KEGG   PATHWAY: umr04020
Entry
umr04020                    Pathway                                
Name
Calcium signaling pathway - Ursus maritimus (polar bear)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
umr04020  Calcium signaling pathway
umr04020

Other DBs
GO: 0019722
Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103674250  SLC8A3; LOW QUALITY PROTEIN: sodium/calcium exchanger 3 [KO:K05849]
103657216  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
103671551  SLC8A1; sodium/calcium exchanger 1 [KO:K05849]
103660077  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
103657738  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
103669556  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
103679703  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
103678244  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
103662000  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
103673502  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
103669201  ADORA2A; adenosine receptor A2a [KO:K04266]
103658552  ADORA2B; adenosine receptor A2b [KO:K04267]
121101313  ADRB1; beta-1 adrenergic receptor [KO:K04141]
103664828  ADRB2; beta-2 adrenergic receptor [KO:K04142]
121105642  ADRB3; beta-3 adrenergic receptor [KO:K04143]
103664469  DRD1; D(1A) dopamine receptor [KO:K04144]
103658352  DRD5; D(1B) dopamine receptor [KO:K05840]
103664466  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
103664829  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
103660931  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
121106397  5-hydroxytryptamine receptor 5B [KO:K04161]
103666599  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
103668075  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
103670935  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
103670936  neuroendocrine secretory protein 55 [KO:K04632]
103673377  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
103674675  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103679250  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103671685  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103679331  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
103673916  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
103661704  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103668547  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103662972  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
103682183  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
103663457  PLN; cardiac phospholamban [KO:K05852]
103662424  SLN; sarcolipin [KO:K22642]
103661782  CUNH4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
103665740  SMIM6; small integral membrane protein 6 isoform X2 [KO:K26468]
103657815  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X3 [KO:K05853] [EC:7.2.2.10]
103667123  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
103661275  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
103657114  sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X2 [KO:K23450]
103678004  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
103658448  STIM2; LOW QUALITY PROTEIN: stromal interaction molecule 2 [KO:K18196]
103661271  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
103670204  ORAI2; protein orai-2 [KO:K16057]
103657878  ORAI3; protein orai-3 isoform X2 [KO:K16058]
103675706  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
103674739  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
103667625  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
103657769  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
103682191  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
103675324  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
103672437  voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
103660890  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
103668755  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
103676370  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
103659968  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
103675310  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
103668590  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
103677769  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
103665926  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
103657232  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
103678631  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
103681771  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
103667126  P2RX1; P2X purinoceptor 1 [KO:K05215]
103678891  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
103666110  P2RX3; P2X purinoceptor 3 [KO:K05217]
103661274  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
103667128  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
103669295  P2RX6; LOW QUALITY PROTEIN: P2X purinoceptor 6 [KO:K05221]
103661168  P2RX7; P2X purinoceptor 7 [KO:K05220]
103661069  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
103662005  RYR2; ryanodine receptor 2 [KO:K04962]
103673560  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
103663525  TRDN; LOW QUALITY PROTEIN: triadin [KO:K23449]
103672048  CASQ1; calsequestrin-1 [KO:K23468]
103669415  CASQ2; calsequestrin-2 [KO:K23445]
103677467  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X4 [KO:K00476] [EC:1.14.11.16]
103675823  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
103677608  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
103669054  CHRM2; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M2 [KO:K04130]
103673285  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
103664794  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
103674534  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
103678133  AGTR1; type-1 angiotensin II receptor [KO:K04166]
103658004  EDNRA; endothelin-1 receptor [KO:K04197]
103659180  EDNRB; LOW QUALITY PROTEIN: endothelin receptor type B [KO:K04198]
103666935  GRM1; LOW QUALITY PROTEIN: metabotropic glutamate receptor 1 [KO:K04603]
103675379  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
103668130  GRPR; gastrin-releasing peptide receptor isoform X1 [KO:K04169]
103669552  HRH1; histamine H1 receptor [KO:K04149]
103662679  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
103677593  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
103679732  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
103671770  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
103660575  NTSR1; neurotensin receptor type 1 [KO:K04211]
121102387  OXTR; oxytocin receptor [KO:K04229]
103656824  AVPR1A; vasopressin V1a receptor [KO:K04226]
103671018  AVPR1B; vasopressin V1b receptor [KO:K04227]
103680475  LOW QUALITY PROTEIN: vasopressin V1b receptor-like [KO:K04227]
103680927  LOW QUALITY PROTEIN: vasopressin V1b receptor-like [KO:K04227]
103680928  vasopressin V1b receptor-like [KO:K04227]
121100309  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
103666496  PTAFR; platelet-activating factor receptor [KO:K04279]
121102528  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
103663132  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
103662981  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
103673646  BDKRB1; B1 bradykinin receptor [KO:K03915]
103669660  BDKRB2; B2 bradykinin receptor [KO:K03916]
103671430  TACR1; substance-P receptor [KO:K04222]
103668005  TACR2; substance-K receptor [KO:K04223]
103661824  TACR3; neuromedin-K receptor [KO:K04224]
121102573  TBXA2R; thromboxane A2 receptor [KO:K04264]
103661558  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
103669850  thyrotropin-releasing hormone receptor-like [KO:K04282]
103658385  CCKAR; cholecystokinin receptor type A [KO:K04194]
103681439  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
103667676  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
103663281  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
103681813  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
103663280  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
103681670  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
103661742  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
103671814  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
103670054  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103676520  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103662543  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
103658054  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
103663709  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103661850  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
103664645  FGF10; fibroblast growth factor 10 [KO:K04358]
103664292  FGF9; fibroblast growth factor 9 [KO:K04358]
103681372  FGF20; fibroblast growth factor 20 [KO:K04358]
103673325  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
103675746  FGF6; fibroblast growth factor 6 [KO:K04358]
103675826  FGF16; fibroblast growth factor 16 [KO:K04358]
103676724  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
103665349  FGF5; fibroblast growth factor 5 [KO:K04358]
103671137  FGF3; fibroblast growth factor 3 [KO:K04358]
103664781  FGF18; fibroblast growth factor 18 [KO:K04358]
103658995  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
121102598  FGF22; fibroblast growth factor 22 [KO:K04358]
121104719  FGF4; fibroblast growth factor 4 [KO:K04358]
103671138  FGF19; fibroblast growth factor 19 [KO:K22603]
103657101  FGF21; fibroblast growth factor 21 [KO:K22429]
103675745  FGF23; fibroblast growth factor 23 [KO:K22428]
103664148  VEGFA; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
103679547  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
103679375  VEGFC; vascular endothelial growth factor C [KO:K05449]
103668144  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
103669449  NGF; beta-nerve growth factor [KO:K02582]
103658669  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
103674817  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
103664851  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
103674660  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103661560  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
103656927  receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
103659965  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
103672737  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
103664600  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
103659146  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103657802  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
103676958  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103664454  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
103664410  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
103680018  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103672740  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
103667631  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
103660166  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
103676585  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103675092  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
103668071  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
103682206  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
103662760  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
103665878  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
103673552  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
103674425  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
103674426  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
103679549  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
121099746  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
103669754  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
103662093  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
103667971  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
103677800  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
103669597  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103665275  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103665553  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103658362  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
103661293  TPCN1; two pore calcium channel protein 1 [KO:K16896]
103671141  TPCN2; two pore calcium channel protein 2 [KO:K14077]
103681745  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
103662964  MCOLN2; mucolipin-2 isoform X3 [KO:K04993]
103662962  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
103657238  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
103665951  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
103668021  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
103663818  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
103667846  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
103677056  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
103656991  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
103681007  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
103677737  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
103666331  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
103668033  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
103675069  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
103669861  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
103670304  CALM1; calmodulin-1 isoform X1 [KO:K02183]
103682041  CALML6; calmodulin-like protein 6 [KO:K02183]
103676238  calmodulin [KO:K02183]
103676239  CALML3; calmodulin-like protein 3 [KO:K02183]
103671240  CALM2; calmodulin-2 [KO:K02183]
103679049  CALML4; calmodulin-like protein 4 isoform X3 [KO:K02183]
103657204  CALM3; calmodulin-3 [KO:K02183]
103657874  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
103670188  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
103668258  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
103673813  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
103680194  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
103665161  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103673818  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
103674343  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
103678824  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
103672536  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
103676294  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
103669575  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
103661761  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
103664598  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
103668027  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
103674683  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
103675811  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
103673318  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103677943  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103667825  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103678534  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
103671340  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
103664168  TFEB; transcription factor EB isoform X1 [KO:K15590]
103658473  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
103669832  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
103673717  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103679332  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
103661304  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
103667420  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
103660958  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
103658951  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
103659643  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
103675567  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
103675966  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
103669029  ITPKB; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
103661102  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
103673539  inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
103665907  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103668895  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
103672914  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
umr04010  MAPK signaling pathway
umr04070  Phosphatidylinositol signaling system
umr04210  Apoptosis
umr04720  Long-term potentiation
umr04730  Long-term depression
KO pathway
ko04020   
LinkDB

DBGET integrated database retrieval system