KEGG   PATHWAY: pale04151
Entry
pale04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Pteropus alecto (black flying fox)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
pale04151  PI3K-Akt signaling pathway
pale04151

Other DBs
GO: 0043491
Organism
Pteropus alecto (black flying fox) [GN:pale]
Gene
102891552  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102887662  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
102884726  EREG; proepiregulin [KO:K09784]
102884477  AREG; amphiregulin [KO:K09782]
102894192  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
107196088  FGF2; fibroblast growth factor 2 [KO:K18497]
102895922  FGF10; fibroblast growth factor 10 [KO:K04358]
102887777  FGF7; fibroblast growth factor 7 [KO:K04358]
102892141  FGF6; fibroblast growth factor 6 [KO:K04358]
102895642  FGF5; fibroblast growth factor 5 [KO:K04358]
102890153  FGF16; fibroblast growth factor 16 [KO:K04358]
102893226  FGF8; fibroblast growth factor 8 isoform X4 [KO:K04358]
102894115  FGF18; fibroblast growth factor 18 [KO:K04358]
102888098  FGF20; fibroblast growth factor 20 [KO:K04358]
102893244  FGF4; fibroblast growth factor 4 [KO:K04358]
102894279  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102887882  FGF9; fibroblast growth factor 9 [KO:K04358]
102896895  FGF22; fibroblast growth factor 22 [KO:K04358]
102885081  FGF19; fibroblast growth factor 19 [KO:K22603]
102886540  FGF21; fibroblast growth factor 21 [KO:K22429]
102883346  FGF23; fibroblast growth factor 23 [KO:K22428]
102885454  NGF; beta-nerve growth factor [KO:K02582]
102896087  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
102891298  NTF3; neurotrophin-3 [KO:K04356]
102884120  NTF4; neurotrophin-4 [KO:K12457]
102881117  insulin [KO:K04526]
102890331  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
102880410  IGF2; insulin-like growth factor II [KO:K13769]
102893670  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102897699  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102894123  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102890668  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102894339  CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]
102884034  KITLG; kit ligand isoform X1 [KO:K05461]
102881080  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
102890394  VEGFA; vascular endothelial growth factor A isoform X2 [KO:K05448]
102883443  vascular endothelial growth factor B [KO:K16858]
102882963  VEGFB; vascular endothelial growth factor B [KO:K16858]
102889783  PGF; placenta growth factor isoform X1 [KO:K16859]
102889143  VEGFD; vascular endothelial growth factor D [KO:K05449]
102884251  VEGFC; vascular endothelial growth factor C [KO:K05449]
102884470  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102886671  ANGPT1; angiopoietin-1 isoform X2 [KO:K05465]
102878662  ANGPT2; angiopoietin-2 [KO:K05466]
102888856  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
102892637  EFNA4; ephrin-A4 [KO:K05462]
102892139  EFNA1; ephrin-A1 [KO:K05462]
102892391  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
102898679  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
102883167  GDNF; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
102883094  NRTN; neurturin [KO:K25414]
102880382  PSPN; persephin [KO:K25416]
102893495  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102885300  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102895392  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
102895574  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
102898943  FGFR1; fibroblast growth factor receptor 1 isoform X9 [KO:K04362] [EC:2.7.10.1]
102882899  FGFR2; fibroblast growth factor receptor 2 isoform X8 [KO:K05093] [EC:2.7.10.1]
102878342  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102879288  FGFR4; fibroblast growth factor receptor 4 isoform X3 [KO:K05095] [EC:2.7.10.1]
102882941  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
112472150  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102882910  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102879346  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102885962  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102895362  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
102887643  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102886964  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102895969  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
102891572  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
102891095  FLT1; vascular endothelial growth factor receptor 1 isoform X2 [KO:K05096] [EC:2.7.10.1]
112469042  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
102889771  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102896638  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102885990  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102894883  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
102898437  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
102878133  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X4 [KO:K05126] [EC:2.7.10.1]
102878822  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
102882462  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102889597  SOS2; son of sevenless homolog 2 [KO:K03099]
102896270  HRAS; GTPase HRas isoform X3 [KO:K02833]
102895590  KRAS; GTPase KRas isoform X1 [KO:K07827]
102885950  NRAS; GTPase NRas isoform X2 [KO:K07828]
102893439  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102897122  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102879034  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102895390  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102885749  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102891583  IRS1; insulin receptor substrate 1 [KO:K16172]
102893057  TLR2; toll-like receptor 2 precursor [KO:K10159]
102897365  TLR4; toll-like receptor 4 precursor [KO:K10160]
102897644  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102892050  immunoglobulin heavy variable 1-46 [KO:K06856]
102888426  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
102885256  CD19; B-lymphocyte antigen CD19 [KO:K06465]
102897337  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
102888823  somatotropin [KO:K05438]
102887064  PRL; prolactin isoform X1 [KO:K05439]
102889450  OSM; oncostatin-M [KO:K05418]
102895516  IL2; interleukin-2 [KO:K05429]
102896574  interleukin-3 [KO:K04736]
102895746  IL6; interleukin-6 [KO:K05405]
102890025  IL4; interleukin-4 [KO:K05430]
112472586  IL7; interleukin-7 [KO:K05431]
102893886  interferon alpha-1 [KO:K05414]
102890009  interferon alpha-4 [KO:K05414]
102890512  IFNB1; interferon beta [KO:K05415]
102883166  EPO; erythropoietin [KO:K05437]
102882020  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
102891638  GHR; growth hormone receptor [KO:K05080]
102890093  PRLR; prolactin receptor [KO:K05081]
102884525  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
102891511  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
102883396  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
102888070  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
102878242  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
102878027  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
102882815  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
102889092  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
102892040  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
102891485  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102886625  EPOR; erythropoietin receptor [KO:K05079]
102897878  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
102880365  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
102882079  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
102898620  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
102886463  COL1A1; collagen alpha-1(I) chain [KO:K06236]
102878069  COL1A2; LOW QUALITY PROTEIN: collagen alpha-2(I) chain [KO:K06236]
102894333  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
102879139  COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
102879385  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102898331  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
102891781  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
102895248  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
102898083  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
102892412  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
102883628  collagen alpha-6(VI) chain [KO:K06238]
102881673  COL6A2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
102883890  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
102896988  COL6A1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
102881112  COL6A3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
102878023  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
102887814  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
102893935  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
102894718  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102884860  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
102897225  LAMA3; laminin subunit alpha-3 isoform X6 [KO:K06240]
102892706  LAMA5; laminin subunit alpha-5 [KO:K06240]
102877962  LAMA4; laminin subunit alpha-4 [KO:K06241]
102881611  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
102889392  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
102896504  LAMB3; laminin subunit beta-3 [KO:K06244]
102896150  LAMB4; laminin subunit beta-4 [KO:K06245]
102885413  LAMC1; laminin subunit gamma-1 [KO:K05635]
102892078  LAMC2; laminin subunit gamma-2 [KO:K06246]
102881476  LAMC3; laminin subunit gamma-3 [KO:K06247]
102887721  CHAD; chondroadherin [KO:K06248]
102898395  RELN; reelin isoform X2 [KO:K06249] [EC:3.4.21.-]
102898784  THBS1; thrombospondin-1 [KO:K16857]
102885384  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
102898345  THBS4; thrombospondin-4 [KO:K04659]
102890277  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
102880862  THBS2; thrombospondin-2 [KO:K04659]
102891509  FN1; fibronectin isoform X1 [KO:K05717]
102890230  SPP1; osteopontin [KO:K06250]
102878956  VTN; vitronectin [KO:K06251]
102898698  TNC; tenascin isoform X4 [KO:K06252]
102879390  TNR; tenascin-R [KO:K06252]
102890398  TNN; LOW QUALITY PROTEIN: tenascin-N [KO:K06252]
102889033  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
102891539  VWF; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
102889561  IBSP; bone sialoprotein 2 [KO:K06253]
102884999  ITGA1; integrin alpha-1 [KO:K06480]
102897185  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
102883900  ITGA2B; integrin alpha-IIb [KO:K06476]
102884713  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
102896887  ITGA4; integrin alpha-4 [KO:K06483]
102889111  ITGA5; integrin alpha-5 [KO:K06484]
102883425  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102890305  ITGA7; integrin alpha-7 isoform X3 [KO:K06583]
102878211  ITGA8; LOW QUALITY PROTEIN: integrin alpha-8 [KO:K06584]
102878201  ITGA9; integrin alpha-9 [KO:K06585]
102896303  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
102890264  ITGA11; integrin alpha-11 [KO:K06587]
102895440  ITGAV; integrin alpha-V [KO:K06487]
102886785  ITGB1; integrin beta-1 [KO:K05719]
102881894  ITGB3; integrin beta-3 [KO:K06493]
102898254  ITGB4; integrin beta-4 [KO:K06525]
102892062  ITGB5; integrin beta-5 [KO:K06588]
102885280  ITGB6; integrin beta-6 isoform X2 [KO:K06589]
102896485  ITGB7; integrin beta-7 [KO:K06590]
102893900  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
102898998  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
102889227  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102880320  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102889576  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102879163  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102891637  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3 [KO:K02649]
102879453  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102886001  F2R; proteinase-activated receptor 1 [KO:K03914]
102885993  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
102883382  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102891503  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
102891807  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102880785  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
102881134  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102892521  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102892775  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
102883771  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102882744  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102893506  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102890410  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
102881664  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
102886028  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
102888735  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
102889599  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
102879439  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102886041  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
112479655  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
107196679  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102898925  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102886682  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102877921  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102892764  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X6 [KO:K04547]
102898674  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
102881686  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
102884972  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
102878262  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
102878019  PIK3R6; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
102896950  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102880044  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
102884524  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
102886520  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
102887761  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
102878835  TSC1; LOW QUALITY PROTEIN: hamartin [KO:K07206]
102898762  TSC2; tuberin isoform X11 [KO:K07207]
102889101  RHEB; GTP-binding protein Rheb [KO:K07208]
102879416  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
102885092  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102885334  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
102881655  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102898578  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
102894970  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
102898723  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
102891214  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
102889369  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
102890117  EIF4B; eukaryotic translation initiation factor 4B isoform X5 [KO:K03258]
102891633  RPS6; 40S ribosomal protein S6 [KO:K02991]
102887078  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102888759  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
102885113  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
102888265  PKN3; serine/threonine-protein kinase N3 isoform X2 [KO:K23692] [EC:2.7.11.13]
102891704  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
102897615  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
102889775  SGK3; serine/threonine-protein kinase Sgk3 isoform X2 [KO:K13304] [EC:2.7.11.1]
102885144  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102879337  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102898305  AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102880778  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X8 [KO:K05631]
102881949  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102897248  THEM4; LOW QUALITY PROTEIN: acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
102885289  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102887013  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102894487  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
102888699  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102888692  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
102882824  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
102892945  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
102896806  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
102891533  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
102884648  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
102879054  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
102897902  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
102895399  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
102881266  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
102898938  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
102879632  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
102887985  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102889156  HSP90B1; endoplasmin [KO:K09487]
102895377  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
102879203  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
102892249  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
102886914  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
102880993  T-cell leukemia/lymphoma protein 1A [KO:K10167]
102898308  MTCP1; protein p13 MTCP-1 [KO:K16837]
102879945  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
102895982  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
102882441  GSK3B; glycogen synthase kinase-3 beta isoform X4 [KO:K03083] [EC:2.7.11.26]
102890809  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
102884634  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
102888528  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
102897596  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
102887492  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
102896886  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
102898137  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
102895524  MYC; myc proto-oncogene protein [KO:K04377]
102885330  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102894049  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102880085  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
102893397  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
102894222  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102896272  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102892640  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102881884  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
102882411  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
102882260  CCNE1; LOW QUALITY PROTEIN: G1/S-specific cyclin-E1 [KO:K06626]
102890472  FOXO3; forkhead box protein O3 [KO:K09408]
102882545  RBL2; retinoblastoma-like protein 2 [KO:K16332]
102883204  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102890309  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
102880620  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
102894826  YWHAQ; 14-3-3 protein theta [KO:K16197]
102893263  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
102885303  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
102895426  YWHAG; 14-3-3 protein gamma [KO:K16198]
102878861  YWHAH; 14-3-3 protein eta [KO:K16198]
102877892  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
102887704  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102896443  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102878565  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
102888198  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102889014  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102896553  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102878515  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
102894633  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
102882888  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
102886510  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
102879289  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
102884583  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
102898128  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X3 [KO:K09049]
102884014  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
102881572  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
102884629  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102880203  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102879469  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
102893261  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102878395  RELA; transcription factor p65 [KO:K04735]
102880692  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102880598  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
102884281  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
102889604  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
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Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
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FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
pale00010  Glycolysis / Gluconeogenesis
pale04010  MAPK signaling pathway
pale04012  ErbB signaling pathway
pale04062  Chemokine signaling pathway
pale04064  NF-kappa B signaling pathway
pale04068  FoxO signaling pathway
pale04110  Cell cycle
pale04115  p53 signaling pathway
pale04150  mTOR signaling pathway
pale04210  Apoptosis
pale04370  VEGF signaling pathway
pale04510  Focal adhesion
pale04620  Toll-like receptor signaling pathway
pale04630  JAK-STAT signaling pathway
pale04662  B cell receptor signaling pathway
pale04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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