bcl2-associated agonist of cell death [KO:K02158]
101276750  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101269181  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X16 [KO:K04515] [EC:2.7.11.17]
101287513  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5 [KO:K04515] [EC:2.7.11.17]
101281498  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X8 [KO:K04515] [EC:2.7.11.17]
101271879  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101282933  IFNG; interferon gamma [KO:K04687]
101276054  IFNGR1; interferon gamma receptor 1 [KO:K05132]
101279441  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
101275383  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101272458  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
101290378  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
101278537  RFX5; DNA-binding protein RFX5 isoform X3 [KO:K08061]
101269571  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
101287764  RFXAP; regulatory factor X-associated protein [KO:K08063]
101278637  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
101288651  NFYB; nuclear transcription factor Y subunit beta isoform X2 [KO:K08065]
101279629  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
101287685  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
101275987  SLA class II histocompatibility antigen, DQ haplotype D alpha chain isoform X2 [KO:K06752]
101287624  HLA class II histocompatibility antigen, DM beta chain isoform X3 [KO:K06752]
101287882  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
101277081  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
101276823  DLA class II histocompatibility antigen, DR-1 beta chain isoform X3 [KO:K06752]
101288385  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
101289225  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101270971  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
101281894  CREBBP; CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]
101287751  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101271889  IL10; interleukin-10 [KO:K05443]
101281088  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
101283710  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
101269523  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
101283525  C-type lectin domain family 4 member E [KO:K10059]
101277161  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
101269997  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
101275089  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101281971  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
101284636  CARD9; caspase recruitment domain-containing protein 9 isoform X2 [KO:K12794]
101272250  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X2 [KO:K07369] [EC:3.4.22.-]
101279677  BCL10; B-cell lymphoma/leukemia 10 [KO:K07368]
105748039  LOW QUALITY PROTEIN: B-cell lymphoma/leukemia 10-like [KO:K07368]
101271819  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
101273094  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
101274472  HSPA9; stress-70 protein, mitochondrial [KO:K04043]
101271413  LOW QUALITY PROTEIN: stress-70 protein, mitochondrial-like [KO:K04043]
101289849  HSPD1; 60 kDa heat shock protein, mitochondrial isoform X2 [KO:K04077] [EC:5.6.1.7]
101274177  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
101277992  LBP; lipopolysaccharide-binding protein isoform X2 [KO:K05399]
101276053  TLR2; toll-like receptor 2 [KO:K10159]
101280548  TLR1; toll-like receptor 1 [KO:K05398]
125960249  TLR6; toll-like receptor 6 [KO:K10169]
101282217  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
101283534  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101284698  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
101278425  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
101283238  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101280639  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X2 [KO:K04730] [EC:2.7.11.1]
101273127  IRAK2; interleukin-1 receptor-associated kinase-like 2 isoform X1 [KO:K04731] [EC:2.7.11.1]
101277553  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
101279857  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101270342  RELA; transcription factor p65 isoform X1 [KO:K04735]
101269212  MAPK13; mitogen-activated protein kinase 13 isoform X7 [KO:K04441] [EC:2.7.11.24]
101269458  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101287579  mitogen-activated protein kinase 12 isoform X6 [KO:K04441] [EC:2.7.11.24]
101287833  mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
101273287  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101289394  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101287701  MAPK9; mitogen-activated protein kinase 9 isoform X5 [KO:K04440] [EC:2.7.11.24]
101277656  MAPK10; mitogen-activated protein kinase 10 isoform X4 [KO:K04440] [EC:2.7.11.24]
101281228  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
101280638  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101281783  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
101279088  IL12A; interleukin-12 subunit alpha [KO:K05406]
101272835  IL12B; interleukin-12 subunit beta [KO:K05425]
101271274  IL18; interleukin-18 isoform X1 [KO:K05482]
101281838  IL23A; interleukin-23 subunit alpha [KO:K05426]
101272616  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
101284892  IL1B; interleukin-1 beta isoform X2 [KO:K04519]
101287847  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
101278254  CCAAT/enhancer-binding protein gamma [KO:K10049]
101273077  CEBPG; CCAAT/enhancer-binding protein gamma [KO:K10049]
101289148  toll-like receptor 9 isoform X3 [KO:K10161]
101274041  interferon alpha-1-like [KO:K05414]
101275016  interferon alpha-1-like [KO:K05414]
101275275  interferon alpha-1-like [KO:K05414]
101287367  interferon alpha-3-like [KO:K05414]
125964698  interferon alpha-1-like [KO:K05414]
125964699  interferon alpha-1-like [KO:K05414]
125964701  interferon alpha-3-like [KO:K05414]
125964702  interferon alpha-3-like [KO:K05414]
125964703  interferon alpha-3-like [KO:K05414]
101289058  IFNB1; interferon beta [KO:K05415]
101288338  CD209; CD209 antigen [KO:K06563]
101272295  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
101273830  RHOA; transforming protein RhoA [KO:K04513]
101274691  LSP1; lymphocyte-specific protein 1 isoform X4 [KO:K14957]
101282052  PLK3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
101281478  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
101272984  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101286197  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
101276254  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
101289027  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101284262  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial isoform X1 [KO:K07438] [EC:1.14.15.18]
101277927  VDR; vitamin D3 receptor isoform X3 [KO:K08539]
101282698  cathelicidin-5-like [KO:K13916]
101282948  cathelicidin-1-like [KO:K13916]
101280877  cathelicidin-4-like isoform X3 [KO:K13916]
117198145  LOW QUALITY PROTEIN: antibacterial peptide PMAP-37-like [KO:K13916]
101281425  C3; complement C3 [KO:K03990]
101290167  CR1; complement receptor type 1 isoform X1 [KO:K04011]
101288051  integrin alpha-X isoform X1 [KO:K06462]
101285903  ITGB2; integrin beta-2 isoform X3 [KO:K06464]
101287801  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
101277808  PLA2R1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
101285113  MRC1; macrophage mannose receptor 1 isoform X1 [KO:K06560]
101273878  MRC2; C-type mannose receptor 2 isoform X2 [KO:K06560]
101289072  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
101286291  SPHK1; sphingosine kinase 1 isoform X2 [KO:K04718] [EC:2.7.1.91]
101278649  CALML6; calmodulin-like protein 6 [KO:K02183]
101273078  CALM2; calmodulin-2 [KO:K02183]
101285814  CALM1; calmodulin-1 [KO:K02183]
101279979  CALM3; calmodulin-3 [KO:K02183]
101282017  calmodulin-alpha-like isoform X1 [KO:K02183]
105748632  LOW QUALITY PROTEIN: myosin light chain 1, skeletal muscle isoform-like [KO:K02183]
101284096  calmodulin-1-like [KO:K02183]
125961823  calmodulin-1-like [KO:K02183]
125961824  calmodulin-1-like [KO:K02183]
125961825  calmodulin-1-like [KO:K02183]
125961826  calmodulin-1-like [KO:K02183]
125961827  calmodulin-1-like [KO:K02183]
125961828  calmodulin-1-like [KO:K02183]
101273072  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
101273864  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
101275059  ras-related protein Rab-5A-like [KO:K07887]
101289329  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
101279258  RAB5C; ras-related protein Rab-5C [KO:K07889]
101290453  EEA1; early endosome antigen 1 isoform X2 [KO:K12478]
101282879  RAB7A; ras-related protein Rab-7a [KO:K07897]
101280086  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
101282573  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
101282363  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X2 [KO:K02154]
101271452  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 isoform X2 [KO:K02154]
101289177  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X2 [KO:K02154]
101288490  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
101289188  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
101283671  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
101274418  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
101271760  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c isoform X1 [KO:K02155]
101286170  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
101287360  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X3 [KO:K06528]
101276949  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
101271019  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X7 [KO:K04348] [EC:3.1.3.16]
101278517  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X3 [KO:K04348] [EC:3.1.3.16]
101286888  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7 [KO:K04348] [EC:3.1.3.16]
105748080  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
101272877  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101288975  CORO1A; coronin-1A isoform X2 [KO:K13882]
101283030  low affinity immunoglobulin gamma Fc region receptor II isoform X3 [KO:K12560]
101270000  low affinity immunoglobulin gamma Fc region receptor III-A-like isoform X1 [KO:K06463]
125964005  low affinity immunoglobulin gamma Fc region receptor III-A-like isoform X1 [KO:K06463]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Mycobacterial trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:21274449
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
PMID:20415982
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
PMID:11932234
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
PMID:18288961
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
PMID:17359235
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
PMID:21274433
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
PMID:15083155
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
PMID:20199890
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
PMID:15228522
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
PMID:19563525
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
PMID:19369951
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
PMID:18541216
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
PMID:19634703
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:17785780
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
PMID:18407066
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
PMID:11378475
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
oor04010  MAPK signaling pathway
oor04210  Apoptosis
oor04612  Antigen processing and presentation
oor04620  Toll-like receptor signaling pathway
oor04621  NOD-like receptor signaling pathway
oor04630  JAK-STAT signaling pathway
KO pathway
ko05152   
LinkDB

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