KEGG   PATHWAY: schu05132
Entry
schu05132                   Pathway                                
Name
Salmonella infection - Siniperca chuatsi (mandarin fish)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
schu05132  Salmonella infection
schu05132

Organism
Siniperca chuatsi (mandarin fish) [GN:schu]
Gene
122877202  ptprc; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
122864828  ras-related protein Rab-5A isoform X1 [KO:K07887]
122881230  ras-related protein Rab-5A-like isoform X1 [KO:K07887]
122885763  rab5b; ras-related protein Rab-5B [KO:K07888]
122868951  rab5c; ras-related protein Rab-5C [KO:K07889]
122867179  ras-related protein Rab-5C-like [KO:K07889]
122870475  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
122888759  ras-related protein rab7 [KO:K07897]
122866819  ras-related protein rab7-like [KO:K07897]
122867470  plekhm1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282]
122888337  vps11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
122871913  vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
122863706  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
122876652  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
122861726  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
122866372  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
122879431  RILP-like protein 1 isoform X1 [KO:K13883]
122861743  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
122879450  cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
122863970  cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
122885521  dync1i2a; dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415]
122886816  dynein, cytoplasmic 1, intermediate chain 2a-like isoform X1 [KO:K10415]
122863952  dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
122880633  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
122884051  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
122875691  dynll1; dynein light chain 1, cytoplasmic [KO:K10418]
122888226  dynll2b; dynein, light chain, LC8-type 2b isoform X1 [KO:K10418]
122879234  dynll2a; dynein, light chain, LC8-type 2a [KO:K10418]
122869826  dynlrb1; dynein light chain roadblock-type 1 [KO:K10419]
122875019  dynein light chain roadblock-type 2 isoform X1 [KO:K10419]
122862782  dynlt1b; dynein light chain Tctex-type 1 [KO:K10420]
122871827  dynein light chain Tctex-type 1-like [KO:K10420]
122885627  dynein light chain Tctex-type 3-like [KO:K10420]
122869977  dynactin subunit 1-like isoform X1 [KO:K04648]
122861850  dctn1b; dynactin subunit 1 isoform X1 [KO:K04648]
122863369  dctn2; dynactin subunit 2 isoform X1 [KO:K10424]
122882278  dctn3; dynactin subunit 3 [KO:K10425]
122880822  dctn4; dynactin subunit 4 isoform X1 [KO:K10426]
122870598  dynactin subunit 6-like [KO:K10428]
122873193  dynactin subunit 6-like [KO:K10428]
122865463  actr1b; actin related protein 1B [KO:K16575]
122863625  actr10; actin-related protein 10 isoform X1 [KO:K16576]
122882529  tuba1c; tubulin alpha-1C chain [KO:K07374]
122882530  tuba1a; LOW QUALITY PROTEIN: tubulin alpha-1A chain [KO:K07374]
122882531  tubulin alpha chain-like [KO:K07374]
122862820  tubulin alpha-1B chain-like [KO:K07374]
122883627  tuba5; tubulin alpha 5 isoform X1 [KO:K07374]
122883693  tubulin alpha chain [KO:K07374]
122871760  tubulin alpha-4A chain-like [KO:K07374]
122871820  tubulin alpha-1A chain-like [KO:K07374]
122871822  tubulin alpha-1D chain-like [KO:K07374]
122886126  LOW QUALITY PROTEIN: tubulin alpha chain-like [KO:K07374]
122886127  tubulin alpha chain-like [KO:K07374]
122886128  tubulin alpha chain-like [KO:K07374]
122868673  tubb4bl; tubulin beta-4B chain [KO:K07375]
122882051  tubb5; tubulin beta-5 chain isoform X1 [KO:K07375]
122862355  tubulin beta-4B chain [KO:K07375]
122876079  tubb2b; tubulin beta-2b chain [KO:K07375]
122864432  tubulin beta chain-like [KO:K07375]
122873339  tubulin beta-4B chain-like [KO:K07375]
122866501  tubb6; tubulin, beta 6 class V isoform X1 [KO:K07375]
122887410  tubb1; tubulin beta-1 chain isoform X1 [KO:K07375]
122887428  tubulin beta-2A chain isoform X1 [KO:K07375]
122877365  fyco1a; FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954]
122886528  FYVE and coiled-coil domain-containing protein 1-like isoform X1 [KO:K21954]
122862072  arl8bb; ADP-ribosylation factor-like 8Bb isoform X1 [KO:K07955]
122882633  ADP-ribosylation factor-like protein 8A [KO:K07955]
122885404  arl8ba; ADP-ribosylation factor-like protein 8B-A [KO:K07955]
122883555  plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
122882738  kif5aa; kinesin family member 5Aa isoform X1 [KO:K10396]
122872370  kinesin heavy chain-like isoform X1 [KO:K10396]
122885456  kinesin heavy chain-like [KO:K10396]
122885496  kif5ab; kinesin heavy chain isoform X1 [KO:K10396]
122866576  kinesin-1 heavy chain-like [KO:K10396]
122886651  kinesin-1 heavy chain [KO:K10396]
122870657  klc2; kinesin light chain 2 isoform X1 [KO:K10407]
122884478  klc1b; kinesin light chain 1b isoform X1 [KO:K10407]
122879598  klc3; kinesin light chain 3 isoform X1 [KO:K10407]
122861828  klc1a; kinesin light chain 1 isoform X1 [KO:K10407]
122863168  acbd3; Golgi resident protein GCP60 isoform X1 [KO:K23935]
122882438  rho-related GTP-binding protein RhoA-D [KO:K04513]
122882439  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
122883454  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
122883743  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
122884474  transforming protein RhoA [KO:K04513]
122884762  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
122882079  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
122872075  ras-related protein Rab-9A-like [KO:K07899]
122885976  rab9a; ras-related protein Rab-9A [KO:K07899]
122880780  rab9b; ras-related protein Rab-9B [KO:K07900]
122885054  GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
122873440  syntaxin-10 isoform X1 [KO:K23937]
122870316  pfn1; profilin-1 [KO:K05759]
122878355  profilin-2-like isoform X1 [KO:K05759]
122887113  profilin-2-like isoform X1 [KO:K05759]
122883096  flna; filamin-A isoform X1 [KO:K04437]
122867229  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
122861433  exoc5; exocyst complex component 5 [KO:K19984]
122871132  exoc4; exocyst complex component 4 [KO:K06111]
122878336  exoc2; exocyst complex component 2 [KO:K17637]
122866319  ralaa; ras-related protein Ral-A [KO:K07834]
122874135  actb1; actin, cytoplasmic 1 isoform X1 [KO:K05692]
122882174  s100a10b; protein S100-A10b [KO:K17274]
122864869  s100a10a; protein S100-A10a [KO:K17274]
122864090  anxa14; annexin A2 [KO:K17092]
122879695  annexin A2-A-like [KO:K17092]
122874776  annexin A2-A-like [KO:K17092]
122884503  si:ch211-125o16.4; neuroblast differentiation-associated protein AHNAK [KO:K23934]
122873173  si:ch211-69b7.6; neuroblast differentiation-associated protein AHNAK [KO:K23934]
122880282  ahnak; neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934]
122861360  neuroblast differentiation-associated protein AHNAK-like isoform X1 [KO:K23934]
122878682  rho guanine nucleotide exchange factor 26-like [KO:K13744]
122887803  rhogb; ras homolog family member Gb [KO:K07863]
122880185  rhogd; ras homolog gene family, member Gd [KO:K07863]
122864031  elmo1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
122867625  elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
122863432  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
122861382  rock2a; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
122868939  myl2a; myosin regulatory light chain 2a [KO:K10351]
122877065  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
122865321  myosin light chain 5-like [KO:K12753]
122876292  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
122868634  myl9b; myosin regulatory light polypeptide 9b isoform X1 [KO:K12755]
122887948  myosin regulatory light chain 2B, cardiac muscle isoform-like [KO:K12756]
122879673  myosin regulatory light chain 2B, cardiac muscle isoform-like isoform X1 [KO:K12756]
122887654  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
122866922  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
122868798  mylpfa; myosin light chain, phosphorylatable, fast skeletal muscle a isoform X1 [KO:K12758]
122868148  mylpfb; myosin light chain, phosphorylatable, fast skeletal muscle b [KO:K12758]
122881682  fhod1; LOW QUALITY PROTEIN: FH1/FH2 domain-containing protein 1 [KO:K23938]
122870568  si:ch211-63p21.2; FH1/FH2 domain-containing protein 1 [KO:K23938]
122882097  cdc42l; cell division cycle 42, like [KO:K04393]
122883122  cell division control protein 42 homolog isoform X1 [KO:K04393]
122864134  cell division control protein 42 homolog [KO:K04393]
122886115  cell division control protein 42 homolog isoform X1 [KO:K04393]
122869368  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122867758  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
122863259  nckap1l; nck-associated protein 1-like [KO:K05750]
122884136  nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
122877403  cyfip1; cytoplasmic FMR1-interacting protein 1 homolog [KO:K05749]
122880874  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
122867090  abi1a; abl interactor 1a isoform X1 [KO:K23649]
122886458  abi1b; abl interactor 1b isoform X1 [KO:K23649]
122886834  brk1; probable protein BRICK1 [KO:K05752]
122887912  wasf3a; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
122870450  zgc:109889; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
122872879  wiskott-Aldrich syndrome protein family member 3-like isoform X1 [KO:K06083]
122866276  wasf3b; wiskott-Aldrich syndrome protein family member 3b [KO:K06083]
122870457  zgc:101810; actin-related protein 2-B [KO:K17260]
122884155  actin-related protein 2-B isoform X1 [KO:K17260]
122873108  actr2a; actin-related protein 2-A [KO:K17260]
122872416  actin-related protein 3 [KO:K18584]
122885503  actin-related protein 3-like [KO:K18584]
122866483  actr3b; actin-related protein 3B [KO:K18584]
122869565  zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
122874039  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
122874043  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
122872402  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
122866092  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
122888977  actin-related protein 2/3 complex subunit 4 [KO:K05755]
122866812  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
122877694  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
122886441  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
122879337  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
122888494  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
122863119  myo6a; myosin VIa [KO:K10358]
122861731  myo6b; myosin VIb [KO:K10358]
122870088  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
122883224  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122878181  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
122878474  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122886592  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122883270  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
122871431  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
122886139  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923] [EC:2.7.1.154]
122874591  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
122874633  pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [KO:K00923] [EC:2.7.1.154]
122868860  cyth1a; cytohesin-1a isoform X1 [KO:K18441]
122868944  cyth4a; cytohesin-4 isoform X1 [KO:K18441]
122881927  cyth2; cytohesin-2 [KO:K18441]
122869370  cytohesin-3 isoform X1 [KO:K18441]
122871471  cyth4b; cytohesin 4b [KO:K18441]
122867273  cytohesin-1-like isoform X1 [KO:K18441]
122867768  cytohesin-3-like [KO:K18441]
122863635  arf6a; ADP-ribosylation factor 6a [KO:K07941]
122861492  arf6b; ADP-ribosylation factor 6b [KO:K07941]
122868360  arf2a; ADP-ribosylation factor 2a [KO:K07937]
122887599  arf1; ADP-ribosylation factor 1 [KO:K07937]
122867662  arf2b; ADP-ribosylation factor 2b [KO:K07937]
122862806  snx9b; sorting nexin-9b isoform X1 [KO:K17923]
122876879  snx18a; sorting nexin-18a [KO:K17923]
122871940  sorting nexin-9-like [KO:K17923]
122865713  sorting nexin-18-like [KO:K17923]
122875022  snx33; sorting nexin-33 [KO:K17923]
122871000  waslb; LOW QUALITY PROTEIN: WASP like actin nucleation promoting factor b [KO:K23612]
122866810  si:dkey-197j19.6; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
122875003  wasla; LOW QUALITY PROTEIN: WASP like actin nucleation promoting factor a [KO:K23612]
122868658  dnm2a; dynamin-3 isoform X1 [KO:K23484] [EC:3.6.5.5]
122872871  LOW QUALITY PROTEIN: dynamin-2-like [KO:K23484] [EC:3.6.5.5]
122870109  toll-like receptor 2 type-2 [KO:K10159]
122874079  LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
122880368  toll-like receptor 2 isoform X1 [KO:K10159]
122881275  tlr18; toll-like receptor 18 [KO:K10159]
122879586  toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
122866653  myd88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
122863272  toll-like receptor 5 [KO:K10168]
122863659  toll-like receptor 5 isoform X1 [KO:K10168]
122882853  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
122874968  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
122870990  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
122862874  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122861795  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
122871523  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
122863405  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
122877675  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
122883045  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122884588  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
122868207  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
122875692  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
122862269  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
122863348  nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734]
122880708  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122870615  rela; transcription factor p65 isoform X1 [KO:K04735]
122881248  nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
122863300  hsp90ab1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
122863642  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 isoform X1 [KO:K04079]
122874946  hsp90b1; endoplasmin [KO:K09487]
122886258  ripk2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
122888646  cse1l; exportin-2 [KO:K18423]
122866301  kpna1; importin subunit alpha-5 [KO:K23940]
122878739  kpna4; importin subunit alpha-3 [KO:K23583]
122885888  kpna3; importin subunit alpha-4 [KO:K23583]
122878881  rps3; 40S ribosomal protein S3 [KO:K02985]
122875107  GTPase HRas [KO:K02833]
122883572  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
122875138  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122877476  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
122886281  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
122876093  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122868911  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
122867604  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
122868217  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
122882679  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
122883274  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
122883528  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
122871338  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122871339  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
122874303  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
122868882  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
122867152  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
122870668  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122883942  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122865666  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122880393  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122867451  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122862302  fosaa; proto-oncogene c-Fos isoform X1 [KO:K04379]
122862755  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
122862756  si:ch211-153j24.3; proto-oncogene c-Fos [KO:K04379]
122887568  transcription factor AP-1-like isoform X1 [KO:K04448]
122878280  jun; transcription factor AP-1 [KO:K04448]
122865896  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
122864206  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
122876711  interleukin-1 beta-like [KO:K04519]
122864664  interleukin-6-like [KO:K05405]
122870413  cxcl19; C-X-C motif chemokine 19 [KO:K10030]
122873767  interleukin-8-like [KO:K10030]
122863950  catenin beta-1-like [KO:K02105]
122880991  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
122888511  tcf7; transcription factor 7 isoform X1 [KO:K02620]
122876664  tcf7l1b; transcription factor 7-like 1-B isoform X1 [KO:K04490]
122865509  transcription factor 7-like 1-B isoform X1 [KO:K04490]
122867452  tcf7l2; LOW QUALITY PROTEIN: transcription factor 7-like 2 [KO:K04491]
122872868  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
122866331  myca; transcriptional regulator Myc-A isoform X1 [KO:K04377]
122886971  transcriptional regulator Myc-2-like isoform X1 [KO:K04377]
122869454  serine/threonine-protein kinase N1-like isoform X1 [KO:K06071] [EC:2.7.11.13]
122874036  pkn1a; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
122873719  fbxo22; F-box only protein 22 [KO:K10302]
122888513  skp1; S-phase kinase-associated protein 1 [KO:K03094]
122882056  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
122883787  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
122876306  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
122865199  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
122865536  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
122875669  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
122888220  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
122887413  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
122882069  gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
122864489  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
122861996  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
122866216  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
122876352  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
122865611  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
122876412  fadd; protein FADD [KO:K02373]
122885921  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
122886611  casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
122886613  caspase-8-like [KO:K04398] [EC:3.4.22.61]
122875537  ankyrin repeat and protein kinase domain-containing protein 1-like isoform X1 [KO:K08847] [EC:2.7.11.1]
122869766  ripk3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
122868367  apoptosis regulator BAX-like [KO:K02159]
122876431  zgc:153993; apoptosis regulator BAX [KO:K02159]
122862992  apoptosis regulator BAX-like isoform X1 [KO:K02159]
122884087  cytochrome c-like [KO:K08738]
122884088  cytochrome c [KO:K08738]
122885212  cytochrome c-like [KO:K08738]
122866503  apoptosis regulator Bcl-2-like [KO:K02161]
122887137  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
122873701  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
122879777  caspase-3-like [KO:K02187] [EC:3.4.22.56]
122865138  caspase-7-like isoform X1 [KO:K04397] [EC:3.4.22.60]
122865510  caspase-3-like [KO:K04397] [EC:3.4.22.60]
122867206  casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
122863444  rho-related GTP-binding protein RhoB [KO:K07856]
122873860  rhoh; rho-related GTP-binding protein RhoH [KO:K07873]
122888423  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
122878451  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122884935  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122873144  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122861346  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122875153  mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
122869448  txn2; thioredoxin, mitochondrial isoform X1 [KO:K03671]
122870018  txn; thioredoxin [KO:K03671]
122881738  pycard; apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
122879677  caspase a-like isoform X1 [KO:K01370] [EC:3.4.22.36]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
schu04010  MAPK signaling pathway
schu04210  Apoptosis
schu04217  Necroptosis
schu04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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