KEGG   PATHWAY: pvt04020
Entry
pvt04020                    Pathway                                
Name
Calcium signaling pathway - Pogona vitticeps (central bearded dragon)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
pvt04020  Calcium signaling pathway
pvt04020

Other DBs
GO: 0019722
Organism
Pogona vitticeps (central bearded dragon) [GN:pvt]
Gene
110079542  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
110076424  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
110083339  sodium/calcium exchanger 1-like [KO:K05849]
110075775  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
110069872  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
110087603  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
110085967  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
110078651  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
110080770  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
110070209  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
110075758  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
110080110  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
110081998  ADORA2A; adenosine receptor A2a [KO:K04266]
110087390  ADORA2B; adenosine receptor A2b isoform X1 [KO:K04267]
110071978  ADRB1; beta-1 adrenergic receptor [KO:K04141]
110086179  beta-2 adrenergic receptor-like [KO:K04142]
110075175  ADRB3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
110086003  DRD1; D(1A) dopamine receptor [KO:K04144]
110072233  D(1) dopamine receptor-like [KO:K05840]
110084122  D(1) dopamine receptor-like [KO:K05840]
110077781  HRH2; histamine H2 receptor [KO:K04150]
110072285  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
110071943  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
110073211  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
110090918  5-hydroxytryptamine receptor 7-like [KO:K04163]
110084119  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
110084741  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
110078908  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
110091617  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110089596  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
110089954  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
110091692  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
110086573  ADCY7; LOW QUALITY PROTEIN: adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
110090751  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
110089110  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
110079750  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110082676  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110083621  PLN; cardiac phospholamban [KO:K05852]
110084080  SLN; sarcolipin [KO:K22642]
110089239  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
110078558  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
110083889  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
110078125  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
110072247  STIM2; stromal interaction molecule 2 [KO:K18196]
110085147  ORAI2; protein orai-2 isoform X1 [KO:K16057]
110076659  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
110084495  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110078615  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
110085291  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
110082653  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
110089800  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
110077061  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
110091119  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
110088075  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
110083158  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
110081449  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
110074548  CHRFAM7A; CHRNA7-FAM7A fusion protein isoform X1 [KO:K04809]
110087451  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
110087033  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
110076081  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
110085794  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
110081819  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
110077723  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
110090584  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
110075497  P2RX1; P2X purinoceptor 1 [KO:K05215]
110082885  P2RX2; P2X purinoceptor 2 [KO:K05216]
110078364  P2RX3; P2X purinoceptor 3 [KO:K05217]
110083823  P2RX4; P2X purinoceptor 4 [KO:K05218]
110087400  P2RX5; P2X purinoceptor 5 [KO:K05219]
110081946  P2RX6; P2X purinoceptor 6 [KO:K05221]
110083862  P2RX7; P2X purinoceptor 7 [KO:K05220]
110075640  RYR1; ryanodine receptor 1 [KO:K04961]
110076303  RYR2; ryanodine receptor 2 [KO:K04962]
110079207  TRDN; triadin [KO:K23449]
110081560  CASQ1; calsequestrin-1 [KO:K23468]
110091118  calsequestrin-2 [KO:K23445]
110088966  ASPH; aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
110086645  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
110078260  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
110090489  alpha-1A adrenergic receptor-like [KO:K04135]
110085985  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
110073044  AGTR1; type-1 angiotensin II receptor [KO:K04166]
110073612  EDNRA; LOW QUALITY PROTEIN: endothelin-1 receptor [KO:K04197]
110088511  EDNRB; endothelin B receptor [KO:K04198]
110088401  endothelin B receptor-like [KO:K04198]
110084596  proteinase-activated receptor 1-like [KO:K03914]
110084597  F2R; proteinase-activated receptor 1 [KO:K03914]
110088369  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
110088579  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
110075459  GRPR; gastrin-releasing peptide receptor [KO:K04169]
110083808  HRH1; histamine H1 receptor [KO:K04149]
110088746  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
110090936  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
110080131  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
110084902  NTSR1; neurotensin receptor type 1 [KO:K04211]
110077877  OXTR; oxytocin receptor isoform X1 [KO:K04229]
110075120  AVPR1A; vasopressin V1a receptor [KO:K04226]
110081422  AVPR1B; vasopressin V1b receptor [KO:K04227]
110091691  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
110088339  PTAFR; platelet-activating factor receptor isoform X1 [KO:K04279]
110082675  PTGER1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
110079866  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
110091232  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
110081349  BDKRB2; B2 bradykinin receptor [KO:K03916]
110072208  substance-P receptor-like [KO:K04222]
110086793  TACR2; substance-K receptor [KO:K04223]
110080469  TACR3; neuromedin-K receptor [KO:K04224]
110079222  TBXA2R; thromboxane A2 receptor [KO:K04264]
110071830  thyrotropin-releasing hormone receptor-like [KO:K04282]
110076294  thyrotropin-releasing hormone receptor-like [KO:K04282]
110073799  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
110072270  CCKAR; cholecystokinin receptor type A [KO:K04194]
110078080  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
110071869  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
110076012  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
110079229  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
110076000  guanine nucleotide-binding protein subunit alpha-14-like [KO:K04636]
110079220  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
110087292  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
110072211  TGFA; protransforming growth factor alpha [KO:K08774]
110090337  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
110075932  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110091114  PDGFD; platelet-derived growth factor D [KO:K05450]
110072781  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
110086304  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110072861  FGF2; fibroblast growth factor 2 [KO:K18497]
110073880  FGF10; fibroblast growth factor 10 [KO:K04358]
110077017  FGF20; fibroblast growth factor 20 [KO:K04358]
110077610  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
110083555  FGF9; fibroblast growth factor 9 [KO:K04358]
110077238  FGF7; fibroblast growth factor 7 [KO:K04358]
110073508  FGF3; fibroblast growth factor 3 [KO:K04358]
110084110  FGF5; fibroblast growth factor 5 [KO:K04358]
110074324  FGF16; fibroblast growth factor 16 [KO:K04358]
110072606  FGF22; fibroblast growth factor 22 [KO:K04358]
110078969  FGF18; fibroblast growth factor 18 [KO:K04358]
110087491  FGF6; fibroblast growth factor 6 [KO:K04358]
110073517  FGF19; fibroblast growth factor 19 [KO:K22603]
110078593  FGF21; fibroblast growth factor 21 [KO:K22429]
110087506  FGF23; fibroblast growth factor 23 [KO:K22428]
110074690  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
110083368  VEGFB; vascular endothelial growth factor B [KO:K16858]
110084103  VEGFC; vascular endothelial growth factor C [KO:K05449]
110075463  VEGFD; vascular endothelial growth factor D [KO:K05449]
110072378  NGF; beta-nerve growth factor [KO:K02582]
110077194  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
110076730  MST1; hepatocyte growth factor-like protein [KO:K23441]
110080092  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
110081594  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
110082059  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
110073465  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
110072384  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
110078407  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110086089  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
110072166  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
110075320  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
110085587  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
110077562  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
110076449  FLT1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
110074293  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
110073488  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
110081467  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
110089898  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
110072967  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
110077032  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
110076841  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
110083673  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
110071048  immunoglobulin alpha-2 heavy chain-like [KO:K06856]
110078238  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
110085836  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
110081386  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
110083359  PLCB3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
110080121  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
110087370  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
110087369  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
110070157  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like [KO:K01116] [EC:3.1.4.11]
110076765  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
110085508  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
110084128  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
110084670  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1-like isoform X1 [KO:K05861] [EC:3.1.4.11]
110084675  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1-like isoform X1 [KO:K05861] [EC:3.1.4.11]
110088203  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
110081241  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
110080162  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
110085956  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
110086274  TPCN1; two pore calcium channel protein 1 [KO:K16896]
110073509  TPCN2; two pore calcium channel protein 2 [KO:K14077]
110077986  MCOLN1; LOW QUALITY PROTEIN: mucolipin-1 [KO:K04992]
110079747  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
110079755  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
110085912  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
110081807  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
110073696  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
110079398  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
110080326  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
110072149  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
110089751  ADP/ATP translocase 3 [KO:K05863]
110072866  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
110090254  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
110083822  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
110083787  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
110080649  TNNC1; troponin C, slow skeletal and cardiac muscles isoform X1 [KO:K05865]
110086216  TNNC2; troponin C, skeletal muscle [KO:K12042]
110073310  CALML6; calmodulin-like protein 6 [KO:K02183]
110086895  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
110075623  CALM3; calmodulin [KO:K02183]
110086592  CALM1; calmodulin isoform X1 [KO:K02183]
110080744  CALM2; calmodulin isoform X1 [KO:K02183]
110081032  calmodulin [KO:K02183]
110090073  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
110084500  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
110076267  PHKB; phosphorylase b kinase regulatory subunit beta [KO:K07190]
110076734  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
110080147  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
110086708  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
110083010  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
110076324  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
110090626  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
110081228  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
110072369  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
110079912  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
110077789  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
110083899  calcium/calmodulin-dependent protein kinase type II delta chain [KO:K04515] [EC:2.7.11.17]
110086082  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
110084335  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
110072022  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
110072612  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
110072175  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110077763  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110085339  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110091682  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
110080514  TFEB; transcription factor EB [KO:K15590]
110072900  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
110071809  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
110085488  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
110091693  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
110090104  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
110088446  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
110082598  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
110088757  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like [KO:K13755] [EC:3.1.4.17]
110083215  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
110086678  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
110084226  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like isoform X1 [KO:K13755] [EC:3.1.4.17]
110071217  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
110089495  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
110079032  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
110075624  inositol-trisphosphate 3-kinase C-like [KO:K00911] [EC:2.7.1.127]
110071116  inositol-trisphosphate 3-kinase B-like [KO:K00911] [EC:2.7.1.127]
110087554  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
110088714  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
110085019  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
110078510  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
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Berridge MJ, Bootman MD, Roderick HL.
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Calcium signalling: dynamics, homeostasis and remodelling.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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PMID:15111104
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FEBS Lett 564:245-50 (2004)
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Reference
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
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Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
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Reference
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  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
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Reference
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  Authors
Fukunaga K, Miyamoto E.
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A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Neurosci Res 38:3-17 (2000)
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Reference
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
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Reference
PMID:10508738
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Extracellular-signal-regulated kinase signalling in neurons.
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Curr Opin Neurobiol 9:544-53 (1999)
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Reference
PMID:12972622
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Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
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Mol Cell Biol 23:7068-81 (2003)
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Hutchins JR, Dikovskaya D, Clarke PR.
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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
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Tornquist K
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
PMID:22129055
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Feske S
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Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
PMID:22002090
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Baba Y, Kurosaki T
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[Regulation of store-operated calcium entry by STIM1].
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Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
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Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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Pflugers Arch 458:869-76 (2009)
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Reference
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Beard NA, Wei L, Dulhunty AF
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
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Marty I
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Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
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Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
pvt04010  MAPK signaling pathway
pvt04070  Phosphatidylinositol signaling system
pvt04210  Apoptosis
KO pathway
ko04020   
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