KEGG   PATHWAY: pcad04062
Entry
pcad04062                   Pathway                                
Name
Chemokine signaling pathway - Physeter catodon (sperm whale)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
pcad04062  Chemokine signaling pathway
pcad04062

Other DBs
GO: 0070098
Organism
Physeter catodon (sperm whale) [GN:pcad]
Gene
102981375  growth-regulated protein homolog gamma-like isoform X1 [KO:K05505]
112062060  growth-regulated protein homolog beta [KO:K05505]
102982314  growth-regulated protein homolog beta [KO:K05505]
102980255  C-X-C motif chemokine 6 [KO:K05506]
102980548  PPBP; platelet basic protein [KO:K10029]
102979960  CXCL8; interleukin-8 [KO:K10030]
102977303  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
102993287  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
102993567  CXCL11; C-X-C motif chemokine 11 isoform X2 [KO:K12672]
102990097  CXCL12; stromal cell-derived factor 1 [KO:K10031]
102979808  CXCL13; C-X-C motif chemokine 13 isoform X1 [KO:K10032]
102976516  C-X-C motif chemokine 16 [KO:K10035]
112065964  C-X-C motif chemokine 16 [KO:K10035]
102980818  platelet factor 4 isoform X1 [KO:K05407]
102988466  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
102985929  lymphotactin-like [KO:K05507]
102986197  lymphotactin-like [KO:K05507]
102992483  CX3CL1; fractalkine isoform X2 [KO:K05508]
102992548  CCL1; C-C motif chemokine 1 [KO:K05514]
102990067  monocyte chemotactic protein 1B [KO:K14624]
102996195  C-C motif chemokine 3 [KO:K05408]
112065981  LOW QUALITY PROTEIN: C-C motif chemokine 3-like [KO:K05408]
102996463  C-C motif chemokine 4 [KO:K12964]
102975625  CCL5; C-C motif chemokine 5 [KO:K12499]
102989537  C-C motif chemokine 8 [KO:K16596]
129391332  eotaxin-like [KO:K16597]
102990890  C-C motif chemokine 14 [KO:K21092]
102990617  C-C motif chemokine 23 [KO:K05511]
102975127  CCL16; C-C motif chemokine 16 [KO:K21093]
102991717  CCL19; C-C motif chemokine 19 [KO:K05512]
102989522  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
102982921  CCL21; C-C motif chemokine 21 [KO:K16062]
102992954  CCL22; C-C motif chemokine 22 [KO:K21095]
102986990  CCL24; LOW QUALITY PROTEIN: C-C motif chemokine 24 [KO:K21097]
102992780  CCL25; C-C motif chemokine 25 isoform X1 [KO:K13072]
112065321  CCL26; LOW QUALITY PROTEIN: C-C motif chemokine 26 [KO:K21096]
102991987  CCL27; LOW QUALITY PROTEIN: C-C motif chemokine 27 [KO:K16598]
102983189  uncharacterized protein LOC102983189 [KO:K16598]
102980969  CCL28; C-C motif chemokine 28 [KO:K05513]
102995856  LOW QUALITY PROTEIN: C-X-C chemokine receptor type 2 [KO:K05050]
102995584  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
102980207  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
102989559  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102984448  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
102990962  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
102991726  XCR1; chemokine XC receptor 1 [KO:K04193]
102985552  CX3CR1; LOW QUALITY PROTEIN: CX3C chemokine receptor 1 [KO:K04192]
102980143  CCR8; C-C chemokine receptor type 8 [KO:K04183]
102995909  CCR6; C-C chemokine receptor type 6 [KO:K04181]
102992256  CCR9; C-C chemokine receptor type 9 [KO:K04184]
102992737  CCR4; C-C chemokine receptor type 4 [KO:K04179]
102979901  CCR7; C-C chemokine receptor type 7 [KO:K04182]
102984380  C-C chemokine receptor type 2 [KO:K04177]
112064940  CCR5; C-C chemokine receptor type 5 [KO:K04180]
102981557  CCR1; C-C chemokine receptor type 1 [KO:K04176]
102981286  CCR3; C-C chemokine receptor type 3 [KO:K04178]
102994952  CCR10; C-C chemokine receptor type 10 [KO:K04185]
102978811  JAK2; tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:2.7.10.2]
102990026  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
102977655  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
102981574  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
102976764  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
102994339  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
102996618  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
102997009  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
102996666  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
102981199  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102991224  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102989136  ADCY3; adenylate cyclase type 3 isoform X3 [KO:K08043] [EC:4.6.1.1]
102985820  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
102983319  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102986152  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
102985075  ADCY7; adenylate cyclase type 7 isoform X4 [KO:K08047] [EC:4.6.1.1]
102975211  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
102995803  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102981091  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102995361  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
102984630  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
102977689  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
102975495  FGR; tyrosine-protein kinase Fgr isoform X1 [KO:K08891] [EC:2.7.10.2]
102983882  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102991486  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
102974315  SHC2; SHC-transforming protein 2 [KO:K17447]
102977456  SHC3; SHC-transforming protein 3 [KO:K17448]
102988652  SHC4; SHC-transforming protein 4 isoform X2 [KO:K17449]
114483947  growth factor receptor-bound protein 2 [KO:K04364]
102991639  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102981677  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
102978925  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
102994715  HRAS; GTPase HRas isoform X2 [KO:K02833]
102977125  KRAS; GTPase KRas isoform X1 [KO:K07827]
102992439  LOW QUALITY PROTEIN: GTPase NRas-like [KO:K07828]
102982641  NRAS; LOW QUALITY PROTEIN: GTPase NRas [KO:K07828]
102987866  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
102986916  BRAF; serine/threonine-protein kinase B-raf isoform X3 [KO:K04365] [EC:2.7.11.1]
102992191  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102984305  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102989074  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102986098  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102978952  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102977108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102975555  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102991779  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102991192  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102983371  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
102976409  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
102979209  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
102988631  PRKCZ; protein kinase C zeta type isoform X2 [KO:K18952] [EC:2.7.11.13]
102981524  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102976971  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
102990087  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102980970  FOXO3; forkhead box protein O3 isoform X2 [KO:K09408]
102977668  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2 [KO:K04467] [EC:2.7.11.10]
102976706  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
114485485  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
102980964  IKBKG; NF-kappa-B essential modulator [KO:K07210]
102973672  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102995931  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
102981135  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102974198  RELA; transcription factor p65 isoform X1 [KO:K04735]
102974655  BAD; bcl2-associated agonist of cell death [KO:K02158]
102991994  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
102978702  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102994407  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
102976346  VAV1; proto-oncogene vav [KO:K05730]
102973743  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
102988564  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
102979195  rho-related BTB domain-containing protein 2 [KO:K04392]
102990276  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
102990552  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102992553  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102992923  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102978005  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
102975958  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102988824  WAS; actin nucleation-promoting factor WAS [KO:K05747]
102983639  RHOA; transforming protein RhoA [KO:K04513]
102987332  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
102994518  ROCK2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
102986172  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102975750  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102982318  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102990164  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
102995518  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
102981323  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2 [KO:K07826]
102975548  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
102976421  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
112063837  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
112062012  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
112064782  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
112067655  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
112067178  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
102985729  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102994418  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
112063854  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102976485  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
112066479  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
112066563  GNGT2; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
102981772  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X3 [KO:K12365]
102994282  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
102994703  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
102982229  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102975066  PXN; paxillin isoform X2 [KO:K05760]
102974736  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X3 [KO:K05726]
102994214  CRK; adapter molecule crk isoform X1 [KO:K04438]
102990100  CRKL; crk-like protein [KO:K04438]
102995810  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
102979158  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
102995357  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
102985636  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
102974165  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102983015  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102992700  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102983230  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
102990537  RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
102985661  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
102980344  RAP1B; ras-related protein Rap-1b [KO:K07836]
102989853  LOW QUALITY PROTEIN: ras-related protein Rap-1b-like [KO:K07836]
102990471  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
102980632  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X2 [KO:K05731]
102974383  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102984279  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
102982542  NCF1; neutrophil cytosol factor 1 isoform X2 [KO:K08011]
102981560  GRK7; LOW QUALITY PROTEIN: rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
102995100  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
102996848  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
114485015  beta-adrenergic receptor kinase 2-like [KO:K00910] [EC:2.7.11.15]
102978788  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
102988242  GRK4; G protein-coupled receptor kinase 4 isoform X2 [KO:K08291] [EC:2.7.11.16]
102988311  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
102979868  G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
102986742  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
102984518  ARRB1; beta-arrestin-1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
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Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
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PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
pcad04010  MAPK signaling pathway
pcad04060  Cytokine-cytokine receptor interaction
pcad04120  Ubiquitin mediated proteolysis
pcad04630  JAK-STAT signaling pathway
pcad04670  Leukocyte transendothelial migration
pcad04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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