KEGG   PATHWAY: pmaj04810
Entry
pmaj04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Parus major (Great Tit)
Class
Cellular Processes; Cell motility
Pathway map
pmaj04810  Regulation of actin cytoskeleton
pmaj04810

Other DBs
GO: 0030036
Organism
Parus major (Great Tit) [GN:pmaj]
Gene
107198333  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
107212973  lysophosphatidic acid receptor 1-like [KO:K04289]
107199132  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
107203848  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
107212790  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
107207018  CXCL12; stromal cell-derived factor 1 [KO:K10031]
107207830  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
107205921  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
107215843  F2R; proteinase-activated receptor 1 [KO:K03914]
107205419  INS; insulin [KO:K04526]
107203603  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
107210662  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
107202986  FGF2; fibroblast growth factor 2 [KO:K18497]
107205474  FGF4; fibroblast growth factor 4 [KO:K04358]
107207567  FGF9; fibroblast growth factor 9 [KO:K04358]
107206622  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
107204934  FGF6; fibroblast growth factor 6 [KO:K04358]
107209251  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
107215713  FGF10; fibroblast growth factor 10 [KO:K04358]
107203620  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
107198543  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
107202807  FGF20; LOW QUALITY PROTEIN: fibroblast growth factor 20 [KO:K04358]
107205342  FGF3; fibroblast growth factor 3 [KO:K04358]
107215372  FGF22; fibroblast growth factor 22 [KO:K04358]
107203899  FGF16; fibroblast growth factor 16 [KO:K04358]
107213981  FGF17; fibroblast growth factor 17 [KO:K04358]
107205427  FGF19; fibroblast growth factor 19 [KO:K22603]
107204156  FGF23; fibroblast growth factor 23 [KO:K22428]
107211209  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
107205105  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
107209392  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
107203600  PDGFC; platelet-derived growth factor C [KO:K05450]
107214586  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
107200328  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107213845  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
107206911  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
107203422  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
107210899  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
107203533  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
107210844  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
107207628  FN1; fibronectin isoform X6 [KO:K05717]
107216171  ITGA1; integrin alpha-1 [KO:K06480]
107216191  ITGA2; integrin alpha-2 isoform X2 [KO:K06481]
107215044  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
107198661  ITGA3; integrin alpha-3 [KO:K06482]
107207539  ITGA4; integrin alpha-4 [KO:K06483]
107207401  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
107200937  ITGA8; integrin alpha-8 [KO:K06584]
107200799  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
107214606  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
107209138  ITGA11; integrin alpha-11 [KO:K06587]
107207631  ITGAV; integrin alpha-V [KO:K06487]
107200467  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
107207766  ITGB2; integrin beta-2 [KO:K06464]
107215302  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
107212403  ITGB4; integrin beta-4 isoform X2 [KO:K06525]
107207337  ITGB5; integrin beta-5 [KO:K06588]
107207823  ITGB6; integrin beta-6 [KO:K06589]
107200580  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
107206367  BDKRB1; B1 bradykinin receptor [KO:K03915]
107206365  BDKRB2; B2 bradykinin receptor [KO:K03916]
107205035  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
107202315  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
107206414  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
107205564  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
107212134  C5; complement C5 isoform X1 [KO:K03994]
107198376  C6; complement component C6 isoform X1 [KO:K03995]
107198232  C7; complement component C7 isoform X1 [KO:K03996]
107208193  C8A; complement component C8 alpha chain [KO:K03997]
107208194  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
107212131  C8G; complement component C8 gamma chain isoform X2 [KO:K03999]
107216253  C9; complement component C9 [KO:K04000]
107211274  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
107212551  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
107208454  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
107210262  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
107199979  PTK2; focal adhesion kinase 1 isoform X5 [KO:K05725] [EC:2.7.10.2]
107209875  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
107212927  CRK; adapter molecule crk isoform X3 [KO:K04438]
107211597  CRKL; crk-like protein [KO:K04438]
107206787  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
107213277  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
107206011  SOS2; son of sevenless homolog 2 [KO:K03099]
107201824  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
107205559  HRAS; GTPase HRas [KO:K02833]
107204562  KRAS; GTPase KRas isoform X1 [KO:K07827]
107214761  NRAS; GTPase NRas [KO:K07828]
107205650  RRAS2; ras-related protein R-Ras2 [KO:K07830]
107207566  MRAS; ras-related protein M-Ras [KO:K07831]
107203828  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
107213667  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107208827  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107208852  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
107215603  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107208273  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
107216262  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107208342  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
107211982  VAV2; guanine nucleotide exchange factor VAV2 isoform X5 [KO:K05730]
107213264  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
107204658  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
107210130  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
107200103  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
107209483  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107215477  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107211727  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107201442  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107205807  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107212151  RGCC; regulator of cell cycle RGCC isoform X1 [KO:K26108]
107203834  regulator of cell cycle RGCC-like isoform X2 [KO:K26108]
107214410  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
107199356  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
107210352  RHOA; transforming protein RhoA [KO:K04513]
107211176  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
107205038  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
107212321  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
107213677  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
107200206  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
107208951  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
107198751  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
107203819  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
107215871  serine/threonine-protein kinase PAK 1-like [KO:K05733] [EC:2.7.11.1]
107201333  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
107205813  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
107204871  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X2 [KO:K13710]
107212869  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
107199098  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
107201732  ROCK2; rho-associated protein kinase 2 isoform X4 [KO:K17388] [EC:2.7.11.1]
107215054  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
107207555  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
107209810  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
107213081  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
107213960  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
107201313  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
107211824  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
107205266  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
107204392  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
107214882  protein phosphatase 1 regulatory subunit 12B [KO:K12329]
107211518  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
107213424  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
107213032  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
107200345  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
107200346  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
107204698  MYH9; myosin-9 [KO:K10352]
107211165  MYH11; myosin-11 isoform X1 [KO:K10352]
107212478  MYH10; myosin-10 isoform X1 [KO:K10352]
107203813  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
107214153  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
107215403  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
107216369  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
107199398  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like [KO:K00920] [EC:2.7.1.149]
107198819  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
107198289  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
107207464  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
107213029  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
107211532  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
107206319  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
107212480  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X4 [KO:K05627]
107201932  ENAH; protein enabled homolog isoform X1 [KO:K05746]
107204603  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
107214034  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
107204746  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
107210775  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
107207527  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
107207407  ABI2; abl interactor 2 isoform X1 [KO:K05751]
107210280  BRK1; protein BRICK1 [KO:K05752]
107201988  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
107201579  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
107207659  ACTR3; actin-related protein 3 [KO:K18584]
107216402  ACTR3B; actin-related protein 3B [KO:K18584]
107211417  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
107211257  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
107207508  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
107211878  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
107210226  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
107212123  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
107207936  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
107212453  ACTG1; actin, cytoplasmic 2 [KO:K05692]
107209164  actin, cytoplasmic type 5 [KO:K05692]
107211173  ACTB; actin, cytoplasmic 1 [KO:K05692]
107208818  PFN2; profilin-2 [KO:K05759]
107198970  PFN1; profilin-1 [KO:K05759]
107211599  PXN; paxillin isoform X1 [KO:K05760]
107202112  EZR; ezrin isoform X1 [KO:K08007]
107206381  RDX; radixin isoform X1 [KO:K05762]
107203993  MSN; moesin isoform X1 [KO:K05763]
107205483  TMSB4X; thymosin beta-4 [KO:K05764]
107210896  thymosin beta-4-like [KO:K05764]
107206355  CFL2; cofilin-2 [KO:K05765]
107211485  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
107206306  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
107212837  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
107206746  VCL; vinculin isoform X2 [KO:K05700]
107209265  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
107214597  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
107216413  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
107200332  SCIN; adseverin [KO:K05768]
107212094  GSN; gelsolin isoform X1 [KO:K05768]
107206008  ACTN1; alpha-actinin-1 [KO:K05699]
107215377  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
107216177  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
107202017  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
107208738  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
pmaj04010  MAPK signaling pathway
pmaj04510  Focal adhesion
pmaj04520  Adherens junction
KO pathway
ko04810   
LinkDB

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