KEGG   NETWORK: N00438
Entry
N00438                      Network                                
Name
TLR2/4-MAPK signaling pathway
Definition
(TLR2,TLR4) -> (TIRAP+MYD88) -> (IRAK4+IRAK1) -> (TRAF6+TAK1+TAB2) -> (MEK,MKK3/6,MKK4/7) -> (ERK,p38,JNK) -> AP1
  Expanded
(7097,7099) -> (114609+4615) -> (51135+3654) -> (7189+6885+23118) -> (5604,5605,5606,5608,6416,5609) -> (5594,5595,1432,5600,5603,6300,5599,5601,5602) -> (2353,3725)
Class
nt06517 TLR signaling
nt06263 Hepatocellular carcinoma
nt06161 Human immunodeficiency virus 1 (HIV-1)
nt06162 Hepatitis B virus (HBV)
nt06180 Pathogenic Escherichia coli
nt06182 Shigella
nt06183 Yersinia
Type
Reference
Pathway
hsa04620  Toll-like receptor signaling pathway
Gene
7097  TLR2; toll like receptor 2
7099  TLR4; toll like receptor 4
114609  TIRAP; TIR domain containing adaptor protein
4615  MYD88; MYD88, innate immune signal transduction adaptor
51135  IRAK4; interleukin 1 receptor associated kinase 4
3654  IRAK1; interleukin 1 receptor associated kinase 1
7189  TRAF6; TNF receptor associated factor 6
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5606  MAP2K3; mitogen-activated protein kinase kinase 3
5608  MAP2K6; mitogen-activated protein kinase kinase 6
6416  MAP2K4; mitogen-activated protein kinase kinase 4
5609  MAP2K7; mitogen-activated protein kinase kinase 7
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
1432  MAPK14; mitogen-activated protein kinase 14
5600  MAPK11; mitogen-activated protein kinase 11
5603  MAPK13; mitogen-activated protein kinase 13
6300  MAPK12; mitogen-activated protein kinase 12
5599  MAPK8; mitogen-activated protein kinase 8
5601  MAPK9; mitogen-activated protein kinase 9
5602  MAPK10; mitogen-activated protein kinase 10
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit
Reference
PMID:15928677
  Authors
Liew FY, Xu D, Brint EK, O'Neill LA
  Title
Negative regulation of toll-like receptor-mediated immune responses.
  Journal
Nat Rev Immunol 5:446-58 (2005)
DOI:10.1038/nri1630
Reference
PMID:23983209
  Authors
Bernard NJ, O'Neill LA
  Title
Mal, more than a bridge to MyD88.
  Journal
IUBMB Life 65:777-86 (2013)
DOI:10.1002/iub.1201
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