| Entry |
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| Gene name |
IRAK4, IPD1, IRAK-4, NY-REN-64, REN64
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| Definition |
(RefSeq) interleukin 1 receptor associated kinase 4
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| KO |
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| Organism |
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| Pathway |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04621 | NOD-like receptor signaling pathway |
| hsa05130 | Pathogenic Escherichia coli infection |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa05168 | Herpes simplex virus 1 infection |
| hsa05170 | Human immunodeficiency virus 1 infection |
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| Network |
nt06110 MAPK signaling (viruses) nt06121 TLR signaling (viruses and bacteria) nt06161 Human immunodeficiency virus type 1 (HIV-1) nt06162 Hepatitis B virus (HBV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06168 Herpes simplex virus 1 (HSV-1) nt06169 Measles virus (MV) nt06211 Other MAPK signaling nt06263 Hepatocellular carcinoma |
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| Element |
| N00186 | IL1-IL1R-p38 signaling pathway |
| N00188 | IL1-IL1R-JNK signaling pathway |
| N00435 | TLR2/4-NFKB signaling pathway |
| N00438 | TLR2/4-MAPK signaling pathway |
| N00549 | HBV HBeAg to TLR2/4-NFKB signaling pathway |
| N00556 | HBV HBe to TLR2/4-NFKB signaling pathway |
| N00557 | HBV HBe to TLR2/4-NFKB signaling pathway |
| N00561 | HSV ICP0 to TLR2/4-NFKB signaling pathway |
| N00690 | TLR7/9-IRF7 signaling pathway |
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| Disease |
| H00096 | Defects of toll-like receptor signaling |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
51135 (IRAK4)
04064 NF-kappa B signaling pathway
51135 (IRAK4)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
51135 (IRAK4)
04621 NOD-like receptor signaling pathway
51135 (IRAK4)
09156 Nervous system
04722 Neurotrophin signaling pathway
51135 (IRAK4)
09160 Human Diseases
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
51135 (IRAK4)
05132 Salmonella infection
51135 (IRAK4)
05135 Yersinia infection
51135 (IRAK4)
05133 Pertussis
51135 (IRAK4)
05152 Tuberculosis
51135 (IRAK4)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
51135 (IRAK4)
05162 Measles
51135 (IRAK4)
05164 Influenza A
51135 (IRAK4)
05161 Hepatitis B
51135 (IRAK4)
05168 Herpes simplex virus 1 infection
51135 (IRAK4)
05169 Epstein-Barr virus infection
51135 (IRAK4)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
51135 (IRAK4)
05140 Leishmaniasis
51135 (IRAK4)
05142 Chagas disease (American trypanosomiasis)
51135 (IRAK4)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
51135 (IRAK4)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
51135 (IRAK4)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: TKL group
IRAK family
51135 (IRAK4)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Structure |
PDB: |
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| Position |
12q12
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| AA seq |
460 aa  
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS |
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| NT seq |
1383 nt  +upstreamnt +downstreamnt
atgaacaaacccataacaccatcaacatatgtgcgctgcctcaatgttggactaattagg
aagctgtcagattttattgatcctcaagaaggatggaagaagttagctgtagctattaaa
aaaccatctggtgatgatagatacaatcagtttcacataaggagatttgaagcattactt
caaactggaaaaagtcccacttctgaattactgtttgactggggcaccacaaattgcaca
gttggtgatcttgtggatcttttgatccaaaatgaattttttgctcctgcgagtcttttg
ctcccagatgctgttcccaaaactgctaatacactaccttctaaagaagctataacagtt
cagcaaaaacagatgcctttctgtgacaaagacaggacattgatgacacctgtgcagaat
cttgaacaaagctatatgccacctgactcctcaagtccagaaaataaaagtttagaagtt
agtgatacacgttttcacagtttttcattttatgaattgaagaatgtcacaaataacttt
gatgaacgacccatttctgttggtggtaataaaatgggagagggaggatttggagttgta
tataaaggctacgtaaataacacaactgtggcagtgaagaagcttgcagcaatggttgac
attactactgaagaactgaaacagcagtttgatcaagaaataaaagtaatggcaaagtgt
caacatgaaaacttagtagaactacttggtttctcaagtgatggagatgacctctgctta
gtatatgtttacatgcctaatggttcattgctagacagactctcttgcttggatggtact
ccaccactttcttggcacatgagatgcaagattgctcagggtgcagctaatggcatcaat
tttctacatgaaaatcatcatattcatagagatattaaaagtgcaaatatcttactggat
gaagcttttactgctaaaatatctgactttggccttgcacgggcttctgagaagtttgcc
cagacagtcatgactagcagaattgtgggaacaacagcttatatggcaccagaagctttg
cgtggagaaataacacccaaatctgatatttacagctttggtgtggttttactagaaata
ataactggacttccagctgtggatgaacaccgtgaacctcagttattgctagatattaaa
gaagaaattgaagatgaagaaaagacaattgaagattatattgataaaaagatgaatgat
gctgattccacttcagttgaagctatgtactctgttgctagtcaatgtctgcatgaaaag
aaaaataagagaccagacattaagaaggttcaacagctgctgcaagagatgacagcttct
taa |
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