KEGG   PATHWAY: ptg04151
Entry
ptg04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Panthera tigris altaica (Amur tiger)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
ptg04151  PI3K-Akt signaling pathway
ptg04151

Other DBs
GO: 0043491
Organism
Panthera tigris altaica (Amur tiger) [GN:ptg]
Gene
102959656  EGF; epidermal growth factor [KO:K04357]
102956554  TGFA; transforming growth factor alpha [KO:K08774]
102967796  EREG; epiregulin [KO:K09784]
102954670  AREG; amphiregulin [KO:K09782]
102967663  FGF1; fibroblast growth factor 1 [KO:K18496]
102969772  FGF2; fibroblast growth factor 2 [KO:K18497]
102970275  FGF9; fibroblast growth factor 9 [KO:K04358]
102949835  FGF5; fibroblast growth factor 5 [KO:K04358]
102971941  FGF22; fibroblast growth factor 22 [KO:K04358]
102964398  FGF18; fibroblast growth factor 18 [KO:K04358]
102959014  FGF8; fibroblast growth factor 8 [KO:K04358]
102956185  FGF7; fibroblast growth factor 7 [KO:K04358]
102970087  FGF17; fibroblast growth factor 17 [KO:K04358]
102957299  FGF20; fibroblast growth factor 20 [KO:K04358]
102970576  FGF10; fibroblast growth factor 10 [KO:K04358]
102969970  FGF6; fibroblast growth factor 6 [KO:K04358]
102966317  FGF19; fibroblast growth factor 19 [KO:K22603]
102963142  FGF21; fibroblast growth factor 21 [KO:K22429]
102958480  FGF23; fibroblast growth factor 23 [KO:K22428]
102961057  NGF; nerve growth factor [KO:K02582]
102958723  BDNF; brain derived neurotrophic factor [KO:K04355]
102966385  NTF3; neurotrophin 3 [KO:K04356]
102951714  NTF4; neurotrophin 4 [KO:K12457]
102962543  IGF1; insulin like growth factor 1 [KO:K05459]
102971867  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102970530  PDGFC; platelet derived growth factor C [KO:K05450]
102949957  PDGFD; platelet derived growth factor D [KO:K05450]
102972710  CSF1; colony stimulating factor 1 [KO:K05453]
102951678  KITLG; KIT ligand [KO:K05461]
102967169  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
102954556  VEGFA; vascular endothelial growth factor A [KO:K05448]
102961989  VEGFB; vascular endothelial growth factor B [KO:K16858]
102960599  PGF; placental growth factor [KO:K16859]
102952237  VEGFC; vascular endothelial growth factor C [KO:K05449]
102965995  VEGFD; vascular endothelial growth factor D [KO:K05449]
102952318  HGF; hepatocyte growth factor [KO:K05460]
102958985  ANGPT1; angiopoietin 1 [KO:K05465]
102954855  ANGPT2; angiopoietin 2 [KO:K05466]
102955835  ANGPT4; angiopoietin 4 [KO:K05467]
102956614  EFNA5; ephrin A5 [KO:K05462]
102971902  EFNA1; ephrin A1 [KO:K05462]
102961174  GDNF; glial cell derived neurotrophic factor [KO:K05452]
102967370  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102961961  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
102948909  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
102950188  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
102972346  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102964142  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102965504  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102953999  NGFR; nerve growth factor receptor [KO:K02583]
102950315  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
102967156  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102949680  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102955481  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102954207  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102953056  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102960767  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
102955843  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
102955273  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
102960922  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
102955197  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
102953616  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
102954161  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
102962818  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
102951366  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
102970459  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102949403  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102950748  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102952119  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102957350  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102952980  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102955852  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102969757  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102956808  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102964841  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102960964  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102965599  IRS1; insulin receptor substrate 1 [KO:K16172]
102962241  toll-like receptor 2 [KO:K10159]
102964242  toll-like receptor 2 [KO:K10159]
102959529  TLR4; toll like receptor 4 [KO:K10160]
102968561  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102964642  SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
102953595  CD19; CD19 molecule [KO:K06465]
102951851  PIK3AP1; phosphoinositide-3-kinase adaptor protein 1 [KO:K12230]
102954011  GH1; somatotropin [KO:K05438]
102970648  PRL; prolactin [KO:K05439]
102967884  OSM; oncostatin M [KO:K05418]
102957506  IL2; interleukin 2 [KO:K05429]
102968780  IL6; interleukin 6 [KO:K05405]
102963113  IL4; interleukin 4 [KO:K05430]
102960296  IL7; interleukin 7 [KO:K05431]
102956750  interferon alpha-2-like [KO:K05414]
102960421  IFNB1; interferon beta 1 [KO:K05415]
102949527  EPO; erythropoietin [KO:K05437]
102965612  CSF3; colony stimulating factor 3 [KO:K05423]
102952019  GHR; growth hormone receptor [KO:K05080]
102955301  PRLR; prolactin receptor [KO:K05081]
102959455  OSMR; oncostatin M receptor [KO:K05057]
102965369  IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
102966580  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
102951407  IL6R; interleukin 6 receptor [KO:K05055]
102949893  IL4R; interleukin 4 receptor [KO:K05071]
102953956  IL7R; interleukin 7 receptor [KO:K05072]
102955444  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
102954859  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
102948529  EPOR; erythropoietin receptor [KO:K05079]
102961715  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
102960189  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
102950330  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
102966280  JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
102967512  COL1A1; collagen type I alpha 1 chain [KO:K06236]
102971076  COL1A2; collagen type I alpha 2 chain [KO:K06236]
102956312  COL2A1; collagen type II alpha 1 chain [KO:K19719]
102965922  COL4A2; collagen type IV alpha 2 chain [KO:K06237]
102966202  COL4A1; collagen type IV alpha 1 chain [KO:K06237]
102965883  COL4A3; collagen type IV alpha 3 chain [KO:K06237]
102962233  COL4A4; collagen type IV alpha 4 chain [KO:K06237]
102951304  COL4A6; collagen type IV alpha 6 chain [KO:K06237]
102951890  COL4A5; collagen type IV alpha 5 chain [KO:K06237]
102954671  COL6A5; collagen type VI alpha 5 chain [KO:K06238]
102965155  COL6A1; collagen type VI alpha 1 chain [KO:K06238]
102965452  COL6A2; collagen type VI alpha 2 chain [KO:K06238]
102949405  COL6A3; collagen type VI alpha 3 chain [KO:K06238]
102950795  collagen alpha-4(VI) chain-like [KO:K06238]
102955253  COL6A6; collagen type VI alpha 6 chain [KO:K06238]
102961364  COL9A2; collagen type IX alpha 2 chain [KO:K08131]
107180364  COL9A1; collagen type IX alpha 1 chain [KO:K08131]
102958473  COL9A3; collagen type IX alpha 3 chain [KO:K08131]
102950444  LAMA2; laminin subunit alpha 2 [KO:K05637]
102969465  LAMA1; laminin subunit alpha 1 [KO:K05637]
102956725  LAMA3; laminin subunit alpha 3 [KO:K06240]
102953957  LAMA4; laminin subunit alpha 4 [KO:K06241]
102962439  LAMB1; laminin subunit beta 1 [KO:K05636]
102950017  LAMB2; laminin subunit beta 2 [KO:K06243]
102966519  LAMB3; laminin subunit beta 3 [KO:K06244]
102953694  LAMB4; laminin subunit beta 4 [KO:K06245]
102970302  LAMC1; laminin subunit gamma 1 [KO:K05635]
102966330  LAMC2; laminin subunit gamma 2 [KO:K06246]
102961184  LAMC3; laminin subunit gamma 3 [KO:K06247]
107180075  CHAD; chondroadherin [KO:K06248]
102959297  RELN; reelin [KO:K06249] [EC:3.4.21.-]
102969748  THBS1; thrombospondin 1 [KO:K16857]
102961939  THBS4; thrombospondin 4 [KO:K04659]
102970726  THBS3; thrombospondin 3 [KO:K04659]
102970054  THBS2; thrombospondin 2 [KO:K04659]
102971808  COMP; cartilage oligomeric matrix protein [KO:K04659]
102970250  FN1; fibronectin 1 [KO:K05717]
102951907  SPP1; secreted phosphoprotein 1 [KO:K06250]
102951541  VTN; vitronectin [KO:K06251]
102957683  TNN; tenascin N [KO:K06252]
102970818  TNR; tenascin R [KO:K06252]
102961256  TNC; tenascin C [KO:K06252]
102971740  tenascin-X-like [KO:K06252]
102965421  VWF; von Willebrand factor [KO:K03900]
102952675  IBSP; integrin binding sialoprotein [KO:K06253]
102959454  ITGA1; integrin subunit alpha 1 [KO:K06480]
102958888  ITGA2; integrin subunit alpha 2 [KO:K06481]
102951724  ITGA2B; integrin subunit alpha 2b [KO:K06476]
102966946  ITGA3; integrin subunit alpha 3 [KO:K06482]
102966166  ITGA4; integrin subunit alpha 4 [KO:K06483]
102959936  ITGA5; integrin subunit alpha 5 [KO:K06484]
102963994  ITGA6; integrin subunit alpha 6 [KO:K06485]
102954733  ITGA7; integrin subunit alpha 7 [KO:K06583]
102963555  ITGA8; integrin subunit alpha 8 [KO:K06584]
102953513  ITGA9; integrin subunit alpha 9 [KO:K06585]
102962579  ITGA10; integrin subunit alpha 10 [KO:K06586]
102964245  ITGA11; integrin subunit alpha 11 [KO:K06587]
102972745  ITGAV; integrin subunit alpha V [KO:K06487]
102967350  ITGB1; integrin subunit beta 1 [KO:K05719]
102963673  ITGB3; integrin subunit beta 3 [KO:K06493]
102948858  ITGB4; integrin subunit beta 4 [KO:K06525]
102969248  ITGB5; integrin subunit beta 5 [KO:K06588]
102949682  ITGB6; integrin subunit beta 6 [KO:K06589]
102956549  ITGB7; integrin subunit beta 7 [KO:K06590]
102970624  ITGB8; integrin subunit beta 8 [KO:K06591]
102953254  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
102953082  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102965070  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102972487  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102949853  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102952993  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102967709  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102964799  F2R; coagulation factor II thrombin receptor [KO:K03914]
102964850  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
102950279  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
102968521  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
102966758  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102968459  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
102962731  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102965799  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
102950533  GNB1; G protein subunit beta 1 [KO:K04536]
102955271  GNB2; G protein subunit beta 2 [KO:K04537]
102953535  GNB3; G protein subunit beta 3 [KO:K07825]
102963895  GNB4; G protein subunit beta 4 [KO:K04538]
102954935  GNB5; G protein subunit beta 5 [KO:K04539]
102962902  GNG2; G protein subunit gamma 2 [KO:K07826]
102968307  GNG3; G protein subunit gamma 3 [KO:K04540]
102953604  GNG4; G protein subunit gamma 4 [KO:K04541]
102963799  GNG7; G protein subunit gamma 7 [KO:K04543]
102956095  GNG10; G protein subunit gamma 10 [KO:K04545]
102972135  GNG11; G protein subunit gamma 11 [KO:K04546]
102951416  GNG12; G protein subunit gamma 12 [KO:K04347]
102949358  GNG13; G protein subunit gamma 13 [KO:K04547]
102972425  GNGT1; G protein subunit gamma transducin 1 [KO:K04548]
102967045  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
102953306  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
102954383  PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290]
102954665  PIK3R6; phosphoinositide-3-kinase regulatory subunit 6 [KO:K21290]
102960424  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102949361  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
102970831  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
102956343  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
102952604  DDIT4; DNA damage inducible transcript 4 [KO:K08270]
102953770  TSC1; tuberous sclerosis 1 [KO:K07206]
102956176  TSC2; tuberous sclerosis 2 [KO:K07207]
102970146  RHEB; Ras homolog enriched in brain [KO:K07208]
102971776  MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
102967196  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102958566  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
102961839  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
102971781  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
102971119  EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
102952167  EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
102950850  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
102960736  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102950764  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
102962132  RPS6; ribosomal protein S6 [KO:K02991]
102968590  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102960418  PKN1; protein kinase N1 [KO:K06071] [EC:2.7.11.13]
102961482  PKN2; protein kinase N2 [KO:K23691] [EC:2.7.11.13]
102967199  PKN3; protein kinase N3 [KO:K23692] [EC:2.7.11.13]
102966723  SGK1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
102955962  SGK2; SGK2, serine/threonine kinase 2 [KO:K13303] [EC:2.7.11.1]
102968087  SGK3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
102952603  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102954757  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102963813  MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
102960493  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
102972446  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102968396  THEM4; thioesterase superfamily member 4 [KO:K16339] [EC:3.1.2.2]
102956715  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
102954008  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
102951141  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
102961543  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
102970289  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
102949872  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
102951261  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
102952971  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
102956705  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
102964542  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
102952197  PPP2R5B; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
102954989  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
102949460  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
102951047  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
102959589  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
102954497  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
102950898  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
102959647  HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487]
102971846  hsp90 co-chaperone Cdc37-like [KO:K09554]
102953123  CRTC2; CREB regulated transcription coactivator 2 [KO:K16333]
102949246  PHLPP2; PH domain and leucine rich repeat protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
102956659  PHLPP1; PH domain and leucine rich repeat protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
102971945  TCL1B; T-cell leukemia/lymphoma 1B [KO:K16836]
102956303  MTCP1; mature T-cell proliferation 1 [KO:K16837]
102967516  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
102966376  BRCA1; BRCA1, DNA repair associated [KO:K10605] [EC:2.3.2.27]
102961382  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102950123  GYS1; glycogen synthase 1 [KO:K00693] [EC:2.4.1.11]
102965400  GYS2; glycogen synthase 2 [KO:K00693] [EC:2.4.1.11]
102955973  PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
102967618  PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
102971546  G6PC2; glucose-6-phosphatase catalytic subunit 2 [KO:K01084] [EC:3.1.3.9]
102972701  G6PC3; glucose-6-phosphatase catalytic subunit 3 [KO:K01084] [EC:3.1.3.9]
102963963  G6PC; glucose-6-phosphatase catalytic subunit [KO:K01084] [EC:3.1.3.9]
102954147  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
102959906  CCND1; cyclin D1 [KO:K04503]
102964051  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
102965656  CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
102959572  CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
102970281  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102967948  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102970259  CCND2; cyclin D2 [KO:K10151]
102970915  CCND3; cyclin D3 [KO:K10152]
102955833  CCNE2; cyclin E2 [KO:K06626]
102966425  CCNE1; cyclin E1 [KO:K06626]
102961930  FOXO3; forkhead box O3 [KO:K09408]
102970305  RBL2; RB transcriptional corepressor like 2 [KO:K16332]
102953222  FASLG; Fas ligand [KO:K04389]
102956471  BCL2L11; BCL2 like 11 [KO:K16341]
102962314  YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [KO:K16197]
102966103  YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [KO:K16197]
102960626  14-3-3 protein zeta/delta-like [KO:K16197]
102948901  YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [KO:K16197]
102960323  14-3-3 protein epsilon [KO:K06630]
102970295  YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [KO:K06630]
102965301  YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta [KO:K16198]
102972607  YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma [KO:K16198]
102956027  BAD; BCL2 associated agonist of cell death [KO:K02158]
102950221  BCL2L1; BCL2 like 1 [KO:K04570]
102953487  BCL2; BCL2, apoptosis regulator [KO:K02161]
102967404  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
102971333  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
102954603  ATF2; activating transcription factor 2 [KO:K04450]
102950077  ATF4; activating transcription factor 4 [KO:K04374]
102956516  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
102949885  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
102949496  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
102950730  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
102954009  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
102972337  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
102965640  ATF6B; activating transcription factor 6 beta [KO:K09049]
102965985  MCL1; BCL2 family apoptosis regulator [KO:K02539]
102972691  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102949289  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102963734  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102951132  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102964232  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102971577  MYB; MYB proto-oncogene, transcription factor [KO:K09420]
102965880  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
102962571  TP53; tumor protein p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
ptg00010  Glycolysis / Gluconeogenesis
ptg04010  MAPK signaling pathway
ptg04012  ErbB signaling pathway
ptg04062  Chemokine signaling pathway
ptg04064  NF-kappa B signaling pathway
ptg04068  FoxO signaling pathway
ptg04110  Cell cycle
ptg04115  p53 signaling pathway
ptg04150  mTOR signaling pathway
ptg04210  Apoptosis
ptg04370  VEGF signaling pathway
ptg04510  Focal adhesion
ptg04620  Toll-like receptor signaling pathway
ptg04630  JAK-STAT signaling pathway
ptg04662  B cell receptor signaling pathway
ptg04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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