KEGG   PATHWAY: ppad05415
Entry
ppad05415                   Pathway                                
Name
Diabetic cardiomyopathy - Panthera pardus (leopard)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
ppad05415  Diabetic cardiomyopathy
ppad05415

Organism
Panthera pardus (leopard) [GN:ppad]
Gene
109254908  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
109245971  SLC2A4; LOW QUALITY PROTEIN: solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
109278972  GFPT2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
109275467  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 [KO:K00820] [EC:2.6.1.16]
109264424  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109275954  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
109248360  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109267916  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109259919  TNNI3; troponin I, cardiac muscle isoform X1 [KO:K12044]
109248970  RYR2; ryanodine receptor 2 [KO:K04962]
109248471  PLN; cardiac phospholamban [KO:K05852]
109256497  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
109255119  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
109277669  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
109249199  SP1; transcription factor Sp1 [KO:K04684]
109248942  AGT; angiotensinogen [KO:K09821]
109256860  REN; renin isoform X1 [KO:K01380] [EC:3.4.23.15]
109254960  CMA1; chymase isoform X1 [KO:K01329] [EC:3.4.21.39]
109255537  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
109260522  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
109248000  cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
109250624  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
109245544  cytochrome b-245 light chain [KO:K08009]
109253911  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
109265518  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
109251192  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
109265228  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109260696  AGTR1; type-1 angiotensin II receptor [KO:K04166]
109247385  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109246747  RELA; transcription factor p65 isoform X1 [KO:K04735]
109265257  MAPK11; LOW QUALITY PROTEIN: mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
109265767  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
109271512  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
109271515  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
109278973  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109276314  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
109264550  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109270907  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
109272345  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
109263702  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
109247299  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
109274385  COL3A1; collagen alpha-1(III) chain isoform X1 [KO:K19720]
109258015  transforming growth factor beta-1 isoform X1 [KO:K13375]
109257972  transforming growth factor beta-1-like isoform X1 [KO:K13375]
109276581  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
109253865  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
109268146  CD36; platelet glycoprotein 4 [KO:K06259]
109265727  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
109265787  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
109249360  PDK3; pyruvate dehydrogenase kinase, isozyme 3 isoform X1 [KO:K00898] [EC:2.7.11.2]
109247310  PDK2; pyruvate dehydrogenase kinase, isozyme 2 [KO:K00898] [EC:2.7.11.2]
109263716  PDK4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
109277056  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
109247926  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
109250044  PTPA; serine/threonine-protein phosphatase 2A activator isoform X1 [KO:K17605]
109266491  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
109246846  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
109277658  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
109259409  CTSD; LOW QUALITY PROTEIN: cathepsin D [KO:K01379] [EC:3.4.23.5]
109273956  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
109266859  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
109259395  INS; insulin [KO:K04526]
109254164  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
109264970  IRS1; insulin receptor substrate 1 [KO:K16172]
109274075  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109275159  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
109259912  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109266953  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109275060  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109247606  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109255395  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109256570  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109251379  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109257810  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109274103  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
109266441  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
109268721  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
109253089  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
109264220  TBC1D4; TBC1 domain family member 4 isoform X1 [KO:K17902]
109248027  MPC1L; mitochondrial pyruvate carrier 1-like protein [KO:K22138]
109245414  MPC1; mitochondrial pyruvate carrier 1 isoform X1 [KO:K22138]
109251877  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
109256394  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
109275622  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [KO:K00161] [EC:1.2.4.1]
109279084  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
6262379  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
6262376  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
6262373  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
6262382  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
6262378  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
6262381  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
6262380  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
109246866  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
109248630  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
109256940  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
109250759  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
109252177  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
109259272  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
109270365  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
109263751  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
109268916  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
109265655  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
109254215  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
109269855  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
109276194  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
109264816  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
109255552  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
109255913  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
109265353  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
109247671  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
109274474  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
109269112  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
109254468  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [KO:K03959]
109266455  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform X1 [KO:K03960]
109275170  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
109252058  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
109253972  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
109272773  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
109273168  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
109278136  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
109248171  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
109265174  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
109257265  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
109245162  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
109275900  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
109255473  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
109267857  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
109257694  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
109246872  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
109249489  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
109267264  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
109260209  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
109274188  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
109257257  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
109278657  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
109251558  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
6262383  CYTB; cytochrome b [KO:K00412]
109258332  cytochrome c1, heme protein, mitochondrial [KO:K00413]
109247770  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
109255573  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
109266948  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
109278057  cytochrome b-c1 complex subunit 7 [KO:K00417]
109250878  cytochrome b-c1 complex subunit 8 [KO:K00418]
109253571  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
109257700  cytochrome b-c1 complex subunit 10 [KO:K00420]
6262375  COX3; cytochrome c oxidase subunit III [KO:K02262]
6262371  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
6262377  COX2; cytochrome c oxidase subunit II [KO:K02261]
109245584  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
109272593  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
109262678  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
109252223  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
109273931  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
109247133  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
109267662  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
109261012  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
109277532  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
109278211  cytochrome c oxidase subunit 6B1-like [KO:K02267]
109251499  cytochrome c oxidase subunit 6B1 isoform X1 [KO:K02267]
109259941  cytochrome c oxidase subunit 6B2 isoform X1 [KO:K02267]
109278022  cytochrome c oxidase subunit 6C [KO:K02268]
109265251  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
109251497  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
109261722  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
109263306  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
109245506  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
109258957  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
109274895  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
109246642  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
109275772  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
109270344  ATP5B; ATP synthase subunit beta, mitochondrial isoform X1 [KO:K02133] [EC:7.1.2.2]
109273752  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
109257693  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
109257217  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
109253461  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
6262372  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
109272040  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
109273398  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
109247338  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
109249209  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
109276954  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
109249730  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
109277860  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
6262374  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
109250866  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
109264442  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
109262260  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
109250770  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
109251009  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
109256146  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
109249044  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
109264473  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
109259277  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
109252365  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
109261880  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
109276130  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
109272914  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
109253639  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
109250200  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
109261144  glucose-6-phosphate 1-dehydrogenase-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109261146  glucose-6-phosphate 1-dehydrogenase isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109277268  GSR; glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
109270084  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
109251365  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
109275745  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
109262802  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
109246661  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
109274721  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
109274722  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
109263166  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
109277113  LOW QUALITY PROTEIN: angiotensin-converting enzyme-like [KO:K01283] [EC:3.4.15.1]
109277114  angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
Riehle C, Bauersachs J
  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
DOI:10.1007/s00395-018-0711-0
Reference
PMID:24462787
  Authors
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
  Title
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
  Journal
Pharmacol Ther 142:375-415 (2014)
DOI:10.1016/j.pharmthera.2014.01.003
Reference
PMID:28231848
  Authors
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Related
pathway
ppad00010  Glycolysis / Gluconeogenesis
ppad00020  Citrate cycle (TCA cycle)
ppad00190  Oxidative phosphorylation
ppad00520  Amino sugar and nucleotide sugar metabolism
ppad03320  PPAR signaling pathway
ppad04071  Sphingolipid signaling pathway
ppad04150  mTOR signaling pathway
ppad04210  Apoptosis
ppad04260  Cardiac muscle contraction
ppad04350  TGF-beta signaling pathway
ppad04614  Renin-angiotensin system
ppad04910  Insulin signaling pathway
ppad04930  Type II diabetes mellitus
ppad04931  Insulin resistance
ppad04933  AGE-RAGE signaling pathway in diabetic complications
ppad04940  Type I diabetes mellitus
KO pathway
ko05415   
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