Entry
Name
Cytokine-cytokine receptor interaction - Pteronotus mesoamericanus (Parnell's mustached bat)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
ppam04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Pteronotus mesoamericanus (Parnell's mustached bat) [GN:
ppam ]
Gene
129066446 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
129087056 CSF3; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor [KO:K05423 ]
129073129 IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406 ]
129072130 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
129061407 TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
129081899 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
129079623 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
129076417 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
129081082 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
129072297 TNFSF12; tumor necrosis factor ligand superfamily member 12 isoform X1 [KO:K05474 ]
129079323 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
129061386 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
129081936 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
129081898 TNFSF18; tumor necrosis factor ligand superfamily member 18 isoform X1 [KO:K05479 ]
129072296 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
129071161 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
129072973 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
129069069 LOW QUALITY PROTEIN: bone morphogenetic protein 8B-like [KO:K16622 ]
129077533 LOW QUALITY PROTEIN: C-X-C chemokine receptor type 2-like [KO:K05050 ]
129084554 IL15RA; LOW QUALITY PROTEIN: interleukin-15 receptor subunit alpha [KO:K05074 ]
129079763 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066 ]
129079765 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066 ]
129069057 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
129071271 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
129078198 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
129067220 IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136 ]
129079880 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
129074270 IL1RL2; LOW QUALITY PROTEIN: interleukin-1 receptor-like 2 [KO:K05172 ]
129088534 IL17RE; LOW QUALITY PROTEIN: interleukin-17 receptor E [KO:K05168 ]
129071445 CD4; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD4 [KO:K06454 ]
129071418 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
129075646 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
129071421 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
129079049 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
129073860 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
129069755 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
129078433 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
129068452 tumor necrosis factor receptor superfamily member 1A-like [KO:K04722 ]
129074927 tumor necrosis factor receptor superfamily member 10B-like [KO:K04722 ]
129067509 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
129085603 EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
129071060 EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
129080218 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
129084069 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
129078598 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
129083378 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
129075593 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
129070434 CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
129075608 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
129078687 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
129078689 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
129083401 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
129068717 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
129077941 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
129081138 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
129072627 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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