KEGG   PATHWAY: tmu05208
Entry
tmu05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Trichechus manatus latirostris (Florida manatee)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
tmu05208  Chemical carcinogenesis - reactive oxygen species
tmu05208

Organism
Trichechus manatus latirostris (Florida manatee) [GN:tmu]
Gene
101356087  arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
101361989  glutathione S-transferase omega-1 isoform X2 [KO:K00799] [EC:2.5.1.18]
101340607  glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
101340888  LOW QUALITY PROTEIN: microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
101345400  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
101349477  LOW QUALITY PROTEIN: glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
101344077  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101344746  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101344569  microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
101348971  glutathione S-transferase theta-2B-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101360022  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
101360282  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
101340258  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
101340508  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
101358030  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101360033  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
101354972  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
101344502  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101357584  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
101349230  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
101349733  LOW QUALITY PROTEIN: glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
101342189  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
101344328  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X2 [KO:K03943] [EC:7.1.1.2]
101352739  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X2 [KO:K03944]
111821539  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
111821167  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101347434  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
101356399  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
101341663  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
101356177  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101362071  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
101342417  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
101351585  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101352289  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101347207  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
101355425  acyl carrier protein, mitochondrial [KO:K03955]
101353746  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101343020  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
111822042  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
101361940  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
101345814  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
101343512  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101348161  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101347019  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
101361585  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
101350430  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101342802  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
101348157  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
101356612  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101355955  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101354085  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
101348326  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101355560  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101349133  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
101357778  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101340730  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101347171  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
101341003  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
101346167  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101345302  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101357812  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X2 [KO:K00234] [EC:1.3.5.1]
101353562  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101346550  succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
101348027  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
101349349  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
101359231  cytochrome c1, heme protein, mitochondrial [KO:K00413]
101350351  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
101350954  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101349519  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
101359862  cytochrome b-c1 complex subunit 7 [KO:K00417]
101353511  cytochrome b-c1 complex subunit 8 [KO:K00418]
101358587  cytochrome b-c1 complex subunit 9 [KO:K00419]
101352977  cytochrome b-c1 complex subunit 10 [KO:K00420]
101346963  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
101351241  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
101357118  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
101343047  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101358698  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
101358762  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
101357728  cytochrome c oxidase subunit 6B2 [KO:K02267]
101349067  cytochrome c oxidase subunit 6B1 [KO:K02267]
101354643  cytochrome c oxidase subunit 6C [KO:K02268]
101355564  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
101346028  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
101353725  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
101355622  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
101347679  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
111821449  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
101345533  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
111821885  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
101357898  ATP synthase subunit alpha, mitochondrial [KO:K02132]
101346922  ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101354520  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
101354265  ATP synthase subunit delta, mitochondrial [KO:K02134]
111822811  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
101353320  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101361354  ATP synthase F(0) complex subunit C1, mitochondrial isoform X2 [KO:K02128]
101359449  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101356865  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
101355087  ATP synthase subunit d, mitochondrial [KO:K02138]
101340662  ATP synthase subunit O, mitochondrial isoform X2 [KO:K02137]
101359345  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
101345412  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
105756103  superoxide dismutase [Mn], mitochondrial-like [KO:K04564] [EC:1.15.1.1]
101351096  voltage-dependent anion-selective channel protein 1 [KO:K05862]
101346677  voltage-dependent anion-selective channel protein 2 [KO:K15040]
101351954  voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
101351885  ADP/ATP translocase 3 [KO:K05863]
101350620  ADP/ATP translocase 4 [KO:K05863]
101341492  ADP/ATP translocase 2 [KO:K05863]
101354695  ADP/ATP translocase 1 [KO:K05863]
101361632  peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101341738  LOW QUALITY PROTEIN: superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
101358349  superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
101361987  catalase [KO:K03781] [EC:1.11.1.6]
105756664  sulfate anion transporter 1 [KO:K14700]
101361547  sulfate transporter [KO:K14701]
101342132  solute carrier family 26 member 6 [KO:K14704]
101346476  solute carrier family 26 member 9 [KO:K14706]
101359541  LOW QUALITY PROTEIN: cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
101343596  LOW QUALITY PROTEIN: cytochrome P450 2E1-like [KO:K07415] [EC:1.14.14.-]
101344375  LOW QUALITY PROTEIN: cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
101357107  LOW QUALITY PROTEIN: cytochrome P450 2F1 [KO:K07416] [EC:1.14.14.1]
101359275  cytochrome P450 1A1 isoform X1 [KO:K07408] [EC:1.14.14.1]
101340605  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
101360751  epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
101343713  bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
101356492  epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
101341840  epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
101352511  alcohol dehydrogenase [NADP(+)] [KO:K00002] [EC:1.1.1.2]
101353378  alcohol dehydrogenase [NADP(+)] [KO:K00002] [EC:1.1.1.2]
101342771  aldo-keto reductase family 1 member C3 homolog [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101360332  LOW QUALITY PROTEIN: prostaglandin-E(2) 9-reductase-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101354535  NAD(P)H dehydrogenase [quinone] 1 isoform X1 [KO:K00355] [EC:1.6.5.2]
101361316  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
101351498  aryl hydrocarbon receptor [KO:K09093]
101340636  lactoperoxidase isoform X1 [KO:K12550] [EC:1.11.1.7]
101356942  NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
101355438  cytochrome b-245 light chain isoform X1 [KO:K08009]
101343104  neutrophil cytosol factor 1 isoform X1 [KO:K08011]
101356954  neutrophil cytosol factor 2 [KO:K08010]
101355971  pro-epidermal growth factor [KO:K04357]
101356822  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101344799  hepatocyte growth factor isoform X3 [KO:K05460]
101345595  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101359012  growth factor receptor-bound protein 2 [KO:K04364]
101359592  son of sevenless homolog 1 isoform X1 [KO:K03099]
101347392  son of sevenless homolog 2 isoform X1 [KO:K03099]
101342804  GTPase HRas isoform X2 [KO:K02833]
101347525  GTPase KRas isoform X3 [KO:K07827]
101344230  GTPase NRas isoform X1 [KO:K07828]
101351589  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101353421  serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101357840  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101343332  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101341078  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101340589  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101358526  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101346612  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101349700  dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101346746  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101351734  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101351967  mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
101343546  mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
101352466  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101347350  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101361614  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101361872  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101361653  transcription factor AP-1 [KO:K04448]
101357016  proto-oncogene c-Fos [KO:K04379]
101351035  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101343804  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101347746  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101358678  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101346849  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101359658  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101356054  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101353040  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101360493  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101356099  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101350197  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101354741  forkhead box protein O3 [KO:K09408]
101352047  bcl2-associated agonist of cell death [KO:K02158]
101358370  tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
101355243  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101341290  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101351256  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101347574  NF-kappa-B essential modulator isoform X1 [KO:K07210]
101355353  NF-kappa-B inhibitor alpha [KO:K04734]
101361706  transcription factor p65 [KO:K04735]
101351866  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101355651  protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
101340933  receptor-type tyrosine-protein phosphatase eta-like isoform X1 [KO:K05698] [EC:3.1.3.48]
101340957  low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
101348102  tyrosine-protein phosphatase non-receptor type 11 isoform X2 [KO:K07293] [EC:3.1.3.48]
101342555  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
101341732  tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
101351045  Abelson tyrosine-protein kinase 2 isoform X1 [KO:K08887] [EC:2.7.10.2]
101341622  serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
101341230  serine/threonine-protein kinase D1 isoform X2 [KO:K06070] [EC:2.7.11.13]
101361533  serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
101351714  focal adhesion kinase 1 isoform X2 [KO:K05725] [EC:2.7.10.2]
101343866  phospholipase D2 [KO:K01115] [EC:3.1.4.4]
101358169  phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101343418  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101347136  hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
101340519  aryl hydrocarbon receptor nuclear translocator [KO:K09097]
101341920  vascular endothelial growth factor A [KO:K05448]
101356221  kelch-like ECH-associated protein 1 [KO:K10456]
101356462  nuclear factor erythroid 2-related factor 2 isoform X2 [KO:K05638]
101351050  heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
Reference
PMID:24281075
  Authors
Henkler F, Brinkmann J, Luch A
  Title
The role of oxidative stress in carcinogenesis induced by metals and xenobiotics.
  Journal
Cancers (Basel) 2:376-96 (2010)
DOI:10.3390/cancers2020376
Reference
PMID:22705365
  Authors
Lee JC, Son YO, Pratheeshkumar P, Shi X
  Title
Oxidative stress and metal carcinogenesis.
  Journal
Free Radic Biol Med 53:742-57 (2012)
DOI:10.1016/j.freeradbiomed.2012.06.002
Reference
PMID:32033297
  Authors
Hu Y, Li J, Lou B, Wu R, Wang G, Lu C, Wang H, Pi J, Xu Y
  Title
The Role of Reactive Oxygen Species in Arsenic Toxicity.
  Journal
Biomolecules 10:E240 (2020)
DOI:10.3390/biom10020240
Reference
PMID:33864199
  Authors
Ozturk M, Metin M, Altay V, Bhat RA, Ejaz M, Gul A, Unal BT, Hasanuzzaman M, Nibir L, Nahar K, Bukhari A, Dervash MA, Kawano T
  Title
Arsenic and Human Health: Genotoxicity, Epigenomic Effects, and Cancer Signaling.
  Journal
Biol Trace Elem Res 10.1007/s12011-021-02719-w (2021)
DOI:10.1007/s12011-021-02719-w
Reference
PMID:23510327
  Authors
Hubaux R, Becker-Santos DD, Enfield KS, Rowbotham D, Lam S, Lam WL, Martinez VD
  Title
Molecular features in arsenic-induced lung tumors.
  Journal
Mol Cancer 12:20 (2013)
DOI:10.1186/1476-4598-12-20
Reference
PMID:21648415
  Authors
Naranmandura H, Xu S, Sawata T, Hao WH, Liu H, Bu N, Ogra Y, Lou YJ, Suzuki N
  Title
Mitochondria are the main target organelle for trivalent monomethylarsonous acid (MMA(III))-induced cytotoxicity.
  Journal
Chem Res Toxicol 24:1094-103 (2011)
DOI:10.1021/tx200156k
Reference
PMID:23583964
  Authors
Faita F, Cori L, Bianchi F, Andreassi MG
  Title
Arsenic-induced genotoxicity and genetic susceptibility to arsenic-related pathologies.
  Journal
Int J Environ Res Public Health 10:1527-46 (2013)
DOI:10.3390/ijerph10041527
Reference
PMID:28179585
  Authors
Sage AP, Minatel BC, Ng KW, Stewart GL, Dummer TJB, Lam WL, Martinez VD
  Title
Oncogenomic disruptions in arsenic-induced carcinogenesis.
  Journal
Oncotarget 8:25736-25755 (2017)
DOI:10.18632/oncotarget.15106
Reference
PMID:21414382
  Authors
Jomova K, Valko M
  Title
Advances in metal-induced oxidative stress and human disease.
  Journal
Toxicology 283:65-87 (2011)
DOI:10.1016/j.tox.2011.03.001
Reference
PMID:16430879
  Authors
Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M
  Title
Free radicals, metals and antioxidants in oxidative stress-induced cancer.
  Journal
Chem Biol Interact 160:1-40 (2006)
DOI:10.1016/j.cbi.2005.12.009
Reference
PMID:32731582
  Authors
Tumolo M, Ancona V, De Paola D, Losacco D, Campanale C, Massarelli C, Uricchio VF
  Title
Chromium Pollution in European Water, Sources, Health Risk, and Remediation Strategies: An Overview.
  Journal
Int J Environ Res Public Health 17:E5438 (2020)
DOI:10.3390/ijerph17155438
Reference
PMID:28860815
  Authors
Wang Y, Su H, Gu Y, Song X, Zhao J
  Title
Carcinogenicity of chromium and chemoprevention: a brief update.
  Journal
Onco Targets Ther 10:4065-4079 (2017)
DOI:10.2147/OTT.S139262
Reference
PMID:24820114
  Authors
Jin X, Chen M, Song L, Li H, Li Z
  Title
The evaluation of p,p'-DDT exposure on cell adhesion of hepatocellular carcinoma.
  Journal
Toxicology 322:99-108 (2014)
DOI:10.1016/j.tox.2014.05.002
Reference
PMID:20370557
  Authors
Liou GY, Storz P
  Title
Reactive oxygen species in cancer.
  Journal
Free Radic Res 44:479-96 (2010)
DOI:10.3109/10715761003667554
Reference
PMID:11275476
  Authors
Murata M, Tamura A, Tada M, Kawanishi S
  Title
Mechanism of oxidative DNA damage induced by carcinogenic 4-aminobiphenyl.
  Journal
Free Radic Biol Med 30:765-73 (2001)
DOI:10.1016/S0891-5849(01)00463-4
Reference
PMID:31283132
  Authors
  Title
  Journal
Pentachlorophenol and Some Related Compounds (2019)
Reference
PMID:19408893
  Authors
Zhu BZ, Shan GQ
  Title
Potential mechanism for pentachlorophenol-induced carcinogenicity: a novel mechanism for metal-independent production of hydroxyl radicals.
  Journal
Chem Res Toxicol 22:969-77 (2009)
DOI:10.1021/tx900030v
Reference
PMID:22166497
  Authors
McHale CM, Zhang L, Smith MT
  Title
Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment.
  Journal
Carcinogenesis 33:240-52 (2012)
DOI:10.1093/carcin/bgr297
Reference
PMID:32977499
  Authors
Scharf P, Broering MF, Oliveira da Rocha GH, Farsky SHP
  Title
Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis.
  Journal
Int J Mol Sci 21:E6996 (2020)
DOI:10.3390/ijms21196996
Reference
PMID:23066403
  Authors
Snyder R
  Title
Leukemia and benzene.
  Journal
Int J Environ Res Public Health 9:2875-93 (2012)
DOI:10.3390/ijerph9082875
Reference
PMID:9118888
  Authors
Snyder R, Hedli CC
  Title
An overview of benzene metabolism.
  Journal
Environ Health Perspect 104 Suppl 6:1165-71 (1996)
DOI:10.1289/ehp.961041165
Reference
PMID:11978484
  Authors
Kawanishi S, Hiraku Y, Murata M, Oikawa S
  Title
The role of metals in site-specific DNA damage with reference to carcinogenesis.
  Journal
Free Radic Biol Med 32:822-32 (2002)
DOI:10.1016/S0891-5849(02)00779-7
Reference
PMID:27919191
  Authors
Das DN, Panda PK, Naik PP, Mukhopadhyay S, Sinha N, Bhutia SK
  Title
Phytotherapeutic approach: a new hope for polycyclic aromatic hydrocarbons induced cellular disorders, autophagic and apoptotic cell death.
  Journal
Toxicol Mech Methods 27:1-17 (2017)
DOI:10.1080/15376516.2016.1268228
Reference
PMID:21910479
  Authors
Shultz CA, Quinn AM, Park JH, Harvey RG, Bolton JL, Maser E, Penning TM.
  Title
Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone.
  Journal
Chem Res Toxicol 24:2153-66 (2011)
DOI:10.1021/tx200294c
Reference
PMID:25279998
  Authors
Penning TM
  Title
Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons.
  Journal
Chem Res Toxicol 27:1901-17 (2014)
DOI:10.1021/tx500298n
Reference
PMID:10706104
  Authors
Burczynski ME, Penning TM
  Title
Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor.
  Journal
Cancer Res 60:908-15 (2000)
Reference
PMID:15963346
  Authors
Xue W, Warshawsky D
  Title
Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review.
  Journal
Toxicol Appl Pharmacol 206:73-93 (2005)
DOI:10.1016/j.taap.2004.11.006
Reference
PMID:15142886
  Authors
Chen ZH, Hurh YJ, Na HK, Kim JH, Chun YJ, Kim DH, Kang KS, Cho MH, Surh YJ
  Title
Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells.
  Journal
Carcinogenesis 25:2005-13 (2004)
DOI:10.1093/carcin/bgh183
Reference
PMID:16684662
  Authors
Rifkind AB
  Title
CYP1A in TCDD toxicity and in physiology-with particular reference to CYP dependent arachidonic acid metabolism and other endogenous substrates.
  Journal
Drug Metab Rev 38:291-335 (2006)
DOI:10.1080/03602530600570107
Reference
PMID:9380738
  Authors
Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML, Gooden JK, Ramanathan R, Cerny RL, Rogan EG
  Title
Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.
  Journal
Proc Natl Acad Sci U S A 94:10937-42 (1997)
DOI:10.1073/pnas.94.20.10937
Reference
PMID:9472688
  Authors
Zhu BT, Conney AH
  Title
Functional role of estrogen metabolism in target cells: review and perspectives.
  Journal
Carcinogenesis 19:1-27 (1998)
DOI:10.1093/carcin/19.1.1
Reference
PMID:19387921
  Authors
McKillop IH, Schrum LW
  Title
Role of alcohol in liver carcinogenesis.
  Journal
Semin Liver Dis 29:222-32 (2009)
DOI:10.1055/s-0029-1214377
Reference
PMID:15603755
  Authors
Gonzalez FJ
  Title
Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1.
  Journal
Mutat Res 569:101-10 (2005)
DOI:10.1016/j.mrfmmm.2004.04.021
Reference
PMID:31864052
  Authors
Montalbano AM, Albano GD, Anzalone G, Moscato M, Gagliardo R, Di Sano C, Bonanno A, Ruggieri S, Cibella F, Profita M
  Title
Cytotoxic and genotoxic effects of the flame retardants (PBDE-47, PBDE-99 and PBDE-209) in human bronchial epithelial cells.
  Journal
Chemosphere 245:125600 (2020)
DOI:10.1016/j.chemosphere.2019.125600
Reference
PMID:33907575
  Authors
Sun HN, Ren CX, Gong YX, Xie DP, Kwon T
  Title
Regulatory function of peroxiredoxin I on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer development.
  Journal
Oncol Lett 21:465 (2021)
DOI:10.3892/ol.2021.12726
Reference
PMID:25372613
  Authors
Pluchino LA, Wang HC
  Title
Chronic exposure to combined carcinogens enhances breast cell carcinogenesis with mesenchymal and stem-like cell properties.
  Journal
PLoS One 9:e108698 (2014)
DOI:10.1371/journal.pone.0108698
Reference
PMID:25535943
  Authors
Pluchino LA, Liu AK, Wang HC
  Title
Reactive oxygen species-mediated breast cell carcinogenesis enhanced by multiple carcinogens and intervened by dietary ergosterol and mimosine.
  Journal
Free Radic Biol Med 80:12-26 (2015)
DOI:10.1016/j.freeradbiomed.2014.12.015
Reference
PMID:30327380
  Authors
Moldogazieva NT, Lutsenko SV, Terentiev AA
  Title
Reactive Oxygen and Nitrogen Species-Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy.
  Journal
Cancer Res 78:6040-6047 (2018)
DOI:10.1158/0008-5472.CAN-18-0980
Reference
PMID:32358622
  Authors
Kirtonia A, Sethi G, Garg M
  Title
The multifaceted role of reactive oxygen species in tumorigenesis.
  Journal
Cell Mol Life Sci 77:4459-4483 (2020)
DOI:10.1007/s00018-020-03536-5
Reference
PMID:29449774
  Authors
Kumari S, Badana AK, G MM, G S, Malla R
  Title
Reactive Oxygen Species: A Key Constituent in Cancer Survival.
  Journal
Biomark Insights 13:1177271918755391 (2018)
DOI:10.1177/1177271918755391
Reference
PMID:28881698
  Authors
Gao X, Schottker B
  Title
Reduction-oxidation pathways involved in cancer development: a systematic review of literature reviews.
  Journal
Oncotarget 8:51888-51906 (2017)
DOI:10.18632/oncotarget.17128
Reference
PMID:15769673
  Authors
Storz P
  Title
Reactive oxygen species in tumor progression.
  Journal
Front Biosci 10:1881-96 (2005)
DOI:10.2741/1667
Reference
PMID:28835450
  Authors
Assi M
  Title
The differential role of reactive oxygen species in early and late stages of cancer.
  Journal
Am J Physiol Regul Integr Comp Physiol 313:R646-R653 (2017)
DOI:10.1152/ajpregu.00247.2017
Reference
PMID:15024053
  Authors
Storz P, Doppler H, Toker A
  Title
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling.
  Journal
Mol Cell Biol 24:2614-26 (2004)
DOI:10.1128/MCB.24.7.2614-2626.2004
Reference
PMID:24998536
  Authors
Nourazarian AR, Kangari P, Salmaninejad A
  Title
Roles of oxidative stress in the development and progression of breast cancer.
  Journal
Asian Pac J Cancer Prev 15:4745-51 (2014)
DOI:10.7314/apjcp.2014.15.12.4745
Reference
PMID:32336668
  Authors
Zheng F, Goncalves FM, Abiko Y, Li H, Kumagai Y, Aschner M
  Title
Redox toxicology of environmental chemicals causing oxidative stress.
  Journal
Redox Biol 34:101475 (2020)
DOI:10.1016/j.redox.2020.101475
Related
pathway
tmu00190  Oxidative phosphorylation
tmu00980  Metabolism of xenobiotics by cytochrome P450
tmu04010  MAPK signaling pathway
tmu04064  NF-kappa B signaling pathway
tmu04066  HIF-1 signaling pathway
tmu04151  PI3K-Akt signaling pathway
tmu04370  VEGF signaling pathway
tmu05207  Chemical carcinogenesis - receptor activation
tmu05211  Renal cell carcinoma
tmu05215  Prostate cancer
tmu05219  Bladder cancer
tmu05221  Acute myeloid leukemia
tmu05222  Small cell lung cancer
tmu05223  Non-small cell lung cancer
tmu05224  Breast cancer
tmu05225  Hepatocellular carcinoma
KO pathway
ko05208   
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