KEGG   PATHWAY: tru04530
Entry
tru04530                    Pathway                                
Name
Tight junction - Takifugu rubripes (torafugu)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
tru04530  Tight junction
tru04530

Other DBs
GO: 0005923
Organism
Takifugu rubripes (torafugu) [GN:tru]
Gene
105416459  crb3; protein crumbs homolog 3 [KO:K06090]
101067187  cldn34; claudin-34 [KO:K06087]
105418062  cldn20; claudin-20 [KO:K06087]
101074489  claudin-10 [KO:K06087]
101064239  cldn32a; claudin-4 [KO:K06087]
101062178  cldn15; claudin-15 [KO:K06087]
101068746  cldn31; claudin-4 [KO:K06087]
101072386  cldn5b; claudin-5 [KO:K06087]
105416804  putative claudin-24 [KO:K06087]
101077835  claudin-10-like [KO:K06087]
101063270  claudin-10 isoform X2 [KO:K06087]
101078063  claudin-10 [KO:K06087]
101065049  claudin-11 [KO:K06087]
101072996  claudin-10 [KO:K06087]
101073215  claudin-10 isoform X2 [KO:K06087]
105418560  claudin-23 [KO:K06087]
101061109  claudin-23 [KO:K06087]
101074578  cldn27b; claudin-4 [KO:K06087]
101075528  cldn28a; claudin-4 [KO:K06087]
101074797  claudin-4 isoform X2 [KO:K06087]
101072119  claudin-17 [KO:K06087]
101074865  cldn3a; claudin-3 [KO:K06087]
101074127  claudin-3 [KO:K06087]
101074352  cldn5c; claudin-4 [KO:K06087]
101075086  claudin-4 [KO:K06087]
101075311  cldn27a; claudin-4 [KO:K06087]
101068982  cldn11b; claudin-11 [KO:K06087]
101073605  claudin-8 [KO:K06087]
101071893  cldn8d; claudin-8 [KO:K06087]
101066951  claudin-14 [KO:K06087]
101079463  cldn30d; claudin-4 [KO:K06087]
105417471  claudin-4 [KO:K06087]
101070141  cldn29a; claudin-like protein ZF-A89 [KO:K06087]
101070371  cldn29b; claudin-4 [KO:K06087]
101079915  claudin-4 [KO:K06087]
101070604  cldn30c; claudin-4 [KO:K06087]
101070831  cldn3d; claudin-4 [KO:K06087]
101071057  cldn3c; claudin-3 [KO:K06087]
101079688  claudin-4 isoform X1 [KO:K06087]
101078104  cldn7; claudin-7 [KO:K06087]
101067711  claudin-15 isoform X2 [KO:K06087]
101078420  cldn33c; putative claudin-24 [KO:K06087]
101064656  cldn5; claudin-5 [KO:K06087]
101065380  claudin-1 [KO:K06087]
101064208  claudin-18 [KO:K06087]
101066964  cldn33b; putative claudin-24 [KO:K06087]
101074604  cldn19; claudin-19 isoform X1 [KO:K06087]
101068555  claudin-15 [KO:K06087]
101075935  claudin-19 [KO:K06087]
101074608  cldn7b; claudin-7-A [KO:K06087]
101070637  claudin-9-like [KO:K06087]
105417191  claudin-9 [KO:K06087]
115248182  claudin-7-A-like [KO:K06087]
115246461  claudin-14-like [KO:K06087]
105416698  cldn12; claudin-12 [KO:K06087]
101061452  occludin-like isoform X1 [KO:K06088]
101066033  occludin-like [KO:K06088]
101071307  occludin [KO:K06088]
101068432  occludin-like [KO:K06088]
115247549  occludin-like [KO:K06088]
101074136  junctional adhesion molecule A [KO:K06089]
101074464  junctional adhesion molecule B-like [KO:K06735]
101066342  jam2; junctional adhesion molecule B isoform X1 [KO:K06735]
101068475  jam3; junctional adhesion molecule C [KO:K06785]
101063296  junctional adhesion molecule C-like [KO:K06785]
101071119  blood vessel epicardial substance [KO:K21108]
115248628  blood vessel epicardial substance-like [KO:K21108]
101073733  cell division control protein 42 homolog isoform X1 [KO:K04393]
101068145  cell division control protein 42 homolog [KO:K04393]
101067723  cell division control protein 42 homolog isoform X1 [KO:K04393]
101073683  partitioning defective 6 homolog gamma [KO:K06093]
101076234  pard6b; partitioning defective 6 homolog beta [KO:K06093]
105418538  partitioning defective 6 homolog alpha-like isoform X1 [KO:K06093]
101062525  MAGUK p55 subfamily member 5-A-like [KO:K06091]
101079240  mpp5; MAGUK p55 subfamily member 5 isoform X2 [KO:K06091]
101070435  mpp4; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
105419928  MAGUK p55 subfamily member 4-like isoform X1 [KO:K21109]
101070237  tight junction protein ZO-3 isoform X3 [KO:K06097]
101079719  patj; inaD-like protein isoform X1 [KO:K06092]
105419919  multiple PDZ domain protein-like isoform X1 [KO:K06095]
101078693  mpdz; LOW QUALITY PROTEIN: multiple PDZ domain protein [KO:K06095]
105419958  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
101080003  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
101079837  angiomotin-like [KO:K16819]
101063691  amotl2; angiomotin-like protein 2 [KO:K06104]
101065638  arhgap17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
101075514  rho GTPase-activating protein 17 isoform X1 [KO:K20638]
101063410  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101067160  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101073618  merlin-like [KO:K16684]
101065777  nf2; merlin isoform X1 [KO:K16684]
101077214  llgl1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
101061910  llgl2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
101063550  dlg1; disks large homolog 1 isoform X1 [KO:K12076]
101067056  discs large homolog 1-like protein isoform X4 [KO:K12076]
101068159  scrib; protein scribble homolog isoform X15 [KO:K16175]
101068850  ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101065017  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101075238  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
101064532  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
101068762  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X2 [KO:K04354]
101067566  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
101061085  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform-like [KO:K04354]
101071776  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
101064734  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform-like [KO:K04354]
101067082  pard3; partitioning defective 3 homolog isoform X5 [KO:K04237]
101079238  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
101072336  LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1-like [KO:K05731]
101073904  tight junction protein ZO-1-like isoform X1 [KO:K05701]
101069449  tight junction protein ZO-1-like isoform X1 [KO:K05701]
101072987  tjap1; tight junction-associated protein 1 [KO:K06105]
101064665  disks large homolog 2 isoform X11 [KO:K12075]
101070759  dlg3; disks large homolog 3 isoform X2 [KO:K21098]
101074061  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X4 [KO:K10591] [EC:2.3.2.26]
101075517  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X3 [KO:K13305] [EC:2.3.2.26]
101070816  cgn; cingulin isoform X1 [KO:K06102]
101075973  cingulin-like [KO:K06102]
101072934  cgnl1; cingulin-like protein 1 isoform X1 [KO:K21110]
101072555  cingulin-like protein 1 isoform X1 [KO:K21110]
101073609  arhgef2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
101075812  rho guanine nucleotide exchange factor 2-like [KO:K12791]
115251698  LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 2-like [KO:K12791]
101064166  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
101070117  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
101076147  transforming protein RhoA [KO:K04513]
101079239  gata4; transcription factor GATA-4 [KO:K09183]
101070683  MARVEL domain-containing protein 3 isoform X2 [KO:K21099]
101065028  uncharacterized protein LOC101065028 [KO:K21099]
115247210  uncharacterized protein LOC115247210 [KO:K21099]
101073575  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101070190  mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
101067839  mapk10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
101078548  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101077059  transcription factor AP-1 [KO:K04448]
101064806  jun; transcription factor AP-1 [KO:K04448]
492310  cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
101063081  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101078518  sympk; symplekin [KO:K06100]
101076907  pcna; proliferating cell nuclear antigen [KO:K04802]
101061278  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
101074842  receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
115246515  LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
100049631  runx1; runt-related transcription factor 1 [KO:K08367]
101062856  heat shock 70 kDa protein 4-like [KO:K09489]
101062258  hspa4; heat shock 70 kDa protein 4 [KO:K09489]
101067452  Na(+)/H(+) exchange regulatory cofactor NHE-RF1-like [KO:K13365]
101076548  slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X1 [KO:K13365]
101073621  radixin-like [KO:K08007]
101078436  ezrin-like [KO:K08007]
101072012  radixin [KO:K05762]
101062757  radixin-like [KO:K05762]
101068079  moesin-like isoform X2 [KO:K05763]
101079839  msn; moesin [KO:K05763]
101067313  protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
101073327  prkce; LOW QUALITY PROTEIN: protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
101069102  actin, cytoplasmic 3 [KO:K05692]
101073736  actb; actin, cytoplasmic 1 [KO:K05692]
101079312  actbb; actin, cytoplasmic 2 [KO:K05692]
101070235  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X9 [KO:K04851]
101066777  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
101071039  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
101061432  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101064650  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101065281  proto-oncogene tyrosine-protein kinase Src isoform X4 [KO:K05704] [EC:2.7.10.2]
101078636  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101064862  cttn; src substrate cortactin [KO:K06106]
101076067  src substrate cortactin-like isoform X1 [KO:K06106]
101062388  actr2; actin-related protein 2 [KO:K17260]
101079033  actin-related protein 2-like [KO:K17260]
101074914  actin-related protein 3-like [KO:K18584]
101066039  actin-related protein 3 [KO:K18584]
101079431  actin-related protein 2/3 complex subunit 1A-A-like [KO:K05757]
101078408  actin-related protein 2/3 complex subunit 1B-A [KO:K05757]
101078633  actin-related protein 2/3 complex subunit 1A [KO:K05757]
101067101  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
115250773  actin-related protein 2/3 complex subunit 2-like isoform X1 [KO:K05758]
101069177  arpc3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
101067348  actin-related protein 2/3 complex subunit 4 [KO:K05755]
101066900  actin-related protein 2/3 complex subunit 4 [KO:K05755]
101062581  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
101065032  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
101069762  whamm; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
101071646  wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
105417035  vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
101062854  vasodilator-stimulated phosphoprotein-like [KO:K06274]
101069822  cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
101067856  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101066292  cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
101062935  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101077332  rab13; ras-related protein Rab-13 [KO:K06109]
101061451  rho guanine nucleotide exchange factor 18-like isoform X1 [KO:K21066]
101061443  LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 18-like [KO:K21066]
101070472  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101068674  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101067715  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
101064268  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101071916  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like isoform X1 [KO:K10351]
101068824  epb41l4b; band 4.1-like protein 4B isoform X1 [KO:K21111]
101074528  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
101076074  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2 [KO:K07198] [EC:2.7.11.31]
101065197  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
101077063  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
101075190  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
101077896  prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
105416222  prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
101064981  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
101074638  prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
101070084  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
101071631  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
778025  myosin-10 [KO:K10352]
101069272  myh9; myosin-9 [KO:K10352]
777989  myh11; myosin-11 isoform X1 [KO:K10352]
101062147  myosin-10-like isoform X1 [KO:K10352]
101065564  myosin-10-like isoform X1 [KO:K10352]
777991  myosin-9 isoform X1 [KO:K10352]
101062528  myosin light polypeptide 6-like isoform X2 [KO:K12751]
101078789  myosin light polypeptide 6-like [KO:K12751]
101062217  myosin regulatory light polypeptide 9 [KO:K12755]
101069867  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
101079067  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
105417038  immunoglobulin superfamily member 5-like isoform X1 [KO:K06786]
105418293  immunoglobulin superfamily member 5-like [KO:K06786]
101064875  magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2 [KO:K05631]
101076482  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1-like isoform X1 [KO:K05631]
105417392  synpo; synaptopodin [KO:K21112]
101075286  alpha-actinin-1 isoform X3 [KO:K05699]
101078391  actn4; alpha-actinin-4 isoform X2 [KO:K05699]
101065881  micall2; MICAL-like protein 2 isoform X1 [KO:K21068]
101076978  MICAL-like protein 2 isoform X1 [KO:K21068]
101062202  rab8a; ras-related protein Rab-8A [KO:K07901]
101063247  ras-related protein Rab-8A-like [KO:K07901]
101062021  rab8b; ras-related protein Rab-8B [KO:K07902]
101064738  ras-related protein Rab-8B [KO:K07902]
101075836  rapgef6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
101064935  ras-related protein Rap-1A [KO:K04353]
101074250  ras-related protein Rap-1A [KO:K04353]
101061453  integrin beta-1-like [KO:K05719]
101067303  integrin beta-1-like [KO:K05719]
101078746  afadin-like [KO:K05702]
101063677  afdn; afadin [KO:K05702]
101076035  tight junction protein ZO-2-like isoform X5 [KO:K06098]
101077970  tight junction protein ZO-2 isoform X1 [KO:K06098]
101068626  rapgef2; rap guanine nucleotide exchange factor 2 isoform X2 [KO:K08018]
101074132  rap2c; ras-related protein Rap-2c [KO:K07839]
101065810  marveld2; MARVEL domain-containing protein 2 [KO:K17291]
101061678  MARVEL domain-containing protein 2-like [KO:K17291]
101071077  MARVEL domain-containing protein 2 [KO:K17291]
101061990  tubulin alpha chain-like isoform X1 [KO:K07374]
101067763  tubulin alpha-1C chain-like [KO:K07374]
101062460  tubulin alpha-8 chain-like [KO:K07374]
101061790  tubulin alpha-1A chain-like [KO:K07374]
101079025  tubulin alpha-1C chain-like [KO:K07374]
101062302  tubulin alpha-1C chain [KO:K07374]
101072310  tubulin alpha-1C chain-like [KO:K07374]
101074770  tubulin alpha chain-like [KO:K07374]
101063283  tubulin alpha chain [KO:K07374]
101067442  tubulin alpha chain-like [KO:K07374]
101067523  tubulin alpha chain [KO:K07374]
101079871  tubulin alpha chain-like [KO:K07374]
101074678  tubulin alpha chain-like [KO:K07374]
105418721  LOW QUALITY PROTEIN: tubulin alpha chain-like [KO:K07374]
101066234  LOW QUALITY PROTEIN: tubulin alpha chain [KO:K07374]
105419347  tubulin alpha chain-like [KO:K07374]
101072673  tubulin alpha-1B chain-like [KO:K07374]
115249092  tubulin alpha-1C chain-like [KO:K07374]
115249138  tubulin alpha-1C chain-like [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
tru04520  Adherens junction
tru04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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