KEGG   NETWORK: N01086
Entry
N01086                      Network                                

Name
Escherichia EspT to RAC signaling pathway
Definition
EspT -> RAC1 -> (WASF2+ABI1) -> ARP2/3 -> (ACTB,ACTG1)
  Expanded
K23651 -> 5879 -> (10163+10006) -> (10097+10096+10552+10095+10109+10094+10093+10092+81873) -> (60,71)
Class
nt06135 Cytoskeletal regulation (viruses)
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
5879  RAC1; Rac family small GTPase 1
10163  WASF2; WASP family member 2
10006  ABI1; abl interactor 1
10097  ACTR2; actin related protein 2
10096  ACTR3; actin related protein 3
10552  ARPC1A; actin related protein 2/3 complex subunit 1A
10095  ARPC1B; actin related protein 2/3 complex subunit 1B
10109  ARPC2; actin related protein 2/3 complex subunit 2
10094  ARPC3; actin related protein 2/3 complex subunit 3
10093  ARPC4; actin related protein 2/3 complex subunit 4
10092  ARPC5; actin related protein 2/3 complex subunit 5
81873  ARPC5L; actin related protein 2/3 complex subunit 5 like
60  ACTB; actin beta
71  ACTG1; actin gamma 1
Perturbant
K23651 (EspT)  espT; T3SS secreted effector EspT
Reference
  Authors
Bulgin R, Arbeloa A, Goulding D, Dougan G, Crepin VF, Raymond B, Frankel G
  Title
The T3SS effector EspT defines a new category of invasive enteropathogenic E. coli (EPEC) which form intracellular actin pedestals.
  Journal
PLoS Pathog 5:e1000683 (2009)
DOI:10.1371/journal.ppat.1000683
LinkDB

DBGET integrated database retrieval system