KEGG   PATHWAY: plop04151
Entry
plop04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Perognathus longimembris pacificus (Pacific pocket mouse)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
plop04151  PI3K-Akt signaling pathway
plop04151

Other DBs
GO: 0043491
Organism
Perognathus longimembris pacificus (Pacific pocket mouse) [GN:plop]
Gene
125341585  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
125356867  Tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
125364700  Ereg; proepiregulin [KO:K09784]
125364638  Areg; amphiregulin [KO:K09782]
125339912  Fgf1; fibroblast growth factor 1 [KO:K18496]
125341650  Fgf2; fibroblast growth factor 2 [KO:K18497]
125339311  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
125353688  fibroblast growth factor 7-like [KO:K04358]
125367755  Fgf10; fibroblast growth factor 10 [KO:K04358]
125339607  Fgf20; fibroblast growth factor 20 [KO:K04358]
125361340  Fgf4; fibroblast growth factor 4 [KO:K04358]
125348427  Fgf9; fibroblast growth factor 9 [KO:K04358]
125348544  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
125340912  Fgf7; fibroblast growth factor 7 [KO:K04358]
125362639  Fgf3; fibroblast growth factor 3 [KO:K04358]
125341935  Fgf18; fibroblast growth factor 18 [KO:K04358]
125342829  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
125343498  Fgf16; fibroblast growth factor 16 [KO:K04358]
125364746  Fgf5; fibroblast growth factor 5 [KO:K04358]
125362638  Fgf19; fibroblast growth factor 19 [KO:K22603]
125338869  Fgf21; fibroblast growth factor 21 [KO:K22429]
125355459  Ngf; beta-nerve growth factor isoform X1 [KO:K02582]
125361587  Bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
125338868  Ntf4; neurotrophin-4 [KO:K12457]
125359379  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
125361599  Igf2; insulin-like growth factor II isoform X1 [KO:K13769]
125339510  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
125358224  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
125349532  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
125364930  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
125355432  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
125360533  Kitlg; kit ligand isoform X1 [KO:K05461]
125339049  Flt3lg; fms-related tyrosine kinase 3 ligand [KO:K05454]
125352543  Vegfa; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
125361173  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
125363322  Pgf; placenta growth factor isoform X1 [KO:K16859]
125339553  Vegfc; vascular endothelial growth factor C [KO:K05449]
125343391  Vegfd; vascular endothelial growth factor D [KO:K05449]
125346953  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
125360970  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
125339236  Angpt2; angiopoietin-2 isoform X1 [KO:K05466]
125353338  Angpt4; angiopoietin-4 isoform X1 [KO:K05467]
125339978  Efna5; ephrin-A5 isoform X1 [KO:K05462]
125347918  Efna2; ephrin-A2 isoform X1 [KO:K05462]
125358982  Efna3; ephrin-A3 isoform X1 [KO:K05462]
125358984  Efna4; ephrin-A4 [KO:K05462]
125358985  Efna1; ephrin-A1 [KO:K05462]
125367500  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
125347931  Nrtn; neurturin [KO:K25414]
125348565  Pspn; persephin [KO:K25416]
125346757  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
125365164  Erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
125363113  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
125350336  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
125339698  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
125345313  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
125345984  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
125364429  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
125341968  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
125365936  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
125360177  Ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
125340063  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
125348697  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
125368530  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
125364960  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
125339985  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
125340058  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
125364419  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
125348391  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
125348386  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
125344151  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
125342051  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
125364405  Kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
125347055  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
125361448  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
125354623  Epha2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
125344289  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
125365698  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
125356532  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
125363420  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
125362333  Hras; GTPase HRas isoform X1 [KO:K02833]
125342925  Kras; GTPase KRas isoform X1 [KO:K07827]
125355453  Nras; GTPase NRas [KO:K07828]
125358819  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125340362  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125348606  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125340801  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125349325  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125350245  Irs1; insulin receptor substrate 1 [KO:K16172]
125341577  Tlr2; toll-like receptor 2 [KO:K10159]
125347394  Tlr4; toll-like receptor 4 [KO:K10160]
125343037  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
125366701  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
125346974  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
125340339  Cd19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
125346212  Pik3ap1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
125366293  Gh1; somatotropin [KO:K05438]
125352248  Prl; prolactin [KO:K05439]
125347750  Osm; oncostatin-M [KO:K05418]
125341318  Il2; interleukin-2 [KO:K05429]
125360703  Il7; interleukin-7 [KO:K05431]
125355685  interferon alpha-3-like [KO:K05414]
125355696  interferon alpha-3-like [KO:K05414]
125355728  interferon alpha-3-like [KO:K05414]
125355740  interferon alpha-3-like [KO:K05414]
125355751  interferon alpha-3-like [KO:K05414]
125352688  interferon alpha-3-like [KO:K05414]
125352696  interferon alpha-3-like [KO:K05414]
125352709  interferon alpha-3-like [KO:K05414]
125352673  Ifnb1; interferon beta [KO:K05415]
125350710  Epo; erythropoietin [KO:K05437]
125365657  Csf3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
125367503  Ghr; growth hormone receptor [KO:K05080]
125367681  Prlr; prolactin receptor [KO:K05081]
125367623  Osmr; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
125367340  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
125353753  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
125343243  Il2rg; cytokine receptor common subunit gamma [KO:K05070]
125345392  interleukin-3 receptor subunit alpha-like [KO:K04737]
125359167  Il6r; LOW QUALITY PROTEIN: interleukin-6 receptor subunit alpha [KO:K05055]
125341213  Il4r; interleukin-4 receptor subunit alpha [KO:K05071]
125367735  Il7r; interleukin-7 receptor subunit alpha [KO:K05072]
125351500  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
125351502  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
125348745  Epor; erythropoietin receptor [KO:K05079]
125354924  Csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
125355256  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
125339535  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
125348908  Jak3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
125347013  Col1a2; collagen alpha-2(I) chain [KO:K06236]
125365631  Col1a1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
125354877  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
125348106  Col4a1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
125348107  Col4a2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
125350237  Col4a4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
125350238  Col4a3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
125343870  Col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
125344255  Col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
125342346  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
125350154  Col6a3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
125351377  Col6a2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
125351379  Col6a1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
125344999  collagen alpha-1(VI) chain [KO:K06238]
125353783  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
125354978  Col9a2; collagen alpha-2(IX) chain [KO:K08131]
125357626  Col9a1; collagen alpha-1(IX) chain [KO:K08131]
125357277  Lama2; laminin subunit alpha-2 [KO:K05637]
125364133  Lama1; laminin subunit alpha-1 [KO:K05637]
125353773  Lama5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
125363903  Lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
125357195  Lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
125346879  Lamb1; laminin subunit beta-1 isoform X1 [KO:K05636]
125342554  Lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
125359631  Lamb3; laminin subunit beta-3 isoform X1 [KO:K06244]
125346878  Lamb4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
125360004  Lamc1; laminin subunit gamma-1 [KO:K05635]
125359512  Lamc2; laminin subunit gamma-2 [KO:K06246]
125353209  Lamc3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
125365545  Chad; chondroadherin [KO:K06248]
125346913  Reln; reelin [KO:K06249] [EC:3.4.21.-]
125340576  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
125339848  Thbs4; thrombospondin-4 [KO:K04659]
125348933  cartilage oligomeric matrix protein [KO:K04659]
125357497  Thbs2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
125344998  thrombospondin-2 [KO:K04659]
125359140  Thbs3; thrombospondin-3 [KO:K04659]
125350332  Fn1; fibronectin isoform X1 [KO:K05717]
125364494  Spp1; osteopontin [KO:K06250]
125365546  Vtn; vitronectin [KO:K06251]
125347252  Tnc; tenascin isoform X1 [KO:K06252]
125359257  Tnr; tenascin-R isoform X1 [KO:K06252]
125352745  Tnxb; tenascin-X [KO:K06252]
125360095  Tnn; tenascin-N isoform X1 [KO:K06252]
125364844  bone sialoprotein 2 [KO:K06253]
125367498  Itga1; integrin alpha-1 [KO:K06480]
125367487  Itga2; integrin alpha-2 [KO:K06481]
125365988  Itga2b; integrin alpha-IIb isoform X1 [KO:K06476]
125365969  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
125350497  Itga4; integrin alpha-4 [KO:K06483]
125363601  Itga5; integrin alpha-5 [KO:K06484]
125350555  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
125363375  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
125366767  Itga8; integrin alpha-8 [KO:K06584]
125342437  Itga9; integrin alpha-9 [KO:K06585]
125355511  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
125338720  Itga11; integrin alpha-11 [KO:K06587]
125350485  Itgav; integrin alpha-V [KO:K06487]
125366727  Itgb1; integrin beta-1 [KO:K05719]
125366291  Itgb3; integrin beta-3 [KO:K06493]
125365686  Itgb4; integrin beta-4 isoform X1 [KO:K06525]
125351789  Itgb5; integrin beta-5 [KO:K06588]
125350628  Itgb6; integrin beta-6 [KO:K06589]
125364132  Itgb7; integrin beta-7 isoform X1 [KO:K06590]
125346836  Itgb8; integrin beta-8 isoform X1 [KO:K06591]
125360764  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
125354550  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125342393  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
125351954  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125367817  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125355095  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
125348916  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
125367653  F2r; proteinase-activated receptor 1 [KO:K03914]
125361709  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
125345881  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
125346394  Lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
125347962  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
125355349  Lpar3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
125343970  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
125348279  Lpar6; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 6 [KO:K04273]
125354342  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like [KO:K04536]
125354476  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
125367713  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
125351951  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
125340508  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
125362976  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
125362753  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
125367180  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
125355344  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
125348661  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
125338821  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
125346482  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
125366881  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
125347860  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
125364853  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
125365699  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
125347011  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
125355284  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
125340963  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
125345835  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
125365469  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
125346892  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
125365865  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
125365866  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
125341041  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
125348513  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
125367450  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
125355214  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
125346440  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
125350743  Tsc1; hamartin isoform X1 [KO:K07206]
125340703  Tsc2; tuberin isoform X1 [KO:K07207]
125347331  Rheb; GTP-binding protein Rheb [KO:K07208]
125340827  Mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
125354571  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
125366164  Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
125339287  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
125367676  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
125356602  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
125339567  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
125354756  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-like [KO:K03259]
125341419  Eif4e; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
125341772  Eif4e1b; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
125350194  Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
125345110  eukaryotic translation initiation factor 4E type 1B-like [KO:K03259]
125361319  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
125366566  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
125364165  Eif4b; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
125359349  Rps6; 40S ribosomal protein S6 [KO:K02991]
125366443  Prkca; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125348804  Pkn1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
125355372  Pkn2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
125349985  Pkn3; LOW QUALITY PROTEIN: serine/threonine-protein kinase N3 [KO:K23692] [EC:2.7.11.13]
125357304  Sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
125353796  Sgk2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
125360985  Sgk3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
125338979  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125363440  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
125363452  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125359645  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125358725  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
125346944  Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
125343908  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125339471  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
125342175  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
125339058  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
125349569  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
125339250  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
125340030  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
125364547  Ppp2r2c; LOW QUALITY PROTEIN: protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
125345937  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
125363344  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
125342663  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
125361732  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
125363404  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
125363454  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
125359169  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
125352573  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
125363295  Hsp90aa1; LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha [KO:K04079]
125352537  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
125359316  Hsp90b1; endoplasmin [KO:K09487]
125348758  Cdc37; hsp90 co-chaperone Cdc37 [KO:K09554]
125359104  Crtc2; CREB-regulated transcription coactivator 2 [KO:K16333]
125364141  Phlpp1; LOW QUALITY PROTEIN: PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
125358212  Phlpp2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
125343765  Mtcp1; protein p13 MTCP-1 [KO:K16837]
125347314  Nos3; LOW QUALITY PROTEIN: nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
125366407  Brca1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
125351736  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125338850  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
125342859  Gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
125353913  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
125363475  Pck2; LOW QUALITY PROTEIN: phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
125349988  G6pc2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
125366384  G6pc1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
125366385  G6pc3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
125360808  Myc; myc proto-oncogene protein [KO:K04377]
125362637  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
125352645  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
125342836  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
125363256  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
125362060  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
125347003  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
125352590  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
125338744  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
125360962  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
125357071  Foxo3; forkhead box protein O3 [KO:K09408]
125358458  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
125360260  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125356068  Bcl2l11; bcl-2-like protein 11 isoform X1 [KO:K16341]
125360428  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
125353817  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
125356548  14-3-3 protein beta/alpha-like [KO:K16197]
125356744  Ywhaq; 14-3-3 protein theta [KO:K16197]
125367231  14-3-3 protein epsilon-like [KO:K06630]
125365431  Ywhae; 14-3-3 protein epsilon [KO:K06630]
125344870  14-3-3 protein epsilon-like [KO:K06630]
125345592  14-3-3 protein epsilon-like [KO:K06630]
125345599  14-3-3 protein epsilon-like [KO:K06630]
125366748  14-3-3 protein epsilon-like [KO:K06630]
125368078  Ywhag; 14-3-3 protein gamma [KO:K16198]
125349313  Ywhah; 14-3-3 protein eta [KO:K16198]
125362685  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
125353354  Bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
125363906  Bcl2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
125354603  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
125350355  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
125350538  Atf2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
125358158  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
125347188  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
125339860  Creb3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
125362185  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
125348600  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
125359105  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
125346776  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
125352747  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
125359248  Mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
125350952  Rxra; LOW QUALITY PROTEIN: retinoic acid receptor RXR-alpha [KO:K08524]
125364508  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
125343265  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
125346167  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
125339226  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
125361933  Rela; transcription factor p65 isoform X1 [KO:K04735]
125341680  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125357309  Myb; transcriptional activator Myb isoform X1 [KO:K09420]
125361439  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
125365886  Tp53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
plop00010  Glycolysis / Gluconeogenesis
plop04010  MAPK signaling pathway
plop04012  ErbB signaling pathway
plop04062  Chemokine signaling pathway
plop04064  NF-kappa B signaling pathway
plop04068  FoxO signaling pathway
plop04110  Cell cycle
plop04115  p53 signaling pathway
plop04150  mTOR signaling pathway
plop04210  Apoptosis
plop04370  VEGF signaling pathway
plop04510  Focal adhesion
plop04620  Toll-like receptor signaling pathway
plop04630  JAK-STAT signaling pathway
plop04662  B cell receptor signaling pathway
plop04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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