KEGG   PATHWAY: pki04020
Entry
pki04020                    Pathway                                
Name
Calcium signaling pathway - Paramormyrops kingsleyae
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
pki04020  Calcium signaling pathway
pki04020

Other DBs
GO: 0019722
Organism
Paramormyrops kingsleyae [GN:pki]
Gene
111835102  sodium/calcium exchanger 1-like [KO:K05849]
111839525  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
111833395  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
111835697  slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
111844092  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
111856225  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
111853804  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
111837534  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
111842312  plasma membrane calcium-transporting ATPase 3-like isoform X1 [KO:K05850] [EC:7.2.2.10]
111838113  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
111840344  plasma membrane calcium-transporting ATPase 2-like isoform X1 [KO:K05850] [EC:7.2.2.10]
111835444  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
111857002  atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
111839509  muscarinic acetylcholine receptor M1-like isoform X1 [KO:K04129]
111859856  muscarinic acetylcholine receptor M1-like [KO:K04129]
111859619  muscarinic acetylcholine receptor M3-like [KO:K04131]
111853675  chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
111838822  chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
111842040  adenosine receptor A2a-like isoform X1 [KO:K04266]
111855108  adenosine receptor A2a-like [KO:K04266]
111855112  adenosine receptor A2a-like [KO:K04266]
111854790  adora2b; adenosine receptor A2b isoform X1 [KO:K04267]
111836057  adrb1; beta-1 adrenergic receptor [KO:K04141]
111848908  adrb2; beta-2 adrenergic receptor [KO:K04142]
111850095  beta-2 adrenergic receptor-like [KO:K04142]
111838809  beta-3 adrenergic receptor-like [KO:K04143]
111857312  adrb3; beta-3 adrenergic receptor [KO:K04143]
111857458  D(1) dopamine receptor-like [KO:K04144]
111859588  D(1) dopamine receptor-like [KO:K04144]
111837733  drd5; D(1B) dopamine receptor [KO:K05840]
111859577  D(5)-like dopamine receptor [KO:K05840]
111834671  histamine H2 receptor-like [KO:K04150]
111859894  histamine H2 receptor-like [KO:K04150]
111842057  5-hydroxytryptamine receptor 4-like isoform X1 [KO:K04160]
111834968  5-hydroxytryptamine receptor 4-like isoform X1 [KO:K04160]
111850426  5-hydroxytryptamine receptor 4-like [KO:K04160]
111840236  5-hydroxytryptamine receptor 5A-like [KO:K04161]
111858568  5-hydroxytryptamine receptor 5A-like [KO:K04161]
111853896  htr6; 5-hydroxytryptamine receptor 6 isoform X1 [KO:K04162]
111849856  5-hydroxytryptamine receptor 7-like [KO:K04163]
111857489  5-hydroxytryptamine receptor 7-like [KO:K04163]
111853740  htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
111844707  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
111835288  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
111840799  guanine nucleotide-binding protein G(olf) subunit alpha-like isoform X1 [KO:K04633]
111851408  gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
111845834  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
111850159  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
111844387  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
111852779  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
111851542  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
111856451  adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
111848207  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
111832687  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
111845896  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
111860576  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
111843208  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
111840961  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
111847642  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111849218  prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
111860532  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
111836118  pln; cardiac phospholamban [KO:K05852]
111833773  sln; sarcolipin [KO:K22642]
111842228  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
111855121  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
111861055  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
111854734  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
111833752  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
111840495  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like isoform X1 [KO:K05853] [EC:7.2.2.10]
111852167  stim1; stromal interaction molecule 1 isoform X1 [KO:K16059]
111857723  stromal interaction molecule 1-like isoform X1 [KO:K16059]
111835633  stim2; stromal interaction molecule 2 isoform X1 [KO:K18196]
111839328  orai1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
111842172  calcium release-activated calcium channel protein 1-like [KO:K16056]
111847880  protein orai-2-like isoform X1 [KO:K16057]
111843125  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
111852542  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
111833375  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
111857113  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04853]
111847817  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
111858929  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
111834368  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
111845281  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
111843226  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
111853984  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
111833410  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
111844635  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
111847625  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
111856689  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
111845539  cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
111859731  voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04856]
111843189  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
111847328  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
111844189  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
111836040  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
111845602  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
111840889  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
111858193  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
111853980  glutamate receptor ionotropic, NMDA 1-like isoform X1 [KO:K05208]
111833407  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
111845544  glutamate receptor ionotropic, NMDA 2A-like isoform X1 [KO:K05209]
111849101  grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
111853219  glutamate receptor ionotropic, NMDA 2B-like isoform X1 [KO:K05210]
111837626  glutamate receptor ionotropic, NMDA 2B-like isoform X1 [KO:K05210]
111847897  grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
111856733  glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
111853320  glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
111837764  glutamate receptor ionotropic, NMDA 2D-like isoform X1 [KO:K05212]
111842112  glutamate receptor ionotropic, NMDA 3A-like [KO:K05213]
111860233  grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
111854696  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
111854914  p2rx2; P2X purinoceptor 2 [KO:K05216]
111834179  P2X purinoceptor 3-like [KO:K05217]
111861068  P2X purinoceptor 3-like isoform X1 [KO:K05217]
111842061  p2rx4; P2X purinoceptor 4 isoform X1 [KO:K05218]
111854771  P2X purinoceptor 5-like isoform X1 [KO:K05219]
111859702  P2X purinoceptor 5-like [KO:K05219]
111858758  p2rx7; P2X purinoceptor 7 [KO:K05220]
111841417  ryr1; ryanodine receptor 1 isoform X1 [KO:K04961]
111838045  ryanodine receptor 1-like [KO:K04961]
111853670  ryr2; ryanodine receptor 2 isoform X1 [KO:K04962]
111838853  ryr3; ryanodine receptor 3 [KO:K04963]
111836096  trdn; triadin isoform X1 [KO:K23449]
111854550  calsequestrin-1-like [KO:K23468]
111858084  calsequestrin-1-like isoform X1 [KO:K23468]
111852684  calsequestrin-2-like [KO:K23445]
111841074  calsequestrin-2-like isoform X1 [KO:K23445]
111847235  asph; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
111846309  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
111836327  cysteinyl leukotriene receptor 2-like [KO:K04322]
111858051  cysteinyl leukotriene receptor 2-like [KO:K04323]
111843396  muscarinic acetylcholine receptor M2-like [KO:K04130]
111846991  muscarinic acetylcholine receptor M2-like [KO:K04130]
111836953  alpha-1A adrenergic receptor-like [KO:K04135]
111839412  alpha-1A adrenergic receptor-like [KO:K04135]
111850207  alpha-1A adrenergic receptor-like [KO:K04136]
111855193  adra1b; alpha-1B adrenergic receptor [KO:K04136]
111837244  adra1d; alpha-1D adrenergic receptor isoform X1 [KO:K04137]
111850479  agtr1; type-1 angiotensin II receptor [KO:K04166]
111837314  ednra; endothelin-1 receptor isoform X1 [KO:K04197]
111832936  endothelin receptor type B-like [KO:K04197]
111846353  endothelin receptor type B-like [KO:K04198]
111855597  endothelin receptor type B-like [KO:K04198]
111836076  proteinase-activated receptor 1-like [KO:K03914]
111849769  f2r; proteinase-activated receptor 1 [KO:K03914]
111857957  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
111833937  grm5; metabotropic glutamate receptor 5 [KO:K04604]
111850255  gastrin-releasing peptide receptor-like [KO:K04169]
111838255  grpr; gastrin-releasing peptide receptor [KO:K04169]
111837497  hrh1; histamine H1 receptor [KO:K04149]
111836544  5-hydroxytryptamine receptor 2B-like isoform X1 [KO:K04157]
111836399  5-hydroxytryptamine receptor 2A-like [KO:K04157]
111848166  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
111856908  5-hydroxytryptamine receptor 2C-like [KO:K04157]
111854111  htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
111848818  lutropin-choriogonadotropic hormone receptor-like isoform X1 [KO:K04248]
111849532  lutropin-choriogonadotropic hormone receptor-like isoform X1 [KO:K04248]
111839874  neurotensin receptor type 1-like [KO:K04211]
111848381  neurotensin receptor type 1-like [KO:K04211]
111858946  ntsr1; neurotensin receptor type 1 [KO:K04211]
111840533  oxtr; oxytocin receptor [KO:K04229]
111833322  avpr1a; vasopressin V1a receptor isoform X1 [KO:K04226]
111854725  ptafr; platelet-activating factor receptor isoform X1 [KO:K04279]
111833463  ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
111856343  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
111858575  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
111846020  ptgfr; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
111841778  B2 bradykinin receptor-like [KO:K03916]
111834507  B2 bradykinin receptor-like [KO:K03916]
111851472  substance-P receptor-like [KO:K04222]
111848612  substance-P receptor-like isoform X1 [KO:K04222]
111837257  tacr3; neuromedin-K receptor [KO:K04224]
111859275  neuromedin-K receptor-like [KO:K04224]
111858793  thromboxane A2 receptor-like [KO:K04264]
111858804  thromboxane A2 receptor-like isoform X1 [KO:K04264]
111860398  tbxa2r; thromboxane A2 receptor [KO:K04264]
111843778  thyrotropin-releasing hormone receptor-like isoform X1 [KO:K04282]
111839675  thyrotropin-releasing hormone receptor-like [KO:K04282]
111851894  thyrotropin-releasing hormone receptor-like isoform X1 [KO:K04282]
111855760  thyrotropin-releasing hormone receptor-like [KO:K04282]
111843689  cholecystokinin receptor-like isoform X1 [KO:K04194]
111835635  cholecystokinin receptor type A-like [KO:K04194]
111849246  C-X-C chemokine receptor type 4-like [KO:K04189]
111858385  C-X-C chemokine receptor type 4-like [KO:K04189]
111839234  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111836597  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
111860249  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
111839333  guanine nucleotide-binding protein subunit alpha-14-like [KO:K04636]
111851433  guanine nucleotide-binding protein subunit alpha-14-like [KO:K04636]
111860311  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
111836595  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
111849374  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
111848546  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
111843309  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
111860586  platelet-derived growth factor subunit A-like [KO:K04359]
111845270  uncharacterized protein LOC111845270 [KO:K17386]
111846386  platelet-derived growth factor subunit B-like isoform X1 [KO:K17386]
111833654  platelet-derived growth factor C-like isoform X1 [KO:K05450]
111833932  pdgfd; platelet-derived growth factor D [KO:K05450]
111837344  platelet-derived growth factor C-like isoform X1 [KO:K05450]
111833360  putative fibroblast growth factor 1 [KO:K18496]
111832812  fibroblast growth factor 2-like [KO:K18497]
111835519  fgf2; fibroblast growth factor 2 [KO:K18497]
111836472  fibroblast growth factor 8-like [KO:K04358]
111841195  fibroblast growth factor 4B-like isoform X1 [KO:K04358]
111841200  fibroblast growth factor 3-like isoform X1 [KO:K04358]
111844970  fibroblast growth factor 7-like [KO:K04358]
111834059  fibroblast growth factor 4A-like [KO:K04358]
111842069  fgf10; fibroblast growth factor 10 [KO:K04358]
111851847  fgf3; fibroblast growth factor 3 [KO:K04358]
111851956  fibroblast growth factor 4B-like [KO:K04358]
111845370  fibroblast growth factor 20-like [KO:K04358]
111845778  fibroblast growth factor 18-like [KO:K04358]
111846686  fibroblast growth factor 7-like [KO:K04358]
111853601  fgf20; fibroblast growth factor 20 [KO:K04358]
111846342  fgf16; fibroblast growth factor 16 isoform X1 [KO:K04358]
111851225  fibroblast growth factor 6-like [KO:K04358]
111834660  fibroblast growth factor 18-like isoform X1 [KO:K04358]
111848574  fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
111836682  fibroblast growth factor 22-like [KO:K04358]
111857297  fgf6; fibroblast growth factor 6 [KO:K04358]
111858411  fibroblast growth factor 8 [KO:K04358]
111860524  fgf22; fibroblast growth factor 22 [KO:K04358]
111857500  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
111859862  fibroblast growth factor 18-like [KO:K04358]
111859334  fibroblast growth factor 18-like isoform X1 [KO:K04358]
111851964  fgf19; fibroblast growth factor 19 [KO:K22603]
111841255  fibroblast growth factor 19-like isoform X1 [KO:K22603]
111836837  fibroblast growth factor 21-like [KO:K22429]
111858263  fibroblast growth factor 21-like isoform X1 [KO:K22429]
111857581  fgf23; fibroblast growth factor 23 [KO:K22428]
111851553  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
111844528  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
111845763  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
111838191  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
111850116  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
111855173  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
111856976  nerve growth factor-like [KO:K02582]
111855250  neurotrophin-7-like isoform X1 [KO:K02582]
111846155  hgf; hepatocyte growth factor [KO:K05460]
111833314  hepatocyte growth factor-like isoform X1 [KO:K05460]
111848783  mst1; hepatocyte growth factor-like protein [KO:K23441]
111842191  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
111856500  glial cell line-derived neurotrophic factor-like isoform X1 [KO:K05452]
111845900  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
111841598  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
111854099  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
111837750  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
111854164  erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
111852228  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
111851594  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
111850064  platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
111855164  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111857512  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
111843816  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
111839944  fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
111844207  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
111847950  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
111860895  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
111835053  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
111837761  vascular endothelial growth factor receptor 1-like isoform X1 [KO:K05096] [EC:2.7.10.1]
111838006  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
111857710  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
111850117  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
111838441  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
111853509  high affinity nerve growth factor receptor-like isoform X1 [KO:K03176] [EC:2.7.10.1]
111851431  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
111839208  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
111845116  NT-3 growth factor receptor-like isoform X1 [KO:K05101] [EC:2.7.10.1]
111845753  NT-3 growth factor receptor-like isoform X1 [KO:K05101] [EC:2.7.10.1]
111842454  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111836018  hepatocyte growth factor receptor-like isoform X1 [KO:K05099] [EC:2.7.10.1]
111840572  macrophage-stimulating protein receptor-like isoform X1 [KO:K05100] [EC:2.7.10.1]
111839870  mst1r; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
111848989  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
111847682  uncharacterized protein LOC111847682 [KO:K10784]
111837245  immunoglobulin alpha-2 heavy chain-like [KO:K06856]
111842377  immunoglobulin gamma-1 heavy chain-like [KO:K06856]
111842004  immunoglobulin gamma-1 heavy chain-like [KO:K06856]
111837813  plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
111845412  plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
111840031  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like isoform X1 [KO:K05857] [EC:3.1.4.11]
111849737  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like isoform X1 [KO:K05857] [EC:3.1.4.11]
111855980  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like isoform X1 [KO:K05857] [EC:3.1.4.11]
111834703  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
111837852  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
111838879  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
111837866  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
111857883  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
111835929  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like isoform X1 [KO:K01116] [EC:3.1.4.11]
111837772  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like isoform X1 [KO:K01116] [EC:3.1.4.11]
111837114  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
111851875  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
111859557  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
111839848  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
111840603  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111845672  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
111844730  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
111850018  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
111850115  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
111847466  tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
111851957  two pore calcium channel protein 2-like isoform X1 [KO:K14077]
111848057  tpcn2; two pore calcium channel protein 2 [KO:K14077]
111833579  mucolipin-1-like isoform X1 [KO:K04992]
111856354  mucolipin-1-like isoform X1 [KO:K04992]
111847627  mcoln2; mucolipin-2 isoform X1 [KO:K04993]
111847519  mucolipin-3-like isoform X1 [KO:K04994]
111860457  mcoln3; mucolipin-3 [KO:K04994]
111853337  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
111848492  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
111849606  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
111847941  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
111839550  voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
111839289  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
111837041  voltage-dependent anion-selective channel protein 2 [KO:K15040]
111842143  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
111854366  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
111837930  ADP/ATP translocase 1 [KO:K05863]
111838180  ADP/ATP translocase 3-like isoform X1 [KO:K05863]
111853629  slc25a4; ADP/ATP translocase 1 [KO:K05863]
111835009  ADP/ATP translocase 3 [KO:K05863]
111841911  ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
111861170  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase-like [KO:K09565] [EC:5.2.1.8]
111857563  peptidyl-prolyl cis-trans isomerase [KO:K09565] [EC:5.2.1.8]
111842269  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
111837476  troponin C, slow skeletal and cardiac muscles [KO:K05865]
111855508  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
111839854  troponin C, skeletal muscle [KO:K12042]
111839855  troponin C, skeletal muscle-like [KO:K12042]
111851888  troponin C, skeletal muscle-like [KO:K12042]
111836038  calml4; calmodulin-like protein 4 [KO:K02183]
111839522  calmodulin [KO:K02183]
111852631  calm1; calmodulin-1 [KO:K02183]
111844882  calm3; calmodulin-3 [KO:K02183]
111839995  calmodulin [KO:K02183]
111848450  calmodulin-A isoform X1 [KO:K02183]
111841764  calmodulin [KO:K02183]
111858903  calml6; calmodulin-like protein 6 [KO:K02183]
111847182  phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
111836388  phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
111838251  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
111847085  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
111839803  mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
111858342  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
111847736  mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
111850056  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
111856005  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
111854340  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
111842518  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
111833094  camk1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
111840525  calcium/calmodulin-dependent protein kinase type 1-like isoform X1 [KO:K08794] [EC:2.7.11.17]
111834319  calcium/calmodulin-dependent protein kinase type 1D-like isoform X1 [KO:K08794] [EC:2.7.11.17]
111837182  camk1d; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
111858914  calcium/calmodulin-dependent protein kinase type 1D-like isoform X1 [KO:K08794] [EC:2.7.11.17]
111850968  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
111851449  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
111857505  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
111853011  calcium/calmodulin-dependent protein kinase type II subunit alpha-like [KO:K04515] [EC:2.7.11.17]
111850351  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
111853435  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
111848433  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
111844630  calcium/calmodulin-dependent protein kinase type IV-like isoform X1 [KO:K05869] [EC:2.7.11.17]
111836089  camk4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
111848699  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111849849  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111853026  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111836737  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111857559  ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
111850760  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
111859769  calcineurin subunit B type 1 isoform X1 [KO:K06268]
111854442  tfeb; transcription factor EB [KO:K15590]
111852343  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111845775  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
111835865  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
111855820  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
111832689  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111843522  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
111854528  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
111851114  nitric oxide synthase, brain-like [KO:K13240] [EC:1.14.13.39]
111852748  nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
111856407  nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
111832853  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like isoform X1 [KO:K13755] [EC:3.1.4.17]
111845987  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like isoform X1 [KO:K13755] [EC:3.1.4.17]
111835231  pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
111838643  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
111841315  protein-tyrosine kinase 2-beta-like isoform X1 [KO:K05871] [EC:2.7.10.2]
111857950  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
111834259  inositol-trisphosphate 3-kinase B-like [KO:K00911] [EC:2.7.1.127]
111852372  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
111844861  inositol-trisphosphate 3-kinase A-like [KO:K00911] [EC:2.7.1.127]
111843225  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
111848649  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111845521  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111849289  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111853291  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
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Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
pki04010  MAPK signaling pathway
pki04070  Phosphatidylinositol signaling system
pki04210  Apoptosis
KO pathway
ko04020   
LinkDB

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