KEGG   Homo sapiens (human): 10552
Entry
10552             CDS       T01001                                 
Symbol
ARPC1A, Arc40, HEL-68, HEL-S-307, SOP2Hs, SOP2L
Name
(RefSeq) actin-related protein 2/3 complex subunit 1A isoform 1
  KO
K05757  actin related protein 2/3 complex, subunit 1A/1B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04144  Endocytosis
hsa04517  IgSF CAM signaling
hsa04519  Cadherin signaling
hsa04530  Tight junction
hsa04666  Fc gamma R-mediated phagosome formation
hsa04810  Regulation of actin cytoskeleton
hsa05100  Bacterial invasion of epithelial cells
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05135  Yersinia infection
Network
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06549  Cadherin signaling
  Element
N01066  ARNO-ARF-ACTB_G signaling pathway
N01067  Shigella IpgD to ARNO-ARF-ACTB_G signaling pathway
N01078  EGF-EGFR-Actin signaling pathway
N01079  Shigella IpaC to Actin signaling pathway
N01086  Escherichia EspT to RAC signaling pathway
N01092  Escherichia Eae/Tir to Actin signaling pathway
N01094  Escherichia Eae/Tir/TccP to Actin signaling pathway
N01096  Escherichia Map to CDC42 signaling pathway
N01128  Salmonella SopE to RAC signaling pathway
N01129  Salmonella SopB to ARNO-ARF-ACTB/G signaling pathway
N01287  Tight junction-Actin signaling pathway
N02004  clustered PCDH signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    10552 (ARPC1A)
   04519 Cadherin signaling
    10552 (ARPC1A)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    10552 (ARPC1A)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    10552 (ARPC1A)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    10552 (ARPC1A)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagosome formation
    10552 (ARPC1A)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    10552 (ARPC1A)
   05132 Salmonella infection
    10552 (ARPC1A)
   05131 Shigellosis
    10552 (ARPC1A)
   05135 Yersinia infection
    10552 (ARPC1A)
   05100 Bacterial invasion of epithelial cells
    10552 (ARPC1A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    10552 (ARPC1A)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10552 (ARPC1A)
Membrane trafficking [BR:hsa04131]
 Others
  Actin-binding proteins
   Arp2/3 complex
    10552 (ARPC1A)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Arp2/3 complex
     10552 (ARPC1A)
SSDB
Motif
Pfam: Beta-prop_THOC3 Beta-prop_EML_2 Beta-prop_IFT122_1st Beta-prop_WDR3_1st WD40 Beta-prop_WDR5 WD40_WDHD1_1st WD40_Prp19 WD40_CDC20-Fz Beta-prop_RIG_2nd Beta-prop_CAF1B_HIR1 ANAPC4_WD40 Beta-prop_WDR36-Utp21_2nd WDR55 Beta-prop_Aladin Beta-prop_WDR35_TULP_N Beta-prop_WDR3_2nd Beta-prop_IFT140_1st Beta-prop_WDR75_1st Beta-prop_WDR19_1st EIF3I Rax2 Beta-prop_HPS5 WD40_Gbeta Beta-prop_TEP1_2nd Beta-prop_EML Beta-prop_SPT8 Beta-prop_EIPR1 DUF7711
Other DBs
NCBI-GeneID: 10552
NCBI-ProteinID: NP_006400
OMIM: 604220
HGNC: 703
Ensembl: ENSP00000262942.5
UniProt: Q92747 V9HVZ6
Structure
LinkDB
Position
7:99325898..99366262
AA seq 370 aa
MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDW
APKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLI
SVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKP
ASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVS
TLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAM
ERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTL
ESSIQGLRIM
NT seq 1113 nt   +upstreamnt  +downstreamnt
atgtcactgcatcagtttttactagagccaatcacctgtcatgcctggaacagggatcgt
actcagattgccctcagtcccaataatcacgaagtgcacatctataagaagaacgggagc
cagtgggtgaaagctcatgaactcaaggagcacaacggacacatcacaggtattgactgg
gctcccaagagcgaccgcattgtcacttgtggggcagaccgcaatgcctatgtctggagt
cagaaagatggtgtttggaagccaaccctggtgatcctgagaattaatcgcgcagctact
tttgtgaagtggtcccccctagagaacaaatttgctgtgggaagtggagcacgactcatt
tctgtttgttactttgagtctgaaaatgactggtgggtgagcaagcacattaaaaagccg
attcgctccacagtcctcagcttggattggcatcccaacaacgttttgctggcagcagga
tcatgtgacttcaaatgcagagtgttttctgcctacattaaagaagtggatgaaaagcca
gccagcacgccctggggcagcaagatgccttttgggcagctgatgtcagagtttggtggc
agtggcactggtggctgggtccacggggtaagcttctctgccagtgggagccgcctggcc
tgggtcagccacgacagcaccgtgtctgttgctgatgcctcaaaaagtgtgcaggtctcg
actctgaagacagagttcctgccgctcctaagtgtgtcatttgtctcagagaacagcgtc
gtggctgctggccatgactgctgcccaatgctctttaactacgatgaccgcggctgcctg
accttcgtctccaagttagatattccaaaacagagcatccaacgcaacatgtctgccatg
gaacgcttccgcaacatggacaagagagccacaactgaggaccgcaacacggccttggag
acgctgcaccagaatagcatcactcaagtctctatttatgaggtggacaagcaagattgt
cgcaaattttgcactactggcatcgatggagccatgacaatttgggatttcaagaccctc
gagtcttccatccagggcctccggataatgtga

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