Entry
Name
Cytokine-cytokine receptor interaction - Rattus norvegicus (rat)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
rno04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Rattus norvegicus (rat) [GN:
rno ]
Gene
25542 Ccl3; C-C motif chemokine 3 precursor [KO:K05408 ]
81780 Ccl5; C-C motif chemokine 5 precursor [KO:K12499 ]
287562 Ccl12; C-C motif chemokine ligand 12 precursor [KO:K14624 ]
24770 Ccl2; C-C motif chemokine 2 precursor [KO:K14624 ]
29538 Ccl20; C-C motif chemokine 20 precursor [KO:K14625 ]
81503 Cxcl1; growth-regulated alpha protein precursor [KO:K05505 ]
60665 Cxcl6; C-X-C motif chemokine 5 precursor [KO:K05506 ]
245920 Cxcl10; C-X-C motif chemokine 10 precursor [KO:K12671 ]
305236 Cxcl11; C-X-C motif chemokine 11 precursor [KO:K12672 ]
498335 Cxcl13; C-X-C motif chemokine 13 isoform 2 precursor [KO:K10032 ]
24772 Cxcl12; stromal cell-derived factor 1 isoform beta precursor [KO:K10031 ]
497942 Cxcl16; C-X-C motif chemokine 16 precursor [KO:K10035 ]
306748 Cxcl14; C-X-C motif chemokine 14 precursor [KO:K10033 ]
308436 Cxcl17; C-X-C motif chemokine 17 precursor [KO:K22627 ]
688621 Tslp; thymic stromal lymphopoietin isoform X1 [KO:K05436 ]
116630 Csf2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
25610 Csf3; granulocyte colony-stimulating factor precursor [KO:K05423 ]
84405 Il12a; interleukin-12 subunit alpha precursor [KO:K05406 ]
64546 Il12b; interleukin-12 subunit beta precursor [KO:K05425 ]
155140 Il23a; interleukin-23 subunit alpha precursor [KO:K05426 ]
680609 Ebi3; interleukin-27 subunit beta precursor [KO:K24476 ]
365395 Clcf1; cardiotrophin-like cytokine factor 1 isoform 1 precursor [KO:K05421 ]
60584 Lif; leukemia inhibitory factor precursor [KO:K05419 ]
298213 Ifna2; interferon alpha family, gene 2 precursor [KO:K05414 ]
690894 Ifna1; interferon alpha family, gene 5 precursor [KO:K05414 ]
502961 Ifna4l2; similar to Interferon alpha-1 precursor [KO:K05414 ]
500491 Ifna16l1; interferon, alpha 16-like 1 precursor [KO:K05414 ]
502959 Ifna1l1; similar to put. precursor MuIFN-alpha 5 precursor [KO:K05414 ]
60582 Il1rn; interleukin-1 receptor antagonist protein precursor [KO:K05481 ]
311783 Il36rn; interleukin-36 receptor antagonist protein [KO:K05483 ]
78965 Csf1; macrophage colony-stimulating factor 1 precursor [KO:K05453 ]
301133 Tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
25385 Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
252878 Tnfsf15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
246775 Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
117516 Tnfsf11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
360548 Tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
683163 Tnfsf8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
353218 Tnfsf9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
89814 Tnfsf4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
364031 Tnfsf18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
287437 Tnfsf13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
59086 Tgfb1; transforming growth factor beta-1 proprotein precursor [KO:K13375 ]
81809 Tgfb2; transforming growth factor beta-2 proprotein precursor [KO:K13376 ]
25717 Tgfb3; transforming growth factor beta-3 proprotein preproprotein [KO:K13377 ]
29455 Gdf15; growth/differentiation factor 15 precursor [KO:K05504 ]
290921 Gdf2; growth/differentiation factor 2 precursor [KO:K05503 ]
500245 Bmp10; bone morphogenetic protein 10 precursor [KO:K22670 ]
25667 Bmp3; bone morphogenetic protein 3 precursor [KO:K05496 ]
79216 Gdf10; growth/differentiation factor 10 precursor [KO:K22674 ]
29454 Gdf11; growth/differentiation factor 11 precursor [KO:K22679 ]
29152 Mstn; growth/differentiation factor 8 precursor [KO:K05497 ]
29200 Inhba; inhibin beta A chain preproprotein [KO:K04667 ]
25196 Inhbb; inhibin beta B chain precursor [KO:K22687 ]
306351 Gdf1; embryonic growth/differentiation factor 1 precursor [KO:K05495 ]
500311 Gdf3; growth/differentiation factor 3 precursor [KO:K22672 ]
59304 Gdf9; growth/differentiation factor 9 precursor [KO:K22673 ]
64549 Inhbc; inhibin beta C chain precursor [KO:K22688 ]
83711 Inhbe; inhibin beta E chain precursor [KO:K22689 ]
25378 Amh; muellerian-inhibiting factor precursor [KO:K04665 ]
29373 Bmp2; bone morphogenetic protein 2 precursor [KO:K21283 ]
25296 Bmp4; bone morphogenetic protein 4 precursor [KO:K04662 ]
252835 Gdf5; growth/differentiation factor 5 preproprotein [KO:K04664 ]
252834 Gdf6; growth/differentiation factor 6 precursor [KO:K20012 ]
252833 Gdf7; growth/differentiation factor 7 isoform 2 precursor [KO:K20013 ]
59302 Bmp15; bone morphogenetic protein 15 precursor [KO:K05498 ]
315824 Bmp5; bone morphogenetic protein 5 precursor [KO:K04663 ]
25644 Bmp6; bone morphogenetic protein 6 precursor [KO:K16620 ]
85272 Bmp7; bone morphogenetic protein 7 precursor [KO:K16621 ]
679119 Bmp8b; bone morphogenetic protein 8B isoform X2 [KO:K16622 ]
680931 Bmp8a; bone morphogenetic protein 8A precursor [KO:K16622 ]
287673 Ccr7; C-C chemokine receptor type 7 precursor [KO:K04182 ]
301088 Ccr1l1; C-C chemokine receptor 1-like protein 1 [KO:K04176 ]
54258 Cxcr1; C-X-C chemokine receptor type 1 [KO:K04175 ]
29385 Cxcr2; C-X-C chemokine receptor type 2 [KO:K05050 ]
84475 Cxcr3; C-X-C chemokine receptor type 3 [KO:K04188 ]
29363 Cxcr5; C-X-C chemokine receptor type 5 [KO:K04190 ]
60628 Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189 ]
25704 Il2ra; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
25746 Il2rb; interleukin-2 receptor subunit beta precursor [KO:K05069 ]
140924 Il2rg; cytokine receptor common subunit gamma precursor [KO:K05070 ]
25084 Il4r; interleukin-4 receptor subunit alpha precursor [KO:K05071 ]
294797 Il7r; interleukin-7 receptor subunit alpha precursor [KO:K05072 ]
690369 Il15ra; interleukin-15 receptor subunit alpha precursor [KO:K05074 ]
171499 Crlf2; cytokine receptor-like factor 2 precursor [KO:K05078 ]
246144 Il3ra; interleukin-3 receptor subunit alpha precursor [KO:K04737 ]
171081 Csf2rb; cytokine receptor common subunit beta precursor [KO:K04738 ]
114103 Il5ra; interleukin-5 receptor subunit alpha precursor [KO:K05067 ]
652957 Csf2ra; granulocyte-macrophage colony-stimulating factor receptor subunit alpha precursor [KO:K05066 ]
252963 Il13ra1; interleukin-13 receptor subunit alpha-1 precursor [KO:K05076 ]
171060 Il13ra2; interleukin-13 receptor subunit alpha-2 precursor [KO:K05077 ]
24336 Epor; erythropoietin receptor precursor [KO:K05079 ]
25235 Ghr; growth hormone receptor precursor [KO:K05080 ]
24684 Prlr; prolactin receptor isoform a precursor [KO:K05081 ]
298518 Csf3r; granulocyte colony-stimulating factor receptor precursor [KO:K05061 ]
24499 Il6r; interleukin-6 receptor subunit alpha precursor [KO:K05055 ]
25205 Il6st; interleukin-6 receptor subunit beta precursor [KO:K05060 ]
245983 Il11ra1; interleukin-11 receptor subunit alpha precursor [KO:K05056 ]
171333 Il12rb1; interleukin-12 receptor subunit beta-1 precursor [KO:K05063 ]
171334 Il12rb2; interleukin-12 receptor subunit beta-2 precursor [KO:K05064 ]
689932 Il23r; interleukin-23 receptor isoform X1 [KO:K05065 ]
688622 Il31ra; interleukin-31 receptor subunit alpha precursor [KO:K22630 ]
313173 Cntfr; ciliary neurotrophic factor receptor subunit alpha precursor [KO:K05059 ]
81680 Lifr; leukemia inhibitory factor receptor precursor [KO:K05058 ]
310132 Osmr; oncostatin-M-specific receptor subunit beta precursor [KO:K05057 ]
117539 Il10ra; interleukin-10 receptor subunit alpha precursor [KO:K05134 ]
304091 Il10rb; interleukin-10 receptor subunit beta precursor [KO:K05135 ]
308716 Il20ra; interleukin-20 receptor subunit alpha precursor [KO:K05136 ]
501043 Il20rb; interleukin-20 receptor subunit beta [KO:K05137 ]
362629 Il22ra1; interleukin-22 receptor subunit alpha-1 [KO:K05138 ]
362628 Ifnlr1; interferon lambda receptor 1 precursor [KO:K05140 ]
288264 Ifnar1; interferon alpha/beta receptor 1 isoform 1 precursor [KO:K05130 ]
686326 Ifnar2; interferon alpha and beta receptor subunit 2 isoform 1 precursor [KO:K05131 ]
116465 Ifngr1; interferon gamma receptor 1 precursor [KO:K05132 ]
360697 Ifngr2; interferon gamma receptor 2 precursor [KO:K05133 ]
25663 Il1r1; interleukin-1 receptor type 1 precursor [KO:K04386 ]
25466 Il1rap; interleukin-1 receptor accessory protein precursor [KO:K04723 ]
117022 Il1r2; interleukin-1 receptor type 2 precursor [KO:K04387 ]
171106 Il1rl2; interleukin-1 receptor-like 2 precursor [KO:K05172 ]
301365 Il18r1; interleukin-18 receptor 1 precursor [KO:K05173 ]
373540 Il18rap; interleukin-18 receptor accessory protein precursor [KO:K05174 ]
25556 Il1rl1; interleukin-1 receptor-like 1 isoform Fit-1M precursor [KO:K05171 ]
297520 Il17rc; interleukin-17 receptor C precursor [KO:K05166 ]
306247 Il17rb; interleukin-17 receptor B isoform 1 [KO:K05165 ]
362417 Il17re; interleukin-17 receptor E precursor [KO:K05168 ]
24932 Cd4; T-cell surface glycoprotein CD4 precursor [KO:K06454 ]
25625 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158 ]
156767 Tnfrsf1b; tumor necrosis factor receptor superfamily member 1B precursor [KO:K05141 ]
297604 Ltbr; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159 ]
366518 Tnfrsf14; tumor necrosis factor receptor superfamily member 14 precursor [KO:K05152 ]
246097 Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
500592 Tnfrsf25; tumor necrosis factor receptor superfamily member 25 precursor [KO:K05160 ]
316256 Tnfrsf21; tumor necrosis factor receptor superfamily member 21 precursor [KO:K05157 ]
365581 Edar; tumor necrosis factor receptor superfamily member EDAR precursor [KO:K05162 ]
296872 Eda2r; tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
24596 Ngfr; tumor necrosis factor receptor superfamily member 16 precursor [KO:K02583 ]
25341 Tnfrsf11b; tumor necrosis factor receptor superfamily member 11B precursor [KO:K05148 ]
498206 Tnfrsf11a; tumor necrosis factor receptor superfamily member 11A precursor [KO:K05147 ]
302965 Tnfrsf12a; tumor necrosis factor receptor superfamily member 12A precursor [KO:K05149 ]
25069 Tnfrsf8; tumor necrosis factor receptor superfamily member 8 precursor [KO:K05145 ]
171369 Cd40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160 ]
500590 Tnfrsf9; tumor necrosis factor receptor superfamily member 9 precursor [KO:K05146 ]
25572 Tnfrsf4; tumor necrosis factor receptor superfamily member 4 precursor [KO:K05142 ]
500598 Tnfrsf18; tumor necrosis factor receptor superfamily member 18 precursor [KO:K05154 ]
287034 Tnfrsf17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
103693341 Tnfrsf13b; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
500910 Tnfrsf13c; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
290300 Tnfrsf19; tumor necrosis factor receptor superfamily member 19 precursor [KO:K05155 ]
361615 Relt; tumor necrosis factor receptor superfamily member 19L precursor [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
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Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
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Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
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Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
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Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
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Title
The TGF-beta superfamily in dendritic cell biology.
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Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
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Title
Promiscuity and specificity in BMP receptor activation.
Journal
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