KEGG   PATHWAY: ppam05208
Entry
ppam05208                   Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Pteronotus mesoamericanus (Parnell's mustached bat)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
ppam05208  Chemical carcinogenesis - reactive oxygen species
ppam05208

Organism
Pteronotus mesoamericanus (Parnell's mustached bat) [GN:ppam]
Gene
129082071  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
129063749  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
129063750  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
129063751  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
129063886  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
129077163  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
129077310  GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
129064549  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
129084994  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
129086197  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
129086206  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
129086347  glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
129086348  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
129067092  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
129067094  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
129067524  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
129061152  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
129068534  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
129081681  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
129074799  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
129076111  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
129066622  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
129081580  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
129073794  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
129075808  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
129062810  LOW QUALITY PROTEIN: cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129062895  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
129062966  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
129063510  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
129077877  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
129075999  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like [KO:K03951]
129078572  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
129079300  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
129074234  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
129068255  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
129076737  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
129061573  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
129071413  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
129075001  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
129065821  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
129063444  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
129062202  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
129080430  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
129071855  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
129080483  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
129076733  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
129078219  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
129073965  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6-like [KO:K03962]
129061437  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
129077119  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
129084321  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
129083592  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
129063038  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
129065242  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
129080402  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
129082090  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
129081425  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
129071966  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
129069068  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
129074405  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
129080072  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
129068340  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
129062244  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
129072781  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
129074559  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
129075622  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
129082086  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
129085977  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
129068180  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
129084412  cytochrome c1, heme protein, mitochondrial [KO:K00413]
129087602  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
129076751  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
129078685  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
129069416  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
129063220  cytochrome b-c1 complex subunit 7-like [KO:K00417]
129084220  cytochrome b-c1 complex subunit 7 [KO:K00417]
129066439  cytochrome b-c1 complex subunit 8 [KO:K00418]
129087380  cytochrome b-c1 complex subunit 9 [KO:K00419]
129081642  cytochrome b-c1 complex subunit 10 [KO:K00420]
129083132  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
129070485  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
129064218  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
129080578  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
129077999  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
129087477  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
129082512  cytochrome c oxidase subunit 6B2 [KO:K02267]
129069210  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129083194  cytochrome c oxidase subunit 6B1 [KO:K02267]
129070176  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129077881  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129071519  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129072246  cytochrome c oxidase subunit 6B1-like [KO:K02267]
129074723  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6B1-like [KO:K02267]
129084242  cytochrome c oxidase subunit 6C [KO:K02268]
129083211  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
129065908  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
129067112  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
129087868  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
129077717  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
129084869  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
129065349  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
129086072  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
129074346  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
129088401  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
129074665  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
129068626  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
129069924  ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
129078697  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
129075788  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
129087071  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
129080666  ATP synthase subunit gamma, mitochondrial-like [KO:K02136]
129073752  ATP synthase subunit delta, mitochondrial [KO:K02134]
129073755  ATP synthase subunit delta, mitochondrial [KO:K02134]
129063885  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
129061960  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
129088538  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
129084810  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
129080120  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
129083505  ATP synthase subunit d, mitochondrial-like [KO:K02138]
129086489  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
129074314  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
129075499  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
129067887  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
129066687  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
129069854  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
129071050  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15040]
129067084  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
129075491  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
129075707  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
129064788  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
129062855  ADP/ATP translocase 3-like [KO:K05863]
129076152  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
129069951  ADP/ATP translocase 2-like [KO:K05863]
129083503  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
129064550  ADP/ATP translocase 2-like [KO:K05863]
129064887  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
129085704  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
129079754  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
129061237  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
129069841  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
129074132  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
129080471  CAT; catalase [KO:K03781] [EC:1.11.1.6]
129077465  SLC26A1; sulfate anion transporter 1 [KO:K14700]
129066553  SLC26A2; sulfate transporter [KO:K14701]
129087712  SLC26A6; solute carrier family 26 member 6 isoform X1 [KO:K14704]
129062409  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
129079804  LOW QUALITY PROTEIN: cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
129064162  cytochrome P450 1A1-like [KO:K07408] [EC:1.14.14.1]
129066174  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
129073004  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
129072532  EPHX2; bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
129074801  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
129085638  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
129069398  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
129084610  aldo-keto reductase family 1 member C15-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
129084627  aldo-keto reductase family 1 member C4-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
129075232  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
129074367  CBR1; carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
129062817  AHR; aryl hydrocarbon receptor [KO:K09093]
129080178  LPO; lactoperoxidase [KO:K12550] [EC:1.11.1.7]
129072826  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
129083060  cytochrome b-245 light chain [KO:K08009]
129069623  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
129083412  NCF1; neutrophil cytosol factor 1 [KO:K08011]
129081874  NCF2; neutrophil cytosol factor 2 [KO:K08010]
129085287  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
129068919  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
129063396  HGF; hepatocyte growth factor [KO:K05460]
129063382  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
129086587  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
129064134  son of sevenless homolog 2 isoform X1 [KO:K03099]
129066034  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
129073113  HRAS; GTPase HRas isoform X1 [KO:K02833]
129084969  KRAS; GTPase KRas isoform X1 [KO:K07827]
129063946  NRAS; GTPase NRas [KO:K07828]
129065223  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
129062984  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129088423  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129064157  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129078155  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129078069  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129086248  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129067800  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
129068797  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
129078555  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
129069687  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129065007  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129085376  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129068299  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
129068300  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
129067412  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
129067413  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
129070771  JUN; transcription factor Jun [KO:K04448]
129065732  FOS; protein c-Fos [KO:K04379]
129074969  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129069407  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129074590  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
129075675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129076577  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129088291  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129078413  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
129068140  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129083615  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
129076641  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129066231  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129073033  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129067686  FOXO3; forkhead box protein O3 [KO:K09408]
129068612  BAD; bcl2-associated agonist of cell death [KO:K02158]
129070618  PTPN1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
129069750  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
129077110  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
129064790  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
129074378  IKBKG; NF-kappa-B essential modulator [KO:K07210]
129082066  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
129068571  RELA; transcription factor p65 [KO:K04735]
129085322  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129087905  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
129081418  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
129067816  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
129087362  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
129070719  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
129079203  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
129082005  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
129082876  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
129066203  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
129074178  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
129084348  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
129076361  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
129072342  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
129086451  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
129065977  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
129076824  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
129076825  aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
129067485  VEGFA; vascular endothelial growth factor A [KO:K05448]
129061548  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
129061765  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
129071260  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Redox toxicology of environmental chemicals causing oxidative stress.
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Related
pathway
ppam00190  Oxidative phosphorylation
ppam00980  Metabolism of xenobiotics by cytochrome P450
ppam04010  MAPK signaling pathway
ppam04064  NF-kappa B signaling pathway
ppam04066  HIF-1 signaling pathway
ppam04151  PI3K-Akt signaling pathway
ppam04370  VEGF signaling pathway
ppam05207  Chemical carcinogenesis - receptor activation
ppam05211  Renal cell carcinoma
ppam05215  Prostate cancer
ppam05219  Bladder cancer
ppam05221  Acute myeloid leukemia
ppam05222  Small cell lung cancer
ppam05223  Non-small cell lung cancer
ppam05224  Breast cancer
ppam05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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