KEGG   PATHWAY: sbq04020
Entry
sbq04020                    Pathway                                
Name
Calcium signaling pathway - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
sbq04020  Calcium signaling pathway
sbq04020

Other DBs
GO: 0019722
Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101046902  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
101042047  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
101049275  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
101028696  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X6 [KO:K05850] [EC:7.2.2.10]
101032189  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
101033947  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X2 [KO:K05850] [EC:7.2.2.10]
101035927  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101051843  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101042089  CHRM5; muscarinic acetylcholine receptor M5 isoform X1 [KO:K04133]
101042110  ADORA2A; adenosine receptor A2a [KO:K04266]
101044944  ADORA2B; adenosine receptor A2b [KO:K04267]
101034868  ADRB2; beta-2 adrenergic receptor isoform X1 [KO:K04142]
101029188  ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
101036344  DRD1; D(1A) dopamine receptor [KO:K04144]
101041026  DRD5; D(1B) dopamine receptor [KO:K05840]
101035394  HRH2; histamine H2 receptor isoform X2 [KO:K04150]
101033707  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
101043237  5-hydroxytryptamine receptor 5B [KO:K04161]
101054360  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
101033924  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101029408  HTR7; 5-hydroxytryptamine receptor 7 isoform X2 [KO:K04163]
101043452  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
104652116  neuroendocrine secretory protein 55 [KO:K04632]
101050072  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X2 [KO:K04633]
101027981  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101043334  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101040601  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101044688  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
101032672  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101034552  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
101052034  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
101034152  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
101036705  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101043989  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
101047300  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101053908  PLN; cardiac phospholamban [KO:K05852]
101043278  SLN; sarcolipin [KO:K22642]
101037264  LOW QUALITY PROTEIN: uncharacterized protein C4orf3 homolog [KO:K26467]
101036006  SMIM6; small integral membrane protein 6 [KO:K26468]
101036977  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
101049289  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
101053869  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101040633  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
101047752  STIM1; stromal interaction molecule 1 isoform X3 [KO:K16059]
101052890  STIM2; stromal interaction molecule 2 [KO:K18196]
101044294  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
101040377  ORAI2; protein orai-2 isoform X1 [KO:K16057]
101043870  ORAI3; protein orai-3 [KO:K16058]
101040048  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101043152  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101034685  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101042219  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101046396  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101049976  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101040860  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X2 [KO:K04852]
101028952  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X14 [KO:K04854]
101029677  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
101034125  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101050618  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
101054145  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
101030380  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
101036659  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101040894  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101036810  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101039341  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101032406  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101034335  P2RX1; P2X purinoceptor 1 [KO:K05215]
101028224  P2RX2; P2X purinoceptor 2 [KO:K05216]
101044762  P2RX3; P2X purinoceptor 3 [KO:K05217]
101046432  P2RX4; P2X purinoceptor 4 [KO:K05218]
101035805  P2RX5; P2X purinoceptor 5 [KO:K05219]
101053195  P2X purinoceptor 6 isoform X1 [KO:K05221]
101044494  uncharacterized protein LOC101044494 [KO:K05221]
101046955  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
101040405  RYR1; ryanodine receptor 1 [KO:K04961]
101044099  RYR2; ryanodine receptor 2 [KO:K04962]
101038051  RYR3; ryanodine receptor 3 [KO:K04963]
101027767  TRDN; triadin isoform X1 [KO:K23449]
101033838  CASQ1; calsequestrin-1 isoform X1 [KO:K23468]
101040044  CASQ2; calsequestrin-2 [KO:K23445]
101045507  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
101045917  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
101040002  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
104649836  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
101030040  ADRA1A; alpha-1A adrenergic receptor isoform X2 [KO:K04135]
101040811  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
101050070  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
101037991  AGTR1; type-1 angiotensin II receptor [KO:K04166]
101032195  EDNRA; endothelin-1 receptor [KO:K04197]
101052365  EDNRB; endothelin B receptor [KO:K04198]
101048036  F2R; proteinase-activated receptor 1 [KO:K03914]
101036619  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101043023  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
101047820  GRPR; gastrin-releasing peptide receptor [KO:K04169]
101030933  HRH1; histamine H1 receptor [KO:K04149]
104651786  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
101034608  HTR2A; 5-hydroxytryptamine receptor 2A isoform X2 [KO:K04157]
101050137  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
101042120  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
101049491  NTSR1; neurotensin receptor type 1 [KO:K04211]
101050643  OXTR; oxytocin receptor [KO:K04229]
101051368  AVPR1A; vasopressin V1a receptor [KO:K04226]
101030321  AVPR1B; vasopressin V1b receptor [KO:K04227]
101045329  LTB4R2; leukotriene B4 receptor 2 isoform X2 [KO:K04297]
101039470  PTAFR; platelet-activating factor receptor [KO:K04279]
104649855  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
101046055  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
101044388  BDKRB1; B1 bradykinin receptor [KO:K03915]
101043867  BDKRB2; B2 bradykinin receptor [KO:K03916]
101044785  TACR1; substance-P receptor [KO:K04222]
101047997  TACR2; substance-K receptor [KO:K04223]
101029895  TACR3; neuromedin-K receptor [KO:K04224]
101037534  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
101052026  CCKAR; cholecystokinin receptor type A [KO:K04194]
101052300  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
101042221  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101051855  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101032578  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
101042720  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
101030896  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
101052478  EGF; pro-epidermal growth factor [KO:K04357]
101045311  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
101034511  PDGFA; platelet-derived growth factor subunit A isoform X6 [KO:K04359]
101043776  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
101038849  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
101049234  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101040924  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101030554  FGF2; fibroblast growth factor 2 [KO:K18497]
101048161  FGF8; fibroblast growth factor 8 [KO:K04358]
101040388  FGF20; fibroblast growth factor 20 [KO:K04358]
101040926  FGF17; fibroblast growth factor 17 isoform X2 [KO:K04358]
101047221  FGF4; fibroblast growth factor 4 [KO:K04358]
101046667  FGF18; fibroblast growth factor 18 [KO:K04358]
101046606  FGF10; fibroblast growth factor 10 [KO:K04358]
101042449  FGF3; fibroblast growth factor 3 [KO:K04358]
101048187  FGF6; fibroblast growth factor 6 [KO:K04358]
101052821  FGF9; fibroblast growth factor 9 [KO:K04358]
101031255  FGF7; fibroblast growth factor 7 [KO:K04358]
101050264  FGF16; fibroblast growth factor 16 [KO:K04358]
101031426  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101047544  FGF19; fibroblast growth factor 19 [KO:K22603]
101048392  FGF21; fibroblast growth factor 21 [KO:K22429]
101048503  FGF23; fibroblast growth factor 23 [KO:K22428]
101032691  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
101028762  VEGFB; vascular endothelial growth factor B [KO:K16858]
101044650  FIGF; vascular endothelial growth factor D isoform X1 [KO:K05449]
101048128  VEGFC; vascular endothelial growth factor C [KO:K05449]
101038561  NGF; beta-nerve growth factor [KO:K02582]
101045517  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101047182  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
101037236  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101047461  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101043415  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X2 [KO:K05083] [EC:2.7.10.1]
101030064  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101049355  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
101040156  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
101040158  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101033213  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101033845  FGFR2; fibroblast growth factor receptor 2 isoform X11 [KO:K05093] [EC:2.7.10.1]
101051421  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101027585  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101053773  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101033672  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
101036336  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101035626  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
101053284  NTRK2; BDNF/NT-3 growth factors receptor isoform X2 [KO:K04360] [EC:2.7.10.1]
101048153  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
101038696  MET; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
101044314  MST1R; macrophage-stimulating protein receptor isoform X2 [KO:K05100] [EC:2.7.10.1]
101053966  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101031681  uncharacterized protein LOC101031681 [KO:K10785]
101040997  LOW QUALITY PROTEIN: putative V-set and immunoglobulin domain-containing protein 7 [KO:K06856]
101054381  putative V-set and immunoglobulin domain-containing-like protein IGHV1OR21-1 [KO:K06856]
101033685  uncharacterized protein LOC101033685 [KO:K06856]
101041646  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
101053112  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2 [KO:K05857] [EC:3.1.4.11]
101030401  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
101045153  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
101046851  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
101047168  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
101052271  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101029401  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101046976  PLCG1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101030999  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101043700  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
101050254  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
101029556  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101049881  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101048916  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101036203  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
101040801  TPCN1; two pore calcium channel protein 1 [KO:K16896]
101043722  TPCN2; two pore calcium channel protein 2 [KO:K14077]
101031418  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
101044222  MCOLN2; mucolipin-2 isoform X2 [KO:K04993]
101043691  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
101029043  SPHK1; sphingosine kinase 1 isoform X3 [KO:K04718] [EC:2.7.1.91]
101044895  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
101031167  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
101031406  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
104649961  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
101038914  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101045138  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101034520  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101037746  LOW QUALITY PROTEIN: ADP/ATP translocase 3-like [KO:K05863]
101030497  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
101048239  LOW QUALITY PROTEIN: ADP/ATP translocase 3-like [KO:K05863]
101039411  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101043018  SLC25A4; LOW QUALITY PROTEIN: ADP/ATP translocase 1 [KO:K05863]
101036833  ADP/ATP translocase 3 [KO:K05863]
101032370  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101050687  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
101031098  TNNC2; troponin C, skeletal muscle [KO:K12042]
101036413  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101031785  calmodulin-alpha-like [KO:K02183]
101041174  CALML6; calmodulin-like protein 6 isoform X2 [KO:K02183]
101029957  CALM3; calmodulin [KO:K02183]
101047982  CALM2; calmodulin [KO:K02183]
101039332  CALML3; calmodulin-like protein 3 [KO:K02183]
101039863  CALML5; calmodulin-like protein 5 [KO:K02183]
101049022  CALM1; LOW QUALITY PROTEIN: calmodulin [KO:K02183]
101045885  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
101048522  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
101039573  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X2 [KO:K07190]
101052401  PHKB; phosphorylase b kinase regulatory subunit beta isoform X2 [KO:K07190]
101054139  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X2 [KO:K07190]
101038668  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101049056  MYLK4; myosin light chain kinase family member 4 isoform X2 [KO:K00907] [EC:2.7.11.18]
101050910  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
101029220  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
101042674  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X2 [KO:K08794] [EC:2.7.11.17]
101041865  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X2 [KO:K08794] [EC:2.7.11.17]
101042068  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
101031635  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101041452  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101052251  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
101041781  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II delta chain-like [KO:K04515] [EC:2.7.11.17]
101038342  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X10 [KO:K04515] [EC:2.7.11.17]
101053463  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101045514  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101035788  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101032266  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101039659  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
104650539  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101046155  TFEB; transcription factor EB [KO:K15590]
101049490  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101040060  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101043069  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101034544  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
101041016  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
101034220  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
101045533  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
101037516  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2 [KO:K13755] [EC:3.1.4.17]
101044880  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
101032561  PTK2B; protein-tyrosine kinase 2-beta isoform X2 [KO:K05871] [EC:2.7.10.2]
101030634  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
101030447  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
101041209  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
101046010  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101039384  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101032613  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
sbq04010  MAPK signaling pathway
sbq04070  Phosphatidylinositol signaling system
sbq04210  Apoptosis
sbq04720  Long-term potentiation
sbq04730  Long-term depression
KO pathway
ko04020   
LinkDB

DBGET integrated database retrieval system