KEGG   PATHWAY: xma04145
Entry
xma04145                    Pathway                                
Name
Phagosome - Xiphophorus maculatus (southern platyfish)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
xma04145  Phagosome
xma04145

Other DBs
GO: 0045335
Organism
Xiphophorus maculatus (southern platyfish) [GN:xma]
Gene
102220953  vamp3; vesicle-associated membrane protein 3 [KO:K13505]
102233632  stx12; syntaxin-12 [KO:K13813]
102235669  stx7; syntaxin-7 [KO:K08488]
102218394  actin, cytoplasmic 2 [KO:K05692]
102222885  actb; actin, cytoplasmic 1 [KO:K05692]
102236460  coronin-1A-like [KO:K13882]
102223185  stx18; syntaxin-18 [KO:K08492]
102223038  vesicle-trafficking protein SEC22b [KO:K08517]
102229565  vesicle-trafficking protein SEC22b-B isoform X1 [KO:K08517]
102223722  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
102225479  LOW QUALITY PROTEIN: major histocompatibility complex class I-related gene protein-like [KO:K06751]
102233148  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
102230961  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
102228868  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102229128  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
102219761  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
102224240  HLA class I histocompatibility antigen, B-38 alpha chain-like isoform X1 [KO:K06751]
102221188  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
102220021  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102223985  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
102232511  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
102223409  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102223660  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102217443  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102224183  hereditary hemochromatosis protein-like [KO:K06751]
102223924  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111610621  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102224690  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
102219346  HLA class II histocompatibility antigen, DQ beta 2 chain-like precursor [KO:K06752]
102237122  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
102223319  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
102225334  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
102236725  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
102229989  H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752]
102225679  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
102236986  H-2 class II histocompatibility antigen, E-S beta chain isoform X1 [KO:K06752]
106700297  HLA class II histocompatibility antigen, DRB1-14 beta chain-like [KO:K06752]
102225594  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
102221989  ras-related protein Rab-5A [KO:K07887]
102233132  ras-related protein Rab-5A-like [KO:K07887]
102224939  ras-related protein Rab-5B-like isoform X2 [KO:K07888]
102225780  rab5c; ras-related protein Rab-5C [KO:K07889]
102231109  ras-related protein Rab-5C [KO:K07889]
102234691  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
102231703  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
102225844  transferrin receptor protein 1-like isoform X1 [KO:K06503]
102228337  tfrc; transferrin receptor protein 1 [KO:K06503]
102228811  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
102221550  atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
102233759  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
102217378  V-type proton ATPase subunit B, brain isoform [KO:K02147]
102233783  V-type proton ATPase subunit B, brain isoform [KO:K02147]
102223539  V-type proton ATPase subunit C 1-A-like [KO:K02148]
102220532  atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
102232436  V-type proton ATPase subunit C 1-B [KO:K02148]
102218369  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
102223352  V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
102220204  V-type proton ATPase subunit E 1-like [KO:K02150]
102233195  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
111609451  V-type proton ATPase subunit G 1-like [KO:K02152]
102219703  V-type proton ATPase subunit e 2 [KO:K02153]
102231567  V-type proton ATPase subunit e 2-like [KO:K02153]
102217135  atp6v0a2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
102231475  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
102226300  V-type proton ATPase 116 kDa subunit a isoform X3 [KO:K02154]
102227465  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
102235252  V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
102225589  atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
102231382  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
102236513  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
102230164  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
102219123  atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
102231626  V-type proton ATPase subunit S1-like [KO:K03662]
102218503  V-type proton ATPase subunit S1 [KO:K03662]
102221039  ras-related protein rab7-like isoform X1 [KO:K07897]
102230535  ras-related protein rab7 [KO:K07897]
102219790  ras-related protein rab7-like [KO:K07897]
102231506  RILP-like protein 1 [KO:K13883]
102224928  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
102220918  dync2h1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
102216642  cytoplasmic dynein 1 intermediate chain 2-like isoform X2 [KO:K10415]
102234260  cytoplasmic dynein 1 intermediate chain 2-like isoform X2 [KO:K10415]
102220424  dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X3 [KO:K10415]
102236636  cytoplasmic dynein 1 light intermediate chain 1-like [KO:K10416]
102231867  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X3 [KO:K10416]
102234423  tubulin alpha-1B chain [KO:K07374]
102223550  tubulin alpha chain [KO:K07374]
102224061  tubulin alpha chain-like [KO:K07374]
102217094  tubulin alpha-1A chain [KO:K07374]
102217348  tubulin alpha-1B chain-like isoform X2 [KO:K07374]
102226394  tubulin alpha chain-like [KO:K07374]
102218092  tubulin alpha-8 chain-like [KO:K07374]
102223804  tubulin alpha-1C chain-like [KO:K07374]
102223433  tuba4a; tubulin alpha-4A chain [KO:K07374]
102224440  tubulin alpha-1B chain-like [KO:K07374]
102221968  tubulin alpha-1C chain-like [KO:K07374]
102217235  tubulin alpha chain-like [KO:K07374]
102223894  tubulin alpha-1B chain-like [KO:K07374]
106700148  tubulin alpha-1B chain-like [KO:K07374]
102226042  tubulin beta chain-like isoform X1 [KO:K07375]
102217151  tubulin beta-4B chain-like isoform X2 [KO:K07375]
102231664  tubulin beta chain-like [KO:K07375]
102232796  tubulin beta chain [KO:K07375]
102228617  tubulin beta-4B chain-like [KO:K07375]
102229930  tubulin beta-4B chain-like [KO:K07375]
102226155  tubulin beta-4B chain-like [KO:K07375]
102230583  tubulin beta-4B chain isoform X1 [KO:K07375]
102237703  tubulin beta chain-like [KO:K07375]
102236594  tubulin beta-1 chain [KO:K07375]
102228734  tubb4b; tubulin beta-4B chain [KO:K07375]
111610383  tubulin beta chain-like [KO:K07375]
102230526  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
102237515  lamp2; lysosome-associated membrane glycoprotein 2 isoform X2 [KO:K06528]
102236259  lamp1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
102220346  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
102218174  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
102233853  nos1; nitric oxide synthase, brain isoform X2 [KO:K13240] [EC:1.14.13.39]
102237729  ctsl; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
102230347  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
102237609  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
102237985  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
102238247  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
102235885  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
102230330  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
102228108  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
102227331  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
102227074  protein transport protein Sec61 subunit alpha-like [KO:K10956]
102221758  sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
106699749  sec61g; protein transport protein Sec61 subunit gamma [KO:K07342]
102217160  tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
102218472  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
102236923  antigen peptide transporter 2-like isoform X2 [KO:K05654] [EC:7.4.2.14]
102217437  calreticulin-like [KO:K08057]
102220809  calreticulin-like [KO:K08057]
102223465  canx; calnexin [KO:K08054]
102220103  low affinity immunoglobulin gamma Fc region receptor III-like [KO:K06498]
111611255  uncharacterized protein LOC111611255 [KO:K06472]
111611193  Fc receptor-like B [KO:K06472]
111611195  Fc receptor-like protein 5 isoform X1 [KO:K06463]
111611614  Ig heavy chain Mem5-like [KO:K06856]
102236483  c1r; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
102236233  mannan-binding lectin serine protease 2-like [KO:K01330] [EC:3.4.21.41]
102225401  integrin alpha-D-like [KO:K06461]
102230682  integrin alpha-D-like [KO:K06461]
102225668  integrin alpha-M-like [KO:K06461]
102231373  integrin beta-2-like [KO:K06464]
102235663  complement C3-like [KO:K03990]
102230801  colec11; collectin-11 isoform X1 [KO:K10066]
102220583  colec12; collectin-12 [KO:K10062]
102228282  collectin-12-like [KO:K10062]
111610425  collectin-43-like isoform X1 [KO:K10068]
102222465  pulmonary surfactant-associated protein D-like [KO:K10068]
111610088  pulmonary surfactant-associated protein D-like [KO:K10068]
111610285  pulmonary surfactant-associated protein D-like [KO:K10068]
102223753  itgav; integrin alpha-V [KO:K06487]
102225347  itga2; integrin alpha-2 [KO:K06481]
102234716  integrin alpha-5-like [KO:K06484]
102222515  integrin alpha-5 [KO:K06484]
102223796  itgb1; integrin beta-1 isoform X2 [KO:K05719]
102221802  integrin beta-3 [KO:K06493]
102227385  itgb3; integrin beta-3 [KO:K06493]
102223398  itgb5; integrin beta-5 [KO:K06588]
102236898  thbs1; thrombospondin-1 [KO:K16857]
102222883  thrombospondin-1-like [KO:K16857]
102220992  thbs3; thrombospondin-3 [KO:K04659]
102228505  thrombospondin-2-like isoform X1 [KO:K04659]
102223797  thrombospondin-4-B-like [KO:K04659]
102223727  thrombospondin-4-B isoform X1 [KO:K04659]
102231215  thbs2; thrombospondin-2 isoform X1 [KO:K04659]
102232822  thrombospondin-4-like isoform X1 [KO:K04659]
102226787  toll-like receptor 2 type-2 [KO:K10159]
102227045  toll-like receptor 2 type-1 [KO:K10159]
102230797  toll-like receptor 2 type-2 isoform X1 [KO:K10159]
102236905  pla2r1; secretory phospholipase A2 receptor isoform X3 [KO:K06560]
102226999  macrophage mannose receptor 1-like isoform X1 [KO:K06560]
102227252  macrophage mannose receptor 1-like [KO:K06560]
102219883  macrophage mannose receptor 1-like [KO:K06560]
102221105  mrc1; macrophage mannose receptor 1 [KO:K06560]
102219468  mrc2; C-type mannose receptor 2 [KO:K06560]
111608715  CD209 antigen-like protein E [KO:K06563]
102231894  marco; macrophage receptor MARCO [KO:K13884]
102223566  scarb1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
102229773  cd36; platelet glycoprotein 4 [KO:K06259]
102219145  cytochrome b-245 light chain [KO:K08009]
102232835  cytochrome b-245 heavy chain isoform X2 [KO:K21421] [EC:1.-.-.-]
102216748  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
102217008  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
102218748  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
102226330  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102217124  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
102233177  ncf1; neutrophil cytosol factor 1 [KO:K08011]
102222030  ncf2; neutrophil cytosol factor 2 [KO:K08010]
102235088  ncf4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
xma04142  Lysosome
xma04144  Endocytosis
xma04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
LinkDB

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