KEGG   PATHWAY: shr04530
Entry
shr04530                    Pathway                                
Name
Tight junction - Sarcophilus harrisii (Tasmanian devil)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
shr04530  Tight junction
shr04530

Other DBs
GO: 0005923
Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100933372  CRB3; protein crumbs homolog 3 [KO:K06090]
100923112  protein crumbs homolog 3-like isoform X3 [KO:K06090]
105749987  CLDN34; claudin-34 [KO:K06087]
100917763  CLDN10; claudin-10 isoform X1 [KO:K06087]
100929293  CLDN6; claudin-6 [KO:K06087]
100919092  CLDN23; claudin-23 [KO:K06087]
100923805  putative claudin-24 [KO:K06087]
100926163  claudin-22 [KO:K06087]
100914548  CLDN25; putative claudin-25 [KO:K06087]
100917543  CLDN2; claudin-2 [KO:K06087]
100933653  CLDN1; claudin-1 [KO:K06087]
100929550  CLDN9; claudin-9 [KO:K06087]
100931651  CLDN14; claudin-14 [KO:K06087]
100932176  CLDN17; claudin-17 [KO:K06087]
100926734  CLDN18; claudin-18 [KO:K06087]
105750643  CLDN15; claudin-15 [KO:K06087]
100933398  CLDN19; claudin-19 [KO:K06087]
100914556  claudin-16-like isoform X3 [KO:K06087]
100917327  claudin-10 [KO:K06087]
100929412  CLDN7; claudin-7 [KO:K06087]
100917778  CLDN20; claudin-20 [KO:K06087]
100924917  CLDN11; claudin-11 [KO:K06087]
100917588  CLDN16; claudin-16 isoform X1 [KO:K06087]
100920747  CLDN12; claudin-12 [KO:K06087]
116420868  CLDN5; claudin-5 [KO:K06087]
116423477  CLDN4; claudin-4 [KO:K06087]
116423479  CLDN3; claudin-3 [KO:K06087]
100925944  occludin isoform X1 [KO:K06088]
100921400  OCLN; occludin [KO:K06088]
100920907  F11R; junctional adhesion molecule A [KO:K06089]
100916278  JAM2; junctional adhesion molecule B [KO:K06735]
100934598  JAM3; junctional adhesion molecule C isoform X1 [KO:K06785]
100933664  BVES; blood vessel epicardial substance isoform X1 [KO:K21108]
100918370  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100927657  PARD6G; partitioning defective 6 homolog gamma isoform X1 [KO:K06093]
100913302  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
100917902  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
116423715  LOW QUALITY PROTEIN: partitioning defective 6 homolog gamma-like [KO:K06093]
100920505  MPP5; MAGUK p55 subfamily member 5 [KO:K06091]
100926826  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
100915046  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
100919857  PATJ; inaD-like protein isoform X1 [KO:K06092]
100933466  MPDZ; multiple PDZ domain protein isoform X14 [KO:K06095]
100916377  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
100925605  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
100923995  AMOT; angiomotin isoform X1 [KO:K16819]
100918880  AMOTL1; angiomotin-like protein 1 isoform X2 [KO:K06104]
100923151  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
100931648  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
100919657  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100915840  NF2; merlin isoform X1 [KO:K16684]
100917518  merlin-like isoform X1 [KO:K16684]
100927347  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
100921321  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
100924037  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
100919917  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
100921980  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100927043  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100932648  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
100922551  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
100927161  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100931978  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
100935274  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100922930  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
100933266  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3 [KO:K04354]
100914747  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100920711  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100924427  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
100926925  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
100922041  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
100930826  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
100916239  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
100925489  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X6 [KO:K13305] [EC:2.3.2.26]
100931770  CGN; cingulin isoform X1 [KO:K06102]
100913985  CGNL1; cingulin-like protein 1 [KO:K21110]
100933486  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X8 [KO:K12791]
100921931  RHOA; transforming protein RhoA [KO:K04513]
100921034  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
100928419  MARVELD3; MARVEL domain-containing protein 3 [KO:K21099]
100913571  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X2 [KO:K04416] [EC:2.7.11.25]
100930815  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100928480  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100924267  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116423739  JUN; transcription factor AP-1 [KO:K04448]
100928203  antigen-presenting glycoprotein CD1d [KO:K06448]
100919086  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
100932899  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100931940  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
100930611  SYMPK; symplekin isoform X1 [KO:K06100]
100924873  PCNA; proliferating cell nuclear antigen [KO:K04802]
100917462  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100914727  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100921236  RUNX1; runt-related transcription factor 1 [KO:K08367]
100915725  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
100923352  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X1 [KO:K13365]
100921438  EZR; ezrin [KO:K08007]
100924383  RDX; radixin isoform X1 [KO:K05762]
100920767  MSN; moesin [KO:K05763]
100921656  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
100928302  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100923807  actin, cytoplasmic type 5 [KO:K05692]
100919051  ACTB; actin, cytoplasmic 1 [KO:K05692]
100916712  LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
100919750  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100917439  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100926110  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100926529  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
100919804  CTTN; src substrate cortactin isoform X1 [KO:K06106]
100925593  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
100928345  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
100920835  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
100928704  ACTR3; actin-related protein 3 [KO:K18584]
100922101  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
100924548  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
100921689  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X2 [KO:K05758]
100921837  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
116421787  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
100922309  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
100921388  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
100913192  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
100934222  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
100931658  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100929360  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100915481  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100934183  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
100913731  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
100916293  RAB13; ras-related protein Rab-13 isoform X1 [KO:K06109]
100929463  rho guanine nucleotide exchange factor 18 [KO:K21066]
100916611  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
100916865  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100917142  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100915485  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
100927576  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
100926139  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
100928944  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
100919221  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
105750525  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
100918024  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
100919530  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
100927282  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
100918032  MYH10; myosin-10 isoform X1 [KO:K10352]
100933421  MYH9; myosin-9 [KO:K10352]
100929982  MYH11; myosin-11 isoform X2 [KO:K10352]
100923799  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
100918747  MYL6B; myosin light chain 6B [KO:K12751]
100917897  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100920097  myosin regulatory light chain 12B [KO:K12757]
100919651  myosin regulatory light polypeptide 9 isoform X2 [KO:K12757]
100928183  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
100917989  SYNPO; synaptopodin [KO:K21112]
100917501  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
100924961  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
100932505  MICALL2; MICAL-like protein 2 [KO:K21068]
100935197  RAB8A; LOW QUALITY PROTEIN: ras-related protein Rab-8A [KO:K07901]
100933086  RAB8B; ras-related protein Rab-8B [KO:K07902]
100931445  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
100935403  RAP1A; ras-related protein Rap-1A isoform X2 [KO:K04353]
100913968  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100934446  AFDN; afadin isoform X1 [KO:K05702]
100925154  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
100923893  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X3 [KO:K08018]
100922336  RAP2C; ras-related protein Rap-2c [KO:K07839]
100918087  MARVELD2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
100932522  tubulin alpha-1D chain isoform X2 [KO:K07374]
100932786  tubulin alpha-4A chain [KO:K07374]
100920562  tubulin alpha-8 chain [KO:K07374]
100914278  LOW QUALITY PROTEIN: tubulin alpha chain [KO:K07374]
100923972  TUBA1C; tubulin alpha-1C chain [KO:K07374]
100927621  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
105750812  LOW QUALITY PROTEIN: tubulin alpha-1A chain [KO:K07374]
100920490  tubulin alpha-1A chain [KO:K07374]
100923223  tubulin alpha-1C chain-like [KO:K07374]
116420883  tubulin alpha-3 chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
shr04520  Adherens junction
shr04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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