KEGG   PATHWAY: shr04020
Entry
shr04020                    Pathway                                
Name
Calcium signaling pathway - Sarcophilus harrisii (Tasmanian devil)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
shr04020  Calcium signaling pathway
shr04020

Other DBs
GO: 0019722
Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100914566  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
100916944  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
100930572  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
100922398  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X3 [KO:K05850] [EC:7.2.2.10]
100921801  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
100926374  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
100930479  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
100914244  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X3 [KO:K05850] [EC:7.2.2.10]
100919191  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100916387  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
100916942  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
116420902  ADORA2A; adenosine receptor A2a [KO:K04266]
100913531  ADORA2B; adenosine receptor A2b [KO:K04267]
116421895  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100928854  ADRB2; beta-2 adrenergic receptor [KO:K04142]
100935351  ADRB3; beta-3 adrenergic receptor [KO:K04143]
100928335  DRD1; D(1A) dopamine receptor [KO:K04144]
100920062  DRD5; D(1B) dopamine receptor [KO:K05840]
100933003  HRH2; histamine H2 receptor [KO:K04150]
100931189  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
100927922  5-hydroxytryptamine receptor 5B [KO:K04161]
116419427  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
105750230  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
100923811  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
100930666  GNAS; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
100931638  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
100922193  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100922434  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100925657  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100920243  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100929278  ADCY7; adenylate cyclase type 7 isoform X3 [KO:K08047] [EC:4.6.1.1]
100923926  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100926025  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100929360  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100915481  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100934183  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
100913731  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
100921965  PLN; cardiac phospholamban [KO:K05852]
100927763  SLN; sarcolipin [KO:K22642]
100915439  C6H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
100918964  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
105750215  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
100922099  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
111720266  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
100935384  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
100927031  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
111719559  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
100927278  ORAI2; protein orai-2 [KO:K16057]
100929039  ORAI3; protein orai-3 [KO:K16058]
100926503  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
100919750  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100927554  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100917433  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100925240  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
100933192  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100915867  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X6 [KO:K04852]
100921267  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
100934677  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
100916832  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
100930913  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
100922600  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X3 [KO:K05208]
100920008  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100926323  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100922827  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
111720153  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100923411  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
100931204  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
100930241  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
100929173  P2RX3; P2X purinoceptor 3 [KO:K05217]
100923139  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
100923604  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
105749675  P2RX6; P2X purinoceptor 6 [KO:K05221]
100922617  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
100922880  P2X purinoceptor 7 [KO:K05220]
100916717  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
100916914  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
100919981  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
100918037  triadin isoform X1 [KO:K23449]
100913866  CASQ1; calsequestrin-1 isoform X1 [KO:K23468]
100930799  CASQ2; calsequestrin-2 [KO:K23445]
100923835  aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
100913557  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
100913672  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
100925629  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100931456  ADRA1A; alpha-1A adrenergic receptor isoform X2 [KO:K04135]
100933002  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
100927259  AGTR1; type-1 angiotensin II receptor [KO:K04166]
100918230  EDNRA; endothelin-1 receptor [KO:K04197]
100931399  EDNRB; endothelin receptor type B [KO:K04198]
100934757  F2R; proteinase-activated receptor 1 [KO:K03914]
100919608  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
100913241  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
100914557  GRPR; gastrin-releasing peptide receptor [KO:K04169]
100927238  HRH1; histamine H1 receptor [KO:K04149]
100916548  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
100925360  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
100923468  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
100918852  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
100921214  NTSR1; neurotensin receptor type 1 [KO:K04211]
100928438  OXTR; oxytocin receptor [KO:K04229]
100915619  AVPR1A; vasopressin V1a receptor [KO:K04226]
100916913  AVPR1B; vasopressin V1b receptor isoform X2 [KO:K04227]
100919719  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
100914118  PTAFR; platelet-activating factor receptor [KO:K04279]
100921047  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
116423723  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
100928989  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
100917896  BDKRB1; B1 bradykinin receptor [KO:K03915]
100918161  BDKRB2; B2 bradykinin receptor [KO:K03916]
100932058  TACR1; substance-P receptor [KO:K04222]
100913896  TACR3; neuromedin-K receptor [KO:K04224]
100918784  TBXA2R; thromboxane A2 receptor [KO:K04264]
100913207  thyrotropin-releasing hormone receptor-like [KO:K04282]
100931976  thyrotropin-releasing hormone receptor-like [KO:K04282]
100916623  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
100930299  CCKAR; cholecystokinin receptor type A [KO:K04194]
100916108  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
100934336  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
100916183  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100920179  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100915922  guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
100918864  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
100933169  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100928770  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
100924985  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116422035  platelet-derived growth factor subunit A-like [KO:K04359]
100917875  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
100928148  PDGFC; platelet-derived growth factor C [KO:K05450]
100916102  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100929695  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
100934542  FGF2; fibroblast growth factor 2 [KO:K18497]
100923118  FGF18; fibroblast growth factor 18 [KO:K04358]
100925286  FGF20; fibroblast growth factor 20 [KO:K04358]
100928224  FGF5; fibroblast growth factor 5 [KO:K04358]
100934722  FGF6; fibroblast growth factor 6 [KO:K04358]
100921812  FGF4; fibroblast growth factor 4 [KO:K04358]
100922075  FGF3; fibroblast growth factor 3 [KO:K04358]
100925381  FGF8; fibroblast growth factor 8 isoform X3 [KO:K04358]
100925383  FGF7; fibroblast growth factor 7 [KO:K04358]
100932059  FGF17; fibroblast growth factor 17 [KO:K04358]
100934743  FGF16; fibroblast growth factor 16 [KO:K04358]
100915656  FGF22; fibroblast growth factor 22 [KO:K04358]
100920456  FGF9; fibroblast growth factor 9 [KO:K04358]
116423189  FGF10; fibroblast growth factor 10 [KO:K04358]
100916676  FGF19; fibroblast growth factor 19 [KO:K22603]
100931317  FGF21; fibroblast growth factor 21 [KO:K22429]
100914586  FGF23; fibroblast growth factor 23 [KO:K22428]
100913423  VEGFA; vascular endothelial growth factor A [KO:K05448]
100922413  VEGFB; vascular endothelial growth factor B [KO:K16858]
100918372  VEGFD; vascular endothelial growth factor D [KO:K05449]
100928742  VEGFC; vascular endothelial growth factor C [KO:K05449]
100930279  NGF; beta-nerve growth factor [KO:K02582]
100915696  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100934331  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
100932324  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
100914017  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100914727  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100924586  receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100931663  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
100925116  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
100917212  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100914347  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100932215  FGFR2; fibroblast growth factor receptor 2 isoform X4 [KO:K05093] [EC:2.7.10.1]
100913979  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100919819  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100930426  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
111721579  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
100932306  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
100929091  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100916388  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100927322  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100926082  NTRK3; NT-3 growth factor receptor isoform X2 [KO:K05101] [EC:2.7.10.1]
100917007  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
100913662  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
100927200  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100918091  uncharacterized protein LOC100918091 [KO:K06856]
100935579  Ig heavy chain V region 914 [KO:K06856]
100925503  Ig heavy chain Mem5 isoform X1 [KO:K06856]
100916816  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
100933386  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
100919591  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X2 [KO:K05857] [EC:3.1.4.11]
100922938  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100934049  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100934311  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100929015  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100923119  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100919206  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
100917022  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
116419277  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
100918532  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X7 [KO:K04958]
100921270  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100916996  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X2 [KO:K04960]
105751033  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
100926196  TPCN1; two pore calcium channel protein 1 isoform X3 [KO:K16896]
100921551  TPCN2; two pore calcium channel protein 2 [KO:K14077]
100928178  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
100932791  MCOLN2; mucolipin-2 [KO:K04993]
100915340  MCOLN3; mucolipin-3 [KO:K04994]
100914991  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
100933142  SPHK2; LOW QUALITY PROTEIN: sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
100913360  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
100927813  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100920408  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100923123  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
100920060  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100929945  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
116422319  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100925120  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
111719477  TNNC1; troponin C, slow skeletal and cardiac muscles isoform X1 [KO:K05865]
100914874  TNNC2; troponin C, skeletal muscle [KO:K12042]
100929017  CALM1; calmodulin-1 isoform X2 [KO:K02183]
100920429  CALM2; calmodulin-2 [KO:K02183]
105750699  calmodulin-A [KO:K02183]
100935134  CALM3; calmodulin-3 isoform X1 [KO:K02183]
100925046  CALML4; calmodulin-like protein 4 [KO:K02183]
116419081  calmodulin [KO:K02183]
116423459  calmodulin-like [KO:K02183]
116423460  calmodulin-like [KO:K02183]
100920220  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
100927663  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
100922305  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
100923997  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
100926705  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
100918090  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
100925131  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
100922469  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X2 [KO:K08794] [EC:2.7.11.17]
100927184  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
100929212  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
100934917  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100916233  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100913975  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
100918427  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100920792  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
100917281  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100915297  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
100918408  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100918689  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
100919073  TFEB; transcription factor EB [KO:K15590]
100926364  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100920251  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
100917473  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100920502  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
100921140  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
100927789  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100913437  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100924108  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
100926211  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
100920837  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
100923387  PTK2B; protein-tyrosine kinase 2-beta isoform X2 [KO:K05871] [EC:2.7.10.2]
100935263  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
100915595  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
100928977  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
100913337  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100924022  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100935225  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
shr04010  MAPK signaling pathway
shr04070  Phosphatidylinositol signaling system
shr04210  Apoptosis
shr04720  Long-term potentiation
shr04730  Long-term depression
KO pathway
ko04020   
LinkDB

DBGET integrated database retrieval system