KEGG   PATHWAY: pee04020
Entry
pee04020                    Pathway                                
Name
Calcium signaling pathway - Phycodurus eques (leafy seadragon)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
pee04020  Calcium signaling pathway
pee04020

Other DBs
GO: 0019722
Organism
Phycodurus eques (leafy seadragon) [GN:pee]
Gene
133413104  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
133403708  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
133409566  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
133397650  LOW QUALITY PROTEIN: sodium/calcium exchanger 1-like [KO:K05849]
133415724  slc8a2a; sodium/calcium exchanger 2a [KO:K05849]
133415814  slc8a4a; solute carrier family 8 member 4a isoform X1 [KO:K05849]
133405615  slc8a2b; sodium/calcium exchanger 2b isoform X1 [KO:K05849]
133408417  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
133408633  atp2b3b; plasma membrane calcium-transporting ATPase 3b isoform X1 [KO:K05850] [EC:7.2.2.10]
133402856  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
133409170  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
133397461  atp2b1a; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
133417865  chrm3b; muscarinic acetylcholine receptor M1 [KO:K04129]
133410018  chrm3a; muscarinic acetylcholine receptor M3 [KO:K04131]
133417412  chrm5b; muscarinic acetylcholine receptor M5b [KO:K04133]
133412756  chrm5a; muscarinic acetylcholine receptor M5a [KO:K04133]
133400358  adora2aa; adenosine A2a receptor a [KO:K04266]
133413788  adora2ab; adenosine A2a receptor b [KO:K04266]
133415656  adora2b; adenosine receptor A2b isoform X1 [KO:K04267]
133417573  adrb1; beta-1 adrenergic receptor [KO:K04141]
133407565  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
133399742  adrb3a; adrenoceptor beta 3a [KO:K04143]
133407633  D(1) dopamine receptor-like [KO:K04144]
133416152  drd1b; dopamine receptor D1b [KO:K04144]
133395233  D(5)-like dopamine receptor [KO:K05840]
133408630  drd5a; D(1B) dopamine receptor [KO:K05840]
133416386  hrh2b; histamine receptor H2b [KO:K04150]
133407613  htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
133413669  si:dkey-247m21.3; 5-hydroxytryptamine receptor 4 [KO:K04160]
133404162  trace amine-associated receptor 3 [KO:K04160]
133396729  htr5ab; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate b [KO:K04161]
133399490  htr7c; 5-hydroxytryptamine receptor 7 [KO:K04163]
133408810  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
133399614  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
133396369  guanine nucleotide-binding protein G(olf) subunit alpha-like [KO:K04633]
133411382  guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
133406201  adcy1a; LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
133411174  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
133395411  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
133401813  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
133417375  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
133401105  adcy3a; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
133397769  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
133411300  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
133417224  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
133414441  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
133403587  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
133414665  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
133404060  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
133405975  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
133411404  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
133405264  sarcolipin [KO:K22642]
133400354  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
133418197  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like [KO:K05853] [EC:7.2.2.10]
133413352  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
133414881  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
133416508  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
133415919  stim1b; stromal interaction molecule 1b isoform X1 [KO:K16059]
133404755  stromal interaction molecule 1-like isoform X1 [KO:K16059]
133397821  stim2b; stromal interaction molecule 2 isoform X1 [KO:K18196]
133413491  orai1b; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
133399685  calcium release-activated calcium channel protein 1-like [KO:K16056]
133416232  orai2; protein orai-2 [KO:K16057]
133397145  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
133408965  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
133399393  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
133407340  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
133401401  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04853]
133402394  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
133408910  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
133414507  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
133404583  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
133414234  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
133406774  voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
133411137  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
133417578  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
133414436  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04855]
133414365  LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
133403676  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
133407392  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
133395570  chrna11; cholinergic receptor, nicotinic, alpha 11 [KO:K04809]
133402043  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
133403991  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
133416162  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
133413356  grin1a; glutamate receptor ionotropic, NMDA 1a isoform X1 [KO:K05208]
133399616  grin1b; glutamate receptor ionotropic, NMDA 1b isoform X1 [KO:K05208]
133414571  grin2aa; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
133414717  grin2ba; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
133404453  grin2bb; glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b [KO:K05210]
133417764  glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
133414765  grin2ca; glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca [KO:K05211]
133401938  glutamate receptor ionotropic, NMDA 2D [KO:K05212]
133395867  grin2da; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
133414121  grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
133412680  grin3ba; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
133416456  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
133399793  p2rx2; P2X purinoceptor 2 [KO:K05216]
133413057  P2X purinoceptor 3-like [KO:K05217]
133408039  p2rx3a; P2X purinoceptor 3a [KO:K05217]
133416312  p2rx5; P2X purinoceptor 5 [KO:K05219]
133405337  P2X purinoceptor 5-like [KO:K05219]
133400168  LOW QUALITY PROTEIN: P2X purinoceptor 4-like [KO:K05220]
133415578  ryanodine receptor 1-like [KO:K04961]
133405560  ryr1b; ryanodine receptor 1b [KO:K04961]
133417542  ryr2a; ryanodine receptor 2 isoform X1 [KO:K04962]
133410078  ryr2b; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
133417411  ryr3; ryanodine receptor 3 [KO:K04963]
133412675  ryanodine receptor 3-like isoform X1 [KO:K04963]
133411992  casq1a; calsequestrin-1a [KO:K23468]
133397663  casq1b; calsequestrin-1b [KO:K23468]
133410446  calsequestrin-2-like [KO:K23445]
133410693  calsequestrin-2-like [KO:K23445]
133396703  unm_hu7910; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
133408089  cysteinyl leukotriene receptor 1-like [KO:K04322]
133397342  chrm2a; muscarinic acetylcholine receptor M2a [KO:K04130]
133413879  alpha-1A adrenergic receptor-like [KO:K04135]
133399713  adra1aa; LOW QUALITY PROTEIN: adrenoceptor alpha 1Aa [KO:K04135]
133407647  alpha-1A adrenergic receptor-like isoform X1 [KO:K04136]
133416366  alpha-1A adrenergic receptor-like [KO:K04136]
133404160  adra1d; alpha-1A adrenergic receptor [KO:K04137]
133396347  agtr1b; type-1 angiotensin II receptor [KO:K04166]
133403704  ednraa; endothelin receptor type Aa isoform X1 [KO:K04197]
133412038  ednrba; endothelin receptor Ba [KO:K04198]
133407935  endothelin receptor type B-like [KO:K04198]
133410449  endothelin receptor type B-like [KO:K04198]
133413813  proteinase-activated receptor 1-like [KO:K03914]
133399843  f2r; proteinase-activated receptor 1 isoform X1 [KO:K03914]
133413028  grm1b; metabotropic glutamate receptor 1b [KO:K04603]
133416788  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
133404824  grm5b; metabotropic glutamate receptor 5b [KO:K04604]
133416507  grm5a; glutamate receptor, metabotropic 5a [KO:K04604]
133399309  grpr; gastrin-releasing peptide receptor [KO:K04169]
133409023  hrh1; LOW QUALITY PROTEIN: histamine H1 receptor [KO:K04149]
133406213  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
133397818  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
133411036  htr2aa; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
133409395  lhcgr; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
133412814  ntsr1; neurotensin receptor type 1 [KO:K04211]
133408451  oxtra; oxytocin receptor [KO:K04229]
133409072  isotocin receptor-like [KO:K04229]
133403234  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
133412032  ltb4r2b; leukotriene B4 receptor 2b isoform X1 [KO:K04297]
133413119  ptafr; platelet-activating factor receptor isoform X1 [KO:K04279]
133414841  ptger1b; prostaglandin E receptor 1b (subtype EP1) [KO:K04258]
133404231  prostaglandin E2 receptor EP1 subtype-like isoform X1 [KO:K04258]
133406516  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
133406535  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
133412779  bdkrb2; B2 bradykinin receptor [KO:K03916]
133413000  bdkrb1; B1 bradykinin receptor isoform X1 [KO:K03916]
133399478  tacr1a; tachykinin receptor 1a [KO:K04222]
133396666  tacr2; substance-K receptor isoform X1 [KO:K04223]
133404051  neuromedin-K receptor-like [KO:K04224]
133404096  tacr3a; tachykinin receptor 3a [KO:K04224]
133406781  tbxa2r; thromboxane A2 receptor [KO:K04264]
133400937  thyrotropin-releasing hormone receptor [KO:K04282]
133401916  thyrotropin-releasing hormone receptor-like [KO:K04282]
133395636  trhrb; thyrotropin-releasing hormone receptor b [KO:K04282]
133411719  neuromedin-U receptor 1-like [KO:K04282]
133402994  trhr2; thyrotropin releasing hormone receptor 2 isoform X1 [KO:K04282]
133406032  cckbra; cholecystokinin receptor-like [KO:K04194]
133397877  cholecystokinin receptor type A-like [KO:K04194]
133410554  cckbrb; cholecystokinin receptor [KO:K04194]
133410506  C-X-C chemokine receptor type 4-like [KO:K04189]
133411479  C-X-C chemokine receptor type 4-like [KO:K04189]
133400075  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
133413293  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
133406857  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04635]
133413257  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04635]
133400647  guanine nucleotide-binding protein subunit alpha-14-like isoform X1 [KO:K04636]
133405968  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
133407368  egf; pro-epidermal growth factor [KO:K04357]
133408919  tgfa; protransforming growth factor alpha [KO:K08774]
133415223  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
133404330  platelet-derived growth factor subunit A-like [KO:K04359]
133404446  pdgfba; platelet-derived growth factor beta polypeptide a [KO:K17386]
133407885  pdgfc; platelet-derived growth factor C [KO:K05450]
133404990  pdgfd; platelet-derived growth factor D [KO:K05450]
133407634  fgf1a; putative fibroblast growth factor 1 isoform X1 [KO:K18496]
133415954  fibroblast growth factor 1-like [KO:K18496]
133408191  fgf2; fibroblast growth factor 2 [KO:K18497]
133400272  fgf5; fibroblast growth factor 5 [KO:K04358]
133406425  fgf22; fibroblast growth factor 22 [KO:K04358]
133400607  fibroblast growth factor 10-like [KO:K04358]
133407540  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
133407566  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
133407813  fgf16; fibroblast growth factor 16 [KO:K04358]
133408092  fibroblast growth factor 20-like [KO:K04358]
133402501  fgf6a; fibroblast growth factor 6a [KO:K04358]
133413830  fgf10a; fibroblast growth factor 10a [KO:K04358]
133396922  fibroblast growth factor 6-like [KO:K04358]
133409765  fgf8a; fibroblast growth factor 8 [KO:K04358]
133404302  fgf20a; fibroblast growth factor 20a [KO:K04358]
133404536  fgf8b; fibroblast growth factor 8b [KO:K04358]
133399351  fgf7; LOW QUALITY PROTEIN: fibroblast growth factor 7 [KO:K04358]
133399222  fgf19; fibroblast growth factor 19 [KO:K22603]
133418131  fgf21; fibroblast growth factor 21 [KO:K22429]
133397488  fgf23; fibroblast growth factor 23 [KO:K22428]
133401100  vegfaa; vascular endothelial growth factor A-A [KO:K05448]
133407348  vegfba; vascular endothelial growth factor A [KO:K05448]
133416936  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
133399149  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
133399308  vegfd; vascular endothelial growth factor D [KO:K05449]
133409141  ngfb; nerve growth factor [KO:K02582]
133398716  ngfa; neurotrophin-7 [KO:K02582]
133403145  hgfb; hepatocyte growth factor isoform X1 [KO:K05460]
133397395  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
133408782  mst1; hepatocyte growth factor-like protein [KO:K23441]
133414184  gdnfa; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
133399863  glial cell line-derived neurotrophic factor-like [KO:K05452]
133396747  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
133411354  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
133417636  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
133402191  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
133408295  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
133410327  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
133405123  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
133406249  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
133407552  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
133415885  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
133400419  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
133413432  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
133410174  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
133412419  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
133415690  fgfr4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
133407770  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
133396297  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
133407933  flt4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
133406030  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
133401853  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
133413559  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
133399870  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
133402598  NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
133398119  ntrk3b; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
133403286  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
133408740  mst1ra; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
133409140  mst1rb; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
133409412  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
133417772  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like [KO:K05857] [EC:3.1.4.11]
133396564  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a [KO:K05857] [EC:3.1.4.11]
133414806  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A isoform X1 [KO:K05857] [EC:3.1.4.11]
133410991  plcd4a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
133411214  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like [KO:K05857] [EC:3.1.4.11]
133412553  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
133409831  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
133397600  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
133416892  plcb1l; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
133416950  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
133413447  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
133402913  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
133417918  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
133402467  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1-like [KO:K05861] [EC:3.1.4.11]
133408302  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
133409234  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
133403056  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
133411488  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
133396678  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
133399801  tpcn1; two pore channel protein 1 isoform X1 [KO:K16896]
133399227  tpcn2; two pore channel protein 2 isoform X1 [KO:K14077]
133414756  mucolipin-1-like isoform X1 [KO:K04992]
133403604  mucolipin-1-like [KO:K04992]
133406469  mcoln2; mucolipin-2 isoform X1 [KO:K04993]
133406151  mcoln3b; mucolipin-3 [KO:K04994]
133411509  mcoln3a; mucolipin-3 isoform X1 [KO:K04994]
133401494  sphk2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
133414499  sphingosine kinase 1-like isoform X1 [KO:K04718] [EC:2.7.1.91]
133404333  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
133410133  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
133416250  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
133417608  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
133409845  voltage-dependent anion-selective channel protein 2 [KO:K15040]
133399975  vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
133413486  zgc:56235; voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
133408115  slc25a5; ADP/ATP translocase 2 [KO:K05863]
133403980  slc25a4; ADP/ATP translocase 1 [KO:K05863]
133415605  si:dkey-251i10.1; ADP/ATP translocase 3 [KO:K05863]
133417596  ppifb; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
133410189  ppifa; peptidylprolyl isomerase Fa isoform X1 [KO:K09565] [EC:5.2.1.8]
133414378  LOW QUALITY PROTEIN: troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
133416164  tnnc1a; troponin C type 1a (slow) [KO:K05865]
133399272  troponin C, skeletal muscle-like [KO:K12042]
133399277  troponin C, skeletal muscle [KO:K12042]
133417437  calm1b; calmodulin-1b [KO:K02183]
133413241  calmodulin isoform X1 [KO:K02183]
133409720  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
133404714  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
133416190  calml4a; calmodulin-like protein 4a [KO:K02183]
133417600  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
133404930  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like [KO:K00871] [EC:2.7.11.19]
133397816  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
133398572  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
133399318  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
133406186  mylk4b; LOW QUALITY PROTEIN: myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
133417751  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
133415023  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
133410432  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
133411176  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
133411675  calcium/calmodulin-dependent protein kinase type 1D-like isoform X1 [KO:K08794] [EC:2.7.11.17]
133408314  calcium/calmodulin-dependent protein kinase type 1D-like isoform X1 [KO:K08794] [EC:2.7.11.17]
133408658  camk1b; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
133409069  camk1a; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
133397308  camk1da; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
133400165  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
133417907  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
133413439  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
133403800  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
133410203  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
133416464  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
133406865  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K05869] [EC:2.7.11.17]
133400332  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
133407807  protein phosphatase 3 catalytic subunit alpha-like isoform X1 [KO:K04348] [EC:3.1.3.16]
133413450  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
133415821  protein phosphatase 3 catalytic subunit alpha-like isoform X1 [KO:K04348] [EC:3.1.3.16]
133398066  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
133403799  ppp3r1b; calcineurin subunit B type 1b isoform X1 [KO:K06268]
133409619  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
133409065  tfeb; transcription factor EB isoform X1 [KO:K15590]
133395438  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
133401997  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
133413115  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
133409042  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
133397202  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
133412114  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
133399636  nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
133408593  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like isoform X1 [KO:K13755] [EC:3.1.4.17]
133410496  pde1a; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
133411455  pde1cb; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
133411001  protein-tyrosine kinase 2-beta-like isoform X1 [KO:K05871] [EC:2.7.10.2]
133417259  ptk2bb; protein tyrosine kinase 2 beta, b [KO:K05871] [EC:2.7.10.2]
133417428  itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
133413172  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
133405563  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
133414406  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
133404595  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
133414687  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
133403675  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
133401470  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
pee04010  MAPK signaling pathway
pee04070  Phosphatidylinositol signaling system
pee04210  Apoptosis
KO pathway
ko04020   
LinkDB

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